Nigella sativa, belonging to the Ranunculacea family, is a versatile phytochemical mine bestowed with multi-dimensional medicinal effects. The current study was performed to investigate the chemopreventive efficacy, i...Nigella sativa, belonging to the Ranunculacea family, is a versatile phytochemical mine bestowed with multi-dimensional medicinal effects. The current study was performed to investigate the chemopreventive efficacy, if any, of the ethanolic extract of indigenous Nigella sativa seeds (ENS) and to evaluate its potentials on tumor progression during the initiation and post initiation phases of Dimethylhydrazine-induced colon carcinogenesis in a rat model. ENS treatment during the initiation phase unveiled chemopreventive effect manifested by significant reductions in tumor incidence, multiplicity and tumor volumes. Histopathological findings and modified Duke’s classification of tumors provided evidence that ENS, administered in the initiation phase, is capable of delaying progression, restricting invasion and attenuating aggressiveness of colon tumors. These results imply that ENS may be a promising candidate in the primary prevention of colon cancer. On the contrary, we demonstrated that ENS lacked chemopreventive and tumorigenesis inhibitory effects in the post initiation phase. We speculate that the chemopreventive effect of ENS might be due to the synergistic actions of various constituents present in the extract. However, extensive studies are warranted and more efforts need to be dedicated to fractionate, analyze and to further appraise the anticancer effect of ENS before any definitive conclusions can be drawn.展开更多
Objective:To investigate the current situation of nurses’lack of nursing care in southern Xinjiang and analyze its influencing factors.Methods:A convenient sampling method was used to select 1476 nurses from two tert...Objective:To investigate the current situation of nurses’lack of nursing care in southern Xinjiang and analyze its influencing factors.Methods:A convenient sampling method was used to select 1476 nurses from two tertiary hospitals in Kashi from May 2022 to December 2022 as the subjects of a cross-sectional survey.The nurses in southern Xinjiang were investigated by general information questionnaire and nursing deficiency scale-nurse version.Results:A total of 1476 valid questionnaires were collected in this study.The score of nurses’lack of care in southern Xinjiang was(56.05±9.36),which was above the middle level.Among them,the scores of timely responses to call bells,view patient medical records,fully understand their own patient’s condition,and provide emotional support for patients and/or family members were relatively low.Univariate analysis showed that there were significant differences in the scores of nurses’age,nurses’level,nursing career satisfaction and nursing job satisfaction(p<0.05).Multivariate analysis showed that the occupational satisfaction and nursing job satisfaction of nursing staff were the main factors affecting the lack of nursing work(p<0.05).Conclusion:The lack of nursing care of nurses in southern Xinjiang is at the upper middle level.The younger the age,the lower the satisfaction of nursing profession and the lower the satisfaction of nursing position,the more serious the lack of nursing care.In order to solve this problem,nursing managers should actively respond to the influencing factors of nursing absence and actively seek effective management measures to reduce the incidence of nursing absence and ensure the safety of patients.展开更多
利什曼原虫的 L ACK抗原是利什曼原虫活性蛋白激酶 C受体同源物 ,是一种新发现的抗原蛋白。我们以本实验室的重组质粒 T- L ACK为模板 ,PCR扩增获得 L ACK基因 ,与真核表达载体 pc DNA3.1(+)定向重组 ,重组质粒经酶切和 PCR分析 ,含有约...利什曼原虫的 L ACK抗原是利什曼原虫活性蛋白激酶 C受体同源物 ,是一种新发现的抗原蛋白。我们以本实验室的重组质粒 T- L ACK为模板 ,PCR扩增获得 L ACK基因 ,与真核表达载体 pc DNA3.1(+)定向重组 ,重组质粒经酶切和 PCR分析 ,含有约 95 0 bp的 L ACK基因 ,成功构建含有 L ACK基因的真核表达重组质粒 pc D-NA3- L ACK。将此重组质粒转染 COS- 7细胞 ,通过 RT- PCR及免疫荧光检测 L ACK基因在真核细胞中的表达。实验结果显示转染了重组质粒的 COS- 7细胞 ,其 RT- PCR及免疫荧光检测均呈阳性反应 ,证实重组质粒 pc DNA3-L ACK能在 COS- 7细胞中有效表达 L ACK蛋白。展开更多
[Objective] Long-term （over 18 years） fertilization experiments were con- ducted to study the responses of crop yields and soil fertility to long-term nutrient lacking at Zhengzhou in China. [Method] The present stu...[Objective] Long-term （over 18 years） fertilization experiments were con- ducted to study the responses of crop yields and soil fertility to long-term nutrient lacking at Zhengzhou in China. [Method] The present study consisted of five treat- ments： 1 CK （no fertilizer or manure）, （2） NP （nitrogen and phosphorus fertilizer applied）, 31 NK （nitrogen and potassium fertilizer applied）, 4 PK （phosphorus and potassium fertilizer applied） and ：5 NPK （nitrogen, phosphorus and potassium fertil- izer applied）. [Result] Lacking of nitrogen or phosphorus led to a low yield; however, there was no significant difference in grain yields between the NP and NPK treat- ments which maintained a higher yield. Receiving no phosphorus, soil available phosphorus content declined to about 2.5 mg/kg. The concentration of soil ex- changeable potassium remained constant at a level of 60 mg/kg under the treat- ments without potassium fertilizer addition. Soil potassium spontaneous supply ca- pacity fluctuated around 100%.[Conclusion] In fluvo-aquic soil, nitrogen and phos- phorus were two key limiting factors to grain yields, biomass and yield component factors of wheat and maize, while potassium was not. However, potassium defi- ciency may occur in the future if there was still no potassium fertilizer applied.展开更多
This essay put emphasis on the analysis T.S. Eliot's The Waste Land, pointing the masterpiece can be interpreted by three- levels, the person, the society and human race. Eliot also indicated two kinds of people, ...This essay put emphasis on the analysis T.S. Eliot's The Waste Land, pointing the masterpiece can be interpreted by three- levels, the person, the society and human race. Eliot also indicated two kinds of people, the one is just secularized, and the other one is lack of faith in The Waste Land. We can analyze the feeling of protagonist is afraid to live new life, but afraid of death, the important theme is corruption of sex.展开更多
AIM: To study the impact of scleral flap position, under which the posterior chamber intraocular lenses (PC-IOL) were sulcus-fixed by trans-scleral suture, on cornea astigmatism. METHODS: Twenty-six aphakic or catarac...AIM: To study the impact of scleral flap position, under which the posterior chamber intraocular lenses (PC-IOL) were sulcus-fixed by trans-scleral suture, on cornea astigmatism. METHODS: Twenty-six aphakic or cataract eyes were comprised in this prospective noncomparative case series study. Eleven eyes had traumatic cataract removed without sufficient capsular support, 3 had blunt trauma with subluxated traumatic cataract, 8 had undergone vitreoretinal surgery and 4 had congenital cataract removed. The average age was 54 years (range 21-74 years), with 17 men and 7 women. The foldable PC-IOL was fixed in sulcus by trans-scleral suture. The incision for IOL implantation was made 1mm posterior to limbus along the steepest meridian of cornea, while scleral flaps to bury the knots of trans-scleral suture were made along the flattest meridian. All the surgeries were performed by a single doctor (Ma L), and the follow up was at least 13 months (range 13-28 months). The preoperative, 3 months and 1 year postoperative corneal curvature along the steepest and flattest cornea meridian and overall cornea astigmatism were compared. RESULTS: The curvature along the steepest meridian changed from 44.25 +/- 2.22D preoperatively to 44.08 +/- 2.16D at 3 months postoperatively, and 43.65 +/- 5.23D at 1 year postoperatively (P>0.05); the curvature along the flattest meridian changed from 41.24 +/- 2.21D preoperatively to 43.15 +/- 3.94D at 3 months postoperatively, and 42.85 +/- 5.17D at 1 year postoperatively (P<0.05); and the surgery induced astigmatism (SIA) on cornea was calculated by vector analysis, which was 2.42 +/- 2.13D at 3 months postoperatively, and 2.18 +/- 3.42D at 1 year postoperatively, the difference was statistically significant (P<0.05). CONCLUSION: The scleral flap made along the flattest meridian, under which the posterior chamber intraocular lenses (PCIOL) were sulcus-fixed by trans-scleral suture, can steepen the cornea in varying degrees, thus reducing preexisting corneal astigmatism.展开更多
Debris flows are the one type of natural disaster that is most closely associated with hu- man activities. Debris flows are characterized as being widely distributed and frequently activated. Rainfall is an important ...Debris flows are the one type of natural disaster that is most closely associated with hu- man activities. Debris flows are characterized as being widely distributed and frequently activated. Rainfall is an important component of debris flows and is the most active factor when debris flows oc- cur. Rainfall also determines the temporal and spatial distribution characteristics of the hazards. A reasonable rainfall threshold target is essential to ensuring the accuracy of debris flow pre-warning. Such a threshold is important for the study of the mechanisms of debris flow formation, predicting the characteristics of future activities and the design of prevention and engineering control measures. Most mountainous areas have little data regarding rainfall and hazards, especially in debris flow forming re- gions. Therefore, both the traditional demonstration method and frequency calculated method cannot satisfy the debris flow pre-warning requirements. This study presents the characteristics of pre-warning regions, included the rainfall, hydrologic and topographic conditions. An analogous area with abundant data and the same conditions as the pre-warning region was selected, and the rainfall threshold was calculated by proxy. This method resolved the problem of debris flow pre-warning in ar- eas lacking data and provided a new approach for debris flow pre-warning in mountainous areas.展开更多
The use of anti-tumor necrosis factor-α therapy for inflammatory bowel disease represents the most important advance in the care of these patients since the publication of the National Co-operative Crohn＇s disease s...The use of anti-tumor necrosis factor-α therapy for inflammatory bowel disease represents the most important advance in the care of these patients since the publication of the National Co-operative Crohn＇s disease study thirty years ago. The recommendations of numerous consensus groups worldwide are now supported by a wealth of clinical trials and several meta-analyses. In general, it is suggested that tumor necrosis factor-c~ blockers （TNFBs） are indicated （1） for persons with moderately-severe Crohn＇s disease or ulcerative colitis （UC） who have failed two or more causes of glucocorticosteroids and an acceptably long cause （8 wk to 12 wk） of an immune modulator such as azathioprine or methotrexate; （2） non-responsive perianal disease; and （3） severe UC not responding to a 3-d to 5-d course of steroids. Once TNFBs have been introduced and the patient is responsive, therapy given by the IV and SC rate must be continued. It remains open to definitive evidence if concomitant immune modulators are required with TNFB maintenance ther- apy, and when or if TNFB may be weaned and discon- tinued. The supportive evidence from a single study on the role of early versus later introduction of TNFB in the course of a patient＇s illness needs to be confirmed. The risk/benefit profile of TNFB appears to be accept- able as long as the patient is immunized and tested for tuberculosis and viral hepatitis before the initiation of TNFB, and as long as the long-term adverse effects on the development of lymphoma and other tumors do not prone to be problematic. Because the rates of ben- efits to TNFB are modest from a population perspec- tive and the cost of therapy is very high, the ultimate application of use of TNFBs will likely be established by cost/benefit studies.展开更多
This paper contributes about the behaviour of Acoustic Emission (AE) signatures of implanted weld defects of SS 316L materials. Lack of penetration and lack of side fusion defects were implanted in weld bead region of...This paper contributes about the behaviour of Acoustic Emission (AE) signatures of implanted weld defects of SS 316L materials. Lack of penetration and lack of side fusion defects were implanted in weld bead region of the materials. Tungsten Inert Gas Welding (TIG) is adopted to weld the Stainless Steel (SS316L) nuclear grade materials. The material is fabricated with dimensions of 140 × 16 × 10 mm and AE signatures are studied under preload conditions. Mechanical Jig is fabricated to maintain constant load in concentrated weld region. When external load is applied on the weld region, the deformed specimen experiences acoustic emission signals form the weld defect region which are potential source of releasing stress energy. Liner Location Technique (LLT) is adopted for AE singal studies and the generated signal is processed by 2-channel USB—AE node and AE-WIN software. The tests are conducted on two different samples having each defect. A conventional NDT method i.e. X-ray Radiography is conducted on the samples to know the defect ranging and correlated with AE signatures. This study will be helpful to standardize the AE signals for different implanted weld defects of SS 316L materials and it is found that, the parameter “counts vs. amplitude” has given the widest distinction with respect to the type of defects.展开更多
An experimental system was set up to measure the temperature, pressure, heat transfer rate and mass flow rate in a semi-open two-phase thermosyphon. The behaviors of a semi-open two-phase thermosyphon during startup, ...An experimental system was set up to measure the temperature, pressure, heat transfer rate and mass flow rate in a semi-open two-phase thermosyphon. The behaviors of a semi-open two-phase thermosyphon during startup, shutdown and lack of water were studied to get complete understanding of its thermal characteristics. The variation of wall temperature, heat-exchange condition and pressure fluctuations of semi-open two-phase thermosyphons showed that the startup of SOTPT needs about 60-70 min; the startup speed of SOTPT is determined by the startup speed of the condensation section; the average pressure in the heat pipe is equal to the environmental pressure usually; the shutdown of SOTPT needs about 30-50min; a semi-open two-phase thermosyphon has good response to lack of water accident.展开更多
AIM To investigate the clinical outcomes of transcatheter aortic valve implantation(TAVI) with the SAPIEN 3 transcatheter heart valve(S3-THV) vs the SAPIEN XT valve(XT-THV).METHODS We retrospectively analyzed 507 pati...AIM To investigate the clinical outcomes of transcatheter aortic valve implantation(TAVI) with the SAPIEN 3 transcatheter heart valve(S3-THV) vs the SAPIEN XT valve(XT-THV).METHODS We retrospectively analyzed 507 patients that underwent TAVI with the XT-THV and 283 patients that received the S3-THV at our institution between March 2010 and December 2015.RESULTS Thirty-day mortality(3.5% vs 8.7%:OR=0.44,P=0.21) and 1-year mortality(25.7% vs 20.1%,P=0.55) were similar in the S3-THV and the XT-THV groups.The rates of both major vascular complication and paravalvular regurgitation(PVR)>1 were almost 4 times lower in the S3-THV group than the XT-THV group(major vascular complication: 2.8% vs 9.9%,P<0.0001:PVR>1: 2.4% vs 9.7%,P<0.0001).However,the rate of new pacemaker implantation was almost twice as high in the S3-THV group(17.3% vs 9.8%,P=0.03).In the S3 group,independent predictors of new permanent pacemaker were pre-procedural RBBB(OR=4.9:P=0.001),pre-procedural PR duration(OR=1.14,P=0.05) and device lack of coaxiality(OR=1.13:P=0.05) during deployment.CONCLUSION The S3-THV is associated to lower rates of major vascular complications and PVR but higher rates of new pacemaker compared to the XT-THV.Sub-optimal visualization of the S3-THV in relation to the aortic valvular complex during deployment is a predictor of new permanent pacemaker.展开更多
BACKGROUND Because immediate implant surgery is not recommended for patients who have been diagnosed with periodontitis,researchers have treated these patients with a variety of methods,including combining orthodontic...BACKGROUND Because immediate implant surgery is not recommended for patients who have been diagnosed with periodontitis,researchers have treated these patients with a variety of methods,including combining orthodontic and periodontal surgeries as well as implantation.However,these treatments cost time and money for the patient.Although it has been reported that temporary implants released a severe gag reflex in 1 case,only a few studies have documented using temporary implants to treat patients diagnosed with severe periodontitis.CASE SUMMARY The patient was a 49-year-old female who was missing the majority of her teeth and had gingival atrophy and severe alveolar bone atrophy.After being diagnosed with severe periodontitis,the patient underwent staged load applied implant restoration therapy.The first load-bearing stage was carried out immediately by inserting temporary Osstem mini implants.Maxillary teeth were extracted by using the guided bone regeneration technique,and lateral maxillary sinus lifting was conducted on both sides.During the second load-bearing stage,temporary implants were removed,and permanent implants were placed.The resin bridge was segmented during the third load-bearing stage.During the fourth load-bearing stage,the permanent prosthesis was positioned in the patient’s mouth.CONCLUSION By conducting the load-bearing treatment in stages,the patient’s mouth contained restorations throughout the procedure,thus guaranteeing basic function and appearance.展开更多
Samples of the cross section microstructures of galvannealed steel sheets that lack alloying were analyzed. X-ray diffraction （XRD） tests were carried out. The study discovers that the deficit of alloying was higher...Samples of the cross section microstructures of galvannealed steel sheets that lack alloying were analyzed. X-ray diffraction （XRD） tests were carried out. The study discovers that the deficit of alloying was higher on both sides of the steel sheet when compared to the center and the thickness of the coating on the sides was also higher than the center. The results of the XRD tests demonstrate that the microstructure of the coating with a lack of alloy is mainly composed of zinc,ζ and δ. They also indicate that the lack of alloying is mainly due to a lower galvannealing temperature and thicker coating. It is shown by the optical micrographs of coating that the δ phase forms first in a discontinuous manner at the interface and then rapidly pushes towards the coating and enlarges.展开更多
文摘Nigella sativa, belonging to the Ranunculacea family, is a versatile phytochemical mine bestowed with multi-dimensional medicinal effects. The current study was performed to investigate the chemopreventive efficacy, if any, of the ethanolic extract of indigenous Nigella sativa seeds (ENS) and to evaluate its potentials on tumor progression during the initiation and post initiation phases of Dimethylhydrazine-induced colon carcinogenesis in a rat model. ENS treatment during the initiation phase unveiled chemopreventive effect manifested by significant reductions in tumor incidence, multiplicity and tumor volumes. Histopathological findings and modified Duke’s classification of tumors provided evidence that ENS, administered in the initiation phase, is capable of delaying progression, restricting invasion and attenuating aggressiveness of colon tumors. These results imply that ENS may be a promising candidate in the primary prevention of colon cancer. On the contrary, we demonstrated that ENS lacked chemopreventive and tumorigenesis inhibitory effects in the post initiation phase. We speculate that the chemopreventive effect of ENS might be due to the synergistic actions of various constituents present in the extract. However, extensive studies are warranted and more efforts need to be dedicated to fractionate, analyze and to further appraise the anticancer effect of ENS before any definitive conclusions can be drawn.
文摘Objective:To investigate the current situation of nurses’lack of nursing care in southern Xinjiang and analyze its influencing factors.Methods:A convenient sampling method was used to select 1476 nurses from two tertiary hospitals in Kashi from May 2022 to December 2022 as the subjects of a cross-sectional survey.The nurses in southern Xinjiang were investigated by general information questionnaire and nursing deficiency scale-nurse version.Results:A total of 1476 valid questionnaires were collected in this study.The score of nurses’lack of care in southern Xinjiang was(56.05±9.36),which was above the middle level.Among them,the scores of timely responses to call bells,view patient medical records,fully understand their own patient’s condition,and provide emotional support for patients and/or family members were relatively low.Univariate analysis showed that there were significant differences in the scores of nurses’age,nurses’level,nursing career satisfaction and nursing job satisfaction(p<0.05).Multivariate analysis showed that the occupational satisfaction and nursing job satisfaction of nursing staff were the main factors affecting the lack of nursing work(p<0.05).Conclusion:The lack of nursing care of nurses in southern Xinjiang is at the upper middle level.The younger the age,the lower the satisfaction of nursing profession and the lower the satisfaction of nursing position,the more serious the lack of nursing care.In order to solve this problem,nursing managers should actively respond to the influencing factors of nursing absence and actively seek effective management measures to reduce the incidence of nursing absence and ensure the safety of patients.
文摘利什曼原虫的 L ACK抗原是利什曼原虫活性蛋白激酶 C受体同源物 ,是一种新发现的抗原蛋白。我们以本实验室的重组质粒 T- L ACK为模板 ,PCR扩增获得 L ACK基因 ,与真核表达载体 pc DNA3.1(+)定向重组 ,重组质粒经酶切和 PCR分析 ,含有约 95 0 bp的 L ACK基因 ,成功构建含有 L ACK基因的真核表达重组质粒 pc D-NA3- L ACK。将此重组质粒转染 COS- 7细胞 ,通过 RT- PCR及免疫荧光检测 L ACK基因在真核细胞中的表达。实验结果显示转染了重组质粒的 COS- 7细胞 ,其 RT- PCR及免疫荧光检测均呈阳性反应 ,证实重组质粒 pc DNA3-L ACK能在 COS- 7细胞中有效表达 L ACK蛋白。
基金Support by the Special Fund for Agro-scientific Research in the Public Interest of China(201203030-5)National Natural Science Foundation of China(41201288,41201255,31301284)+2 种基金Key Programs for Science and Technology Development of Henan Province(132102110068)Excellent Youth Science and Technology Foundation of Henan Academy of Agricultural Sciences(2013YQ15)JIRCAS-IARRP collaborative research:Estimation of the Present States of Fertilizer Use and Livestock Production and Their Environmental Load~~
文摘[Objective] Long-term （over 18 years） fertilization experiments were con- ducted to study the responses of crop yields and soil fertility to long-term nutrient lacking at Zhengzhou in China. [Method] The present study consisted of five treat- ments： 1 CK （no fertilizer or manure）, （2） NP （nitrogen and phosphorus fertilizer applied）, 31 NK （nitrogen and potassium fertilizer applied）, 4 PK （phosphorus and potassium fertilizer applied） and ：5 NPK （nitrogen, phosphorus and potassium fertil- izer applied）. [Result] Lacking of nitrogen or phosphorus led to a low yield; however, there was no significant difference in grain yields between the NP and NPK treat- ments which maintained a higher yield. Receiving no phosphorus, soil available phosphorus content declined to about 2.5 mg/kg. The concentration of soil ex- changeable potassium remained constant at a level of 60 mg/kg under the treat- ments without potassium fertilizer addition. Soil potassium spontaneous supply ca- pacity fluctuated around 100%.[Conclusion] In fluvo-aquic soil, nitrogen and phos- phorus were two key limiting factors to grain yields, biomass and yield component factors of wheat and maize, while potassium was not. However, potassium defi- ciency may occur in the future if there was still no potassium fertilizer applied.
文摘This essay put emphasis on the analysis T.S. Eliot's The Waste Land, pointing the masterpiece can be interpreted by three- levels, the person, the society and human race. Eliot also indicated two kinds of people, the one is just secularized, and the other one is lack of faith in The Waste Land. We can analyze the feeling of protagonist is afraid to live new life, but afraid of death, the important theme is corruption of sex.
基金Government Foundation of Liaoning Province, Shenyang,China(No.20081059,2008860)
文摘AIM: To study the impact of scleral flap position, under which the posterior chamber intraocular lenses (PC-IOL) were sulcus-fixed by trans-scleral suture, on cornea astigmatism. METHODS: Twenty-six aphakic or cataract eyes were comprised in this prospective noncomparative case series study. Eleven eyes had traumatic cataract removed without sufficient capsular support, 3 had blunt trauma with subluxated traumatic cataract, 8 had undergone vitreoretinal surgery and 4 had congenital cataract removed. The average age was 54 years (range 21-74 years), with 17 men and 7 women. The foldable PC-IOL was fixed in sulcus by trans-scleral suture. The incision for IOL implantation was made 1mm posterior to limbus along the steepest meridian of cornea, while scleral flaps to bury the knots of trans-scleral suture were made along the flattest meridian. All the surgeries were performed by a single doctor (Ma L), and the follow up was at least 13 months (range 13-28 months). The preoperative, 3 months and 1 year postoperative corneal curvature along the steepest and flattest cornea meridian and overall cornea astigmatism were compared. RESULTS: The curvature along the steepest meridian changed from 44.25 +/- 2.22D preoperatively to 44.08 +/- 2.16D at 3 months postoperatively, and 43.65 +/- 5.23D at 1 year postoperatively (P>0.05); the curvature along the flattest meridian changed from 41.24 +/- 2.21D preoperatively to 43.15 +/- 3.94D at 3 months postoperatively, and 42.85 +/- 5.17D at 1 year postoperatively (P<0.05); and the surgery induced astigmatism (SIA) on cornea was calculated by vector analysis, which was 2.42 +/- 2.13D at 3 months postoperatively, and 2.18 +/- 3.42D at 1 year postoperatively, the difference was statistically significant (P<0.05). CONCLUSION: The scleral flap made along the flattest meridian, under which the posterior chamber intraocular lenses (PCIOL) were sulcus-fixed by trans-scleral suture, can steepen the cornea in varying degrees, thus reducing preexisting corneal astigmatism.
基金supported by the National Natural Science Foundation of China(Nos.40830742 and 40901007)
文摘Debris flows are the one type of natural disaster that is most closely associated with hu- man activities. Debris flows are characterized as being widely distributed and frequently activated. Rainfall is an important component of debris flows and is the most active factor when debris flows oc- cur. Rainfall also determines the temporal and spatial distribution characteristics of the hazards. A reasonable rainfall threshold target is essential to ensuring the accuracy of debris flow pre-warning. Such a threshold is important for the study of the mechanisms of debris flow formation, predicting the characteristics of future activities and the design of prevention and engineering control measures. Most mountainous areas have little data regarding rainfall and hazards, especially in debris flow forming re- gions. Therefore, both the traditional demonstration method and frequency calculated method cannot satisfy the debris flow pre-warning requirements. This study presents the characteristics of pre-warning regions, included the rainfall, hydrologic and topographic conditions. An analogous area with abundant data and the same conditions as the pre-warning region was selected, and the rainfall threshold was calculated by proxy. This method resolved the problem of debris flow pre-warning in ar- eas lacking data and provided a new approach for debris flow pre-warning in mountainous areas.
文摘The use of anti-tumor necrosis factor-α therapy for inflammatory bowel disease represents the most important advance in the care of these patients since the publication of the National Co-operative Crohn＇s disease study thirty years ago. The recommendations of numerous consensus groups worldwide are now supported by a wealth of clinical trials and several meta-analyses. In general, it is suggested that tumor necrosis factor-c~ blockers （TNFBs） are indicated （1） for persons with moderately-severe Crohn＇s disease or ulcerative colitis （UC） who have failed two or more causes of glucocorticosteroids and an acceptably long cause （8 wk to 12 wk） of an immune modulator such as azathioprine or methotrexate; （2） non-responsive perianal disease; and （3） severe UC not responding to a 3-d to 5-d course of steroids. Once TNFBs have been introduced and the patient is responsive, therapy given by the IV and SC rate must be continued. It remains open to definitive evidence if concomitant immune modulators are required with TNFB maintenance ther- apy, and when or if TNFB may be weaned and discon- tinued. The supportive evidence from a single study on the role of early versus later introduction of TNFB in the course of a patient＇s illness needs to be confirmed. The risk/benefit profile of TNFB appears to be accept- able as long as the patient is immunized and tested for tuberculosis and viral hepatitis before the initiation of TNFB, and as long as the long-term adverse effects on the development of lymphoma and other tumors do not prone to be problematic. Because the rates of ben- efits to TNFB are modest from a population perspec- tive and the cost of therapy is very high, the ultimate application of use of TNFBs will likely be established by cost/benefit studies.
文摘This paper contributes about the behaviour of Acoustic Emission (AE) signatures of implanted weld defects of SS 316L materials. Lack of penetration and lack of side fusion defects were implanted in weld bead region of the materials. Tungsten Inert Gas Welding (TIG) is adopted to weld the Stainless Steel (SS316L) nuclear grade materials. The material is fabricated with dimensions of 140 × 16 × 10 mm and AE signatures are studied under preload conditions. Mechanical Jig is fabricated to maintain constant load in concentrated weld region. When external load is applied on the weld region, the deformed specimen experiences acoustic emission signals form the weld defect region which are potential source of releasing stress energy. Liner Location Technique (LLT) is adopted for AE singal studies and the generated signal is processed by 2-channel USB—AE node and AE-WIN software. The tests are conducted on two different samples having each defect. A conventional NDT method i.e. X-ray Radiography is conducted on the samples to know the defect ranging and correlated with AE signatures. This study will be helpful to standardize the AE signals for different implanted weld defects of SS 316L materials and it is found that, the parameter “counts vs. amplitude” has given the widest distinction with respect to the type of defects.
文摘An experimental system was set up to measure the temperature, pressure, heat transfer rate and mass flow rate in a semi-open two-phase thermosyphon. The behaviors of a semi-open two-phase thermosyphon during startup, shutdown and lack of water were studied to get complete understanding of its thermal characteristics. The variation of wall temperature, heat-exchange condition and pressure fluctuations of semi-open two-phase thermosyphons showed that the startup of SOTPT needs about 60-70 min; the startup speed of SOTPT is determined by the startup speed of the condensation section; the average pressure in the heat pipe is equal to the environmental pressure usually; the shutdown of SOTPT needs about 30-50min; a semi-open two-phase thermosyphon has good response to lack of water accident.
文摘AIM To investigate the clinical outcomes of transcatheter aortic valve implantation(TAVI) with the SAPIEN 3 transcatheter heart valve(S3-THV) vs the SAPIEN XT valve(XT-THV).METHODS We retrospectively analyzed 507 patients that underwent TAVI with the XT-THV and 283 patients that received the S3-THV at our institution between March 2010 and December 2015.RESULTS Thirty-day mortality(3.5% vs 8.7%:OR=0.44,P=0.21) and 1-year mortality(25.7% vs 20.1%,P=0.55) were similar in the S3-THV and the XT-THV groups.The rates of both major vascular complication and paravalvular regurgitation(PVR)>1 were almost 4 times lower in the S3-THV group than the XT-THV group(major vascular complication: 2.8% vs 9.9%,P<0.0001:PVR>1: 2.4% vs 9.7%,P<0.0001).However,the rate of new pacemaker implantation was almost twice as high in the S3-THV group(17.3% vs 9.8%,P=0.03).In the S3 group,independent predictors of new permanent pacemaker were pre-procedural RBBB(OR=4.9:P=0.001),pre-procedural PR duration(OR=1.14,P=0.05) and device lack of coaxiality(OR=1.13:P=0.05) during deployment.CONCLUSION The S3-THV is associated to lower rates of major vascular complications and PVR but higher rates of new pacemaker compared to the XT-THV.Sub-optimal visualization of the S3-THV in relation to the aortic valvular complex during deployment is a predictor of new permanent pacemaker.
文摘BACKGROUND Because immediate implant surgery is not recommended for patients who have been diagnosed with periodontitis,researchers have treated these patients with a variety of methods,including combining orthodontic and periodontal surgeries as well as implantation.However,these treatments cost time and money for the patient.Although it has been reported that temporary implants released a severe gag reflex in 1 case,only a few studies have documented using temporary implants to treat patients diagnosed with severe periodontitis.CASE SUMMARY The patient was a 49-year-old female who was missing the majority of her teeth and had gingival atrophy and severe alveolar bone atrophy.After being diagnosed with severe periodontitis,the patient underwent staged load applied implant restoration therapy.The first load-bearing stage was carried out immediately by inserting temporary Osstem mini implants.Maxillary teeth were extracted by using the guided bone regeneration technique,and lateral maxillary sinus lifting was conducted on both sides.During the second load-bearing stage,temporary implants were removed,and permanent implants were placed.The resin bridge was segmented during the third load-bearing stage.During the fourth load-bearing stage,the permanent prosthesis was positioned in the patient’s mouth.CONCLUSION By conducting the load-bearing treatment in stages,the patient’s mouth contained restorations throughout the procedure,thus guaranteeing basic function and appearance.
文摘Samples of the cross section microstructures of galvannealed steel sheets that lack alloying were analyzed. X-ray diffraction （XRD） tests were carried out. The study discovers that the deficit of alloying was higher on both sides of the steel sheet when compared to the center and the thickness of the coating on the sides was also higher than the center. The results of the XRD tests demonstrate that the microstructure of the coating with a lack of alloy is mainly composed of zinc,ζ and δ. They also indicate that the lack of alloying is mainly due to a lower galvannealing temperature and thicker coating. It is shown by the optical micrographs of coating that the δ phase forms first in a discontinuous manner at the interface and then rapidly pushes towards the coating and enlarges.
