皮肌炎（dermatomyositis,DM）和多发性肌炎（polymyositis,PM）是一类系统性自身免疫性疾病,主要累及皮肤、骨骼肌、肺等多个器官。其发病机制目前尚不明确,研究发现许多自身抗体与疾病的临床特征具有明显相关性,这些自身抗体包括肌炎...皮肌炎（dermatomyositis,DM）和多发性肌炎（polymyositis,PM）是一类系统性自身免疫性疾病,主要累及皮肤、骨骼肌、肺等多个器官。其发病机制目前尚不明确,研究发现许多自身抗体与疾病的临床特征具有明显相关性,这些自身抗体包括肌炎特异性抗体（myositis specific autoantibodies,MSAs）、肌炎相关性抗体（myositis associated autoantibodies,MAAs）以及组织特异性自身抗体。展开更多
The present study was aimed to assess the ability of Bacillus sp.JDM-2-1 and Staphylococcus capitis to reduce hexavalent chromium into its trivalent form.Bacillus sp.JDM-2-1 could tolerate Cr（Ⅵ）（4800 μg/mL） and ...The present study was aimed to assess the ability of Bacillus sp.JDM-2-1 and Staphylococcus capitis to reduce hexavalent chromium into its trivalent form.Bacillus sp.JDM-2-1 could tolerate Cr（Ⅵ）（4800 μg/mL） and S.capitis could tolerate Cr（Ⅵ）（2800 μg/mL）.Both organisms were able to resist Cd^2＋（50 μg/mL）,Cu^2＋（200 μg/mL）,Pb^2＋（800 μg/mL）,Hg^2＋（50 μg/mL） and Ni2＋（4000 μg/mL）.S.capitis resisted Zn^2＋ at 700 μg/mL while Bacillus sp.JDM-2-1 only showed resistance up to 50 μg/mL.Bacillus sp.JDM-2-1 and S.capitis showed optimum growth at pH 6 and 7,respectively,while both bacteria showed optimum growth at 37°C.Bacillus sp.JDM-2-1 and S.capitis could reduce 85% and 81% of hexavalent chromium from the medium after 96 h and were also capable of reducing hexavalent chromium 86% and 89%,respectively,from the industrial effuents after 144 h.Cell free extracts of Bacillus sp.JDM-2-1 and S.capitis showed reduction of 83% and 70% at concentration of 10 μg Cr（Ⅵ）/mL,respectively.The presence of an induced protein having molecular weight around 25 kDa in the presence of chromium points out a possible role of this protein in chromium reduction.The bacterial isolates can be exploited for the bioremediation of hexavalent chromium containing wastes,since they seem to have a potential to reduce the toxic hexavalent form to its nontoxic trivalent form.展开更多
Objective:To evaluate the impact of duration of untreated symptoms in childre n with juvenile dermatomyositis(JDM)on clinical and laboratory status at diagn osis.Study design:We examined physical and laboratory data f...Objective:To evaluate the impact of duration of untreated symptoms in childre n with juvenile dermatomyositis(JDM)on clinical and laboratory status at diagn osis.Study design:We examined physical and laboratory data from the first phys ician visit for 166 untreated children with JDM.Disease activity scores(DASs)assessed skin and muscle involvement.Height and weight were compared with the N ational Health and Nutrition Examination Survey III dataset.Duration of untreat ed illness was designated as the time from first sign of rash or weakness to dia gnostic visit.Results:Boys and girls with untreated JDM were shorter and light er than national norms(P >.0005 for both),and nonwhite children were weaker than wh ite children(P >.0005).Older children had more dysphagia(P =.017)and arthr itis(P >.001).Duration of untreated JDM was negatively associated with DAS we akness(P >.0005),unrelated to DAS skin,and positively associated with pathol ogical calcifications(P =.006).With untreated disease < 4.7 months,serum lev els of 4 muscle enzymes(aldolase,lactic dehydrogenase,creatine kinase,serum glutamic-oxaloacetic transaminase/aspartate aminotransferase)tended toward nor mal(P >.01 for each).Conclusions:Duration of untreated symptoms is an import ant variable and should be included in decisions concerning both diagnostic crit eria and intensity of therapy for children with JDM.展开更多
文摘皮肌炎（dermatomyositis,DM）和多发性肌炎（polymyositis,PM）是一类系统性自身免疫性疾病,主要累及皮肤、骨骼肌、肺等多个器官。其发病机制目前尚不明确,研究发现许多自身抗体与疾病的临床特征具有明显相关性,这些自身抗体包括肌炎特异性抗体（myositis specific autoantibodies,MSAs）、肌炎相关性抗体（myositis associated autoantibodies,MAAs）以及组织特异性自身抗体。
文摘The present study was aimed to assess the ability of Bacillus sp.JDM-2-1 and Staphylococcus capitis to reduce hexavalent chromium into its trivalent form.Bacillus sp.JDM-2-1 could tolerate Cr（Ⅵ）（4800 μg/mL） and S.capitis could tolerate Cr（Ⅵ）（2800 μg/mL）.Both organisms were able to resist Cd^2＋（50 μg/mL）,Cu^2＋（200 μg/mL）,Pb^2＋（800 μg/mL）,Hg^2＋（50 μg/mL） and Ni2＋（4000 μg/mL）.S.capitis resisted Zn^2＋ at 700 μg/mL while Bacillus sp.JDM-2-1 only showed resistance up to 50 μg/mL.Bacillus sp.JDM-2-1 and S.capitis showed optimum growth at pH 6 and 7,respectively,while both bacteria showed optimum growth at 37°C.Bacillus sp.JDM-2-1 and S.capitis could reduce 85% and 81% of hexavalent chromium from the medium after 96 h and were also capable of reducing hexavalent chromium 86% and 89%,respectively,from the industrial effuents after 144 h.Cell free extracts of Bacillus sp.JDM-2-1 and S.capitis showed reduction of 83% and 70% at concentration of 10 μg Cr（Ⅵ）/mL,respectively.The presence of an induced protein having molecular weight around 25 kDa in the presence of chromium points out a possible role of this protein in chromium reduction.The bacterial isolates can be exploited for the bioremediation of hexavalent chromium containing wastes,since they seem to have a potential to reduce the toxic hexavalent form to its nontoxic trivalent form.
文摘Objective:To evaluate the impact of duration of untreated symptoms in childre n with juvenile dermatomyositis(JDM)on clinical and laboratory status at diagn osis.Study design:We examined physical and laboratory data from the first phys ician visit for 166 untreated children with JDM.Disease activity scores(DASs)assessed skin and muscle involvement.Height and weight were compared with the N ational Health and Nutrition Examination Survey III dataset.Duration of untreat ed illness was designated as the time from first sign of rash or weakness to dia gnostic visit.Results:Boys and girls with untreated JDM were shorter and light er than national norms(P >.0005 for both),and nonwhite children were weaker than wh ite children(P >.0005).Older children had more dysphagia(P =.017)and arthr itis(P >.001).Duration of untreated JDM was negatively associated with DAS we akness(P >.0005),unrelated to DAS skin,and positively associated with pathol ogical calcifications(P =.006).With untreated disease < 4.7 months,serum lev els of 4 muscle enzymes(aldolase,lactic dehydrogenase,creatine kinase,serum glutamic-oxaloacetic transaminase/aspartate aminotransferase)tended toward nor mal(P >.01 for each).Conclusions:Duration of untreated symptoms is an import ant variable and should be included in decisions concerning both diagnostic crit eria and intensity of therapy for children with JDM.
