To investigate the effect of Yikun Neiyi Wan （益坤内异丸YKNYW） and gestrinone on the expression of aromatase P450 （P450arom）, cyclo-oxygenase-2 （COX-2） and estrogen receptor （ER） in isolated ectopic and normal...To investigate the effect of Yikun Neiyi Wan （益坤内异丸YKNYW） and gestrinone on the expression of aromatase P450 （P450arom）, cyclo-oxygenase-2 （COX-2） and estrogen receptor （ER） in isolated ectopic and normal endometriat stroma cells in vitro. Methods： Digestion and serial filtration were used to isolate and culture the ectopic and eutopic endometrial cells from patients with chocolate cyst in virto Transformation of the cell morphology was observed in a inverted microscope. The effect of YKNYW on the expression of aromatase P450, cyclo-oxygenase-2, estrogen receptor in cultured endometriosis cells were detected by immunohistochemical method. Results： The expression levels of P450arom, COX-2 in glandular epithelium cells in vitro were decreased significantly by YKNYW compared with gestrinone （P〈0.05）. ER expression in mesenchymal cells of endometriosis was increased by YKNYW in the large and medium dosage groups compared with gestrinone. Conclusion： The mechanism by which YKNYW alleviates endometriosis pain is possibly related to the decrease in ectopic endometrial P450 arom and COX-2 expression in glandular epithelium, contrary to gestrinone, and the increase in ER expression in mesenchymalis, consistent with gestrione in patients with endometriosis.展开更多
Objective:To evaluate whether Ding Kun Dan(DKD)can improve the vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)outcomes in patients with predicted poor ovarian response(POR)safely ...Objective:To evaluate whether Ding Kun Dan(DKD)can improve the vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)outcomes in patients with predicted poor ovarian response(POR)safely and effectively.Methods:Prospective,multicenter,randomized controlled trial;A total of 278 POR patients were randomized in DKD group or immediate treatment group.Both groups received IVF or ICSI as a standard treatment while in the DKD group,DKD was administrated for 3 months before the IVF/ICSI cycle.The primary outcome was the ongoing pregnancy rate.The secondary outcomes include clinical pregnancy rate,biochemical pregnancy rate,total gonadotropin(Gn)dosage and duration,estradiol(E2)and progesterone(P)levels on human chorionic gonadotropin(hCG)trigger day,cycle cancellation rate,number of oocytes retrieved,high-quality embryo rate and any adverse events.Results:Compared to the immediate IVF treatment group,oral administration of DKD for 3 months before IVF led to a significant increase in ongoing pregnancy rate(30.0%v.s.17.6%,P<0.05),biochemical pregnancy rate(39.2%vs.25.2%,P<0.05),clinical pregnancy rate(36.7%vs.22.7%,P<0.05)and high-quality embryo rate(40.8%vs.32.4%,P<0.05),and a significant decrease in Gn duration(P<0.05).However,no significant differences were found in total dosage of Gn,number of retrieved oocytes,cycle cancellation rate,E2 level and P level on hCG trigger days(P>0.05).No serious adverse events occurred during the intervention period in either group.Conclusion:DKD is a safe and effective intervention to improve the IVF/ICSI-ET outcomes in patients with POR.展开更多
Prof. Huang Kun is an internationally renowned specialist in solid state physics and semi-conductors. He is a CAS member and also a foreign member of the Swedish Academy of Sciences and a fellow of the Third World Aca...Prof. Huang Kun is an internationally renowned specialist in solid state physics and semi-conductors. He is a CAS member and also a foreign member of the Swedish Academy of Sciences and a fellow of the Third World Academy of Sciences. He received China's 2001 Supreme Scientific and Technological Award on February,2002, for his lifetime achievements.展开更多
Together with Prof. Wang Xuan from Peking University, CAS physicist Huang Kun received Supreme Scientific and Technological (S&T) Award in 2001 from Chinese President Jiang Zeming in Beijing on February 2. Eac... Together with Prof. Wang Xuan from Peking University, CAS physicist Huang Kun received Supreme Scientific and Technological (S&T) Award in 2001 from Chinese President Jiang Zeming in Beijing on February 2. Each gets five million yuan (US$ 602,000) as part of the award for their lifetime achievements.……展开更多
Okaze de la Unua Azia Kongreso de Esperanto enanhajo deinio,raportistino Wang Yuqinel Esperanto-redakcio deina Radio Internacia intervjuis s-ron Puramo Chong,prezidanton deKorea Esperanto-Asocio kaj sekretarion de KAEM.
Okaze de la 1-a Azia Kongreso de Esperanto,raportistino Wang Yuqin el Esperanto-redakcio deCina Radio Internacia faris intervjuon kun s-ino Doiieko,redaktorino de"Esperanto en Azio",la organo de KAEM.
Jam sukcese finigis la l-a Azia Kongresode Esperanto,okazinta en Sanhajo de la 22-agis la 25-a de augusto,1996.Dum la Kongre-so,mi,kiel raportisto de la Cirla Radio Inter-nacia, sukcesis intervjui s-ron
Tute ne estas malkonvenajo, familio kunmultaj infanoj. Se estas vilaga familio, mivolas diri. En norda Rumanio la familioj en lavilagetoj kalkulas inter kvar kaj dek sep infanojpo familio. Pro religiaj principoj oni n...Tute ne estas malkonvenajo, familio kunmultaj infanoj. Se estas vilaga familio, mivolas diri. En norda Rumanio la familioj en lavilagetoj kalkulas inter kvar kaj dek sep infanojpo familio. Pro religiaj principoj oni ne mal-helpas al la ido-naskado. La spertoj montras, ke en la familiojmalricaj formigas reguloj kaj estas fartaj展开更多
KUN opera has a history of 5,000 years. It is a classic opera, famous for its festive singing and dancing. It boasts an extensive literature. In thousands of librettos, it has adapted the essence of different types of...KUN opera has a history of 5,000 years. It is a classic opera, famous for its festive singing and dancing. It boasts an extensive literature. In thousands of librettos, it has adapted the essence of different types of Chinese poems,and songs. The more than 4,000 Kun songs include ancient Chinese music, religious, folk, ethnic and foreign music. It combines singing, dancing, acrobatics, wushu, pantomime and many other forms展开更多
文摘To investigate the effect of Yikun Neiyi Wan （益坤内异丸YKNYW） and gestrinone on the expression of aromatase P450 （P450arom）, cyclo-oxygenase-2 （COX-2） and estrogen receptor （ER） in isolated ectopic and normal endometriat stroma cells in vitro. Methods： Digestion and serial filtration were used to isolate and culture the ectopic and eutopic endometrial cells from patients with chocolate cyst in virto Transformation of the cell morphology was observed in a inverted microscope. The effect of YKNYW on the expression of aromatase P450, cyclo-oxygenase-2, estrogen receptor in cultured endometriosis cells were detected by immunohistochemical method. Results： The expression levels of P450arom, COX-2 in glandular epithelium cells in vitro were decreased significantly by YKNYW compared with gestrinone （P〈0.05）. ER expression in mesenchymal cells of endometriosis was increased by YKNYW in the large and medium dosage groups compared with gestrinone. Conclusion： The mechanism by which YKNYW alleviates endometriosis pain is possibly related to the decrease in ectopic endometrial P450 arom and COX-2 expression in glandular epithelium, contrary to gestrinone, and the increase in ER expression in mesenchymalis, consistent with gestrione in patients with endometriosis.
基金This study was supported by the National Natural Science Foundation of China Nos.81774351the Tianjin Health&Family Planning Commission(Tianjin scientific research project of priority area of traditional Chinese medicine,Nos.2018008)Shanxi Guangyuyuan TCM Co.,Ltd.
文摘Objective:To evaluate whether Ding Kun Dan(DKD)can improve the vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)outcomes in patients with predicted poor ovarian response(POR)safely and effectively.Methods:Prospective,multicenter,randomized controlled trial;A total of 278 POR patients were randomized in DKD group or immediate treatment group.Both groups received IVF or ICSI as a standard treatment while in the DKD group,DKD was administrated for 3 months before the IVF/ICSI cycle.The primary outcome was the ongoing pregnancy rate.The secondary outcomes include clinical pregnancy rate,biochemical pregnancy rate,total gonadotropin(Gn)dosage and duration,estradiol(E2)and progesterone(P)levels on human chorionic gonadotropin(hCG)trigger day,cycle cancellation rate,number of oocytes retrieved,high-quality embryo rate and any adverse events.Results:Compared to the immediate IVF treatment group,oral administration of DKD for 3 months before IVF led to a significant increase in ongoing pregnancy rate(30.0%v.s.17.6%,P<0.05),biochemical pregnancy rate(39.2%vs.25.2%,P<0.05),clinical pregnancy rate(36.7%vs.22.7%,P<0.05)and high-quality embryo rate(40.8%vs.32.4%,P<0.05),and a significant decrease in Gn duration(P<0.05).However,no significant differences were found in total dosage of Gn,number of retrieved oocytes,cycle cancellation rate,E2 level and P level on hCG trigger days(P>0.05).No serious adverse events occurred during the intervention period in either group.Conclusion:DKD is a safe and effective intervention to improve the IVF/ICSI-ET outcomes in patients with POR.
文摘Prof. Huang Kun is an internationally renowned specialist in solid state physics and semi-conductors. He is a CAS member and also a foreign member of the Swedish Academy of Sciences and a fellow of the Third World Academy of Sciences. He received China's 2001 Supreme Scientific and Technological Award on February,2002, for his lifetime achievements.
文摘 Together with Prof. Wang Xuan from Peking University, CAS physicist Huang Kun received Supreme Scientific and Technological (S&T) Award in 2001 from Chinese President Jiang Zeming in Beijing on February 2. Each gets five million yuan (US$ 602,000) as part of the award for their lifetime achievements.……
文摘Okaze de la Unua Azia Kongreso de Esperanto enanhajo deinio,raportistino Wang Yuqinel Esperanto-redakcio deina Radio Internacia intervjuis s-ron Puramo Chong,prezidanton deKorea Esperanto-Asocio kaj sekretarion de KAEM.
文摘Okaze de la 1-a Azia Kongreso de Esperanto,raportistino Wang Yuqin el Esperanto-redakcio deCina Radio Internacia faris intervjuon kun s-ino Doiieko,redaktorino de"Esperanto en Azio",la organo de KAEM.
文摘Jam sukcese finigis la l-a Azia Kongresode Esperanto,okazinta en Sanhajo de la 22-agis la 25-a de augusto,1996.Dum la Kongre-so,mi,kiel raportisto de la Cirla Radio Inter-nacia, sukcesis intervjui s-ron
文摘Tute ne estas malkonvenajo, familio kunmultaj infanoj. Se estas vilaga familio, mivolas diri. En norda Rumanio la familioj en lavilagetoj kalkulas inter kvar kaj dek sep infanojpo familio. Pro religiaj principoj oni ne mal-helpas al la ido-naskado. La spertoj montras, ke en la familiojmalricaj formigas reguloj kaj estas fartaj
文摘KUN opera has a history of 5,000 years. It is a classic opera, famous for its festive singing and dancing. It boasts an extensive literature. In thousands of librettos, it has adapted the essence of different types of Chinese poems,and songs. The more than 4,000 Kun songs include ancient Chinese music, religious, folk, ethnic and foreign music. It combines singing, dancing, acrobatics, wushu, pantomime and many other forms
