Purpose-This study aims to research the large cross-section tunnel stability evaluation method corrected after considering the thickness-span ratio.Design/methodology/approach-First,taking the Liuyuan Tunnel of Huangg...Purpose-This study aims to research the large cross-section tunnel stability evaluation method corrected after considering the thickness-span ratio.Design/methodology/approach-First,taking the Liuyuan Tunnel of Huanggang-Huangmei High-Speed Railway as an example and taking deflection of the third principal stress of the surrounding rock at a vault after tunnel excavation as the criterion,the critical buried depth of the large section tunnel was determined.Then,the strength reduction method was employed to calculate the tunnel safety factor under different rock classes and thickness-span ratios,and mathematical statistics was conducted to identify the relationships of the tunnel safety factor with the thickness-span ratio and the basic quality(BQ)index of the rock for different rock classes.Finally,the influences of thickness-span ratio,groundwater,initial stress of rock and structural attitude factors were considered to obtain the corrected BQ,based on which the stability of a large cross-section tunnel with a depth of more than 100 m during mechanized operation was analyzed.This evaluation method was then applied to Liuyuan Tunnel and Cimushan No.2 Tunnel of Chongqing Urban Expressway for verification.Findings-This study shows that under different rock classes,the tunnel safety factor is a strict power function of the thickness-span ratio,while a linear function of the BQ to some extent.It is more suitable to use the corrected BQ as a quantitative index to evaluate tunnel stability according to the actual conditions of the site.Originality/value-The existing industry standards do not consider the influence of buried depth and span in the evaluation of tunnel stability.The stability evaluation method of large section tunnel considering the correction of overburden span ratio proposed in this paper achieves higher accuracy for the stability evaluation of surrounding rock in a full or large-section mechanized excavation of double line high-speed railway tunnels.展开更多
Background:Large language models(LLMs)have shown considerable promise in supporting clinical decision-making.However,their adoption and evaluation in dermatology remains limited.This study aimed to explore the prefere...Background:Large language models(LLMs)have shown considerable promise in supporting clinical decision-making.However,their adoption and evaluation in dermatology remains limited.This study aimed to explore the preferences of Chinese dermatologists regarding LLM-generated responses in clinical psoriasis scenarios and to assess how they prioritize key quality dimensions,including accuracy,traceability,and logicality.Methods:A cross-sectional,web-based survey was conducted between December 25,2024,and January 22,2025,following the Checklist for Reporting Results of Internet E-Surveys guidelines.A total of 1247 valid responses were collected from practicing dermatologists across 33 of China's provincial-level administrative divisions.Participants evaluated responses to five categories of clinical questions(etiology,clinical presentation,differential diagnosis,treatment,and case study)generated by five LLMs:ChatGPT-4o,Kimi.ai,Doubao,ZuoYiGPT,and Lingyi-agent.Statistical associations between participant characteristics and model preferences were examined using chi-square tests.Results:ChatGPT-4o(Model 1)emerged as the most preferred model across all clinical tasks,consistently receiving the highest number of votes in case study(n=740),clinical presentation(n=666),differential diagnosis(n=707),etiology(n=602),and treatment(n=656).Significant variation in model preference by professional title was observed only for the differential diagnosis task(χ^(2)=21.13,df=12,p=0.0485),while no significant differences were found across hospital tiers(p>0.05).In terms of evaluation dimensions,accuracy was most frequently rated as“very important”(n=635).A significant association existed between hospital tier and the most valued dimension(χ^(2)=27.667,df=9,p=0.0011),with dermatologists in primary hospitals prioritizing traceability more than their peers in higher-tier hospitals.No significant associations were found across professional titles(p=0.127).Conclusions:Chinese dermatologists suggest a strong preference for ChatGPT-4o over domestic LLMs in psoriasis-related clinical tasks.While accuracy remains the primary criterion,traceability and logicality are also critical,particularly for clinicians in lower-tier hospitals.These findings suggest that future clinical LLMs should prioritize not only content accuracy but also source transparency and structural clarity to meet the diverse needs of different clinical settings.展开更多
To study the mechanical responses of large cross-section tunnel reinforced by pretensioned rock bolts and anchor cables, an analytical model is proposed. Considering the interaction between rock mass and bolt-cable su...To study the mechanical responses of large cross-section tunnel reinforced by pretensioned rock bolts and anchor cables, an analytical model is proposed. Considering the interaction between rock mass and bolt-cable support, the strain softening characteristic of rock mass, the elastic-plastic characteristic of bolt-cable support, and the delay effect of installation are considered in the model. To solve the different mechanical cases of tunneling reinforced by bolt-cable support, an analytical approach has been put forward to get the solutions of stress and displacement associated with tunneling. The proposed analytical model is verified by numerical simulation. Moreover, parametric analysis is performed to study the effects of pretension force,cross-section area, length, and supporting density of bolt-cable support on tunnel reinforcement, which can provide references for determining these parameters in tunnel design. Based on the analytical model, a new Ground Response Curve(GRC)considering the reinforcement of bolt-cable support is obtained, which shows the pretension forces and the timely installation are important in bolt-cable support. In addition, the proposed model is applied to the analysis of the Great Wall Station Tunnel, a high-speed railway tunnel with a super large cross-section, which shows that the analytical model of bolt-cable support was a useful tool for preliminary design of large cross-section tunnel.展开更多
Over the past decades, low-energy electron accelerators have been used worldwide for surface curing and sterilization. The beam nonuniformity is an important parameter of the low-energy electron beam with large cross-...Over the past decades, low-energy electron accelerators have been used worldwide for surface curing and sterilization. The beam nonuniformity is an important parameter of the low-energy electron beam with large cross-sections. A simple and accurate measurement system of nonuniformity for the low-energy electron beam with large cross-sections was developed. The main concept consists in the measurement of nonuniformity, which is realized by using a linear actuator to drive two scanning wires through the beam's cross-sections at a fixed speed. The beam distribution can be obtained by sending/collecting the current signals to/from the Data Acquisition (DAQ) software on a laptop by a USB DAQ card. This device is very convenient for the performance testing of a new accelerator at the manufacturer's site. The distribution of the homemade low voltage electron accelerator EBS-300-50 was measured and evaluated.展开更多
In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random vari...In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random variables,and another is for sub-orthogonal random variables.Both extend the strong law of large numbers for independent random variables under sublinear expectations to the non-independent case.展开更多
Model evaluation using benchmark datasets is an important method to measure the capability of large language models(LLMs)in specific domains,and it is mainly used to assess the knowledge and reasoning abilities of LLM...Model evaluation using benchmark datasets is an important method to measure the capability of large language models(LLMs)in specific domains,and it is mainly used to assess the knowledge and reasoning abilities of LLMs.Therefore,in order to better assess the capability of LLMs in the agricultural domain,Agri-Eval was proposed as a benchmark for assessing the knowledge and reasoning ability of LLMs in agriculture.The assessment dataset used in Agri-Eval covered seven major disciplines in the agricultural domain:crop science,horticulture,plant protection,animal husbandry,forest science,aquaculture science,and grass science,and contained a total of 2283 questions.Among domestic general-purpose LLMs,DeepSeek R1 performed best with an accuracy rate of 75.49%.In the realm of international general-purpose LLMs,Gemini 2.0 pro exp 0205 standed out as the top performer,achieving an accuracy rate of 74.28%.As an LLMs in agriculture vertical,Shennong V2.0 outperformed all the LLMs in China,and the answer accuracy rate of agricultural knowledge exceeded that of all the existing general-purpose LLMs.The launch of Agri-Eval helped the LLM developers to comprehensively evaluate the model's capability in the field of agriculture through a variety of tasks and tests to promote the development of the LLMs in the field of agriculture.展开更多
Objective:To assess prenatal Bisphenol A(BPA)exposure levels and explore their preliminary associations with maternal and fetal characteristics in a population from Northeastern Yunnan.Methods:A cross-sectional analys...Objective:To assess prenatal Bisphenol A(BPA)exposure levels and explore their preliminary associations with maternal and fetal characteristics in a population from Northeastern Yunnan.Methods:A cross-sectional analysis was performed using data and urine samples from 70 pregnant women in their third trimester recruited at Qujing Central Hospital.Urinary BPA was measured by HPLC-MS/MS.Participants were stratified into high and low BPA exposure groups based on the median concentration.Results:BPA was detected in all samples(100%)with a median concentration of 2.41μg/L(IQR:0.68-4.96).The high BPA exposure group(≥2.41μg/L)had a significantly higher proportion of gestational diabetes mellitus(GDM)(42.9%vs.17.1%,p=0.021)and a lower median fetal birth weight(3250 g vs.3450 g,p=0.048)compared to the low exposure group.Conclusion:This pilot study reveals ubiquitous BPA exposure in pregnant women from Northeastern Yunnan.The observed preliminary associations with GDM and reduced fetal birth weight warrant further investigation in larger,longitudinal studies.展开更多
Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentrat...Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentration,and forming defects are prone to occur during their extrusion.This study focuses on an Al-Zn-Mg-Cu ultra-high-strength aluminum alloy profile with a double-U,multi-cavity thin-walled structure.Firstly,hot compression experiments were conducted at temperatures of 350○C,400○C,and 450○C,with strain rates of 0.01 and 1.0 s^(−1),to investigate the plastic deformation behavior of the material.Subsequently,a 3D coupled thermo-mechanical extrusion simulation model was established using Deform-3D to systematically analyze the influence of die structure and process parameters on metal flow velocity,effective stress/strain,and temperature distribution.The simulation revealed significant velocity differences,stress concentration,and uneven temperature distribution.Key parameters,including mesh density,extrusion ratio,die fillet,and bearing length,were optimized through full-factorial experiments.This optimization,combined with a stepped flow-guiding die design,effectively improved the metal flow pattern during extrusion.Trial production based on both the initial and optimized parameters were carried out.A comparative analysis demonstrates that the optimized scheme results in a final profile whose cross-section matches the target design closely,with complete filling of complex features and no obvious forming defects.This research provides a valuable reference for the extrusion process optimization and die design of complex-section profiles made from ultra-high-strength aluminum alloys.展开更多
To the Editor,Artificial intelligence(AI)usage has been increasing.Many fields have implemented the use of AI and Large LanguageModels(LLMs),especially in medicine.Furthermore,manypatients have increasingly been using...To the Editor,Artificial intelligence(AI)usage has been increasing.Many fields have implemented the use of AI and Large LanguageModels(LLMs),especially in medicine.Furthermore,manypatients have increasingly been using AI;often,they will prompt AI with questions before even stepping into a physi-cian's office.The question lies in whether the information produced by AI is reliable and if this information is concise and easy to read across all patient populations.展开更多
This study evaluated the accuracy,completeness,and comprehensibility of responses from mainstream large language models(LLMs)to hepatitis C virus(HCV)-related questions,aiming to assess their performance in addressing...This study evaluated the accuracy,completeness,and comprehensibility of responses from mainstream large language models(LLMs)to hepatitis C virus(HCV)-related questions,aiming to assess their performance in addressing patient queries about disease and lifestyle behaviors.The models selected were ChatGPT-4o,Gemini 2.0 Pro,Claude 3.5 Sonnet,and DeepSeek V3,with 12 questions chosen by two HCV experts from the domains of prevention,diagnosis,and treatment.展开更多
Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Fa...Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Factors Surveillance)conducted between 2010 and 2018,a total of 645,420 adult participants(97,741 in 2010;175,749 in 2013;187,777 in 2015;and 184,153 in 2018)were included in the trend analysis.Linear and logistic regression models were utilized to assess trends in sleep duration.Results In 2018,the estimated overall mean sleep duration among the Chinese adult population was7.58(SD,1.45)hours per day,with no significant trend from 2010.A significant increase in short sleep duration(≤6 hours)was observed in the total population,from 15.3%(95%CI:14.1%–16.5%)in 2010 to18.5%(95%CI:17.7%–19.3%)in 2018(P<0.001).Similarly,the trend in long sleep duration(>9 hours)was also significant,increasing in weighted prevalence from 7.2%(95%CI:6.3%–8.1%)in 2010 to 9.0%(95%CI:8.2%–9.9%)in 2018(P<0.001).Conclusion The prevalence of both short and long sleep durations significantly increased among Chinese adults from 2010 to 2018,highlighting the urgency of health initiatives to promote optimal sleep duration in China.展开更多
It is known that correlation does not imply causality.Some relationships identified in the analysis of data are coincidental or unknown,and some are produced by real-world causality of the situation,which is problemat...It is known that correlation does not imply causality.Some relationships identified in the analysis of data are coincidental or unknown,and some are produced by real-world causality of the situation,which is problematic,since there is a need to differentiate between these two scenarios.Until recently,the proper−semantic−causality of the relationship could have been determined only by human experts from the area of expertise of the studied data.This has changed with the advance of large language models,which are often utilized as surrogates for such human experts,making the process automated and readily available to all data analysts.This motivates the main objective of this work,which is to introduce the design and implementation of a large language model-based semantic causality evaluator based on correlation analysis,together with its visual analysis model called Causal heatmap.After the implementation itself,the model is evaluated from the point of view of the quality of the visual model,from the point of view of the quality of causal evaluation based on large language models,and from the point of view of comparative analysis,while the results reached in the study highlight the usability of large language models in the task and the potential of the proposed approach in the analysis of unknown datasets.The results of the experimental evaluation demonstrate the usefulness of the Causal heatmap method,supported by the evident highlighting of interesting relationships,while suppressing irrelevant ones.展开更多
Large language models(LLMs)show considerable potential to revolutionize healthcare through their performance across diverse clinical applications.Given the inherent constraints of LLMs and the critical nature of medic...Large language models(LLMs)show considerable potential to revolutionize healthcare through their performance across diverse clinical applications.Given the inherent constraints of LLMs and the critical nature of medical practice,a rigorous and systematic evaluation of their medical competence is imperative.This study presents a comprehensive review of the established methodologies and benchmarks for evaluating the medical competence of LLMs,encompassing a thorough analysis of current assessment practices across medical knowledge,clinical practice competence,and ethical-safety considerations.By integrating clinician competency assessment frameworks into LLMs evaluation,we propose a structured tri-dimensional framework that systematically organizes existing evaluation approaches according to medical theoretical knowledge,clinical practice ability,and ethical-safety considerations.Furthermore,this research provides critical insights into future developmental trajectories while establishing foundational frameworks and standardization protocols for the integration of LLMs into medical practice.展开更多
Background:Despite the promise shown by large language models(LLMs)for standardized tasks,their multidimensional performance in real-world oncology decision-making remains unevaluated.This study aims to introduce a fr...Background:Despite the promise shown by large language models(LLMs)for standardized tasks,their multidimensional performance in real-world oncology decision-making remains unevaluated.This study aims to introduce a framework for evaluating LLMs and physician decisions in challenging lung cancer cases.Methods:We curated 50 challenging lung cancer cases(25 local and 25 published)classified as complex,rare,or refractory.Blinded three-dimensional,five-point Likert evaluations(1–5 for comprehensiveness,specificity,and readability)compared standalone LLMs(DeepSeek R1,Claude 3.5,Gemini 1.5,and GPT-4o),physicians by experience level(junior,intermediate,and senior),and AI-assisted juniors;intergroup differences and augmentation effects were analyzed statistically.Results:Of 50 challenging cases(18 complex,17 rare,and 15 refractory)rated by three experts,DeepSeek R1 achieved scores of 3.95±0.33,3.71±0.53,and 4.26±0.18 for comprehensiveness,specificity,and readability,respectively,positioning it between intermediate(3.68,3.68,3.75)and senior(4.50,4.64,4.53)physicians.GPT-4o and Claude 3.5 reached intermediate physician–level comprehensiveness(3.76±0.39,3.60±0.39)but junior-to-intermediate physician–level specificity(3.39±0.39,3.39±0.49).All LLMs scored higher on rare cases than intermediate physicians but fell below junior physicians in refractory-case specificity.AIassisted junior physicians showed marked gains in rare cases,with comprehensiveness rising from 2.32 to 4.29(84.8%),specificity from 2.24 to 4.26(90.8%),and readability from 2.76 to 4.59(66.0%),while specificity declined by 3.2%(3.17 to 3.07)in refractory cases.Error analysis showed complementary strengths,with physicians demonstrating reasoning stability and LLMs excelling in knowledge updating and risk management.Conclusions:LLMs performed variably in clinical decision-making tasks depending on case type,performing better in rare cases and worse in refractory cases requiring longitudinal reasoning.Complementary strengths between LLMs and physicians support case-and task-tailored human–AI collaboration.展开更多
Polyfluoroalkyl substances(PFAS)have emerged as persistent environmental contaminants because of their chemical stability,degradation-resistance and bioaccumulation potential.However,current studies mainly focus on th...Polyfluoroalkyl substances(PFAS)have emerged as persistent environmental contaminants because of their chemical stability,degradation-resistance and bioaccumulation potential.However,current studies mainly focus on the toxicity of single PFAS such as perfluorooctanoic acid(PFOA)and perfluorobutanoic acid(PFBA),the knowledge of their combined effects is relatively limited.In this study,we explored the immune response of the gut in large yellow croaker(Larimichthys crocea)under the combined stress of PFOA and PFBA.Histologicalanalyses revealed that the combined effect induced intestinal vacuolization and decreased the length of intestinal villi.And it significantly activated pro-inflammatory pathways with marked upregulation of tnfα,il1β,il6 and myd88 expressions,particularly after 14 days of exposure.Gut microbiota analysis revealed substantial dysbiosis,including 1)reduced alpha diversity,2)increased abundance of potential pathogenic taxa(Proteobacteria and Spirochaetota),and 3)depletion of beneficial Firmicutes.PICRUSt-based functional prediction indicated temporal metabolic shifts,with upregulation of DNA repair pathways at day 3 and enhanced bacterial motility protein activity at days 7 and 14 of post-exposure.The Pearson correlation analysis further indicated that these immune genes had significant positive correlations with Vibrio and Brevinema,and negative correlations with Streptococcus.Our present study will provide novel insights into the microbiome-mediated immunomodulation in the larger yellow croaker exposed to combined PFAS,which will be helpful for healthy farming of economically important marine species.展开更多
This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,Calcu...This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,CalculiX,and preCICE to simulate fluid-particle-structure interactions with large deformations.Mesh motion in the fluid field is handled using the radial basis function(RBF)method.The particle phase is modeled by MPPIC,where fluid-particle interaction is described through momentum exchange,and inter-particle collisions are characterized by collision stress.The structural field is solved by nonlinear FEM to capture large deformations induced by geometric nonlinearity.Coupling among fields is realized through a partitioned,parallel,and non-intrusive iterative strategy,ensuring stable transfer and convergence of interface forces and displacements.Notably,the influence of particles on the structure is not direct but mediated by the fluid,while structural motion directly affects particle dynamics.The results demonstrate that the proposed approach effectively captures multiphysics interaction processes and provides a valuable reference for numerical modeling of coupled fluid-particle-structure systems.展开更多
Electrochromic smart windows(ESWs)can significantly reduce building energy consumption,but the high cost hinders large-scale production.The in situ growth of tungsten oxide(WO_(3))films is only by a simple immersion p...Electrochromic smart windows(ESWs)can significantly reduce building energy consumption,but the high cost hinders large-scale production.The in situ growth of tungsten oxide(WO_(3))films is only by a simple immersion process,the silver nanowires(AgNWs)undergo oxidation to Ag^(+)ions through electron loss,and the liberated electrons provide driving force for the deposition of WO_(4)^(2-).Enabled the fabrication of large-area WO_(3)films and ESWs were fabricated under minimal laboratory conditions,demonstrating the economic feasibility,efficient and reliable nature of industrial production.Structural characterization and density functional theory calculations were combined to confirm that AgNWs effectively regulate oxygen vacancies of WO_(3)films and promote the in situ growth process.The optimized WO_(3)exhibits a maximum transmittance modulation of 90.8%and excellent cycling stability of 20,000 cycles.The largescale WO_(3)-based ESWs can save building energy up to 140.0 MJ m^(-2)compared to traditional windows in tropical regions,as verified by simulations more than40 global cities.This research provides a new approach for improving the performance and industrial production of ESW,providing the full understanding and development direction to short the distance of the ESW commercial production.展开更多
This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to use...This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to user behavior and platform-driven moderation on social media.The proposed methodological framework(1)utilizes large language models for social media post analysis and categorization,(2)employs k-means clustering for content characterization,and(3)incorporates the TODIM(Tomada de Decisão Interativa Multicritério)method to determine moderation strategies based on expert judgments.In general,the fully integrated framework leverages the strengths of these intelligent systems in a more systematic evaluation of large-scale decision problems.When applied in social media moderation,this approach promotes nuanced and context-sensitive self-moderation by taking into account factors such as cultural background and geographic location.The application of this framework is demonstrated within Facebook groups.Eight distinct content clusters encompassing safety,harassment,diversity,and misinformation are identified.Analysis revealed a preference for content removal across all clusters,suggesting a cautious approach towards potentially harmful content.However,the framework also highlights the use of other moderation actions,like account suspension,depending on the content category.These findings contribute to the growing body of research on self-moderation and offer valuable insights for creating safer and more inclusive online spaces within smaller communities.展开更多
In materials science and engineering design,high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation.To address longstanding bottlenecks in the deve...In materials science and engineering design,high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation.To address longstanding bottlenecks in the development of conventional material constitutive models—such as lengthy modeling cycles and difficulties in numerical implementation—this study proposes an intelligent modeling and code generation approach powered by large languagemodels.A structured knowledge base integrating constitutive theory,numerical algorithms,and UMAT(User Material)interface specifications is constructed,and a retrieval-augmented generation strategy is employed to establish an end-to-end workflow spanning experimental data parsing,constitutive model formulation,and automatic UMAT subroutine generation.Experimental results show that the method achieves high accuracy for both a classical Johnson–Cookmodel and a physics-informed neural network(PINN)model,with key parameter identification errors below 5%.Moreover,the automatically generated UMAT subroutines yield finite element simulation results in Abaqus that are highly consistent with theoretical predictions(coefficient of determination R2>0.98)while maintaining good numerical stability.This framework is currently focused on the automatic construction of rate-dependent elastoplastic material models,and its core method also provides a clear path for extending to other constitutive categories such as hyperelasticity and viscoelasticity.This work provides an effective technical route for the rapid development and reliable numerical implementation of material constitutive models,significantly advancing the intelligence level of computational mechanics research and improving engineering application efficiency.展开更多
Background:Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology—Head and Neck Surgery systematic literature reviews.Methods:Three PRISMA-based systematic reviews(Ja...Background:Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology—Head and Neck Surgery systematic literature reviews.Methods:Three PRISMA-based systematic reviews(Jabbour et al.2017,Wong et al.2018,and Wu et al.2021)were replicated using ChatGPTv3.5 and Bard.Outputs(author,title,publication year,and journal)were compared to the original references and cross-referenced with medical databases for authenticity and recall.Results:Several themes emerged when comparing Bard and ChatGPT across the three reviews.Bard generated more outputs and had greater recall in Wong et al.'s review,with a broader date range in Jabbour et al.'s review.In Wu et al.'s review,ChatGPT-2 had higher recall and identified more authentic outputs than Bard-2.Conclusion:Large language models(LLMs)failed to fully replicate peer-reviewed methodologies,producing outputs with inaccuracies but identifying relevant,especially recent,articles missed by the references.While human-led PRISMA-based reviews remain the gold standard,refining LLMs for literature reviews shows potential.展开更多
基金supported by the NSFC HSR Fundamental Research Joint Fund (Grant No.U1934213)。
文摘Purpose-This study aims to research the large cross-section tunnel stability evaluation method corrected after considering the thickness-span ratio.Design/methodology/approach-First,taking the Liuyuan Tunnel of Huanggang-Huangmei High-Speed Railway as an example and taking deflection of the third principal stress of the surrounding rock at a vault after tunnel excavation as the criterion,the critical buried depth of the large section tunnel was determined.Then,the strength reduction method was employed to calculate the tunnel safety factor under different rock classes and thickness-span ratios,and mathematical statistics was conducted to identify the relationships of the tunnel safety factor with the thickness-span ratio and the basic quality(BQ)index of the rock for different rock classes.Finally,the influences of thickness-span ratio,groundwater,initial stress of rock and structural attitude factors were considered to obtain the corrected BQ,based on which the stability of a large cross-section tunnel with a depth of more than 100 m during mechanized operation was analyzed.This evaluation method was then applied to Liuyuan Tunnel and Cimushan No.2 Tunnel of Chongqing Urban Expressway for verification.Findings-This study shows that under different rock classes,the tunnel safety factor is a strict power function of the thickness-span ratio,while a linear function of the BQ to some extent.It is more suitable to use the corrected BQ as a quantitative index to evaluate tunnel stability according to the actual conditions of the site.Originality/value-The existing industry standards do not consider the influence of buried depth and span in the evaluation of tunnel stability.The stability evaluation method of large section tunnel considering the correction of overburden span ratio proposed in this paper achieves higher accuracy for the stability evaluation of surrounding rock in a full or large-section mechanized excavation of double line high-speed railway tunnels.
基金National Key Research and Development Program of China,Grant/Award Number:2024YFF0507404Special Clinical Business Fund for High-Level Hospitals of China-Japan Friendship Hospital,Grant/Award Number:2024-NHLHCRF-TS-01。
文摘Background:Large language models(LLMs)have shown considerable promise in supporting clinical decision-making.However,their adoption and evaluation in dermatology remains limited.This study aimed to explore the preferences of Chinese dermatologists regarding LLM-generated responses in clinical psoriasis scenarios and to assess how they prioritize key quality dimensions,including accuracy,traceability,and logicality.Methods:A cross-sectional,web-based survey was conducted between December 25,2024,and January 22,2025,following the Checklist for Reporting Results of Internet E-Surveys guidelines.A total of 1247 valid responses were collected from practicing dermatologists across 33 of China's provincial-level administrative divisions.Participants evaluated responses to five categories of clinical questions(etiology,clinical presentation,differential diagnosis,treatment,and case study)generated by five LLMs:ChatGPT-4o,Kimi.ai,Doubao,ZuoYiGPT,and Lingyi-agent.Statistical associations between participant characteristics and model preferences were examined using chi-square tests.Results:ChatGPT-4o(Model 1)emerged as the most preferred model across all clinical tasks,consistently receiving the highest number of votes in case study(n=740),clinical presentation(n=666),differential diagnosis(n=707),etiology(n=602),and treatment(n=656).Significant variation in model preference by professional title was observed only for the differential diagnosis task(χ^(2)=21.13,df=12,p=0.0485),while no significant differences were found across hospital tiers(p>0.05).In terms of evaluation dimensions,accuracy was most frequently rated as“very important”(n=635).A significant association existed between hospital tier and the most valued dimension(χ^(2)=27.667,df=9,p=0.0011),with dermatologists in primary hospitals prioritizing traceability more than their peers in higher-tier hospitals.No significant associations were found across professional titles(p=0.127).Conclusions:Chinese dermatologists suggest a strong preference for ChatGPT-4o over domestic LLMs in psoriasis-related clinical tasks.While accuracy remains the primary criterion,traceability and logicality are also critical,particularly for clinicians in lower-tier hospitals.These findings suggest that future clinical LLMs should prioritize not only content accuracy but also source transparency and structural clarity to meet the diverse needs of different clinical settings.
基金supported by the National Key Research and Development Program of China (Grant No. 2017YFC0805401)the National Natural Science Foundation of China (Grant No. 51738002)+1 种基金the China Railway Corporation Research and Development Program of Science and Technology (Grant No. 2014004-C)the Fundamental Research Funds for the Central Universities (Grant No. C17JB00030)。
文摘To study the mechanical responses of large cross-section tunnel reinforced by pretensioned rock bolts and anchor cables, an analytical model is proposed. Considering the interaction between rock mass and bolt-cable support, the strain softening characteristic of rock mass, the elastic-plastic characteristic of bolt-cable support, and the delay effect of installation are considered in the model. To solve the different mechanical cases of tunneling reinforced by bolt-cable support, an analytical approach has been put forward to get the solutions of stress and displacement associated with tunneling. The proposed analytical model is verified by numerical simulation. Moreover, parametric analysis is performed to study the effects of pretension force,cross-section area, length, and supporting density of bolt-cable support on tunnel reinforcement, which can provide references for determining these parameters in tunnel design. Based on the analytical model, a new Ground Response Curve(GRC)considering the reinforcement of bolt-cable support is obtained, which shows the pretension forces and the timely installation are important in bolt-cable support. In addition, the proposed model is applied to the analysis of the Great Wall Station Tunnel, a high-speed railway tunnel with a super large cross-section, which shows that the analytical model of bolt-cable support was a useful tool for preliminary design of large cross-section tunnel.
文摘Over the past decades, low-energy electron accelerators have been used worldwide for surface curing and sterilization. The beam nonuniformity is an important parameter of the low-energy electron beam with large cross-sections. A simple and accurate measurement system of nonuniformity for the low-energy electron beam with large cross-sections was developed. The main concept consists in the measurement of nonuniformity, which is realized by using a linear actuator to drive two scanning wires through the beam's cross-sections at a fixed speed. The beam distribution can be obtained by sending/collecting the current signals to/from the Data Acquisition (DAQ) software on a laptop by a USB DAQ card. This device is very convenient for the performance testing of a new accelerator at the manufacturer's site. The distribution of the homemade low voltage electron accelerator EBS-300-50 was measured and evaluated.
文摘In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random variables,and another is for sub-orthogonal random variables.Both extend the strong law of large numbers for independent random variables under sublinear expectations to the non-independent case.
文摘Model evaluation using benchmark datasets is an important method to measure the capability of large language models(LLMs)in specific domains,and it is mainly used to assess the knowledge and reasoning abilities of LLMs.Therefore,in order to better assess the capability of LLMs in the agricultural domain,Agri-Eval was proposed as a benchmark for assessing the knowledge and reasoning ability of LLMs in agriculture.The assessment dataset used in Agri-Eval covered seven major disciplines in the agricultural domain:crop science,horticulture,plant protection,animal husbandry,forest science,aquaculture science,and grass science,and contained a total of 2283 questions.Among domestic general-purpose LLMs,DeepSeek R1 performed best with an accuracy rate of 75.49%.In the realm of international general-purpose LLMs,Gemini 2.0 pro exp 0205 standed out as the top performer,achieving an accuracy rate of 74.28%.As an LLMs in agriculture vertical,Shennong V2.0 outperformed all the LLMs in China,and the answer accuracy rate of agricultural knowledge exceeded that of all the existing general-purpose LLMs.The launch of Agri-Eval helped the LLM developers to comprehensively evaluate the model's capability in the field of agriculture through a variety of tasks and tests to promote the development of the LLMs in the field of agriculture.
文摘Objective:To assess prenatal Bisphenol A(BPA)exposure levels and explore their preliminary associations with maternal and fetal characteristics in a population from Northeastern Yunnan.Methods:A cross-sectional analysis was performed using data and urine samples from 70 pregnant women in their third trimester recruited at Qujing Central Hospital.Urinary BPA was measured by HPLC-MS/MS.Participants were stratified into high and low BPA exposure groups based on the median concentration.Results:BPA was detected in all samples(100%)with a median concentration of 2.41μg/L(IQR:0.68-4.96).The high BPA exposure group(≥2.41μg/L)had a significantly higher proportion of gestational diabetes mellitus(GDM)(42.9%vs.17.1%,p=0.021)and a lower median fetal birth weight(3250 g vs.3450 g,p=0.048)compared to the low exposure group.Conclusion:This pilot study reveals ubiquitous BPA exposure in pregnant women from Northeastern Yunnan.The observed preliminary associations with GDM and reduced fetal birth weight warrant further investigation in larger,longitudinal studies.
基金supported by the National Key Research and Development Program of China(Grant No.2023YFB3710805).
文摘Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentration,and forming defects are prone to occur during their extrusion.This study focuses on an Al-Zn-Mg-Cu ultra-high-strength aluminum alloy profile with a double-U,multi-cavity thin-walled structure.Firstly,hot compression experiments were conducted at temperatures of 350○C,400○C,and 450○C,with strain rates of 0.01 and 1.0 s^(−1),to investigate the plastic deformation behavior of the material.Subsequently,a 3D coupled thermo-mechanical extrusion simulation model was established using Deform-3D to systematically analyze the influence of die structure and process parameters on metal flow velocity,effective stress/strain,and temperature distribution.The simulation revealed significant velocity differences,stress concentration,and uneven temperature distribution.Key parameters,including mesh density,extrusion ratio,die fillet,and bearing length,were optimized through full-factorial experiments.This optimization,combined with a stepped flow-guiding die design,effectively improved the metal flow pattern during extrusion.Trial production based on both the initial and optimized parameters were carried out.A comparative analysis demonstrates that the optimized scheme results in a final profile whose cross-section matches the target design closely,with complete filling of complex features and no obvious forming defects.This research provides a valuable reference for the extrusion process optimization and die design of complex-section profiles made from ultra-high-strength aluminum alloys.
文摘To the Editor,Artificial intelligence(AI)usage has been increasing.Many fields have implemented the use of AI and Large LanguageModels(LLMs),especially in medicine.Furthermore,manypatients have increasingly been using AI;often,they will prompt AI with questions before even stepping into a physi-cian's office.The question lies in whether the information produced by AI is reliable and if this information is concise and easy to read across all patient populations.
基金funded by the National Key Research and Development Program of China(No.2021YFA1100500)the National Natural Science Foundation of China(No.82370662)the Key Research&Development Plan of Zhejiang Province(No.2024C03051).
文摘This study evaluated the accuracy,completeness,and comprehensibility of responses from mainstream large language models(LLMs)to hepatitis C virus(HCV)-related questions,aiming to assess their performance in addressing patient queries about disease and lifestyle behaviors.The models selected were ChatGPT-4o,Gemini 2.0 Pro,Claude 3.5 Sonnet,and DeepSeek V3,with 12 questions chosen by two HCV experts from the domains of prevention,diagnosis,and treatment.
基金supported by the National Natural Science Foundation of China(82341245,82371491)the Chinese Central Government(Key Project of Public Health Program)the National Key Research and Development Program of China(2018YFC1311706,2018YFC1311702)。
文摘Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Factors Surveillance)conducted between 2010 and 2018,a total of 645,420 adult participants(97,741 in 2010;175,749 in 2013;187,777 in 2015;and 184,153 in 2018)were included in the trend analysis.Linear and logistic regression models were utilized to assess trends in sleep duration.Results In 2018,the estimated overall mean sleep duration among the Chinese adult population was7.58(SD,1.45)hours per day,with no significant trend from 2010.A significant increase in short sleep duration(≤6 hours)was observed in the total population,from 15.3%(95%CI:14.1%–16.5%)in 2010 to18.5%(95%CI:17.7%–19.3%)in 2018(P<0.001).Similarly,the trend in long sleep duration(>9 hours)was also significant,increasing in weighted prevalence from 7.2%(95%CI:6.3%–8.1%)in 2010 to 9.0%(95%CI:8.2%–9.9%)in 2018(P<0.001).Conclusion The prevalence of both short and long sleep durations significantly increased among Chinese adults from 2010 to 2018,highlighting the urgency of health initiatives to promote optimal sleep duration in China.
基金supported by University Grant Agency of Matej Bel University in Banská Bystrica project number UGA-14-PDS-2025.
文摘It is known that correlation does not imply causality.Some relationships identified in the analysis of data are coincidental or unknown,and some are produced by real-world causality of the situation,which is problematic,since there is a need to differentiate between these two scenarios.Until recently,the proper−semantic−causality of the relationship could have been determined only by human experts from the area of expertise of the studied data.This has changed with the advance of large language models,which are often utilized as surrogates for such human experts,making the process automated and readily available to all data analysts.This motivates the main objective of this work,which is to introduce the design and implementation of a large language model-based semantic causality evaluator based on correlation analysis,together with its visual analysis model called Causal heatmap.After the implementation itself,the model is evaluated from the point of view of the quality of the visual model,from the point of view of the quality of causal evaluation based on large language models,and from the point of view of comparative analysis,while the results reached in the study highlight the usability of large language models in the task and the potential of the proposed approach in the analysis of unknown datasets.The results of the experimental evaluation demonstrate the usefulness of the Causal heatmap method,supported by the evident highlighting of interesting relationships,while suppressing irrelevant ones.
基金Guangzhou Science and Technology Program,Grant/Award Numbers:2025B03J0110,2024A03J1074,2024A03J0927。
文摘Large language models(LLMs)show considerable potential to revolutionize healthcare through their performance across diverse clinical applications.Given the inherent constraints of LLMs and the critical nature of medical practice,a rigorous and systematic evaluation of their medical competence is imperative.This study presents a comprehensive review of the established methodologies and benchmarks for evaluating the medical competence of LLMs,encompassing a thorough analysis of current assessment practices across medical knowledge,clinical practice competence,and ethical-safety considerations.By integrating clinician competency assessment frameworks into LLMs evaluation,we propose a structured tri-dimensional framework that systematically organizes existing evaluation approaches according to medical theoretical knowledge,clinical practice ability,and ethical-safety considerations.Furthermore,this research provides critical insights into future developmental trajectories while establishing foundational frameworks and standardization protocols for the integration of LLMs into medical practice.
文摘Background:Despite the promise shown by large language models(LLMs)for standardized tasks,their multidimensional performance in real-world oncology decision-making remains unevaluated.This study aims to introduce a framework for evaluating LLMs and physician decisions in challenging lung cancer cases.Methods:We curated 50 challenging lung cancer cases(25 local and 25 published)classified as complex,rare,or refractory.Blinded three-dimensional,five-point Likert evaluations(1–5 for comprehensiveness,specificity,and readability)compared standalone LLMs(DeepSeek R1,Claude 3.5,Gemini 1.5,and GPT-4o),physicians by experience level(junior,intermediate,and senior),and AI-assisted juniors;intergroup differences and augmentation effects were analyzed statistically.Results:Of 50 challenging cases(18 complex,17 rare,and 15 refractory)rated by three experts,DeepSeek R1 achieved scores of 3.95±0.33,3.71±0.53,and 4.26±0.18 for comprehensiveness,specificity,and readability,respectively,positioning it between intermediate(3.68,3.68,3.75)and senior(4.50,4.64,4.53)physicians.GPT-4o and Claude 3.5 reached intermediate physician–level comprehensiveness(3.76±0.39,3.60±0.39)but junior-to-intermediate physician–level specificity(3.39±0.39,3.39±0.49).All LLMs scored higher on rare cases than intermediate physicians but fell below junior physicians in refractory-case specificity.AIassisted junior physicians showed marked gains in rare cases,with comprehensiveness rising from 2.32 to 4.29(84.8%),specificity from 2.24 to 4.26(90.8%),and readability from 2.76 to 4.59(66.0%),while specificity declined by 3.2%(3.17 to 3.07)in refractory cases.Error analysis showed complementary strengths,with physicians demonstrating reasoning stability and LLMs excelling in knowledge updating and risk management.Conclusions:LLMs performed variably in clinical decision-making tasks depending on case type,performing better in rare cases and worse in refractory cases requiring longitudinal reasoning.Complementary strengths between LLMs and physicians support case-and task-tailored human–AI collaboration.
基金supported by the Ningbo Natural Science Foundation(Youth Foundation,No.2024J449)the Scientific Research Foundation for Introduced Talents of Ningbo University(Nos.ZX2022000602 and ZX2024000043)。
文摘Polyfluoroalkyl substances(PFAS)have emerged as persistent environmental contaminants because of their chemical stability,degradation-resistance and bioaccumulation potential.However,current studies mainly focus on the toxicity of single PFAS such as perfluorooctanoic acid(PFOA)and perfluorobutanoic acid(PFBA),the knowledge of their combined effects is relatively limited.In this study,we explored the immune response of the gut in large yellow croaker(Larimichthys crocea)under the combined stress of PFOA and PFBA.Histologicalanalyses revealed that the combined effect induced intestinal vacuolization and decreased the length of intestinal villi.And it significantly activated pro-inflammatory pathways with marked upregulation of tnfα,il1β,il6 and myd88 expressions,particularly after 14 days of exposure.Gut microbiota analysis revealed substantial dysbiosis,including 1)reduced alpha diversity,2)increased abundance of potential pathogenic taxa(Proteobacteria and Spirochaetota),and 3)depletion of beneficial Firmicutes.PICRUSt-based functional prediction indicated temporal metabolic shifts,with upregulation of DNA repair pathways at day 3 and enhanced bacterial motility protein activity at days 7 and 14 of post-exposure.The Pearson correlation analysis further indicated that these immune genes had significant positive correlations with Vibrio and Brevinema,and negative correlations with Streptococcus.Our present study will provide novel insights into the microbiome-mediated immunomodulation in the larger yellow croaker exposed to combined PFAS,which will be helpful for healthy farming of economically important marine species.
基金supported in part by the Mining Hydraulic Technology and Equipment Engineering Research Center,Liaoning Technical University,Fuxin,China(Grant No.MHTE23-R04)the Fundamental Research Funds for the Central Universities(ID N25BSS068).
文摘This study presents an implicit multiphysics coupling method integrating Computational Fluid Dynamics(CFD),the Multiphase Particle-in-Cell(MPPIC)model,and the Finite Element Method(FEM),implemented with OpenFOAM,CalculiX,and preCICE to simulate fluid-particle-structure interactions with large deformations.Mesh motion in the fluid field is handled using the radial basis function(RBF)method.The particle phase is modeled by MPPIC,where fluid-particle interaction is described through momentum exchange,and inter-particle collisions are characterized by collision stress.The structural field is solved by nonlinear FEM to capture large deformations induced by geometric nonlinearity.Coupling among fields is realized through a partitioned,parallel,and non-intrusive iterative strategy,ensuring stable transfer and convergence of interface forces and displacements.Notably,the influence of particles on the structure is not direct but mediated by the fluid,while structural motion directly affects particle dynamics.The results demonstrate that the proposed approach effectively captures multiphysics interaction processes and provides a valuable reference for numerical modeling of coupled fluid-particle-structure systems.
基金the National Natural Science Foundation of China(grant No.52163022,62305076)Sichuan Science and Technology Program(2024ZYD0196)+1 种基金China Postdoctoral Science Foundation(2023M740505)Sichuan Postdoctoral Science Special Foundation(No.TB2023010)。
文摘Electrochromic smart windows(ESWs)can significantly reduce building energy consumption,but the high cost hinders large-scale production.The in situ growth of tungsten oxide(WO_(3))films is only by a simple immersion process,the silver nanowires(AgNWs)undergo oxidation to Ag^(+)ions through electron loss,and the liberated electrons provide driving force for the deposition of WO_(4)^(2-).Enabled the fabrication of large-area WO_(3)films and ESWs were fabricated under minimal laboratory conditions,demonstrating the economic feasibility,efficient and reliable nature of industrial production.Structural characterization and density functional theory calculations were combined to confirm that AgNWs effectively regulate oxygen vacancies of WO_(3)films and promote the in situ growth process.The optimized WO_(3)exhibits a maximum transmittance modulation of 90.8%and excellent cycling stability of 20,000 cycles.The largescale WO_(3)-based ESWs can save building energy up to 140.0 MJ m^(-2)compared to traditional windows in tropical regions,as verified by simulations more than40 global cities.This research provides a new approach for improving the performance and industrial production of ESW,providing the full understanding and development direction to short the distance of the ESW commercial production.
基金funded by the Office of the Vice-President for Research and Development of Cebu Technological University.
文摘This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to user behavior and platform-driven moderation on social media.The proposed methodological framework(1)utilizes large language models for social media post analysis and categorization,(2)employs k-means clustering for content characterization,and(3)incorporates the TODIM(Tomada de Decisão Interativa Multicritério)method to determine moderation strategies based on expert judgments.In general,the fully integrated framework leverages the strengths of these intelligent systems in a more systematic evaluation of large-scale decision problems.When applied in social media moderation,this approach promotes nuanced and context-sensitive self-moderation by taking into account factors such as cultural background and geographic location.The application of this framework is demonstrated within Facebook groups.Eight distinct content clusters encompassing safety,harassment,diversity,and misinformation are identified.Analysis revealed a preference for content removal across all clusters,suggesting a cautious approach towards potentially harmful content.However,the framework also highlights the use of other moderation actions,like account suspension,depending on the content category.These findings contribute to the growing body of research on self-moderation and offer valuable insights for creating safer and more inclusive online spaces within smaller communities.
基金funded by the National Natural Science Foundation of China,grant number 52405341Foundation of National Key Laboratory of Computational Physics,grant number 6142A05QN24012+1 种基金Chongqing Science and Technology Committee,grant number CSTB2023NSCQ-MSX0363The Science and Technology Research Program of Chongqing Municipal Education Commission,grant number KJQN202301117.
文摘In materials science and engineering design,high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation.To address longstanding bottlenecks in the development of conventional material constitutive models—such as lengthy modeling cycles and difficulties in numerical implementation—this study proposes an intelligent modeling and code generation approach powered by large languagemodels.A structured knowledge base integrating constitutive theory,numerical algorithms,and UMAT(User Material)interface specifications is constructed,and a retrieval-augmented generation strategy is employed to establish an end-to-end workflow spanning experimental data parsing,constitutive model formulation,and automatic UMAT subroutine generation.Experimental results show that the method achieves high accuracy for both a classical Johnson–Cookmodel and a physics-informed neural network(PINN)model,with key parameter identification errors below 5%.Moreover,the automatically generated UMAT subroutines yield finite element simulation results in Abaqus that are highly consistent with theoretical predictions(coefficient of determination R2>0.98)while maintaining good numerical stability.This framework is currently focused on the automatic construction of rate-dependent elastoplastic material models,and its core method also provides a clear path for extending to other constitutive categories such as hyperelasticity and viscoelasticity.This work provides an effective technical route for the rapid development and reliable numerical implementation of material constitutive models,significantly advancing the intelligence level of computational mechanics research and improving engineering application efficiency.
文摘Background:Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology—Head and Neck Surgery systematic literature reviews.Methods:Three PRISMA-based systematic reviews(Jabbour et al.2017,Wong et al.2018,and Wu et al.2021)were replicated using ChatGPTv3.5 and Bard.Outputs(author,title,publication year,and journal)were compared to the original references and cross-referenced with medical databases for authenticity and recall.Results:Several themes emerged when comparing Bard and ChatGPT across the three reviews.Bard generated more outputs and had greater recall in Wong et al.'s review,with a broader date range in Jabbour et al.'s review.In Wu et al.'s review,ChatGPT-2 had higher recall and identified more authentic outputs than Bard-2.Conclusion:Large language models(LLMs)failed to fully replicate peer-reviewed methodologies,producing outputs with inaccuracies but identifying relevant,especially recent,articles missed by the references.While human-led PRISMA-based reviews remain the gold standard,refining LLMs for literature reviews shows potential.
