期刊文献+
共找到419篇文章
< 1 2 21 >
每页显示 20 50 100
LAPPED TRANSFORM DOMAIN INTERFERENCE EXCISION USING MODIFIED MEDIAN FILTER
1
作者 李冲泥 胡光锐 《Journal of Shanghai Jiaotong university(Science)》 EI 1999年第2期32-35,共4页
A novel communication receiver which uses lapped transform(LT) incorporating modified median filter(MMF) algorithm was designed for narrow band interference(NBI) excision.Comparing to traditional Fourier Transform,LT ... A novel communication receiver which uses lapped transform(LT) incorporating modified median filter(MMF) algorithm was designed for narrow band interference(NBI) excision.Comparing to traditional Fourier Transform,LT has longer basis vectors,less spectral leakage,thus better frequency resolution.The LT domain MMF algorithm takes full advantages of the direct sequence spread spectrum signal,as well as the characteristics of LT,performs the transform domain filtering twice.The first filtering locates the position of interference and mitigates most of them.The second filtering is performed in a small neighborhood of the located interference.So LT domain MMF algorithm can completely mitigate the interference without distorting the desired signal.The simulation results demonstrate the improved BER(Bit Error Rate)performance and increased robustness of our receiver. 展开更多
关键词 lapped TRANSFORM MEDIAN filter INTERFERENCE EXCISION SPREAD SPECTRUM communication TRANSFORM domain EXCISION
在线阅读 下载PDF
Modulated Lapped Biorthogonal Transform for Non-orthogonal Narrowband Interference Excision in Spread Spectrum Communications
2
作者 朱丽平 胡光锐 +1 位作者 赵海波 朱义胜 《Journal of Shanghai University(English Edition)》 CAS 2005年第3期237-240,共4页
Traditional lapped transform domain excision techniques obtain good performance at the expense of increased processing delay. Extension of transform domain filtering techniques to the lapped biorthogonal transform dom... Traditional lapped transform domain excision techniques obtain good performance at the expense of increased processing delay. Extension of transform domain filtering techniques to the lapped biorthogonal transform domain can help solve the problem. By incorporating biorthogonality into the lapped transforms, more flexibility is obtained in the design of windows. Thus transform bases with better stopband attenuation can be generated by designing windows, but not by increasing the overlapping factor. In this paper, a new modulated lapped biorthogonal transform (MLBT) with optimized windows is introduced for efficient compression of multi-tone interfering signal energy. The bit error rate (BER) performance of the receiver employing the proposed MLBT excision technique is analyzed and compared with that of the lapped transform domain excision-based receivers. Simulation results demonstrate the improved performance and increased robustness of the proposed technique. 展开更多
关键词 modulated lapped biorthogonal transform (MLBT) narrowband interference excision spread spectrum communications.
在线阅读 下载PDF
Experimental investigation of subsurface damage depth of lapped optics by fluorescent method 被引量:5
3
作者 WANG Hong-xiang HOU Jing +2 位作者 WANG Jing-he ZHU Ben-wen ZHANG Yan-hu 《Journal of Central South University》 SCIE EI CAS CSCD 2018年第7期1678-1689,共12页
Subsurface defects were fluorescently tagged with nanoscale quantum dots and scanned layer by layer using confocal fluorescence microscopy to obtain images at various depths. Subsurface damage depths of fused silica o... Subsurface defects were fluorescently tagged with nanoscale quantum dots and scanned layer by layer using confocal fluorescence microscopy to obtain images at various depths. Subsurface damage depths of fused silica optics were characterized quantitatively by changes in the fluorescence intensity of feature points. The fluorescence intensity vs scan depth revealed that the maximum fluorescence intensity decreases sharply when the scan depth exceeds a critical value. The subsurface damage depth could be determined by the actual embedded depth of the quantum dots. Taper polishing and magnetorheological finishing were performed under the same conditions to verify the effectiveness of the nondestructive fluorescence method. The results indicated that the quantum dots effectively tagged subsurface defects of fused-silica optics, and that the nondestructive detection method could effectively evaluate subsurface damage depths. 展开更多
关键词 OPTICS subsurface defect nondestructive detection LAPPING subsurface damage
在线阅读 下载PDF
淫羊藿苷调控LAP自噬促进酒精抑制的MC3T3-E1细胞成骨分化 被引量:2
4
作者 曾麒 陈跃平 +2 位作者 宋世雷 赖渝 吴华华 《中国中药杂志》 北大核心 2025年第3期590-599,共10页
研究细胞自噬在MC3T3-E1细胞成骨诱导(生理)、酒精(alcohol,AL)干预(病理)分化过程中的影响机制,以及淫羊藿苷(icariin,ICA)对AL干预病理状态下MC3T3-E1细胞成骨分化的作用机制。成骨矿化结节染色鉴定该细胞可分化为成骨细胞。CCK-8实... 研究细胞自噬在MC3T3-E1细胞成骨诱导(生理)、酒精(alcohol,AL)干预(病理)分化过程中的影响机制,以及淫羊藿苷(icariin,ICA)对AL干预病理状态下MC3T3-E1细胞成骨分化的作用机制。成骨矿化结节染色鉴定该细胞可分化为成骨细胞。CCK-8实验筛选合适的AL和ICA浓度后,实验分为7组:完全培养基(complete medium,CM)组,成骨诱导培养基(osteogenic induction medium,OIM)组,OIM+0.25 mol·L^(-1)AL组,OIM+0.25 mol·L^(-1)AL+1×10^(-8)mol·L^(-1)ICA组,OIM+0.25 mol·L^(-1)AL+1×10^(-7)mol·L^(-1)ICA组,OIM+0.25 mol·L^(-1)AL+1×10^(-6)mol·L^(-1)ICA组,OIM+0.25 mol·L^(-1)AL+1×10^(-5)mol·L^(-1)ICA组,培养7 d。碱性磷酸酶(alkaline phosphatase,ALP)染色检测ALP相对面积,Western blot、RT-qPCR检测成骨、自噬相关蛋白及mRNA表达情况,活性氧(reactive oxygen species,ROS)染色检测ROS水平,细胞凋亡线粒体膜电位实验检测细胞凋亡情况。结果显示,ICA可上调AL干预后下调的ALP相对面积;AL下调成骨相关蛋白Wnt家族成员1(Wnt family member 1 gene,Wnt1)及成骨相关基因Wnt1、β-连环蛋白(β-catenin)、核心结合因子2(Runt-related transcription factor 2,Runx2)、骨保护素(osteoprotegerin,OPG)、ALP的表达水平,抑制细胞成骨分化,ICA可上调AL抑制的成骨相关蛋白及mRNA的表达水平,促进细胞成骨分化;AL抑制典型自噬,ICA调控Rubicon抑制LC3相关吞噬作用(LC3-associated phagocytosis,LAP)促进典型自噬;ICA下调AL诱导后上升的ROS水平;ICA下调AL干预后导致的成骨细胞凋亡。综上,ICA可调控Rubicon抑制LAP促进典型自噬,清除ROS减少细胞凋亡,最终通过调控Wnt/β-catenin信号通路促进AL干预病理状态下MC3T3-E1细胞的成骨分化。 展开更多
关键词 淫羊藿苷 酒精 成骨细胞 MC3T3-E1细胞 Wnt1/β-catenin通路 成骨分化 骨代谢失衡 自噬 LAP
原文传递
肥胖指标对痰湿型多囊卵巢综合征患者代谢综合征的诊断价值分析 被引量:2
5
作者 向蓉 李欣萌 +2 位作者 雷凯凯 徐芳 孙淼 《现代中医药》 2025年第1期77-82,共6页
目的不同肥胖指标与痰湿型多囊卵巢综合征患者代谢综合征的相关性。方法回顾360例痰湿型多囊卵巢综合征(Polycystic ovary syndrome,PCOS)患者,根据是否符合代谢综合征(metabolic syndrome,MS)诊断标准,将研究对象分为非MS组216例、MS组... 目的不同肥胖指标与痰湿型多囊卵巢综合征患者代谢综合征的相关性。方法回顾360例痰湿型多囊卵巢综合征(Polycystic ovary syndrome,PCOS)患者,根据是否符合代谢综合征(metabolic syndrome,MS)诊断标准,将研究对象分为非MS组216例、MS组144例;比较组内性激素水平及临床特征差异,评估各肥胖指标对痰湿型PCOS患者合并MS的预测价值。结果MS组患者性激素LH、SHBG、P、DHEAS、LH/FSH低于非MS组(P<0.05);MS组BH、BW、WC、HC、BMI、WHR、BRI、ABSI、CI、BAI、AVI、LAP、VAI均高于非MS组(P<0.05);采用受试者工作曲线评估肥胖指标在诊断痰湿型PCOS合并MS时均有预测价值(P<0.05)。结论不同肥胖指标对痰湿型PCOS患者合并MS具有较好的预测价值,其中LAP、VAI、AVI对痰湿型PCOS患者合并MS的预测价值最佳。 展开更多
关键词 多囊卵巢综合征 代谢综合征 肥胖指标 LAP VAI
暂未订购
一种多房棘球绦虫亮氨酸氨基肽酶体外荧光底物酶活性检测方法
6
作者 陈嘉瑀 戴瑶 +7 位作者 王顺娟 肖杨 闫鑫宗 刘通 袁智浩 史凯丽 李润乐 汤锋 《中国人兽共患病学报》 北大核心 2025年第1期23-31,共9页
目的构建多房棘球绦虫亮氨酸氨基肽酶(leucyl aminopeptidase,LAP)体外荧光酶活性检测方法,并与化学发色底物酶活性检测方法进行对比。方法确立荧光底物体外酶活性检测方法的反应条件,并通过分子对接、抑制率、精密度对比荧光底物L-亮氨... 目的构建多房棘球绦虫亮氨酸氨基肽酶(leucyl aminopeptidase,LAP)体外荧光酶活性检测方法,并与化学发色底物酶活性检测方法进行对比。方法确立荧光底物体外酶活性检测方法的反应条件,并通过分子对接、抑制率、精密度对比荧光底物L-亮氨酸-7-氨基-4-甲基香豆素盐酸盐(Leu-AMC)与化学发色底物L-亮氨酸-4-硝基苯氨(Leu-pNA)之间的差异。结果分子对接结果显示荧光底物Leu-AMC与蛋白的亲和力大于化学发色底物Leu-pNA。通过观察改变反应条件对荧光强度的影响,确立荧光酶活性检测方法在反应温度为37℃、反应pH为9.0、蛋白浓度为800 nmol/L、反应时长60 min的情况下该检测方法反应效果明显。Leu-AMC在5μmol/L的底物浓度和底物浓度变化的情况下有明显的反应效果和反应差异,通过加入不同抑制剂,荧光底物检测方法相较于化学发色底物检测方法存在组间差异。结论本研究构建了以Leu-AMC为底物的多房棘球蚴亮氨酸氨基肽酶体外荧光酶活性检测方法,与化学发色底物相比该方法灵敏度更高。 展开更多
关键词 多房棘球蚴 LAP Leu-AMC 酶活性
暂未订购
Dissimilar Friction Stir Lap Welding of Ti Alloy and Al-Li Alloy:Microstructure and Mechanical Property 被引量:1
7
作者 Zhang Wenxin Zhang Xiankun +3 位作者 Shi Lei Li Shengli Jiang Yuanning Wu Chuansong 《稀有金属材料与工程》 北大核心 2025年第2期311-318,共8页
Friction stir lap welding of AA2195 Al-Li alloy and Ti alloy was conducted to investigate the formation,microstructure,and mechanical properties of the joints.Results show that under different welding parameters,with ... Friction stir lap welding of AA2195 Al-Li alloy and Ti alloy was conducted to investigate the formation,microstructure,and mechanical properties of the joints.Results show that under different welding parameters,with the decrease in welding heat input,the weld surface is smoother.The Ti/Al joint interface is flat without obvious Ti and Al mixed structure,and the hook structure is not formed under optimal parameters.Due to the enhanced breaking effect of the stirring head,the hook structural defects and intermetallic compounds are more likely to form at the Ti/Al interface at high rotational speed of 1000 r/min,thereby deteriorating the mechanical properties of joints.Decreasing the heat input is beneficial to hardness enhancement of the aluminum alloy in the weld nugget zone.Under the optimal parameters of rotation speed of 800 r/min and welding speed of 120 mm/min,the maximum tensile shear strength of joint is 289 N/mm. 展开更多
关键词 Ti/Al dissimilar welding friction stir lap welding Ti alloy Al-Li alloy interface bonding mechanical property
原文传递
Elucidating the process mechanism in Mg-to-Al friction stir lap welding enhanced by ultrasonic vibration 被引量:3
8
作者 Ming Zhai Lei Shi ChuanSong Wu 《Journal of Magnesium and Alloys》 2025年第1期338-355,共18页
The composite structures/components made by friction stir lap welding(FSLW)of Mg alloy sheet and Al alloy sheet are of wide application potentials in the manufacturing sector of transportation vehicles.To further impr... The composite structures/components made by friction stir lap welding(FSLW)of Mg alloy sheet and Al alloy sheet are of wide application potentials in the manufacturing sector of transportation vehicles.To further improve the joint quality,the ultrasonic vibration(UV)is exerted in FSLW,and the UV enhanced FSLW(UVeFSLW)was developed for making Mg-to-Al dissimilar joints.The numerical analysis and experimental investigation were combined to study the process mechanism in Mg/Al UVeFSLW.An equation related to the temperature and strain rate was derived to calculate the grain size at different locations of the weld nugget zone,and the effect of grain size distribution on the threshold thermal stress was included,so that the prediction accuracy of flow stress was further improved.With such modified constitutive equation,the numerical simulation was conducted to compare the heat generation,temperature profiles and material flow behaviors in Mg/Al UVeFSLW/FSLW processes.It was found that the exerted UV decreased the temperature at two checking points on the tool/workpiece interface from 707/671 K in FSLW to 689/660 K in UVeFSLW,which suppressed the IMCs thickness at Mg-Al interface from 1.7μm in FSLW to 1.1μm in UVeFSLW.The exerted UV increased the horizontal materials flow ability,and decreased the upward flow ability,which resulted in the increase of effective sheet thickness/effective lap width from 2.01/3.70 mm in FSLW to 2.04/4.84 mm in UVeFSLW.Therefore,the ultrasonic vibration improved the tensile shear strength of Mg-to-Al lap joints by 18%. 展开更多
关键词 Friction stir lap welding Mg-to-Al dissimilar alloys Ultrasonic vibration Numerical simulation Experimental investigation
在线阅读 下载PDF
Fatigue and deformation mechanisms of ultrasonic spot-welded dissimilar joints of a magnesium alloy to a clad aluminum alloy 被引量:1
9
作者 Soumya Sobhan Dash Rylan Christopher Fernandes +7 位作者 Xiao Shang Yu Zou He Peng Xianquan Jiang Xiangfan Fang Ninshu Ma Dongyang Li Daolun Chen 《Journal of Magnesium and Alloys》 2025年第5期1939-1952,共14页
A low rare-earth containing ZEK100-O magnesium alloy was welded to AA1230-clad high-strength AA2024-T3 aluminum alloy via solidstate ultrasonic spot welding(USW)to evaluate the microstructure,tensile lap shear strengt... A low rare-earth containing ZEK100-O magnesium alloy was welded to AA1230-clad high-strength AA2024-T3 aluminum alloy via solidstate ultrasonic spot welding(USW)to evaluate the microstructure,tensile lap shear strength,and fatigue properties.The tensile strength increased with increasing welding energy,peaked at a welding energy of 1000 J,and then decreased due to the formation of an increasingly thick diffusion layer mainly containing Al12Mg17intermetallic compound at higher energy levels.The peak tensile lap shear strength attained at 1000 J was attributed to the optimal inter-diffusion between the magnesium alloy and softer AA1230-clad Al layer along with the presence of‘fishhook'-like mechanical interlocks at the weld interface and the formation of an indistinguishable intermetallic layer.The dissimilar joints welded at 1000 J also exhibited a longer fatigue life than other Mg-Al dissimilar joints,suggesting the beneficial role of the softer clad layer with a better intermingling capacity during USW.While the transverse-through-thickness(TTT)failure mode prevailed at lower cyclic loading levels,interfacial failure was the predominant mode of fatigue failure at higher cyclic loads,where distinctive fatigue striations were also observed on the fracture surface of the softer clad Al layer.This was associated with the presence of opening stress and bending moment near the nugget edge despite the tension-tension lap shear cyclic loading applied. 展开更多
关键词 Ultrasonic spot welding Magnesium alloy Clad aluminum alloy Tensile lap shear strength Fatigue life
在线阅读 下载PDF
Achieving high-performance FSLW AZ31B/TC4 dissimilar joints with ultrastrong interface by Sn addition 被引量:1
10
作者 Yuqing Mao Jinkai Wang +3 位作者 Shaopeng Liu Qianqun Peng Jingxuan Li Liming Ke 《Journal of Magnesium and Alloys》 2025年第4期1799-1814,共16页
Friction stir lap welding(FSLW)was adopted to join successfully dissimilar AZ31B Mg alloy and TC4 Ti alloy with Sn foil addition of 30μm thickness.Interfacial microstructure,tensile shear performances and bonding mec... Friction stir lap welding(FSLW)was adopted to join successfully dissimilar AZ31B Mg alloy and TC4 Ti alloy with Sn foil addition of 30μm thickness.Interfacial microstructure,tensile shear performances and bonding mechanism of the joints obtained using three different rotation speeds were studied.High-performance FSLW Mg/Ti dissimilar joints with maximum tensile shear strength of 593.3 N/mm were produced at 1180 r/min,and which was mainly attributed to ultrastrong reaction interlayer consisting of 125.9 nm thick(Mg_(2)Sn+Mg)transition layer and discontinuous(Ti_(6)Sn_(5)+Ti_(3)Al)IMCs layer with 6.58 nm thickness at the interface.The formation of the reaction interlayer was beneficial for high interfacial strength,resulting in significantly improving the joint strength.The fracture of all FSLW joints located on AZ31B Mg stirred zone adjacent to(Mg_(2)Sn+Mg)transition layer or along the crack propagation direction of the AZ31B/TC4 interface with different fracture mechanisms,and which could be consistent with interfacial microstructure. 展开更多
关键词 Dissimilar AZ31B/TC4 ally Friction stir lap welding Sn addition Tensile shear strength Interfacial microstructure Bonding mechanism
在线阅读 下载PDF
Theoretical and Experimental Investigations on Thickness Uniformity in Double-sided Lapping
11
作者 Zhuolin Cai Zhe Yang +4 位作者 Bo Pan Jiale Lian Lianlin Wang Sergei Pronkevich Jiang Guo 《Chinese Journal of Mechanical Engineering》 2025年第3期151-163,共13页
The double-sided lapping process is extensively employed in the manufacturing of wafers,optical windows,and seal rings due to its high efficiency and ability to achieve precise flatness.However,limited research has ex... The double-sided lapping process is extensively employed in the manufacturing of wafers,optical windows,and seal rings due to its high efficiency and ability to achieve precise flatness.However,limited research has explored the thickness uniformity among different workpieces after double-sided lapping,and the underlying mechanism remains unclear.To address the demand for higher precision,this paper first analyzed the relative kinematic model between the workpiece and the lapping plate to clarify the causes of thickness variations among workpieces after double-sided lapping.Subsequently,a finite element method(FEM)model was developed to account for the pressure distribution on the workpiece surfaces at the initial stage of the process.The results indicate that the number of workpieces influences the final thickness variation.Then,various sets of thin copper plates with different thicknesses were lapped,and the findings revealed that five copper plates processed simultaneously exhibited more uniform thickness compared to the three plates.The experimental results align well with the theoretical analysis.Ultimately,a thickness variation of less than 6μm was achieved on five copper plates measuringΦ100×2.9 mm.This study presents a comprehensive analysis of the mechanisms influencing thickness uniformity in the double-sided lapping process and provides practical guidelines for optimizing the process to achieve stringent precision standards in industrial applications. 展开更多
关键词 Double-sided lapping Thickness uniformity Theoretical analysis FEM Thin copper plate
在线阅读 下载PDF
Hole inhibition mechanisms of Mg/steel lap joint by pinless friction stir spot welding
12
作者 Tao-tao Li Hong-de Ding +5 位作者 Rui-feng Li Kai Qi Zhen-guang Liu Xiao-qiang Zhang Yue Zhao Lei Qiao 《Journal of Iron and Steel Research International》 2025年第4期1085-1101,共17页
Pinless friction stir spot welding(P-FSSW)was performed to manufacture Mg/steel lap joints.Orthogonal tests for P-FSSW of Mg/steel were investigated,and the main factors affecting the properties of Mg/steel lap joints... Pinless friction stir spot welding(P-FSSW)was performed to manufacture Mg/steel lap joints.Orthogonal tests for P-FSSW of Mg/steel were investigated,and the main factors affecting the properties of Mg/steel lap joints were derived.The shear force of the Mg/steel lap joints gradually increased and then decreased as the welding time increased.Maximum shear force was 5.3 kN.Fe-Al intermetallic compound(IMC)was formed at the Mg/steel interface near the steel side,and Mg-Al IMCs were formed at the Mg/steel interface near the Mg alloy side.Mg/steel lap joint was transformed from an initial solid-state welding to fusion-brazing welding as the welding time increased.No hole defects were formed in Mg/steel solid-state welding joints,whereas hole defects appeared in Mg/steel fusion-brazing welding joints.The temperature field of Mg/steel lap joints was simulated to analyze hole defects generated during the welding process.Hole defects can be eliminated by changing the spindle deflection angle,and the shear force decreased.Excessive spindle deflection can also lead to failure to form a stable joint.Hole defects were removed because the spindle deflection angle reduced the interfacial reaction temperature,and a solid-state welding joint was formed,which resulted in an absence of fusion-brazing welding hole formation. 展开更多
关键词 Mg/steel Lap joint Pinless friction stir spot welding Hole inhibition SIMULATION
原文传递
Improving microstructure,tensile properties and corrosion resistance of AA6016 and AA2519 alloys friction stir lap joints via TIG arc
13
作者 Tie YI Sheng-dan LIU +2 位作者 Chen FANG Geng-duo JIANG Xuan-xuan DAI 《Transactions of Nonferrous Metals Society of China》 2025年第2期405-417,共13页
The effects of tungsten inert gas arc-assisted friction stir welding(TIG-FSW)on the microstructure,tensile properties and corrosion resistance of AA6016 and AA2519 alloys lap joints were investigated by means of optic... The effects of tungsten inert gas arc-assisted friction stir welding(TIG-FSW)on the microstructure,tensile properties and corrosion resistance of AA6016 and AA2519 alloys lap joints were investigated by means of optical microscope,scanning electron microscope,tensile test at room temperature,corrosion immersion tests and electrochemical measurements.The results show that the introduction of TIG arc during FSW process results in a more uniform microstructure of the joint with no tunnel hole defects.Furthermore,it enhances tensile strength and elongation of the joint with increased rates of 11.5%and 50.0%,respectively;meanwhile,the corrosion current density and largest corrosion depth are decreased with reduction rates of 78.2%and 45.7%,respectively.TIG-FSW can promote flow,contact and diffusion of materials,thus improving microstructure of the joint.Additionally,it reduces the size and number of secondary phase particles.Consequently,these factors contribute to the higher tensile properties and corrosion resistance of the joints. 展开更多
关键词 friction stir welding lap joint dissimilar aluminum alloys secondary phase particles MICROSTRUCTURE tensile properties corrosion resistance
在线阅读 下载PDF
LAP3经JAK2/STAT3途径促进胃癌MGC-803细胞的增殖
14
作者 伍石华 全婧丹 +2 位作者 王化修 吕小元 张志伟 《湘南学院学报(医学版)》 2025年第3期1-6,共6页
目的探讨胃癌相关蛋白质LAP3对胃癌细胞增殖的影响及其分子机制。方法采用慢病毒感染胃癌MGC-803细胞,筛选后建立LAP3稳定低表达MGC-803细胞系,分为对照组(MGC-803-shCtrl)、干扰组(MGC-803-shLAP3-1和MGC-803-shLAP3-2),实时荧光定量PC... 目的探讨胃癌相关蛋白质LAP3对胃癌细胞增殖的影响及其分子机制。方法采用慢病毒感染胃癌MGC-803细胞,筛选后建立LAP3稳定低表达MGC-803细胞系,分为对照组(MGC-803-shCtrl)、干扰组(MGC-803-shLAP3-1和MGC-803-shLAP3-2),实时荧光定量PCR和Western Blot检测LAP3表达情况;通过CCK-8法和平板克隆形成实验检测LAP3低表达对胃癌MGC-803细胞增殖的影响;采用Western Blot检测LAP3低表达对胃癌MGC-803细胞中JAK2/STAT3途径的影响;构建裸鼠皮下荷瘤模型,观察LAP3低表达对胃癌MGC-803细胞体内成瘤能力的影响,并通过免疫组化染色检测瘤组织中Ki-67的表达情况。结果MGC-803-shLAP3-1和MGC-803-shLAP3-2组细胞增殖率较MGC-803-shCtrl组均下降,细胞集落数减少(均P<0.01)。MGC-803-shLAP3-1和MGC-803-shLAP3-2组JAK2和STAT3蛋白的磷酸化水平较MGC-803-shCtrl组均降低(均P<0.001)。裸鼠成瘤结果显示,MGC-803-shLAP3-1和MGC-803-shLAP3-2组的肿瘤体积与重量较MGC-803-shCtrl组均下降(均P<0.001);MGC-803-shLAP3-1和MGC-803-shLAP3-2组的肿瘤组织Ki-67阳性表达率较MGC-803-shCtrl组均降低(均P<0.001)。结论LAP3可能通过活化JAK2/STAT3途径促进胃癌细胞的增殖。 展开更多
关键词 胃癌 LAP3 JAK2/STAT3途径 细胞增殖
暂未订购
Fabrication of welded hybrid joints of aluminum alloys and polymer composites with significantly enhanced long-term reliability
15
作者 Chunyang Jiang Fengchao Liu +8 位作者 Lihui Wu Ying Kan Xianjun Pei Hao Zhang Zhen Zhang Peng Xue Dingrui Ni Bolv Xiao Zongyi Ma 《International Journal of Minerals,Metallurgy and Materials》 2025年第12期3029-3042,共14页
The effect of thermal degradation on the welded hybrid joints of metal and polymer composites is insufficient,which seriously inhibits the engineering applications of the joints.In this study,robust hybrid joints of m... The effect of thermal degradation on the welded hybrid joints of metal and polymer composites is insufficient,which seriously inhibits the engineering applications of the joints.In this study,robust hybrid joints of metal and polymer composites were fabricated by the combination of friction lap welding(FLW)and laser surface treatment for investigating the effect of accelerated aging on the joint properties.Results showed that the FLW hybrid joints without laser surface treatment exhibited 91%reduction in the tensile shear force(TSF)after 7 days of accelerated aging tests.In contrast,the FLW hybrid joints with suitable laser surface treatment exhibited only 26%reduction in TSF even after 35 days of accelerated aging tests.Fractures of the tensile specimens occurred across the composite plates rather than along the joint interface.The enhanced reliability of the hybrid joints was mainly attributed to(1)the formation of micro-mechanical interlocking between the polymer composites and aluminum alloy plate,and(2)the modification of the stress distribution along the joint interface. 展开更多
关键词 dissimilar material welding fiber reinforced polymers friction lap welding friction stir welding hybrid structures
在线阅读 下载PDF
Experimental assessment of fatigue life and fracture modes in MTS-based bolted joints
16
作者 Kerim Altingeyik Ibrahim T.Teke Ahmet H.Ertas 《Railway Sciences》 2025年第4期464-474,共11页
Purpose–This study aims to investigate the fatigue behavior and failure modes of bolted lap joints using Modified Tensile Specimens(MTS)under various cyclic load conditions.Emphasis is placed on identifying the relat... Purpose–This study aims to investigate the fatigue behavior and failure modes of bolted lap joints using Modified Tensile Specimens(MTS)under various cyclic load conditions.Emphasis is placed on identifying the relationship between load amplitude,fatigue life,and damage progression in low-carbon steel assemblies.Design/methodology/approach–An experimental approach was adopted using MTS specimens fabricated from St 1203 cold-rolled steel,joined with Grade 8.8 M4 bolts.Cyclic fatigue tests were conducted under zerobased loading at seven distinct force levels.Fracture surfaces were visually analyzed to identify dominant failure mechanisms.Findings–The results revealed a strong inverse correlation between applied cyclic load and fatigue life.Three distinct failure modes were identified:bolt shear at high loads(5.4 kN),interface cracking and slippage at moderate loads(4.9–5.1 kN),and plate tearing or stable fatigue behavior at lower loads(54.1 kN).The results highlight a progressive transition in failure mechanisms,from bolt shear at high loads to plate tearing and interface cracking at lower loads,providing essential insights for fatigue-resistant bolted joint design.Originality/value–This study offers original insights into the fatigue behavior of bolted lap joints using MTS,a relatively underexplored configuration in fatigue assessment.By experimentally evaluating failure modes under varied cyclic load levels,the authors uncover critical transitions in damage mechanisms—from bolt shear to interface cracking and plate tearing—depending on the applied load.Unlike many existing studies focused on numerical modeling or bonded joints alone,this work provides empirical data rooted in real-world fastening conditions using cold-rolled low-carbon steel. 展开更多
关键词 Fatigue life Bolted joints Modified tensile specimen(MTS) Failure modes Cyclic loading Fracture analysis Lap joints Low-carbon steel Experimental fatigue testing Shear failure
在线阅读 下载PDF
Achievement of superb-strength lap joint via opposite-directions flowing friction stir lap welding of 2024 aluminum alloys
17
作者 Zhiqing ZHANG Peng GONG +4 位作者 Shude JI Lin MA Chen JIN Xiuyan LI Qi SONG 《Chinese Journal of Aeronautics》 2025年第8期588-603,共16页
It is common for the rotating pin largely plunging into lower sheet to break up lap interface of Friction Stir Lap Welding(FSLW)joint,but the unavoidable up-bending morphology of hook outside Nugget Zone(NZ)largely re... It is common for the rotating pin largely plunging into lower sheet to break up lap interface of Friction Stir Lap Welding(FSLW)joint,but the unavoidable up-bending morphology of hook outside Nugget Zone(NZ)largely reduces the joint bearing ability.Based on the novel Opposite-directions Flowing FSLW(OF-FSLW)by the self-developed rotating tool with an Xshaped right-left thread pin,the 2024 aluminum alloys lap joint was successfully welded in this study.The migration law of lap interface during welding was investigated by the experimental and numerical methods,and then how the rotating pin and its rotating velocity affect the formation and strength of OF-FSLW joint was further analyzed.The results show that the Material Concentrated Zone(MCZ)which formed above the original lap interface made the hook bend downward,the NZ greatly enlarged and the beginning part of cold lap compressed and thickened,thereby heightening the joint bearing ability.For the OF-FSLW joint,its maximum tensile strength was403 MPa,and the corresponding joint efficiency of 90.8%was an incredible and superb value for the 2000 series heat-treatment strengthened aluminum alloys friction stir welded joint.The OF-FSLW technology by the rotating tool with an X-shaped right-left thread pin is proven to be a greatly effective approach for manufacturing the aluminum alloys lap joint with superb strength. 展开更多
关键词 2024-T4 aluminum alloys Opposite-directions flowing friction stir lapwelding Rotatingtool withanXshaped right-left thread pin Lap interface Tensile strength
原文传递
中国南方暴雨野外试验中尺度气象分析场的建立及其质量评估 被引量:23
18
作者 崔春光 倪允琪 +4 位作者 李红莉 彭菊香 张艳霞 邱学兴 许晓林 《气象学报》 CAS CSCD 北大核心 2011年第1期26-40,共15页
利用武汉暴雨研究所从美国引进的LAPS中尺度分析系统,将2008年和2009年5—7月中国南方暴雨野外科学试验(SCHeREX)中所采集的观测资料进行融合、同化,生成了华南、华中、江淮和长江三角洲4个观测区的空间分辨为5 km、时间分辨为3 h的SHCe... 利用武汉暴雨研究所从美国引进的LAPS中尺度分析系统,将2008年和2009年5—7月中国南方暴雨野外科学试验(SCHeREX)中所采集的观测资料进行融合、同化,生成了华南、华中、江淮和长江三角洲4个观测区的空间分辨为5 km、时间分辨为3 h的SHCeREX中尺度气象分析场。文中从两方面对SCHeREX中尺度分析场的质量进行了评估分析。首先,根据野外试验期间在4个观测区出现的暴雨日,结合观测的雷达回波和卫星云图云顶亮温(TBB)资料与SCHeREX中尺度分析资料进行统计分析与比较,结果表明,SCHeREX中尺度分析资料对中尺度强对流系统具有很强的再现能力。同时,以探空观测资料为基准,分析计算了SCHeREX中尺度分析场的平均偏差、平均均方根误差及其随高度的分布,分析结果表明SCHeREX中尺度分析场的位势高度、温度、相对湿度、风向和风速的分析误差均在观测误差范围内,尤其是SCHeREX中尺度分析场700—925 hPa位势高度的平均分析误差为45 gpm,温度的平均分析误差为1.0-1.1℃,相对湿度的平均分析误差不超过20%,风速的平均误差为1.5—2.0m/s,风向为20°—25°。 展开更多
关键词 LAPS 诊断分析 融合和同化 适用性 质量评估
在线阅读 下载PDF
中尺度分析系统LAPS应用雷达资料的个例研究 被引量:32
19
作者 李红莉 崔春光 +2 位作者 王志斌 王晓芳 谢有才 《高原气象》 CSCD 北大核心 2009年第6期1443-1452,共10页
武汉暴雨所引进国际先进的中尺度分析系统LAPS,经成功本地移植后,该系统能融合华中区域多种非常规观测资料,提供包含丰富中尺度信息的高分辨率中尺度分析场。针对一次梅雨期强降水过程,利用LAPS系统进行中尺度分析,通过对比该系统融合... 武汉暴雨所引进国际先进的中尺度分析系统LAPS,经成功本地移植后,该系统能融合华中区域多种非常规观测资料,提供包含丰富中尺度信息的高分辨率中尺度分析场。针对一次梅雨期强降水过程,利用LAPS系统进行中尺度分析,通过对比该系统融合多普勒雷达资料前后各种物理量场的差异,研究了多普勒雷达资料在该系统中的作用。结果表明,LAPS融合雷达径向风后,对风场的改善比较明显,能揭示流场的中尺度信息。融合多种资料后的LAPS中尺度分析场比NCEP再分析场更接近实况,能清楚地反映中尺度特征,可作为分析此次强降水过程发生、发展的工具。融合雷达资料反射率后,LAPS云分析能提供与实况接近的较细致的云信息,有利于了解暴雨过程中云参数的演变,同时也为数值模式热启动提供条件。 展开更多
关键词 LAPS系统 中尺度分析 云分析 多普勒雷达资料
在线阅读 下载PDF
尿mAlb/Cr、NAG、LAP检测对早期糖尿病肾病的诊断价值 被引量:19
20
作者 张晓青 宗成国 +1 位作者 栾旭华 赵黎明 《中国现代医学杂志》 CAS CSCD 北大核心 2009年第1期122-124,共3页
目的研究糖尿病患者的尿液微量白蛋白/肌酐(mAlb/Cr)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)、亮氨酸氨基肽酶(LAP)与早期糖尿病肾病(DN)的诊断价值关系。方法将216例糖尿病患者分为两组:糖尿病无肾病组与早期糖尿病肾病组,采用免疫比浊法测... 目的研究糖尿病患者的尿液微量白蛋白/肌酐(mAlb/Cr)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)、亮氨酸氨基肽酶(LAP)与早期糖尿病肾病(DN)的诊断价值关系。方法将216例糖尿病患者分为两组:糖尿病无肾病组与早期糖尿病肾病组,采用免疫比浊法测定尿微量白蛋白/肌酐,采用速率法检测尿NAG及LAP值,并与49例健康对照组比较。结果糖尿病肾病患者尿mAlb/Cr、NAG、LAP明显高于对照组(P<0.01),且尿微量白蛋白/肌酐与NAG,LAP成正相关(r=0.909,r=0.410,P<0.01)。结论检测尿mAlb/Cr、NAG、LAP有助于尿蛋白阴性的糖尿病肾病的早期诊断。 展开更多
关键词 mAlb/Cr NAG LAP 糖尿病肾病
暂未订购
上一页 1 2 21 下一页 到第
使用帮助 返回顶部