Dear Editor,The T-box transcription factor T(TBXT,T,Brachyuary)gene has been identified as a tissue-specific transcriptional factor in vertebrates,regulating mesoderm formation and notochord differentiation during emb...Dear Editor,The T-box transcription factor T(TBXT,T,Brachyuary)gene has been identified as a tissue-specific transcriptional factor in vertebrates,regulating mesoderm formation and notochord differentiation during embryonic development(Kispert et al.,1995).Tbxt knockout heterozygous mice exhibited varying degrees of tail shortening,while homozygous mice died at approximately E10.0,and displayed severe defects in somite formation and neural tube development(Abe et al.,2000).展开更多
基金supported by the Basic Science Center Program(32488101)Shenzhen Medical Research Fund(B2402004)+1 种基金Sanming Project of Medicine in Shenzhen(SZSM202311005)Shanghai Municipal Science and Technology Major Project(FCK-92724413-2024-025)。
文摘Dear Editor,The T-box transcription factor T(TBXT,T,Brachyuary)gene has been identified as a tissue-specific transcriptional factor in vertebrates,regulating mesoderm formation and notochord differentiation during embryonic development(Kispert et al.,1995).Tbxt knockout heterozygous mice exhibited varying degrees of tail shortening,while homozygous mice died at approximately E10.0,and displayed severe defects in somite formation and neural tube development(Abe et al.,2000).
