NVIDIA Jetson作为先进的嵌入式系统,各行各业的开发人员可以使用它们来构建创新型AI产品。2024年12月,NVIDIA发布了Jetson系列新品—Jetson Orin Nano Super Developer Kit,做为Jetson Nano的升级款,模组售价仅仅249美元,NVIDIA以更加...NVIDIA Jetson作为先进的嵌入式系统,各行各业的开发人员可以使用它们来构建创新型AI产品。2024年12月,NVIDIA发布了Jetson系列新品—Jetson Orin Nano Super Developer Kit,做为Jetson Nano的升级款,模组售价仅仅249美元,NVIDIA以更加亲民的价格,赋予更多领域充足的算力支持。展开更多
It is well known that the kit completeness of parts processed in the previous stage is crucial for the subsequent manufacturing stage.This paper studies the flexible job shop scheduling problem(FJSP)with the objective...It is well known that the kit completeness of parts processed in the previous stage is crucial for the subsequent manufacturing stage.This paper studies the flexible job shop scheduling problem(FJSP)with the objective of material kitting,where a material kit is a collection of components that ensures that a batch of components can be ready at the same time during the product assembly process.In this study,we consider completion time variance and maximumcompletion time as scheduling objectives,continue the weighted summation process formultiple objectives,and design adaptive weighted summation parameters to optimize productivity and reduce the difference in completion time between components in the same kit.The Soft Actor Critic(SAC)algorithm is designed to be combined with the Adaptive Multi-Buffer Experience Replay(AMBER)mechanism to propose the SAC-AMBER algorithm.The AMBER mechanism optimizes the experience sampling and policy updating process and enhances learning efficiency by categorically storing the experience into the standard buffer,the high equipment utilization buffer,and the high productivity buffer.Experimental results show that the SAC-AMBER algorithm can effectively reduce the maximum completion time on multiple datasets,reduce the difference in component completion time in the same kit,and thus optimize the readiness of the part kits,demonstrating relatively good stability and convergence.Compared with traditional heuristics,meta-heuristics,and other deep reinforcement learning methods,the SAC-AMBER algorithm performs better in terms of solution quality and computational efficiency,and through extensive testing on multiple datasets,the algorithm has been confirmed to have good generalization ability,providing an effective solution to the FJSP problem.展开更多
The study was carried out in the Tahoua region at the market gardening sites of the Taddis 1 and 2 valley. Small-scale pumping irrigation is one of the most interesting uses of solar energy. The objective of this stud...The study was carried out in the Tahoua region at the market gardening sites of the Taddis 1 and 2 valley. Small-scale pumping irrigation is one of the most interesting uses of solar energy. The objective of this study is to carry out a comparative analysis of two dewatering pumping systems (Solar Kit and GMP) for water mobilization on a certain number of criteria such as sustainable use, economic aspect and performance. To achieve this, the adapted methodology consisted first of all in the development of a data collection tool in the field. Then flow measurements, estimation of fuel consumption, pressure height, etc., were carried out. Thus, the data collection involved a sample of 120 irrigators who had to use the two (2) types of pumping systems. The collected data were analyzed and processed with appropriate software. The results of the study show that the two pumping systems studied have strengths and constraints. Thus, the solar pumping system has a significant investment cost, very low maintenance and a low operating cost. On the other hand, the system with a generator has a relatively low investment cost (25 to 30 times less than solar), but a relatively high operating, upkeep and maintenance cost. He adds that these assets and constraints must be taken into consideration when an investment is made. This study shows that 74% of producers use GMP compared to 26% who use the Solar Kit. But in practice, the Solar Kit is more reliable for producers from the point of view of planted area, environmental management and investment costs, supply of fuel and lubricant. These results indicate better performance of the solar pumping system compared to GMP at the study sites.展开更多
End-host address mutation is one of the key network moving target defense mechanisms to defend against reconnaissance.However,frequently changing host addresses increases the transmission de-lay of active sessions,whi...End-host address mutation is one of the key network moving target defense mechanisms to defend against reconnaissance.However,frequently changing host addresses increases the transmission de-lay of active sessions,which may cause serious ram-ifications.In this paper,by leveraging the advanced DPDK technology,we proposed a high-performance MTD gateway framework,called HPMG,which can not only prevent adversaries from reconnaissance ef-fectively,but also retain high-speed data packet pro-cessing capabilities.Firstly,every moving target host is assigned three different IP addresses,called real IP,virtual IP,and external IP,to realize multi-level net-work address architecture.To delay the scanning tech-niques of adversaries,HPMG mutates virtual IP and virtual MAC addresses,and replies with fake host re-sponses.Besides,to be transparent to the end-hosts,HPMG keeps real IP and real MAC unchanged.Fi-nally,we optimized the forwarding and processing performance of the HPMG based on the fast path framework of DPDK.Our theoretical analysis,imple-mentation,and evaluation show that HPMG can effec-tively defend against reconnaissance attacks and de-crease the processing delay caused by address muta-tion.展开更多
Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patien...Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patients.Methods:Anti-snake venom immunoglobulin(IgG)was prepared,biotinylated specific IgG was screened,detection enzyme-labeled strips were produced,and rapid identification of snakebites was performed.Pre-experimental verification was conducted to establish standard curves and confirm specificity.The kit was tested on clinical samples and the results were analyzed.Repeatability and stability were evaluated through multiple repeated tests and experiments under different storage conditions.Finally,sensitivity and specificity were calculated,receiver operating characteristic curves(ROC curves)were drawn,and statistical analysis software was used for data analysis to ensure the reliability and effectiveness of the kit.Results:The test showed high sensitivity and specificity.Conclusion:The rapid diagnostic kit for identifying snake venom types in blood tests demonstrates high reliability and effectiveness in clinical diagnosis.展开更多
近日,宝马(BMW)和奇思(Kith)成功合作推出新款车型。宝马XM及其与传奇车型宝马M1的联系是这家高档汽车制造商与罗尼·菲格(Ronnie Fieg)的世界知名品牌Kith第三次合作的焦点。这款高性能插电式混合动力车型将于2025年推出,其被命名...近日,宝马(BMW)和奇思(Kith)成功合作推出新款车型。宝马XM及其与传奇车型宝马M1的联系是这家高档汽车制造商与罗尼·菲格(Ronnie Fieg)的世界知名品牌Kith第三次合作的焦点。这款高性能插电式混合动力车型将于2025年推出,其被命名为2025宝马XM by Kith,并采用独家外观和内饰设计。展开更多
Taste buds relay taste sensory information to the primary taste neurons but depend on those same neurons for essential components to maintain function.While denervation-induced taste bud degeneration and subsequent re...Taste buds relay taste sensory information to the primary taste neurons but depend on those same neurons for essential components to maintain function.While denervation-induced taste bud degeneration and subsequent regeneration were discovered decades ago,the mechanisms underlying these phenomena(e.g.,heterogenous cellular responses to nerve injury and the signaling pathways involved)remain poorly understood.Here,using mouse genetics,nerve injury models,pharmacologic manipulation,and taste bud organoid models,we identify a specific subpopulation of taste cells,predominantly c-Kit-expressing sweet cells,that exhibit superior resistance to nerve injury.We found the c-Kit inhibitor imatinib selectively reduced the number of residual c-Kit-expressing sweet cells at post-operation week 2,subsequently attenuating the re-emergence of other type II cells by post-operation week 4.In taste bud organoids,c-Kit-expressing cells were resistant to R-spondin withdrawal but susceptible to imatinib,while other taste cell types showed the opposite behavior.We also observed a distinct population of residual taste cells that acquired stem-like properties,generating clonal descendent cells among suprabasal keratinocytes independent of c-Kit signaling.Together,our findings reveal that c-Kit signaling confers resilience on c-Kit-expressing sweet cells and supports the broader reconstruction of taste buds during the later regenerative stage following nerve injury.展开更多
In the modern era of 5th generation(5G)networks,the data generated by User Equipments(UE)has increased significantly,with data file sizes varying from modest sensor logs to enormous multimedia files.In modern telecomm...In the modern era of 5th generation(5G)networks,the data generated by User Equipments(UE)has increased significantly,with data file sizes varying from modest sensor logs to enormous multimedia files.In modern telecommunications networks,the need for high-end security and efficient management of these large data files is a great challenge for network designers.The proposed model provides the efficient real-time virtual data storage of UE data files(light and heavy)using an object storage system MinIO having inbuilt Software Development Kits(SDKs)that are compatible with Amazon(S3)Application Program Interface(API)making operations like file uploading,and data retrieval extremely efficient as compared to legacy virtual storage system requiring low-level HTTP requests for data management.To provide integrity,authenticity,and confidentiality(integrity checking via an authentication tag)to the data files of UE,the encrypted algorithm 256-bit oriented-Advanced Encryption Standard(256-AES)in Galois/Counter Mode(GCM)is utilized in combination with MinIO.The AES-based MinIO signifies in more secure and faster approach than older models like Cipher Block Chaining(CBC).The performance of the proposed model is analyzed using the Iperf utility to perform the Teletraffic parametric(bandwidth,throughput,latency,and transmission delay)analysis for three different cases namely:(a)light UE traffic(uploading and retrieval)(b)heavy UE traffic(uploading and retrieval)and(c)comparison of Teletraffic parameters namely:bandwidth(Bava),throughput(Tput),data transfer(D_(Trans)),latency(L_(ms)),and transmission delay(TDelay)obtained from proposed method with legacy virtual storage methods.The results show that the suggested MinIO-based system outperforms conventional systems in terms of latency,encryption efficiency,and performance under varying data load conditions.展开更多
This editorial discusses Wang et al's article on familial gastrointestinal stromal tumors(GISTs).We read with great interest this article concerning the diagnosis,treatment,and post-treatment management of patient...This editorial discusses Wang et al's article on familial gastrointestinal stromal tumors(GISTs).We read with great interest this article concerning the diagnosis,treatment,and post-treatment management of patients with familial GISTs.The actual incidence of GISTs may be underestimated due to diagnostic limitations and the long-term low-risk behavior of some GISTs.The molecular landscape of GISTs is primarily driven by mutations in the KIT and platelet-derived growth factor receptor alpha(PDGFRA)genes.A subset of GISTs without these mutations known as wild-type GISTs,may harbor other rare mutations,impacting their response to targeted therapies.Clinically,patients with GISTs present with nonspecific symptoms,often leading to delayed diagnosis.Genetic predispositions in familial GISTs provide insights into the genetic architecture and extragastrointestinal manifestations of GISTs.Management has evolved from surgical interventions to molecular-based therapies using tyrosine kinase inhibitors.The management of GISTs,especially in familial cases,requires a multidisciplinary approach.Cases of different gene mutations were reported in the same family,suggesting that incorporating genetic testing into routine clinical practice is crucial for the early identification of high-risk individuals and the implementation of tailored surveillance programs.展开更多
文摘NVIDIA Jetson作为先进的嵌入式系统,各行各业的开发人员可以使用它们来构建创新型AI产品。2024年12月,NVIDIA发布了Jetson系列新品—Jetson Orin Nano Super Developer Kit,做为Jetson Nano的升级款,模组售价仅仅249美元,NVIDIA以更加亲民的价格,赋予更多领域充足的算力支持。
文摘It is well known that the kit completeness of parts processed in the previous stage is crucial for the subsequent manufacturing stage.This paper studies the flexible job shop scheduling problem(FJSP)with the objective of material kitting,where a material kit is a collection of components that ensures that a batch of components can be ready at the same time during the product assembly process.In this study,we consider completion time variance and maximumcompletion time as scheduling objectives,continue the weighted summation process formultiple objectives,and design adaptive weighted summation parameters to optimize productivity and reduce the difference in completion time between components in the same kit.The Soft Actor Critic(SAC)algorithm is designed to be combined with the Adaptive Multi-Buffer Experience Replay(AMBER)mechanism to propose the SAC-AMBER algorithm.The AMBER mechanism optimizes the experience sampling and policy updating process and enhances learning efficiency by categorically storing the experience into the standard buffer,the high equipment utilization buffer,and the high productivity buffer.Experimental results show that the SAC-AMBER algorithm can effectively reduce the maximum completion time on multiple datasets,reduce the difference in component completion time in the same kit,and thus optimize the readiness of the part kits,demonstrating relatively good stability and convergence.Compared with traditional heuristics,meta-heuristics,and other deep reinforcement learning methods,the SAC-AMBER algorithm performs better in terms of solution quality and computational efficiency,and through extensive testing on multiple datasets,the algorithm has been confirmed to have good generalization ability,providing an effective solution to the FJSP problem.
文摘The study was carried out in the Tahoua region at the market gardening sites of the Taddis 1 and 2 valley. Small-scale pumping irrigation is one of the most interesting uses of solar energy. The objective of this study is to carry out a comparative analysis of two dewatering pumping systems (Solar Kit and GMP) for water mobilization on a certain number of criteria such as sustainable use, economic aspect and performance. To achieve this, the adapted methodology consisted first of all in the development of a data collection tool in the field. Then flow measurements, estimation of fuel consumption, pressure height, etc., were carried out. Thus, the data collection involved a sample of 120 irrigators who had to use the two (2) types of pumping systems. The collected data were analyzed and processed with appropriate software. The results of the study show that the two pumping systems studied have strengths and constraints. Thus, the solar pumping system has a significant investment cost, very low maintenance and a low operating cost. On the other hand, the system with a generator has a relatively low investment cost (25 to 30 times less than solar), but a relatively high operating, upkeep and maintenance cost. He adds that these assets and constraints must be taken into consideration when an investment is made. This study shows that 74% of producers use GMP compared to 26% who use the Solar Kit. But in practice, the Solar Kit is more reliable for producers from the point of view of planted area, environmental management and investment costs, supply of fuel and lubricant. These results indicate better performance of the solar pumping system compared to GMP at the study sites.
基金supported by National Natural Science Foundation of China(No.61821001)Science and Tech-nology Key Project of Guangdong Province,China(2019B010157001).
文摘End-host address mutation is one of the key network moving target defense mechanisms to defend against reconnaissance.However,frequently changing host addresses increases the transmission de-lay of active sessions,which may cause serious ram-ifications.In this paper,by leveraging the advanced DPDK technology,we proposed a high-performance MTD gateway framework,called HPMG,which can not only prevent adversaries from reconnaissance ef-fectively,but also retain high-speed data packet pro-cessing capabilities.Firstly,every moving target host is assigned three different IP addresses,called real IP,virtual IP,and external IP,to realize multi-level net-work address architecture.To delay the scanning tech-niques of adversaries,HPMG mutates virtual IP and virtual MAC addresses,and replies with fake host re-sponses.Besides,to be transparent to the end-hosts,HPMG keeps real IP and real MAC unchanged.Fi-nally,we optimized the forwarding and processing performance of the HPMG based on the fast path framework of DPDK.Our theoretical analysis,imple-mentation,and evaluation show that HPMG can effec-tively defend against reconnaissance attacks and de-crease the processing delay caused by address muta-tion.
基金Rapid Identification and Analysis of Snake Venom Types in Snakebites in Renshou County,(Project No.:2024KJZD072)。
文摘Objective:To develop a rapid diagnostic kit for identifying snake venom types,aimed at providing a basis for clinical diagnosis and laying a foundation for early treatment through quick blood testing of injured patients.Methods:Anti-snake venom immunoglobulin(IgG)was prepared,biotinylated specific IgG was screened,detection enzyme-labeled strips were produced,and rapid identification of snakebites was performed.Pre-experimental verification was conducted to establish standard curves and confirm specificity.The kit was tested on clinical samples and the results were analyzed.Repeatability and stability were evaluated through multiple repeated tests and experiments under different storage conditions.Finally,sensitivity and specificity were calculated,receiver operating characteristic curves(ROC curves)were drawn,and statistical analysis software was used for data analysis to ensure the reliability and effectiveness of the kit.Results:The test showed high sensitivity and specificity.Conclusion:The rapid diagnostic kit for identifying snake venom types in blood tests demonstrates high reliability and effectiveness in clinical diagnosis.
文摘近日,宝马(BMW)和奇思(Kith)成功合作推出新款车型。宝马XM及其与传奇车型宝马M1的联系是这家高档汽车制造商与罗尼·菲格(Ronnie Fieg)的世界知名品牌Kith第三次合作的焦点。这款高性能插电式混合动力车型将于2025年推出,其被命名为2025宝马XM by Kith,并采用独家外观和内饰设计。
基金supported by a National Research Foundation of Korea(NRF)grant funded by the Korean Government(Ministry of Science and ICT,RS-2023-00208193 to Y.T.J.)by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare(RS-2024-00403511 to D.-H.K.)by a Korea University grant(K2117151 to Y.T.J.)。
文摘Taste buds relay taste sensory information to the primary taste neurons but depend on those same neurons for essential components to maintain function.While denervation-induced taste bud degeneration and subsequent regeneration were discovered decades ago,the mechanisms underlying these phenomena(e.g.,heterogenous cellular responses to nerve injury and the signaling pathways involved)remain poorly understood.Here,using mouse genetics,nerve injury models,pharmacologic manipulation,and taste bud organoid models,we identify a specific subpopulation of taste cells,predominantly c-Kit-expressing sweet cells,that exhibit superior resistance to nerve injury.We found the c-Kit inhibitor imatinib selectively reduced the number of residual c-Kit-expressing sweet cells at post-operation week 2,subsequently attenuating the re-emergence of other type II cells by post-operation week 4.In taste bud organoids,c-Kit-expressing cells were resistant to R-spondin withdrawal but susceptible to imatinib,while other taste cell types showed the opposite behavior.We also observed a distinct population of residual taste cells that acquired stem-like properties,generating clonal descendent cells among suprabasal keratinocytes independent of c-Kit signaling.Together,our findings reveal that c-Kit signaling confers resilience on c-Kit-expressing sweet cells and supports the broader reconstruction of taste buds during the later regenerative stage following nerve injury.
文摘In the modern era of 5th generation(5G)networks,the data generated by User Equipments(UE)has increased significantly,with data file sizes varying from modest sensor logs to enormous multimedia files.In modern telecommunications networks,the need for high-end security and efficient management of these large data files is a great challenge for network designers.The proposed model provides the efficient real-time virtual data storage of UE data files(light and heavy)using an object storage system MinIO having inbuilt Software Development Kits(SDKs)that are compatible with Amazon(S3)Application Program Interface(API)making operations like file uploading,and data retrieval extremely efficient as compared to legacy virtual storage system requiring low-level HTTP requests for data management.To provide integrity,authenticity,and confidentiality(integrity checking via an authentication tag)to the data files of UE,the encrypted algorithm 256-bit oriented-Advanced Encryption Standard(256-AES)in Galois/Counter Mode(GCM)is utilized in combination with MinIO.The AES-based MinIO signifies in more secure and faster approach than older models like Cipher Block Chaining(CBC).The performance of the proposed model is analyzed using the Iperf utility to perform the Teletraffic parametric(bandwidth,throughput,latency,and transmission delay)analysis for three different cases namely:(a)light UE traffic(uploading and retrieval)(b)heavy UE traffic(uploading and retrieval)and(c)comparison of Teletraffic parameters namely:bandwidth(Bava),throughput(Tput),data transfer(D_(Trans)),latency(L_(ms)),and transmission delay(TDelay)obtained from proposed method with legacy virtual storage methods.The results show that the suggested MinIO-based system outperforms conventional systems in terms of latency,encryption efficiency,and performance under varying data load conditions.
基金National Natural Science Foundation of China,No.82370569Basic and Applied Basic Research Foundation of Guangdong Province,No.2022A1515012647the Key Program for Science and Technology Projects of Social Development in Zhuhai,No.2220004000249(to Li XF).
文摘This editorial discusses Wang et al's article on familial gastrointestinal stromal tumors(GISTs).We read with great interest this article concerning the diagnosis,treatment,and post-treatment management of patients with familial GISTs.The actual incidence of GISTs may be underestimated due to diagnostic limitations and the long-term low-risk behavior of some GISTs.The molecular landscape of GISTs is primarily driven by mutations in the KIT and platelet-derived growth factor receptor alpha(PDGFRA)genes.A subset of GISTs without these mutations known as wild-type GISTs,may harbor other rare mutations,impacting their response to targeted therapies.Clinically,patients with GISTs present with nonspecific symptoms,often leading to delayed diagnosis.Genetic predispositions in familial GISTs provide insights into the genetic architecture and extragastrointestinal manifestations of GISTs.Management has evolved from surgical interventions to molecular-based therapies using tyrosine kinase inhibitors.The management of GISTs,especially in familial cases,requires a multidisciplinary approach.Cases of different gene mutations were reported in the same family,suggesting that incorporating genetic testing into routine clinical practice is crucial for the early identification of high-risk individuals and the implementation of tailored surveillance programs.
