Objective:This article uses a meta-analysis system to evaluate the clinical efficacy of the method of spleen-invigorating,kidney-tonifying and blood-activating combined with western medicine in the treatment of diabet...Objective:This article uses a meta-analysis system to evaluate the clinical efficacy of the method of spleen-invigorating,kidney-tonifying and blood-activating combined with western medicine in the treatment of diabetic nephropathy,in order to provide evidence-based medicine for the clinical treatment of this disease.Methods:Computer search(January 2009 to June 2020)published in CNKI,Wanfang database,and Weipu Chinese Science and Technology Journal Database with simple western medicine conventional treatment(control group)and on the basis of control group Randomized Controlled Trial(RCT)of the treatment of diabetic nephropathy with spleen-invigorating,kidney-tonifying and blood-activating(experimental group),and manual retrieval of relevant literature that meets the inclusion criteria.Two researchers independently carried out literature screening,and used the improved Jadad rating scale for quality evaluation,and finally used RevMan5.3 statistical software for meta-analysis.Results:A total of 15 randomized controlled trials were included,with a total of 1218 patients,including 621 in the experimental group and 597 in the control group.Meta-analysis showed that the experimental group was improving clinical efficacy(OR=4.35,95%CI[3.12,6.08],P<0.00001),FPG(MD=-0.49,95%CI[-0.89,-0.09],P=0.02),24h urine protein quantification(MD=-0.54,95%CI[-0.90,-0.18],P=0.003),mALB(MD=-15.95,95%CI[-18.12,-13.79],P<0.0001),BUN(MD=-1.79,95%CI[-2.99,-0.59],P=0.004),SCr(MD=-47.63,95%CI[-83.43,-11.83],P=0.009),TC(MD=-1.02,95%CI[-1.42,-0.62],P<0.00001),etc.may be better than the control group;The test group is improving TG(MD=-1.02,95%CI[-1.42,-0.62],P<0.00001)there is no significant difference compared with the control group.Conclusion:The method of spleen-invigorating,kidney-tonifying and blood-activating combined with conventional western medicine treatment of diabetic nephropathy may be superior to conventional western medicine treatment in terms of improving clinical efficacy,FPG,24h urine protein quantification,mALB,BUN,SCr,TC,etc.However,due to the small number and low quality of the literature included in this study,more in-depth research needs to further expand the sample size and include higher quality RCTs.展开更多
Traditional Chinese medicine(TCM)establishes that the kidney serves vital systemic functions and its deficiency represents a fundamental factor influencing various diseases,including asthma.The kidney-tonifying method...Traditional Chinese medicine(TCM)establishes that the kidney serves vital systemic functions and its deficiency represents a fundamental factor influencing various diseases,including asthma.The kidney-tonifying method represents a widely implemented clinical approach in TCM to address kidney deficiency.This study hypothesized that bone marrow mesenchymal stem cells(BMSCs)function as key contributors to the kidney-tonifying method.An ovalbumin(OVA)-induced asthma mouse model received treatment with the traditional kidney-tonifying formula,Qi-Xian decoction(QXD).QXD demonstrated significant therapeutic efficacy,enhanced BMSC proliferation in mouse bone marrow,and facilitated their migration to lung tissues.Inhibition of the CXCL12/CXCR4 axis diminished the QXD-induced migration of endogenous BMSCs and reduced QXD's efficacy in asthma treatment.QXD-containing serum enhanced BMSC proliferation and promoted CXCL12-induced BMSC migration in vitro.These findings indicate that endogenous BMSCs may serve as a crucial mediator in the therapeutic effects of the kidney-tonifying method.Furthermore,the mild and sustained stimulation of production and enhanced homing of endogenous BMSCs presents a potential novel approach for effective asthma treatment.展开更多
基金The second round of construction project of the National Traditional Chinese Medicine School Inheritance Studio of the State Administration of Traditional Chinese Medicine(Guo TCM Ren Jiao Han[2019]No.62)Scientific Research Project of the Shaanxi Provincial Administration of Traditional Chinese Medicine(No.2019-ZZ-LC006)Shaanxi The construction project of famous traditional Chinese medicine inheritance studio of Provincial Administration of Traditional Chinese Medicine(No.2019017).
文摘Objective:This article uses a meta-analysis system to evaluate the clinical efficacy of the method of spleen-invigorating,kidney-tonifying and blood-activating combined with western medicine in the treatment of diabetic nephropathy,in order to provide evidence-based medicine for the clinical treatment of this disease.Methods:Computer search(January 2009 to June 2020)published in CNKI,Wanfang database,and Weipu Chinese Science and Technology Journal Database with simple western medicine conventional treatment(control group)and on the basis of control group Randomized Controlled Trial(RCT)of the treatment of diabetic nephropathy with spleen-invigorating,kidney-tonifying and blood-activating(experimental group),and manual retrieval of relevant literature that meets the inclusion criteria.Two researchers independently carried out literature screening,and used the improved Jadad rating scale for quality evaluation,and finally used RevMan5.3 statistical software for meta-analysis.Results:A total of 15 randomized controlled trials were included,with a total of 1218 patients,including 621 in the experimental group and 597 in the control group.Meta-analysis showed that the experimental group was improving clinical efficacy(OR=4.35,95%CI[3.12,6.08],P<0.00001),FPG(MD=-0.49,95%CI[-0.89,-0.09],P=0.02),24h urine protein quantification(MD=-0.54,95%CI[-0.90,-0.18],P=0.003),mALB(MD=-15.95,95%CI[-18.12,-13.79],P<0.0001),BUN(MD=-1.79,95%CI[-2.99,-0.59],P=0.004),SCr(MD=-47.63,95%CI[-83.43,-11.83],P=0.009),TC(MD=-1.02,95%CI[-1.42,-0.62],P<0.00001),etc.may be better than the control group;The test group is improving TG(MD=-1.02,95%CI[-1.42,-0.62],P<0.00001)there is no significant difference compared with the control group.Conclusion:The method of spleen-invigorating,kidney-tonifying and blood-activating combined with conventional western medicine treatment of diabetic nephropathy may be superior to conventional western medicine treatment in terms of improving clinical efficacy,FPG,24h urine protein quantification,mALB,BUN,SCr,TC,etc.However,due to the small number and low quality of the literature included in this study,more in-depth research needs to further expand the sample size and include higher quality RCTs.
基金suppout by Putuo District(No.ptkwws202508)the Science and Technology Development Project Funding of Shanghai University of Traditional Chinese Medicine(Nos.23KFL082 and 24KFL057)+1 种基金the Plan of Clinical Specialty Construction in Shanghai Putuo District Health System(No.2020tszk02)the National Natural Science Foundation of China(Youth)Program(No.82405349)。
文摘Traditional Chinese medicine(TCM)establishes that the kidney serves vital systemic functions and its deficiency represents a fundamental factor influencing various diseases,including asthma.The kidney-tonifying method represents a widely implemented clinical approach in TCM to address kidney deficiency.This study hypothesized that bone marrow mesenchymal stem cells(BMSCs)function as key contributors to the kidney-tonifying method.An ovalbumin(OVA)-induced asthma mouse model received treatment with the traditional kidney-tonifying formula,Qi-Xian decoction(QXD).QXD demonstrated significant therapeutic efficacy,enhanced BMSC proliferation in mouse bone marrow,and facilitated their migration to lung tissues.Inhibition of the CXCL12/CXCR4 axis diminished the QXD-induced migration of endogenous BMSCs and reduced QXD's efficacy in asthma treatment.QXD-containing serum enhanced BMSC proliferation and promoted CXCL12-induced BMSC migration in vitro.These findings indicate that endogenous BMSCs may serve as a crucial mediator in the therapeutic effects of the kidney-tonifying method.Furthermore,the mild and sustained stimulation of production and enhanced homing of endogenous BMSCs presents a potential novel approach for effective asthma treatment.
