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Ecological Enhancement of Agaricus bisporus L.Mushrooms’Vitamin Content Using Carbon Nanotubes,Magnetic Iron Nanoparticles,and Biostimulants
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作者 Mustafa Algarawi Hayyawi Al-Juthery Rukaibaa Chechan 《Research in Ecology》 2025年第3期60-71,共12页
The edible mushroom Agaricus bisporus L.plays a crucial ecological role in nutrient cycling and organic matter decomposition,alongside its increasing importance in the food and nutrition industry.This study explored e... The edible mushroom Agaricus bisporus L.plays a crucial ecological role in nutrient cycling and organic matter decomposition,alongside its increasing importance in the food and nutrition industry.This study explored ecological interventions to enhance the mushroom’s vitamin content by enriching its cultivation substrate with nanomaterials and biostimulatory agents.The experiment was conducted within the mushroom production project at Al-Qadisiyah Governorate,Iraq.The compost-based medium was amended with magnetic iron nanoparticles(N-FeO),carbon nanotube(CNT)suspensions,EM biofertilizer,and Atonik growth stimulant.Their ecological impact on the enrichment of fat-soluble(A,D,E)and water-soluble(B2,B3,B5,B6)vitamins in mushrooms was assessed.The study employed a Completely Randomized Design(CRD)with three replicates.Results revealed that the synergistic application of these eco-friendly treatments significantly enhanced the vitamin profiles of A.bisporus.The highest concentrations of vitamins B2 and B5(5.16 and 17.70 mg kg^(-1),respectively)and vitamin A(6.87 IU ml^(-1))were recorded under the combined quadruple treatment.Additionally,the triple treatment(N-FeO+EM+Atonik)notably increased levels of vitamins B2(4.47 mg kg^(-1)),B6(25.66 mg kg^(-1)),D(34.76 mg kg^(-1)),and vitamin A(6.87 IU ml^(-1)).Dual treatments(EM+Atonik)also significantly improved vitamin B2(4.54 mg kg^(-1))and vitamin E(3.30 mg kg^(-1))contents.These findings demonstrate that integrating nanomaterials and biostimulants can serve as an ecological strategy to improve the nutritional quality of mushrooms while promoting sustainable agricultural practices. 展开更多
关键词 Agaricus bisporus l. Ecological Cultivation EM Biofertilizer Iron Nanoparticles Carbon Nanotubes Sustainable Agriculture Water-Soluble Vitamins Fat-Soluble Vitamins
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Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers
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作者 Bridget Martinez Philip V.Peplow 《Neural Regeneration Research》 SCIE CAS 2025年第10期2776-2786,共11页
We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies wer... We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear cells.Most of the studies involved children and the study cohorts were largely males.Many of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA expression.Only five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to controls.The microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of adults.Several important limitations were identified in the studies reviewed,and need to be taken into account in future studies.Further studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy. 展开更多
关键词 autism spectrum disorder BIOMARKER blood cells blood plasma blood serum DIAGNOSIS MICRORNA peripheral blood mononuclear cells serum neural cell adhesion molecule l1-captured extracellular vesicles whole blood
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GPR37L1 in Spinal Astrocytes:A Potential Target for Neuropathic Pain Management
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作者 Jingyang Xu Yufeng Chen +1 位作者 Lerong Chen Boyi Liu 《Neuroscience Bulletin》 2025年第8期1507-1510,共4页
In a recent work published in Neuron,Xu et al.identified a novel contribution of G protein-coupled receptor 37-like 1(GPR37L1),which is identified to be expressed by spinal astrocytes,to the regulation of neuropathic ... In a recent work published in Neuron,Xu et al.identified a novel contribution of G protein-coupled receptor 37-like 1(GPR37L1),which is identified to be expressed by spinal astrocytes,to the regulation of neuropathic pain[1].By interacting and enhancing the activity of glutamate transporter-1(GLT-1)in spinal astrocytes,GPR37L1 promotes glutamate uptake by spinal astrocytes and reduces excitatory synaptic transmission in the spinal dorsal horn,all of which contribute to the resolution of chronic neuropathic pain. 展开更多
关键词 regulation neuropathic pain neuropathic pain spinal astrocytesgpr l reduces excitatory synaptic transmission resolution chronic neuropathic pa spinal astrocytesto GPR l spinal astrocytes
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Antibacterial,antibiofilm,and wound healing activities of Piper longum root in multidrug-resistant Staphylococcus aureus infected mice
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作者 Pooja Gaur Pashupatinath Shukla +1 位作者 Jitesh Yadav Ch.V.Rao 《Asian Pacific Journal of Tropical Biomedicine》 2025年第5期189-199,I0002-I0012,共22页
Objective:To explore the effect of a hydrogel of Piper longum(P.longum)root against biofilm-forming multidrug-resistant(MDR)Staphylococcus aureus(S.aureus)through in vitro,in silico,and in vivo studies.Methods:We isol... Objective:To explore the effect of a hydrogel of Piper longum(P.longum)root against biofilm-forming multidrug-resistant(MDR)Staphylococcus aureus(S.aureus)through in vitro,in silico,and in vivo studies.Methods:We isolated the P.longum root ethanolic extract and the compounds using p-HPLC.In vitro antibacterial and antibiofilm activities of P.longum root extract and isolated alkamide compounds against biofilm-forming MDR S.aureus(ATCC 33591)were assessed using agar diffusion and broth microdilution methods,respectively.In silico investigations were conducted to investigate the interaction of alkamide compounds with three target proteins glycogen synthase kinase 3β(GSK3β),matrix metalloproteinases-8(MMP-8),and inducible nitric oxide synthase(iNOS).In addition,the wound healing effect of P.longum root extract 2%and 5%(w/v)-containing hydrogels was determined in mice.Results:The ethanolic root extract of P.longum and its compounds exhibited in vitro antibacterial activity with minimum inhibitory concentrations between 50µg/mL and 700µg/mL,as well as significantly reduced biofilm formation.Piperdardine isolated from P.longum root extract had the best molecular docking score(-9.7,-9.8,and-9.2 kcal/mol)with target proteins GSK3β,MMP-8,and iNOS.In vivo studies showed that P.longum hydrogels significantly lowered the number of colony-forming units(P<0.05).The P.longum 5%(w/v)hydrogel-treated group showed enhanced wound healing activity,achieving a wound contraction rate of 99.34%on day 14.Furthermore,histopathological analysis confirmed increased re-epithelialization and reduced inflammation in mice treated with P.longum 5%(w/v)hydrogel.Conclusions:P.longum root extract has pharmacological potential as an antibacterial and wound-healing agent,and further research is required to confirm its efficacy and clinical application. 展开更多
关键词 Piper longum l. Wound healing ANTIBIOFIlM ANTIBACTERIAl MDR Staphylococcus aureus In silico docking
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Melon2K array:A versatile 2K liquid SNP chip for melon genetics and breeding
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作者 Qing Yu Shuai Li +7 位作者 Xiaofeng Su Xinxiu Chen Yuanhua Dong Zhiwang Yao Naiyu Jiang Sen Chai Zhonghua Zhang Kuipeng Xu 《Horticultural Plant Journal》 2025年第1期314-322,共9页
High-throughput genotyping tools can effectively promote molecular breeding in crops.In this study,genotyping by target sequencing(GBTS)system was utilized to develop a genome-wide liquid SNP chip for facilitating gen... High-throughput genotyping tools can effectively promote molecular breeding in crops.In this study,genotyping by target sequencing(GBTS)system was utilized to develop a genome-wide liquid SNP chip for facilitating genetics and breeding in melon(Cucumis melo L.),a globally cultivated economically important horticultural crop.Based on over eight million SNPs derived from 823 representative melon accessions,16K,8K,4K,2K,1K,500,250 and 125 informative SNPs were screened and evaluated for their polymorphisms,conservation of flanking sequences,and distributions.The set of 2K SNPs was found to be optimal for representing the maximum diversity with the lowest number of SNPs,and it was selected to develop the liquid chip,named“Melon2K”.Using Melon2K,more than 1500 SNPs were detected across 17 samples of five melon cultivars,and the phylogenetic relationships were clearly constructed.Within the same cultivar,genetic differences were also assessed between different samples.We evaluated the performance of Melon2K in genetic background selection during the breeding process,obtaining the introgression lines of interested trait with more than 97%genetic background of elite variety by only two rounds of backcrossing.These results suggest that Melon2K provides a cost-effective,efficient and reliable platform for genetic analysis and molecular breeding in melon. 展开更多
关键词 MElON Cucumis melo l. Melon2K liquid SNP chip Cultivar identification Background selection
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Innovative pathways to sustainable wheat production
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作者 Xiao Wang Xiangnan Li +1 位作者 Fulai Liu Dong Jiang 《Journal of Integrative Agriculture》 2025年第8期2885-2887,共3页
Wheat(Triticum aestivum L.)is a cornerstone of global food security,feeding over a third of the world’s population and functioning as a critical economic crop across diverse agroecological zones(FAO 2022).However,whe... Wheat(Triticum aestivum L.)is a cornerstone of global food security,feeding over a third of the world’s population and functioning as a critical economic crop across diverse agroecological zones(FAO 2022).However,wheat production faces mounting challenges from climate volatility,resource depletion,and the pressing demand for sustainable intensification. 展开更多
关键词 sustainable wheat production sustainable intensification climate volatility resource depletion Triticum aestivum l global food security innovative pathways
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Achieving significant strength-ductility synergy in a multicomponent alloy via L1_(2) precipitates and twins dispersed in fine grains
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作者 Peng-Peng Pu Ti-Jun Chen 《Rare Metals》 2025年第4期2748-2766,共19页
Face-centered cubic(FCC)-structured multicomponent alloys typically exhibit good ductility but low strength.To simultaneously improve strength and ductility,a multicomponent alloy,Ni_(43.9)Co_(22.4)Fe_(8.8)Al_(10.7)Ti... Face-centered cubic(FCC)-structured multicomponent alloys typically exhibit good ductility but low strength.To simultaneously improve strength and ductility,a multicomponent alloy,Ni_(43.9)Co_(22.4)Fe_(8.8)Al_(10.7)Ti_(11.7)B_(2.5)(at%)with a unique microstructure was developed in this work.The microstructure,which includes 17.8%nanosized L12 precipitates and 26.6%micron-sized annealing twins distributed within~8μm fine FCC grains,was achieved through cryogenic rolling and subsequent annealing.The alloy exhibits a yield strength(YS)of 1063 MPa,ultimate tensile strength(UTS)of 1696 MPa,and excellent elongation of~26%.The L1_(2) precipitates and high-density grain boundaries act as a barrier to the dislocation movement,resulting in a substantial strengthening effect.In addition,the dislocations can cut through the L1_(2) precipitates that are coherent with the FCC matrix,whereas the twin boundaries can effectively absorb and store dislocations,leading to a high work-hardening rate.Furthermore,the stacking faults,Lomer-Cottrell locks,and 9-layer rhombohedral stacking sequence(9R)structures formed during tensile deformation significantly enhance strain hardening by blocking dislocation movement and accumulating dislocations,resulting in excellent comprehensive tensile properties.Theoretical calculations reveal that the grain boundaries,L1_(2)precipitates,and twin boundaries contribute the strengths of 263.8,412.6,and 68.7 MPa,respectively,accounting for 71.9%of the YS.This study introduces a promising strategy for developing multicomponent alloys with significant strength-ductility synergies. 展开更多
关键词 Cryogenic rolling Multicomponent alloy Tensile properties l1_(2)precipitates Annealing twins Strength-ductility synergy
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The Effect of Carrier Doping and Thickness on the Electronic Structures of La_(3)Ni_(2)O_(7)Thin Films
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作者 Haoliang Shi Zihao Huo +4 位作者 Guanlin Li Hao Ma Tian Cui Daoxin Yao Defang Duan 《Chinese Physics Letters》 2025年第8期201-229,共29页
The discovery of high-temperature superconductivity in bilayer nickelate La_(3)Ni_(2)O_(7)under high-pressure conditions has spurred extensive efforts to stabilize superconductivity at ambient pressure.Recently,the re... The discovery of high-temperature superconductivity in bilayer nickelate La_(3)Ni_(2)O_(7)under high-pressure conditions has spurred extensive efforts to stabilize superconductivity at ambient pressure.Recently,the realization of superconductivity in compressively strained La_(3)Ni_(2)O_(7)thin films grown on the SrLaAlO_(4)substrates,with a T_(c)exceeding 40 K,represents a significant step toward this goal.Here,we investigate the influence of film thickness and carrier doping on the electronic structure of La_(3)Ni_(2)O_(7)thin films,ranging from 0.5 to 3 unit cells,using first-principles calculations.For a 2 unit-cell film with an optimal doping concentration of 0.3 hole per formula unit(0.15 hole/Ni),the Ni-d_(z^(2))interlayer bonding state crosses the Fermi level,resulting in the formation ofγpockets at the Fermi surface.These findings align with angle-resolved photoemission spectroscopy experimental data.Our results provide theoretical validation for the recent experimental discovery of ambient-pressure superconductivity in La_(3)Ni_(2)O_(7)thin films and underscore the significant impact of film thickness and carrier doping on electronic property modulation. 展开更多
关键词 bilayer nickelate film thickness electronic structure l electronic structure la ni o thin films carrier doping stabilize superconductivity SUPERCONDUCTIVITY
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Thoughts on the Inheritance and Development of Farming Culture of the Rice Whole Industry Chain in the Yangtze River Economic Belt
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作者 Min ZHANG Juncheng ZHU +2 位作者 Li GAO Bin HU Dongjing LI 《Asian Agricultural Research》 2025年第2期1-10,16,共11页
The Yangtze River Economic Belt is the birthplace of the world s rice farming culture,and is the origin of common rice(Oryza sativa L.),wild rice(Oryza Rufipogon Griff.),medicinal rice(Oryza officinalis Wall.ex G.Watt... The Yangtze River Economic Belt is the birthplace of the world s rice farming culture,and is the origin of common rice(Oryza sativa L.),wild rice(Oryza Rufipogon Griff.),medicinal rice(Oryza officinalis Wall.ex G.Watt),and wart-grain rice(Oryza granate Nees et Arn.ex Hook.f.).Rice culture is the main theme of agricultural culture in this economic belt and an outstanding representative of excellent traditional Chinese culture.This study provides an overview of the history of rice cultivation in the belt from the prehistory,post-history and modern progress.It studies the agricultural cultural heritage resources of the whole rice industry chain from the biological genetic resources,world cultural heritage,key cultural relics protection units,national archaeological site parks,movable cultural relics,important agricultural cultural heritage,intangible cultural heritage,China time-honored brands,historical names,traditional markers,tribute culture,archival and documentary heritage.It also analyzes the six main problems in the inheritance and development of rice farming culture,and proposes 8 strategies,including promoting the inheritance and innovative development of excellent traditional Chinese culture through the inheritance of rice farming culture,promoting the Exploration of the Origins of Chinese Civilization Project through rice farming culture,and creating the Yangtze River National Cultural Park with rice farming culture as the main theme. 展开更多
关键词 Yangtze River Economic Belt Rice(Oryza sativa l.) Whole industry chain Rice cultivation culture Agricultural culture Inheritance and development
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First-principles study of physical properties of L1_(2)-Al_(3)Xstructural phases for heat-resistant aluminum conductors
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作者 Yao-jie KONG Hong-ying LI +1 位作者 Hui-jin TAO Wen-jian LIU 《Transactions of Nonferrous Metals Society of China》 2025年第2期377-391,共15页
The mechanical,thermodynamic properties and electrical conductivities of L1_(2)-Al_(3)X(X=Zr,Sc,Er,Yb,Hf)structural phases in aluminum conductors were investigated through a first-principles study.The results demonstr... The mechanical,thermodynamic properties and electrical conductivities of L1_(2)-Al_(3)X(X=Zr,Sc,Er,Yb,Hf)structural phases in aluminum conductors were investigated through a first-principles study.The results demonstrate that all structural phases have good alloy-forming ability and structural stability,where Al_(3)Zr is the most superior.Al_(3)Zr,Al_(3)Hf and Al_(3)Sc have enhanced shear and deformation resistance in comparison to other phases.Within the temperature range of 200−600 K,Al_(3)Er and Al_(3)Yb possess the greatest thermodynamic stability,followed by Al_(3)Hf,Al_(3)Zr and Al_(3)Sc.Al_(3)Er and Al_(3)Yb have higher thermodynamic stability than Al_(3)Hf,Al_(3)Zr and Al_(3)Sc.All structural phases exhibit substantial metallic properties,indicating their good electrical conductivity.The electrical conductivities of Al_(3)Hf and Al_(3)Zr are higher than those of Al_(3)Er,Al_(3)Yb and Al_(3)Sc.The covalent bond properties in Al_(3)Sc,Al_(3)Er and Al_(3)Yb enhance the hardness,brittleness and thermodynamic stability of the structural phase.The thermodynamic stability of Al_(3)Sc is significantly reduced by ionic bonds. 展开更多
关键词 aluminum conductor l1_(2)-Al_(3)X structural phase FIRST-PRINCIPlES mechanical properties thermodynamic properties electrical conductivity valence bonds
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Novel Design Method for the Roll Forming Process and Improved Forming Quality of 316L Stainless Steel BPP Flow Channels with Right-Angled Sidewalls
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作者 Fuqiang Zhao Hugang Tian +4 位作者 Qingxue Huang Yanlei Zhang Xiaolong Xie Zhigang Qi Shuaifeng Chen 《Chinese Journal of Mechanical Engineering》 2025年第2期163-182,共20页
The forming quality of metal bipolar plate(BPP)flow channels in proton exchange membrane fuel cells(PEMFCs)is a key factor affecting battery performance.A flow channel with straight sidewalls and a low thinning rate c... The forming quality of metal bipolar plate(BPP)flow channels in proton exchange membrane fuel cells(PEMFCs)is a key factor affecting battery performance.A flow channel with straight sidewalls and a low thinning rate can enhance battery output.Roll forming,as a new technology for BPP production,offers advantages such as a low thinning rate and high efficiency.However,existing roll curve design methods struggle to accommodate both low thinning rates and straight sidewall angles simultaneously.This study aims to develop flow channels with right-angled sidewalls,which provide benefits such as a low thinning rate,reduced residual stress,and high accuracy.A roller tooth profile was designed to achieve a flow channel with right-angled sidewalls and minimal thinning.Simulations and experiments were conducted to validate the feasibility of this novel design method for the roll forming process.The study investigated the effects of roller tooth parameters on sidewall angle,thinning rate,and residual stress.A multifactor evaluation method was developed to optimize the tip fillet radius and the tooth profile backlash of the roller.The results indicated that the tip fillet radius and the tooth profile backlash were negatively correlated with the sidewall angle.As the tip fillet radius and tooth profile backlash increased,the thinning rate and residual stress decreased.With a tip fillet radius of 0.25 mm and a tooth profile backlash of 0.19 mm,the flow channel achieved an approximately right-angled sidewall,a maximum thinning rate of 7.7%,a 29.6%reduction in maximum residual stress,and maximum and average residual stress imbalance values of 7.1%and 3.2%,respectively.This study proposes a new design method for a right-angled sidewall runner roller gear profile,facilitating the roll forming of metal BPPs with right-angled sidewalls and minimal thinning.This method provides theoretical support for the large-scale application of roll forming in the manufacture of PEMFC BPPs. 展开更多
关键词 Proton exchange membrane fuel cell 316l stainless steel bipolar plate Roll forming process Roller tooth profile design Flow channel with right-angled sidewall Residaul stress
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Radiometric Characteristics of the Landsat Collection 1 Dataset 被引量:1
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作者 Shuang Li Weile Wang +1 位作者 Sangram Ganguly Ramakrishna R. Nemani 《Advances in Remote Sensing》 2018年第3期203-217,共15页
This study evaluates the long-term radiometric performance of the USGS new released Landsat Collection 1 archive, including the absolute calibration of each Landsat sensor as well as the relative cross-calibration amo... This study evaluates the long-term radiometric performance of the USGS new released Landsat Collection 1 archive, including the absolute calibration of each Landsat sensor as well as the relative cross-calibration among the four most popular Landsat sensors. A total of 920 Landsat Collection 1 scenes were evaluated against the corresponding Pre-Collection images over a Pseudo-Invariant Site, Railroad Valley Playa Nevada, United States (RVPN). The radiometric performance of the six Landsat solar reflective bands, in terms of both Digital Numbers (DNs) and at-sensor Top of Atmosphere (TOA) reflectance, on the sensor cross-calibration was examined. Results show that absolute radiometric calibration at DNs level was applied to the Landsat-4 and -5 TM (L4 TM and L5 TM) by –1.119% to 0.126%. For L4 TM and L5 TM, the cross-calibration decreased the radiometric measurement level by rescaling at-sensor radiance to DN values. The radiometric changes, –0.77% for L4 TM, 0.95% for L5 TM, –0.26% for L7 ETM+, and –0.01% for L8 OLI, were detected during the cross-calibration stage of converting DNs into TOA reflectance. This study has also indicated that the long-term radiometric performance for the Landsat Collection 1 archive is promising. Supports of these conclusions were demonstrated through the time-series analysis based on the Landsat Collection 1 image stack. Nevertheless, the radiometric changes across the four Landsat sensors raised concerns of the previous Landsat Pre-Collection based results. We suggest that Landsat users should pay attention to differences in results from Pre-Collection and Collection 1 time-series data sets. 展开更多
关键词 lANDSAT Collection 1 CROSS-CAlIBRATION landsat-4 (l4) THEMATIC MAPPER (TM) landsat-5 (l5) THEMATIC MAPPER (TM) landsat-7 (l7) Enhanced THEMATIC MAPPER Plus (ETM%PlUS%) landsat-8 (l8) Operational land Imager (OlI)
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The Mathematical and Physical Theory of Rational Human Intelligence: Complete Empirical-Digital Properties;Full Electrochemical-Mechanical Model (Part I: Mathematical Foundations)
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作者 Leo Depuydt 《Advances in Pure Mathematics》 2013年第5期491-561,共71页
The design of this paper is to present the first installment of a complete and final theory of rational human intelligence. The theory is mathematical in the strictest possible sense. The mathematics involved is stric... The design of this paper is to present the first installment of a complete and final theory of rational human intelligence. The theory is mathematical in the strictest possible sense. The mathematics involved is strictly digital—not quantitative in the manner that what is usually thought of as mathematics is quantitative. It is anticipated at this time that the exclusively digital nature of rational human intelligence exhibits four flavors of digitality, apparently no more, and that each flavor will require a lengthy study in its own right. (For more information,please refer to the PDF.) 展开更多
关键词 Artificial INTEllIGENCE Boolean AlGEBRA Boole’s AlGEBRA Black Box Theories Brain Science Cognition Cognitive Science Digital MATHEMATICS Electricity and Magnetism J.-l. lagrange and Partial Differential Equations J. C. Maxwell’s Theory of Electromagnetism Neuroscience Non-Quantitative and Quantitative MATHEMATICS Physics RATIONAl Human INTEllIGENCE COMPlETE Theory of RATIONAl Thought and language
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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice
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作者 Yujia Liu Xue Han +6 位作者 Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia 《Neural Regeneration Research》 SCIE CAS 2025年第9期2727-2736,共10页
Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ... Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction. 展开更多
关键词 Chil1 hippocampus learning and memory M2 microglia NEUROINFlAMMATION postoperative cognitive dysfunction(POCD) recombinant CHI3l1
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Development of Mathematical Model for Calculating Physiological Parameters in Jatropha curcas under Soil Flooding
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作者 CHHEDI LAL VERMA KRISHAN K.VERMA MUNNA SINGH 《农业研究与应用》 2025年第1期19-30,共12页
【Objective】Jatropha curcas is a potential source of biodiesel plant grown on waste and unattended lands,and parts of the areas are often suffered from flooding.The present study was conducted to develop a model to c... 【Objective】Jatropha curcas is a potential source of biodiesel plant grown on waste and unattended lands,and parts of the areas are often suffered from flooding.The present study was conducted to develop a model to calculate the net CO_(2)assimilation rate,transpiration rate and stomatal conductance with respect to leaf position,which affect the J.curcas productivity under soil flooding.【Method】The process of developing mathematical models for physiological responses associated with parameterization,optimization and validation.The concept was applied for the calculation of net CO 2 assimilation rate from transpiration rate and stomatal conductance,transpiration rate from net CO_(2)assimilation rate and stomatal conductance,and stomatal conductance from net CO_(2)assimilation rate and transpiration rate in different leaf positions of J.curcas.The models were tested under soil flooding and normal conditions to suffice its wider applicability.A model was proposed to calculate net CO 2 assimilation rate,transpiration rate and stomatal conductance responses from a known set of response function data by calculating a transformation characteristic constant between any two possible paired response functions.【Result】The mean deviations and root mean square errors(RMSE)of calculated physiological responses were low,which validated the proposed hypothesis and statistical models.The approach was applied for modeling physiological responses successfully in J.curcas.RMSE ranged from1.69%to 11.17%when transpiration rate and stomatal conductance were transformed to net CO_(2)assimilation rate,and from 1.70%to 11.61%in case net CO_(2)assimilation rate and stomatal conductance were transformed to transpiration rate,and from 3.87%to 13.21%if net CO_(2)assimilation rate and transpiration rate were transformed to stomatal conductance,respectively.【Conclusion】The model can be useful for calculating cumulative responses under different conditions from a basic known set of data.The key to successful physiological models is finding the better options that are realistic,easy to understand,interpretative and practical between adherence to reality,comprehensibility,interpretative value,and practical usefulness on sustainable agriculture in years to come. 展开更多
关键词 Jatropha curcas l. leaf position photosynthetic CO_(2)assimilation TRANSPIRATION stomatal conductance soil flooding
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Comparative Study on Leaf Morphology-Venation Pattern of Hedyotis auricularia L.and Its Adulterants
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作者 Luxiao MENG Feipeng HUANG +3 位作者 Xinxin LU Piaoling HUANG Hailin LU Zhonghua DAI 《Medicinal Plant》 2025年第1期35-38,54,共5页
[Objectives]To compare the leaf morphology and leaf venation patterns of Hedyotis auricularia L.and its adulterants,such as Mitracarpus hirtus(L.)DC.,Spermacoce pusilla Wall.and Spermacoce alata Aubl.,produced in Guan... [Objectives]To compare the leaf morphology and leaf venation patterns of Hedyotis auricularia L.and its adulterants,such as Mitracarpus hirtus(L.)DC.,Spermacoce pusilla Wall.and Spermacoce alata Aubl.,produced in Guangxi,so as to provide a simple and rapid identification method for the identification of H.auricularia L.in Guangxi.[Methods]LMVP(leaf morphology-venation pattern)identification method was used to study the characteristics of leaf morphology-venation pattern.[Results]Characteristics of leaf morphology-venation pattern:(i)H.auricularia L.:circular knotted-curved pinnate leaf venation without reaching the margin;the primary veins run straight without branches,the number of secondary veins is 5 to 9,and the angles included in tertiary veins are mostly near right angles or obtuse angles.(ii)M.hirtus(L.)DC.:curved pinnate leaf venation without reaching the margin;the primary veins run straight without obvious changes,the number of secondary veins is 3 to 5,and the tertiary veins are slender,and the included angles are mostly acute.(iii)S.pusilla Wall.:curved leaf venation without reaching the leaf margin;there are 4 to 5 pairs of secondary veins,most of which are opposite;the angle between the secondary veins and the primary veins in the middle and near the petiole is mostly medium acute angle,and the extension of the tertiary veins has no fixed direction.(iv)S.alata Aubl.:circular knotted-curved pinnate leaf venation;the primary veins are convex and straight without branches,and there are 4 to 6 pairs of secondary veins,alternating.The angle between secondary veins and primary veins is mostly medium acute angle,the angle between tertiary veins and secondary veins is near right angle,and the tertiary veins are mostly transversely extended.[Conclusions]The leaf morphology-venation patterns of the above-mentioned H.auricularia L.and M.hirtus(L.)DC.,S.pusilla Wall.,and S.alata Aubl.can be used as their identification features,and the identification method has certain operability,which provides an identification idea for the identification of Chinese herbal medicines. 展开更多
关键词 Hedyotis auricularia l. Mitracarpus hirtus(l.)DC. Spermacoce pusilla Wall. Spermacoce alata Aubl. leaf venation pattern
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Unravelling Teacher Learning Through Teacher-Student Collaborative Assessment(TSCA):Voice From an L2 Writing Teacher in the Chinese Context
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作者 Lin Lin Yue Lin 《Chinese Journal of Applied Linguistics》 2025年第4期600-620,640,共22页
Research in L2 writing assessment has overwhelmingly focused on helping students enhance their writing quality and global development in language proficiency by various means and approaches of assessment.However,studi... Research in L2 writing assessment has overwhelmingly focused on helping students enhance their writing quality and global development in language proficiency by various means and approaches of assessment.However,studies of the learning on the part of EFL writing teachers,especially when engaging in collaborative assessment with students,are few and far between.This qualitative case study therefore fills this void of foregoing research by examining the learning and development of a Chinese EFL writing teacher who employed teacher-student collaborative assessment(TSCA)(Wen,2016)in an L2 academic writing course.Drawing upon multiple types of data,three themes emerged with regard to the learning of the L2 writing teacher:1)becoming more assessment literate and capable of providing constructive feedback;2)gaining more efficacy in instructional tactics,student engagement and classroom management;and 3)developing a better understanding of students’evaluation focus as well as their needs and expertise in writing.This study offers a robust picture of how TSCA can foster multidimensional teacher learning-cognitively,affectively,and relationally-affirming its value not only as an assessment tool but as a transformative pedagogical practice. 展开更多
关键词 teacher-student collaborative assessment(TSCA) teacher learning l2 writing Chinese EFl writing teacher l2 academic writing pedagogy
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Triangle Bounded L⁃algebras and Triangle Ideals
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作者 Hao Chen Xiaolong Xin 《Journal of Harbin Institute of Technology(New Series)》 2025年第5期52-64,共13页
This study mainly focuses on the triangle bounded L⁃algebras and triangle ideals.Firstly,the definition of triangle bounded L⁃algebras is presented,and several examples with different conditions are outlined along wit... This study mainly focuses on the triangle bounded L⁃algebras and triangle ideals.Firstly,the definition of triangle bounded L⁃algebras is presented,and several examples with different conditions are outlined along with an exploration of their properties.Moreover,we investigate the structure of triangle bounded L⁃algebra with a special condition.Secondly,we define the concept of triangle ideals of triangle bounded L⁃algebra and explore the connection between the triangle ideals of triangle bounded L⁃algebra L and the ideals of bounded L⁃algebra E(L).In addition,we classified and studied various classes of triangle ideals,including Stonean triangle ideals,extended Stonean triangle ideals,and lattice ideals,and by introducing the notion of Stonean triangle bounded L algebras,we examine the relationship between Stonean triangle bounded L⁃algebras and Stonean triangle ideals.Finally,we investigate the interrelationships among these various types of triangle ideals. 展开更多
关键词 triangle bounded l⁃algebra Stonean triangle bounded l⁃algebra triangle ideal (extended)Stonean triangle ideal lattice ideal
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Hybrid Wavelet Methods for Nonlinear Multi-Term Caputo Variable-Order Partial Differential Equations
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作者 Junseo Lee Bongsoo Jang Umer Saeed 《Computer Modeling in Engineering & Sciences》 2025年第8期2165-2189,共25页
In recent years,variable-order fractional partial differential equations have attracted growing interest due to their enhanced ability tomodel complex physical phenomena withmemory and spatial heterogeneity.However,ex... In recent years,variable-order fractional partial differential equations have attracted growing interest due to their enhanced ability tomodel complex physical phenomena withmemory and spatial heterogeneity.However,existing numerical methods often struggle with the computational challenges posed by such equations,especially in nonlinear,multi-term formulations.This study introduces two hybrid numerical methods—the Linear-Sine and Cosine(L1-CAS)and fast-CAS schemes—for solving linear and nonlinear multi-term Caputo variable-order(CVO)fractional partial differential equations.These methods combine CAS wavelet-based spatial discretization with L1 and fast algorithms in the time domain.A key feature of the approach is its ability to efficiently handle fully coupled spacetime variable-order derivatives and nonlinearities through a second-order interpolation technique.In addition,we derive CAS wavelet operational matrices for variable-order integration and for boundary value problems,forming the foundation of the spatial discretization.Numerical experiments confirm the accuracy,stability,and computational efficiency of the proposed methods. 展开更多
关键词 CAS wavelets operationalmatrices Caputo variable-order equations exponential-sum-approximation l1 approximation
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Polyphenol-enriched Sophora japonica L. and Rosa rugosa Thunb. composite solid beverage: antioxidant and lipid-lowering effi cacy with stability assessment
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作者 Jianzhuo Du Yunxiao Xia +1 位作者 Pingyu Ge Xu Zhao 《Journal of Polyphenols》 2025年第3期137-149,共13页
In the context of a surging demand for functional foods,this study utilized Sophora japonica L.(SL)and Rosa rugosa Thunb.(RT),which are rich in polyphenols(with flavonoids as the core subclass).High-purity extracts(SL... In the context of a surging demand for functional foods,this study utilized Sophora japonica L.(SL)and Rosa rugosa Thunb.(RT),which are rich in polyphenols(with flavonoids as the core subclass).High-purity extracts(SLE and RTE)were obtained through ethanol reflux extraction and macroporous resin purification,and then formulated with maltodextrin and erythritol to prepare a composite solid beverage.This beverage exhibited excellent antioxidant capabilities.At a concentration of 1 mg/mL,the scavenging rates of DPPH,ABTS,and hydroxyl radicals reached 82.4%,94.6%,and 49.2%,respectively.Network pharmacology indicated that quercetin andβ-sitosterol could modulate lipid metabolism pathways.Moreover,the beverage showed potential for lipid-lowering.Its cholate adsorption capacity was 589.4±2.9 mg/g at pH 7.0,and the IC50 value for pancreatic lipase inhibition was 32.55 mg/mL.However,a 60-day storage stability test revealed that the moisture content approached 5%,likely due to polyphenol-flavonoid reactivity,extending dissolution time to 30.88 s.These changes were attributed to polyphenols(with flavonoids as the core active subclass,and non-flavonoids such as phenolic acids as auxiliary),resulting in color alterations and reduced solubility.This study confirmed the dual functions of the SL-RT beverage in antioxidant and lipid-lowering aspects.Nevertheless,it also pointed out the need to optimize the formula and process to enhance stability,providing an important basis for the development of stable functional beverages. 展开更多
关键词 Sophora japonica l. Rosa rugosa Thunb. POlYPHENOlS FlAVONOIDS antioxidant activity lipid metabolism regulation network pharmacology
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