Kupple like factor 3(KLF3)是kupple like factors(KLFs)家族中的重要成员之一。作为转录因子参与癌症、脂肪细胞分化、血液中细胞生成、免疫B细胞的发育、肌肉基因调节等众多生物学进程。近几年来,被作为一种重要的遗传分子标志而被...Kupple like factor 3(KLF3)是kupple like factors(KLFs)家族中的重要成员之一。作为转录因子参与癌症、脂肪细胞分化、血液中细胞生成、免疫B细胞的发育、肌肉基因调节等众多生物学进程。近几年来,被作为一种重要的遗传分子标志而被科学家们所重视,本文就KLF3基因蛋白的分子结构、生物学功能,以及在家畜育种中的应用和展望进行综述。展开更多
Prostate cancer is one of the most common malignancies.The development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes a...Prostate cancer is one of the most common malignancies.The development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes and chromosomal deletion that inactivates tumor suppressor genes.Whereas gene amplification occurs in human prostate cancer,gene deletion is more common,展开更多
文摘Kupple like factor 3(KLF3)是kupple like factors(KLFs)家族中的重要成员之一。作为转录因子参与癌症、脂肪细胞分化、血液中细胞生成、免疫B细胞的发育、肌肉基因调节等众多生物学进程。近几年来,被作为一种重要的遗传分子标志而被科学家们所重视,本文就KLF3基因蛋白的分子结构、生物学功能,以及在家畜育种中的应用和展望进行综述。
基金supported by the grants from the National Cancer Institute,National Institutes of Health(Nos. R01CA87921 and R01CA171189)the National Natural Science Foundation of China(No.81130044)
文摘Prostate cancer is one of the most common malignancies.The development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes and chromosomal deletion that inactivates tumor suppressor genes.Whereas gene amplification occurs in human prostate cancer,gene deletion is more common,
