Tumor cells undergo metabolic reprogramming to enhance biomass uptake,which is crucial for their survival and proliferation.1,2 Lactate,traditionally considered as an energy substrate,promotes tumor growth by inducing...Tumor cells undergo metabolic reprogramming to enhance biomass uptake,which is crucial for their survival and proliferation.1,2 Lactate,traditionally considered as an energy substrate,promotes tumor growth by inducing histone lactylation,which alters gene expression and chromatin structure.3 This lactylation process influences tumor progression through immunosuppression.展开更多
基金supported by the Shandong Provincial Natural Science Foundation of China(No.ZR2024QH145)the Qingdao Medical Health Research Project(Shandong,China)(No.2024-WJKY040)+2 种基金the Qingdao Traditional Chinese Medicine Science Foundation(Shandong,China)(No.2022-zyym07)the Shandong Provincial Traditional Chinese Medicine Science Foundation(Shandong,China)(No.M-2023176)the Qingdao Outstanding Health Professional Development Fund.
文摘Tumor cells undergo metabolic reprogramming to enhance biomass uptake,which is crucial for their survival and proliferation.1,2 Lactate,traditionally considered as an energy substrate,promotes tumor growth by inducing histone lactylation,which alters gene expression and chromatin structure.3 This lactylation process influences tumor progression through immunosuppression.
