It has been hypothesized that under iron stress high ferric chelate reductase (FCR) activity in the absorptive root of plants tolerant to iron_deficiency will be induced and result in subsequent Fe 2+ transport a...It has been hypothesized that under iron stress high ferric chelate reductase (FCR) activity in the absorptive root of plants tolerant to iron_deficiency will be induced and result in subsequent Fe 2+ transport across the plasmalemma. The activity of FCR and expression of FCR gene (FRO2) in Citrus junos Sieb. ex Tanaka tolerant to iron_deficiency and Poncirus trifoliata (L.) Raf. susceptible to iron_deficiency were determined to elucidate the physiological difference which causes the different tolerance of the two citrus rootstocks to iron stress. The activity of FCR was detectable in excised roots and was stimulated about 20_times in C. junos and only about 3_times in P. trifoliata under iron deficiency for four weeks. The FRO2 of Arabidopsis was used as a probe, the tissue print technique was used to ascertain the expression of the FCR gene in C. junos and P. trifoliata under iron stress. High_level transcripts were observed in the absorptive root, young green stem as well as new leaf of C. junos under iron stress for two weeks, and the transcripts were accumulated only slightly in P. trifoliata at the same time. The results showed that the obvious increase of FCR activity was an important reason for the tolerance of C. junos to iron_deficiency, and the regulation of FCR activity seemed to be at the transcriptional level, and the expression of FRO2 occurred in the root, stem and leaf.展开更多
Aroma touch therapy is widely used in clinical fields for alleviating pain-related symptoms;however, few studies have reported the pain-relief mechanisms. The present study aimed to elucidate the analgesic effects of ...Aroma touch therapy is widely used in clinical fields for alleviating pain-related symptoms;however, few studies have reported the pain-relief mechanisms. The present study aimed to elucidate the analgesic effects of aroma touch therapy with Citrus junos oil based on the quantitative evaluation of deep brain network (DBN) activity using electroencephalogram (EEG) occipital alpha-2 rhythm (10-13 Hz) powers. Experimental investigations were performed with 13 healthy volunteers using the cold pressor task for simulating chronic pain in three different sessions: a baseline session with no therapies, a control session with a touch therapy, and an aroma touch therapy. We have found for the first time that the interviewed pain ratings represented by Numeric Rating Scale (NRS) scores were strongly correlated with a DBN activity index, which was derived from the slow fluctuation components of occipital EEG alpha-2 rhythm powers. The correlation was characterized by a V-shaped curve in the DBN activity index versus the pain rating, i.e., the NRS score, which provided the complete analgesic states (NRS = 0) for some subjects under aroma touch therapy at an appropriate DBN activity index. Such analgesic states were not so strongly correlated with emotional valence. In conclusion, aroma touch therapy may directly modulate DBN activity so that pain-induced outcomes are minimized.展开更多
Detector and event visualization are crucial components of high-energy physics(HEP)experimental software.Virtual reality(VR)technologies and multimedia development platforms,such as Unity,offer enhanced display effect...Detector and event visualization are crucial components of high-energy physics(HEP)experimental software.Virtual reality(VR)technologies and multimedia development platforms,such as Unity,offer enhanced display effects and flexible extensibility for visualization in HEP experiments.In this study,we present a VR-based method for detector and event displays in the Jiangmen Underground Neutrino Observatory(JUNO)experiment.This method shares the same detector geometry descriptions and event data model as those in the offline software and provides the necessary data conversion interfaces.The VR methodology facilitates an immersive exploration of the virtual environment in JUNO,enabling users to investigate the detector geometry,visualize event data,and tune the detector simulation and event reconstruction algorithms.Additionally,this approach supports applications in data monitoring,physics data analysis,and public outreach initiatives.展开更多
The sustainable sourcing of novel bioactive compounds from natural sources is crucial to the success of the pharmaceutical,food,and cosmetics industries.Iris bucharica Foster(syn.Juno bucharica(Foster)Vved.)is a promi...The sustainable sourcing of novel bioactive compounds from natural sources is crucial to the success of the pharmaceutical,food,and cosmetics industries.Iris bucharica Foster(syn.Juno bucharica(Foster)Vved.)is a promising source of novel bioactive molecules,particularly phenolic compounds,which are renowned for their antioxidant properties.In this study,we developed a reliable HPLC-UV-DAD method to identify and quantify phenolic compounds in the leaves and bulbs of I.bucharica,establishing the first set of quality control markers for this species.A total of 21 phenolic compounds were identified in the leaves,with flavonoids isoorientin,guaijaverin,hyperoside,and cosmosiin,the isoflavonoid biochanin A,and the simple phenolic ferulic acid being the most prominent.In comparison,14 compounds were identified in the bulbs,primarily isoflavonoids,including tectoridin and germanaism B,and flavonoid apigenin.The leaves extracts exhibited significant antioxidant activity,whereas the anti-allergic and anti-inflammatory effects were mild.These findings highlight I.bucharica as a sustainable source of bioactive compounds with potential industrial applications.However,further studies are needed to evaluate bioavailability and in vivo efficacy,as well as to optimise extraction methods to realize its industrial potential fully.展开更多
The Taishan Antineutrino Observatory(TAO)is a satellite experiment of the Jiangmen Underground Neutrino Observatory,located near the Taishan nuclear power plant(NPP).The TAO aims to measure the energy spectrum of reac...The Taishan Antineutrino Observatory(TAO)is a satellite experiment of the Jiangmen Underground Neutrino Observatory,located near the Taishan nuclear power plant(NPP).The TAO aims to measure the energy spectrum of reactor antineutrinos with unprecedented precision,which would benefit both reactor neutrino physics and the nuclear database.A detector geometry and event visualization system was developed for the TAO.The software was based on ROOT packages and embedded in the TAO offline software framework.This provided an intuitive tool for visualizing the detector geometry,tuning the reconstruction algorithm,understanding neutrino physics,and monitoring the operation of reactors at NPP.Further applications of the visualization system in the experimental operation of TAO and its future development are discussed.展开更多
A 20-kiloton liquid scintillator detector is under construction at the Jiangmen Underground Neutrino Observatory(JUNO)for several physics purposes.Detecting neutrinos released from nuclear reactors,the sun,supernova b...A 20-kiloton liquid scintillator detector is under construction at the Jiangmen Underground Neutrino Observatory(JUNO)for several physics purposes.Detecting neutrinos released from nuclear reactors,the sun,supernova bursts,and Earth's atmosphere across a wide energy range necessitates efficient reconstruction algorithms.In this study,we introduce a novel method for reconstructing event energy by counting 3-inch photomultiplier tubes(PMTs)with or without signals.The proposed algorithm demonstrated excellent performance in accurate energy reconstruction,validated with electron Monte Carlo samples covering kinetic energies ranging from 10 MeV to 1 GeV.展开更多
INFOCUS|JUNO Formally Comes into Operation A new-generation large-scale neutrino experiment,the Jiangmen Underground Neutrino Observatory(JUNO)formally came into operation and started collecting data in late August.
14日，Juniper推出伙伴方案开发平台（Partner Solution Development Platform，简称PSDP），以协助客户及伙伴开发适用于JUNOS操作系统的各类专门应用软件。PSDP为业界首个适用于电信运营商级网络操作系统的伙伴开发平台，让客户及伙...14日，Juniper推出伙伴方案开发平台（Partner Solution Development Platform，简称PSDP），以协助客户及伙伴开发适用于JUNOS操作系统的各类专门应用软件。PSDP为业界首个适用于电信运营商级网络操作系统的伙伴开发平台，让客户及伙伴能更快开发及架设各种增值服务，以应对业务实际要求，同时提高网络作业生产力。展开更多
精卵融合是受精过程中最为重要的步骤。目前公认IZUMO1、JUNO和CD9(cluster of differentiation antigen 9)为精卵融合的必需蛋白质,其中IZUMO1与JUNO在精卵识别时会形成复合体。有研究表明IZUMO1、JUNO和CD9主要参与精卵融合最初的黏...精卵融合是受精过程中最为重要的步骤。目前公认IZUMO1、JUNO和CD9(cluster of differentiation antigen 9)为精卵融合的必需蛋白质,其中IZUMO1与JUNO在精卵识别时会形成复合体。有研究表明IZUMO1、JUNO和CD9主要参与精卵融合最初的黏附过程,且它们之间是相互关联发挥作用的。近年来由于X射线晶体学相关技术的发展,IZUMO1-JUNO晶体结构基本被阐明,然而精卵融合的具体分子机制仍未被完全揭示。所以,对哺乳动物精卵融合必需蛋白质IZUMO1-JUNO/CD9的结构、功能和分子机制进行阐述是十分必要的。展开更多
文摘It has been hypothesized that under iron stress high ferric chelate reductase (FCR) activity in the absorptive root of plants tolerant to iron_deficiency will be induced and result in subsequent Fe 2+ transport across the plasmalemma. The activity of FCR and expression of FCR gene (FRO2) in Citrus junos Sieb. ex Tanaka tolerant to iron_deficiency and Poncirus trifoliata (L.) Raf. susceptible to iron_deficiency were determined to elucidate the physiological difference which causes the different tolerance of the two citrus rootstocks to iron stress. The activity of FCR was detectable in excised roots and was stimulated about 20_times in C. junos and only about 3_times in P. trifoliata under iron deficiency for four weeks. The FRO2 of Arabidopsis was used as a probe, the tissue print technique was used to ascertain the expression of the FCR gene in C. junos and P. trifoliata under iron stress. High_level transcripts were observed in the absorptive root, young green stem as well as new leaf of C. junos under iron stress for two weeks, and the transcripts were accumulated only slightly in P. trifoliata at the same time. The results showed that the obvious increase of FCR activity was an important reason for the tolerance of C. junos to iron_deficiency, and the regulation of FCR activity seemed to be at the transcriptional level, and the expression of FRO2 occurred in the root, stem and leaf.
文摘Aroma touch therapy is widely used in clinical fields for alleviating pain-related symptoms;however, few studies have reported the pain-relief mechanisms. The present study aimed to elucidate the analgesic effects of aroma touch therapy with Citrus junos oil based on the quantitative evaluation of deep brain network (DBN) activity using electroencephalogram (EEG) occipital alpha-2 rhythm (10-13 Hz) powers. Experimental investigations were performed with 13 healthy volunteers using the cold pressor task for simulating chronic pain in three different sessions: a baseline session with no therapies, a control session with a touch therapy, and an aroma touch therapy. We have found for the first time that the interviewed pain ratings represented by Numeric Rating Scale (NRS) scores were strongly correlated with a DBN activity index, which was derived from the slow fluctuation components of occipital EEG alpha-2 rhythm powers. The correlation was characterized by a V-shaped curve in the DBN activity index versus the pain rating, i.e., the NRS score, which provided the complete analgesic states (NRS = 0) for some subjects under aroma touch therapy at an appropriate DBN activity index. Such analgesic states were not so strongly correlated with emotional valence. In conclusion, aroma touch therapy may directly modulate DBN activity so that pain-induced outcomes are minimized.
基金supported by the National Natural Science Foundation of China(Nos.12175321,W2443004,11975021,11675275,U1932101)Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA10010900)+2 种基金National Key Research and Development Program of China(Nos.2023YFA1606000 and 2020YFA0406400)National College Students Science and Technology Innovation ProjectUndergraduate Base Scientific Research Project of Sun Yat-sen University。
文摘Detector and event visualization are crucial components of high-energy physics(HEP)experimental software.Virtual reality(VR)technologies and multimedia development platforms,such as Unity,offer enhanced display effects and flexible extensibility for visualization in HEP experiments.In this study,we present a VR-based method for detector and event displays in the Jiangmen Underground Neutrino Observatory(JUNO)experiment.This method shares the same detector geometry descriptions and event data model as those in the offline software and provides the necessary data conversion interfaces.The VR methodology facilitates an immersive exploration of the virtual environment in JUNO,enabling users to investigate the detector geometry,visualize event data,and tune the detector simulation and event reconstruction algorithms.Additionally,this approach supports applications in data monitoring,physics data analysis,and public outreach initiatives.
基金supported by grants from the National Science and Technology Council(NSTC),Taiwan(NSTC 114-2320-B-037-020-MY3,113-2320-B-037-023,and 112-2320-B-037-012 granted to M.K.,113-2321-B-255-001,113-2321-B-182-003,112-2321-B-182-003,112-2321-B-255-001,111-2320-B-255-006-MY3,and 111-2321-B-255-001 granted to T.L.H.)Kaohsiung Medical University Research Foundation[KMU-Q113011 awarded to M.K.and KMU-M114020 awarded to B.H.C.]NSYSU-KMU joint research project(NSYSU-KMU-114-P16)awarded to M.K.
文摘The sustainable sourcing of novel bioactive compounds from natural sources is crucial to the success of the pharmaceutical,food,and cosmetics industries.Iris bucharica Foster(syn.Juno bucharica(Foster)Vved.)is a promising source of novel bioactive molecules,particularly phenolic compounds,which are renowned for their antioxidant properties.In this study,we developed a reliable HPLC-UV-DAD method to identify and quantify phenolic compounds in the leaves and bulbs of I.bucharica,establishing the first set of quality control markers for this species.A total of 21 phenolic compounds were identified in the leaves,with flavonoids isoorientin,guaijaverin,hyperoside,and cosmosiin,the isoflavonoid biochanin A,and the simple phenolic ferulic acid being the most prominent.In comparison,14 compounds were identified in the bulbs,primarily isoflavonoids,including tectoridin and germanaism B,and flavonoid apigenin.The leaves extracts exhibited significant antioxidant activity,whereas the anti-allergic and anti-inflammatory effects were mild.These findings highlight I.bucharica as a sustainable source of bioactive compounds with potential industrial applications.However,further studies are needed to evaluate bioavailability and in vivo efficacy,as well as to optimise extraction methods to realize its industrial potential fully.
基金supported by the National Natural Science Foundation of China(Nos.12175321,11975021,and 11675275)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA10010900)。
文摘The Taishan Antineutrino Observatory(TAO)is a satellite experiment of the Jiangmen Underground Neutrino Observatory,located near the Taishan nuclear power plant(NPP).The TAO aims to measure the energy spectrum of reactor antineutrinos with unprecedented precision,which would benefit both reactor neutrino physics and the nuclear database.A detector geometry and event visualization system was developed for the TAO.The software was based on ROOT packages and embedded in the TAO offline software framework.This provided an intuitive tool for visualizing the detector geometry,tuning the reconstruction algorithm,understanding neutrino physics,and monitoring the operation of reactors at NPP.Further applications of the visualization system in the experimental operation of TAO and its future development are discussed.
基金supported by National Key R&D Program of China(No.2023YFA1606103)National Natural Science Foundation of China(Nos.12375105 and 12005044)the Program of Bagui Scholars Program(XF)。
文摘A 20-kiloton liquid scintillator detector is under construction at the Jiangmen Underground Neutrino Observatory(JUNO)for several physics purposes.Detecting neutrinos released from nuclear reactors,the sun,supernova bursts,and Earth's atmosphere across a wide energy range necessitates efficient reconstruction algorithms.In this study,we introduce a novel method for reconstructing event energy by counting 3-inch photomultiplier tubes(PMTs)with or without signals.The proposed algorithm demonstrated excellent performance in accurate energy reconstruction,validated with electron Monte Carlo samples covering kinetic energies ranging from 10 MeV to 1 GeV.
文摘INFOCUS|JUNO Formally Comes into Operation A new-generation large-scale neutrino experiment,the Jiangmen Underground Neutrino Observatory(JUNO)formally came into operation and started collecting data in late August.
文摘14日，Juniper推出伙伴方案开发平台（Partner Solution Development Platform，简称PSDP），以协助客户及伙伴开发适用于JUNOS操作系统的各类专门应用软件。PSDP为业界首个适用于电信运营商级网络操作系统的伙伴开发平台，让客户及伙伴能更快开发及架设各种增值服务，以应对业务实际要求，同时提高网络作业生产力。
文摘精卵融合是受精过程中最为重要的步骤。目前公认IZUMO1、JUNO和CD9(cluster of differentiation antigen 9)为精卵融合的必需蛋白质,其中IZUMO1与JUNO在精卵识别时会形成复合体。有研究表明IZUMO1、JUNO和CD9主要参与精卵融合最初的黏附过程,且它们之间是相互关联发挥作用的。近年来由于X射线晶体学相关技术的发展,IZUMO1-JUNO晶体结构基本被阐明,然而精卵融合的具体分子机制仍未被完全揭示。所以,对哺乳动物精卵融合必需蛋白质IZUMO1-JUNO/CD9的结构、功能和分子机制进行阐述是十分必要的。
