With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare re...With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare resources.Within this context,laboratory data,as a key component of healthcare information systems,urgently requires efficient sharing and intelligent analysis.This paper designs and constructs an intelligent early warning system for laboratory data based on a cloud platform tailored to the medical consortium model.Through standardized data formats and unified access interfaces,the system enables the integration and cleaning of laboratory data across multiple healthcare institutions.By combining medical rule sets with machine learning models,the system achieves graded alerts and rapid responses to abnormal key indicators and potential outbreaks of infectious diseases.Practical deployment results demonstrate that the system significantly improves the utilization efficiency of laboratory data,strengthens public health event monitoring,and optimizes inter-institutional collaboration.The paper also discusses challenges encountered during system implementation,such as inconsistent data standards,security and compliance concerns,and model interpretability,and proposes corresponding optimization strategies.These findings provide a reference for the broader application of intelligent medical early warning systems.展开更多
Background:The aim of this study was to develop and validate a fatty liver index based on laboratory data(FLI-L)and a fatty liver index based on both physical examination and laboratory data(FLI-PL)in the hope of prov...Background:The aim of this study was to develop and validate a fatty liver index based on laboratory data(FLI-L)and a fatty liver index based on both physical examination and laboratory data(FLI-PL)in the hope of providing a more convenient,accurate,and quantitative method for the diagnosis of fatty liver disease.Methods:The study included data for 12,391 patients obtained from the Third Medical Center of Chinese PLA General Hospital.FLI-L and FLI-PL were developed using binary logistic regression analysis.The diagnostic performance of the FLI-L and FLI-PL was evaluated using the area under the receiver-operating characteristic curve(AUC-ROC)with sensitivity,specificity,and positive and negative likelihood ratios.FLI-L and FLI-PL were subsequently validated in 3170 patients from the same hospital.Results:The AUC-ROC for FLI-L was 0.876 with a cut-off value of 55.03.Sensitivity was 81.35 and specificity was 78.28,with an accuracy of 79.99%for discriminating between patients with and without fatty liver disease.The AUC-ROC for FLI-PL was 0.902 with a cut-off value of 20.51.Sensitivity was 85.10 and specificity was 79.64.FLI-PL classified 91.65%of patients correctly.Conclusion:FLI-L and FLI-PL is used for simple and accurate quantitative diagnosis of fatty liver disease.This study provides evidence to support the use of this index in clinical management.展开更多
Objectives:Human papillomavirus(HPV)is a globally prevalent infection,with multiple genotypes strongly associated with cancers and other diseases.While epidemiological studies in females are extensive,research on HPV ...Objectives:Human papillomavirus(HPV)is a globally prevalent infection,with multiple genotypes strongly associated with cancers and other diseases.While epidemiological studies in females are extensive,research on HPV genotype distribution in males remains limited.Methods:We conducted a retrospective study by collecting and analyzing clinical and laboratory data from male patients with confirmed HPV infection at Shenzhen People’s Hospital.The distribution of HPV genotypes and their associations with specific disease types were evaluated.Results:A total of 2,037 male participants were included,with an overall HPV infection rate of 45%.Low-risk genotypes predominated,with HPV 6 and HPV 11 accounting for 25%and 12%of cases,respectively.High-risk genotypes such as HPV 16 and HPV 52 showed low prevalence(<3%)but exhibited a slight upward trend in 2022.No significant age distribution differences were observed between HPVpositive and HPV-negative groups.The frequency of multiple HPV genotype infections increased slightly with age.Specific HPV genotypes showed unique associations with acne(HPV 56),allergic dermatitis(HPV 59),and amyloidosis(HPV 58).Conclusions:Low-risk HPV genotypes predominate in males with confirmed exposure.Older males appear more susceptible to multiple infections,and specific genotypes are associated with distinct diseases,supporting the need for male-targeted HPV vaccination and surveillance programs.展开更多
Objective To retrospectively analyze the dual plasma molecular adsorption system(DPMAS)treatment technology and the laboratory data before and after treatment in patients with liver failure and refractory hyperbilirub...Objective To retrospectively analyze the dual plasma molecular adsorption system(DPMAS)treatment technology and the laboratory data before and after treatment in patients with liver failure and refractory hyperbilirubinemia,so as to provide a clinical basis for the prediction1andpreventionof common related complicationsM.I ethods A retrospective study was conducted on 161 cases with liver failure and 683cases with refractory hyperbilirubinemia whounderwent DPMAS treatment in our department from October 2022 to July 2024.The general clinical data characteristics,DPMAS treatment status,DPMAS-related complications,and changes in important laboratory indicators before and after the initial DPMAS treatment in both patient groups were analyzed.Results Among the 229 enrolled cases,82.53%were male,and the median age was 50 years.The cause of liver failure was hepatitis B virus infection in 84.47%,while hepatitis B accounted for only 51.47%in the other group.There were significant differences in platelets,creatinine,coagulation function,and inflammatory factor-related indicators between the two groups at baseline.The total number of DPMAS treatments given was 4471 times.The proportion of albumin used in the initial stage of treatment was significantly higher inpatients with refractory hyperbilirubinemia than that in the liver failure group,while the proportion of plasma used in the liver failure group was significantly higher(P<0.001).The most commonly used anticoagulation regimen was unfractionated heparin.A combined anticoagulation therapy regimen was used in 9.3%of the refractory hyperbilirubinemia group.The internal jugular vein was selected in nearly half of the treated cases.A peripheral vascular access pathway was the treatment option in 31.2%.The proportion of centrifugal separation was significantly higher than that of membrane separation(76.22%vs.23.78%).The incidence rate of DPMAS-related complicationswas 16%.The most common complication was bleeding,including bleeding at the puncture site(accounting for 32%of the total complications)and bleeding at nonpuncture sites(12%),followed by hypotension(22%),allergic reactions(13%)and infections(11%),respectively.The indexes of hemoglobin,platelets,total bilirubin,and C-reactive protein were significantly decreased within 24-48 hours after DPMAS treatment in both groups of patients.The prothrombin time and international normalized ratio were significantly increased in theliver failure group,while fibrinogen was significantly reduced.Conclusion DPMAS clinical application is generally safe in patients with liver disease.The most common complications are bleeding hypotension,allergic reactions,and infections,which need to be paid special attention and timely intervention to ensure the safety profile of treatment.展开更多
文摘With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare resources.Within this context,laboratory data,as a key component of healthcare information systems,urgently requires efficient sharing and intelligent analysis.This paper designs and constructs an intelligent early warning system for laboratory data based on a cloud platform tailored to the medical consortium model.Through standardized data formats and unified access interfaces,the system enables the integration and cleaning of laboratory data across multiple healthcare institutions.By combining medical rule sets with machine learning models,the system achieves graded alerts and rapid responses to abnormal key indicators and potential outbreaks of infectious diseases.Practical deployment results demonstrate that the system significantly improves the utilization efficiency of laboratory data,strengthens public health event monitoring,and optimizes inter-institutional collaboration.The paper also discusses challenges encountered during system implementation,such as inconsistent data standards,security and compliance concerns,and model interpretability,and proposes corresponding optimization strategies.These findings provide a reference for the broader application of intelligent medical early warning systems.
基金supported by the National Natural Science Foundation of China(grant number 81972696).
文摘Background:The aim of this study was to develop and validate a fatty liver index based on laboratory data(FLI-L)and a fatty liver index based on both physical examination and laboratory data(FLI-PL)in the hope of providing a more convenient,accurate,and quantitative method for the diagnosis of fatty liver disease.Methods:The study included data for 12,391 patients obtained from the Third Medical Center of Chinese PLA General Hospital.FLI-L and FLI-PL were developed using binary logistic regression analysis.The diagnostic performance of the FLI-L and FLI-PL was evaluated using the area under the receiver-operating characteristic curve(AUC-ROC)with sensitivity,specificity,and positive and negative likelihood ratios.FLI-L and FLI-PL were subsequently validated in 3170 patients from the same hospital.Results:The AUC-ROC for FLI-L was 0.876 with a cut-off value of 55.03.Sensitivity was 81.35 and specificity was 78.28,with an accuracy of 79.99%for discriminating between patients with and without fatty liver disease.The AUC-ROC for FLI-PL was 0.902 with a cut-off value of 20.51.Sensitivity was 85.10 and specificity was 79.64.FLI-PL classified 91.65%of patients correctly.Conclusion:FLI-L and FLI-PL is used for simple and accurate quantitative diagnosis of fatty liver disease.This study provides evidence to support the use of this index in clinical management.
基金Supported by the National Natural Science Foundation of China(No.81971464)the China National Postdoctoral Program for Innovative Talents(BX20200151)+2 种基金Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(No.SZXK011)the Sanming Project of Medicine in Shenzhen(SZSM201512019)the Research and Development Projects in Key Fields of Guangdong Science and Technology Department(2019B020229001).
文摘Objectives:Human papillomavirus(HPV)is a globally prevalent infection,with multiple genotypes strongly associated with cancers and other diseases.While epidemiological studies in females are extensive,research on HPV genotype distribution in males remains limited.Methods:We conducted a retrospective study by collecting and analyzing clinical and laboratory data from male patients with confirmed HPV infection at Shenzhen People’s Hospital.The distribution of HPV genotypes and their associations with specific disease types were evaluated.Results:A total of 2,037 male participants were included,with an overall HPV infection rate of 45%.Low-risk genotypes predominated,with HPV 6 and HPV 11 accounting for 25%and 12%of cases,respectively.High-risk genotypes such as HPV 16 and HPV 52 showed low prevalence(<3%)but exhibited a slight upward trend in 2022.No significant age distribution differences were observed between HPVpositive and HPV-negative groups.The frequency of multiple HPV genotype infections increased slightly with age.Specific HPV genotypes showed unique associations with acne(HPV 56),allergic dermatitis(HPV 59),and amyloidosis(HPV 58).Conclusions:Low-risk HPV genotypes predominate in males with confirmed exposure.Older males appear more susceptible to multiple infections,and specific genotypes are associated with distinct diseases,supporting the need for male-targeted HPV vaccination and surveillance programs.
文摘Objective To retrospectively analyze the dual plasma molecular adsorption system(DPMAS)treatment technology and the laboratory data before and after treatment in patients with liver failure and refractory hyperbilirubinemia,so as to provide a clinical basis for the prediction1andpreventionof common related complicationsM.I ethods A retrospective study was conducted on 161 cases with liver failure and 683cases with refractory hyperbilirubinemia whounderwent DPMAS treatment in our department from October 2022 to July 2024.The general clinical data characteristics,DPMAS treatment status,DPMAS-related complications,and changes in important laboratory indicators before and after the initial DPMAS treatment in both patient groups were analyzed.Results Among the 229 enrolled cases,82.53%were male,and the median age was 50 years.The cause of liver failure was hepatitis B virus infection in 84.47%,while hepatitis B accounted for only 51.47%in the other group.There were significant differences in platelets,creatinine,coagulation function,and inflammatory factor-related indicators between the two groups at baseline.The total number of DPMAS treatments given was 4471 times.The proportion of albumin used in the initial stage of treatment was significantly higher inpatients with refractory hyperbilirubinemia than that in the liver failure group,while the proportion of plasma used in the liver failure group was significantly higher(P<0.001).The most commonly used anticoagulation regimen was unfractionated heparin.A combined anticoagulation therapy regimen was used in 9.3%of the refractory hyperbilirubinemia group.The internal jugular vein was selected in nearly half of the treated cases.A peripheral vascular access pathway was the treatment option in 31.2%.The proportion of centrifugal separation was significantly higher than that of membrane separation(76.22%vs.23.78%).The incidence rate of DPMAS-related complicationswas 16%.The most common complication was bleeding,including bleeding at the puncture site(accounting for 32%of the total complications)and bleeding at nonpuncture sites(12%),followed by hypotension(22%),allergic reactions(13%)and infections(11%),respectively.The indexes of hemoglobin,platelets,total bilirubin,and C-reactive protein were significantly decreased within 24-48 hours after DPMAS treatment in both groups of patients.The prothrombin time and international normalized ratio were significantly increased in theliver failure group,while fibrinogen was significantly reduced.Conclusion DPMAS clinical application is generally safe in patients with liver disease.The most common complications are bleeding hypotension,allergic reactions,and infections,which need to be paid special attention and timely intervention to ensure the safety profile of treatment.
