Mendelian randomisation(MR)is a widely used method that employs genetic variants as instrumental variables(IVs,also referred to as genetic instruments below and they represent eligible genetic variants in MR)from geno...Mendelian randomisation(MR)is a widely used method that employs genetic variants as instrumental variables(IVs,also referred to as genetic instruments below and they represent eligible genetic variants in MR)from genome-wide association studies(GWAS)to explore the causative relationship between putative risk factors(ie,exposures)and outcomes.1 According to a Web of Science literature search conducted at the end of 2024,the number of related publications has grown exponentially,reaching 3545 in 2023 and 6607 in 2024(figure 1).Almost simultaneously,we observed a peak of citations from 2019 to 2021,which reflected the popularity and acknowledgement of papers published in these 3 years.However,a decline in citations has been witnessed from 2022 and here are two possible explanations for it:(1)papers published in 2022 or later only have two or fewer years to be cited,and it can lead to fewer citations absolutely;(2)some papers published from 2022 are of low quality and may even be redundant analyses,thus,they are less likely to be cited.展开更多
文摘Mendelian randomisation(MR)is a widely used method that employs genetic variants as instrumental variables(IVs,also referred to as genetic instruments below and they represent eligible genetic variants in MR)from genome-wide association studies(GWAS)to explore the causative relationship between putative risk factors(ie,exposures)and outcomes.1 According to a Web of Science literature search conducted at the end of 2024,the number of related publications has grown exponentially,reaching 3545 in 2023 and 6607 in 2024(figure 1).Almost simultaneously,we observed a peak of citations from 2019 to 2021,which reflected the popularity and acknowledgement of papers published in these 3 years.However,a decline in citations has been witnessed from 2022 and here are two possible explanations for it:(1)papers published in 2022 or later only have two or fewer years to be cited,and it can lead to fewer citations absolutely;(2)some papers published from 2022 are of low quality and may even be redundant analyses,thus,they are less likely to be cited.
