Two new ent-kaurane diterpenoids, sculponeatins L (1) and M (2), were isolated from the EtOAc extract of Isodon sculponeata. Their structures were elucidated by spectroscopic evidences. The cytotoxicities of 1 and 2...Two new ent-kaurane diterpenoids, sculponeatins L (1) and M (2), were isolated from the EtOAc extract of Isodon sculponeata. Their structures were elucidated by spectroscopic evidences. The cytotoxicities of 1 and 2 against human tumor cells K562 and T24 were tested.展开更多
Further investigation on the aerial parts of Isodon enanderianus afforded a novel asymmetric ent kauranoid dimer, enanderinanin J (1). The structure of the dimer was elucidated by means of spectroscopic m...Further investigation on the aerial parts of Isodon enanderianus afforded a novel asymmetric ent kauranoid dimer, enanderinanin J (1). The structure of the dimer was elucidated by means of spectroscopic methods (including 2D NMR techniques). Enanderinanin J was a dimer of xerophilusin A and probably formed by cycloaddition.展开更多
Objective To study the ent-kaurane diterpenoids from Rabdosia rubescens. Methods The compounds were isolated by chromatographies and their structures were identified by spectral analyses. Results Four compounds were i...Objective To study the ent-kaurane diterpenoids from Rabdosia rubescens. Methods The compounds were isolated by chromatographies and their structures were identified by spectral analyses. Results Four compounds were isolated, and they were identified as bisrubescensin E (1), 2α,3α,24-trihydroxyurs-12-en-28-oic acid (2), 2α,3α,24-trihydroxyurs-12,20-(30)-dien-28-oic acid (3), and 6,7-dihydroxycoumarin (4). Conclusion Compound 1 is a new asymmetric ent-kauranoid dimer. Compound 2 is isolated from the plant for the first time. Compounds 3 and 4 are isolated from the plants of Rabdosia (Bl.) Hassk for the first time.展开更多
Two new ent-kauranoids, named maoyecrystals A (1) and B (2), were isolated from the EtOAc extract of the dried leaves of Isodon japonica (Burman f.) Hara collected in Tongbai mountains, Henan Province. Their structur...Two new ent-kauranoids, named maoyecrystals A (1) and B (2), were isolated from the EtOAc extract of the dried leaves of Isodon japonica (Burman f.) Hara collected in Tongbai mountains, Henan Province. Their structures were determined on the basis of spectral data, especially by 2D NMR.展开更多
b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isod...b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isodon sculponeatus afforded two new ent kaurane diterpenoids, sculponeatins J and K . Their structures were elucidated on the basis of their spectral properties, as well as X ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC 50 values less than 1.0 μg/mL.展开更多
文摘Two new ent-kaurane diterpenoids, sculponeatins L (1) and M (2), were isolated from the EtOAc extract of Isodon sculponeata. Their structures were elucidated by spectroscopic evidences. The cytotoxicities of 1 and 2 against human tumor cells K562 and T24 were tested.
文摘Further investigation on the aerial parts of Isodon enanderianus afforded a novel asymmetric ent kauranoid dimer, enanderinanin J (1). The structure of the dimer was elucidated by means of spectroscopic methods (including 2D NMR techniques). Enanderinanin J was a dimer of xerophilusin A and probably formed by cycloaddition.
文摘Objective To study the ent-kaurane diterpenoids from Rabdosia rubescens. Methods The compounds were isolated by chromatographies and their structures were identified by spectral analyses. Results Four compounds were isolated, and they were identified as bisrubescensin E (1), 2α,3α,24-trihydroxyurs-12-en-28-oic acid (2), 2α,3α,24-trihydroxyurs-12,20-(30)-dien-28-oic acid (3), and 6,7-dihydroxycoumarin (4). Conclusion Compound 1 is a new asymmetric ent-kauranoid dimer. Compound 2 is isolated from the plant for the first time. Compounds 3 and 4 are isolated from the plants of Rabdosia (Bl.) Hassk for the first time.
文摘Two new ent-kauranoids, named maoyecrystals A (1) and B (2), were isolated from the EtOAc extract of the dried leaves of Isodon japonica (Burman f.) Hara collected in Tongbai mountains, Henan Province. Their structures were determined on the basis of spectral data, especially by 2D NMR.
文摘b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isodon sculponeatus afforded two new ent kaurane diterpenoids, sculponeatins J and K . Their structures were elucidated on the basis of their spectral properties, as well as X ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC 50 values less than 1.0 μg/mL.
