Inductively coupled plasma optical emission spectrometric approach（ICP-OES）is used to determine the magnesium and aluminum content as principal components in pyrotechnic compositions used for fireworks and firecrack...Inductively coupled plasma optical emission spectrometric approach（ICP-OES）is used to determine the magnesium and aluminum content as principal components in pyrotechnic compositions used for fireworks and firecrackers. Elements of magnesium and aluminum are commonly found in aluminum powder or magnesium-aluminum alloy powder in pyrotechnic compositions in fireworks and firecrackers. Statistical analysis shows that the magnesium content in pyrotechnics is between 8% to 30% and the aluminum content is between 8% to 35%（roughly）.Concept of this method： suppose the weight of the sample is 400rag,constant volume is IL and the concentlation of magnesium and aluminum is between 12mg/L to 160mg/L in sample solution, the determination scope of the method for magnesium and aluminum content would be between 3% to 40%.Further experiments proved that the fitting correlation coefficient of the magnesium calibration curve is 0.9999 or higher, recovery is 101.01% -101.96%.The fitting correlation coefficient of the aluminum calibration curve is 0.9999 or higher, recovery is 99.36%-103.07%. The allowable differential value is 0.4% between two single tests under repeatable conditions. This method can completely satisfy the requirements of the fireworks and firecrackers industry with high accuracy and good precision.展开更多
This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble lear...This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.展开更多
Fenton and Fenton-like processes,which could produce highly reactive species to degrade organic contaminants,have been widely used in the field of wastewater treatment.Therein,the chemistry of Fenton process including...Fenton and Fenton-like processes,which could produce highly reactive species to degrade organic contaminants,have been widely used in the field of wastewater treatment.Therein,the chemistry of Fenton process including the nature of active oxidants,the complicated reactions involved,and the behind reason for its strongly pH-dependent performance,is the basis for the application of Fenton and Fenton-like processes in wastewater treatment.Nevertheless,the conflicting views still exist about the mechanism of the Fenton process.For instance,reaching a unanimous consensus on the nature of active oxidants(hydroxyl radical or tetravalent iron)in this process remains challenging.This review comprehensively examined the mechanism of the Fenton process including the debate on the nature of active oxidants,reactions involved in the Fenton process,and the behind reason for the pH-dependent degradation of contaminants in the Fenton process.Then,we summarized several strategies that promote the Fe(Ⅱ)/Fe(Ⅲ)cycle,reduce the competitive consumption of active oxidants by side reactions,and replace the Fenton reagent,thus improving the performance of the Fenton process.Furthermore,advances for the future were proposed including the demand for the high-accuracy identification of active oxidants and taking advantages of the characteristic of target contaminants during the degradation of contaminants by the Fenton process.展开更多
Treatment of precious metals in electronic waste has attracted tremendous attention and is essential for both environmental protection and resource sustainable development.In this study,a novel adsorbent for precious ...Treatment of precious metals in electronic waste has attracted tremendous attention and is essential for both environmental protection and resource sustainable development.In this study,a novel adsorbent for precious metal ions,V_(2)O_(3)spiny hollow nanospheres(pV_(2)O_(3)SHN),was synthe sized through a one-step hydrothermal-as sis ted methodology for the adsorption of Au(Ⅲ),Ag(Ⅰ),Pd(Ⅱ),and Pt(Ⅳ) from the leaching solution of electronic waste.The results reveal that the p-V2O3SHN hierarchy was successfully constructed with a hollow structure and dense spiny morphology.The prepared p-V2O3SHN can effectively remove precious metal ions such as Au(Ⅲ),Ag(Ⅰ),Pd(Ⅱ),and Pt(Ⅳ),with the selective capture order being Au(Ⅲ)> Ag(Ⅰ)> Pt(Ⅳ)> Pd(Ⅱ)> other metal ions.This superior adsorption capability can be attributed to the multi-diffusible,intermingled composition,and numerous active sites decorating the p-V2O3SHN hierarchy,facilitating the uptake of Au(Ⅲ),Ag(Ⅰ),Pd(Ⅱ),and Pt(Ⅳ) ions from electronic waste.The Langmuir model provided a better fit for the uptake process,revealing maximum uptake capacities of 833.33 mg/g for Au(Ⅲ),370.37 mg/g for Ag(Ⅰ),42.01 mg/g for Pd(Ⅱ),and 77.51 mg/g for Pt(Ⅳ) on p-V_(2)O_(3)SHN.Remarkably,p-V_(2)O_(3)SHN exhibited a robust affinity for the adsorbate due to the presence of surface defects and reduction reactions.The new p-V2O3SHN also demonstrated good reusability for three sorption cycles,highlighting its potential for electronic waste treatment.Due to its facile synthesis and excellent efficiency,hierarchical p-V2O3SHN presents itself as a promising candidate for the selective uptake of Au(Ⅲ),Ag(Ⅰ),Pt(Ⅳ),and Pd(Ⅱ) from electronic waste.展开更多
BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in childhood.AIM To develop a psycho-gastroenterolo...BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in childhood.AIM To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without DGBI.METHODS One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy controls.They filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of digital-ization.RESULTS Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.展开更多
BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To...BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To provide fair organ distribution,predictive mortality scores have been developed.AIM To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of mortality.METHODS Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to 2018.RESULTS The transplant recipients were mainly male,with a mean age of 58.1 years.Donors were mostly male,with a mean age of 41.6 years.The median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 days.For APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD 24.2.The 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<0.008.At 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and survivors.As for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.展开更多
Objective:Peritoneal fibrosis(PF)is an adverse event that occurs during long-term peritoneal dialysis,significantly impairing treatment efficiency and adversely affecting patient outcomes.Astragaloside IV(AS-Ⅳ),a pri...Objective:Peritoneal fibrosis(PF)is an adverse event that occurs during long-term peritoneal dialysis,significantly impairing treatment efficiency and adversely affecting patient outcomes.Astragaloside IV(AS-Ⅳ),a principal active component derived from Astragalus membranaceus(Fisch.)Bunge,has exhibited anti-inflammatory and antifibrotic effects in various settings.This study aims to investigate the potential therapeutic efficacy and mechanism of AS-Ⅳin the treatment of PF.Methods:The PF mouse model was established by intraperitoneal injection of 4.25%peritoneal dialysis fluid(100 mL/kg).The epithelial-mesenchymal transition(EMT)of HMrSV5 cells was induced by the addition of 10 ng/mL transforming growth factorβ(TGF-β).The differentially expressed genes in HMrSV5 cells treated with AS-Ⅳwere screened using transcriptome sequencing analysis.The potential targets of AS-Ⅳwere screened using network pharmacology and analyzed using molecular docking and molecular dynamics simulations.Results:Administration of AS-Ⅳat doses of 20,40,or 80 mg/kg effectively mitigated the increase in peritoneal thickness and the development of fibrosis in mice with PF.The expression of the fibrosis markerα-smooth muscle actin in the peritoneum was significantly decreased in AS-Ⅳ-treated mice.The treatment of AS-Ⅳ(10,20,and 40μmol/L)significantly delayed the EMT of HMrSV5 cells induced by TGF-β,as demonstrated by the decreased number of 5-ethynyl-2'-deox yuridine-positive cells,reduced migrated area,and decreased expression of fibrosis markers.A total of 460 differentially expressed genes were detected in AS-Ⅳ-treated HMrSV5 cells through transcriptome sequencing,with notable enrichment in the phosphatidylinositol-4,5-bisphosphate3-kinase(PI3K)-AKT serine/threonine kinase 1(AKT)signaling pathway.The reduced levels of phosphorylated PI3K(p-PI3K)and p-AKT were detected in HMrSV5 cells with AS-Ⅳtreatment.Epidermal growth factor receptor(EGFR)was predicted as a direct target of AS-Ⅳ,exhibiting strong hydrogen bond interactions.The activation of the PI3K-AKT pathway by the compound740Y-P,and the activation of the EGFR pathway by NSC 228155 each partially counteracted the inhibitory effect of AS-Ⅳon the EMT of HMrSV5 cells.Conclusion:AS-Ⅳdelayed the EMT process in peritoneal mesothelial cells and slowed the progression of PF,potentially serving as a therapeutic agent for the early prevention and treatment of PF.展开更多
In the current era marked by energy shortages,the advancement of nuclear energy stands as an inevitable progression.The reprocessing of spent nuclear fuel plays a crucial role in determining the sustainability of nucl...In the current era marked by energy shortages,the advancement of nuclear energy stands as an inevitable progression.The reprocessing of spent nuclear fuel plays a crucial role in determining the sustainability of nuclear energy as a viable energy source.Among these processes,the separation and recovery of Pu(Ⅳ)from high-level liquid waste(HLLW)hold paramount significance in terms of safety and strategic implications.Herein,this work focused on the synthesis of two acid-and radiation-resistant pyridine-based sp^(2)c-COFs(COF-IHEP3 and COF-IHEP4),followed by the creation of two pyridine-based ionized sp^(2)c-COFs named COF-IHEP3-CH_(3)NO_(3)and COF-IHEP4-CH3NO3through post-modification.These materials have potential anion exchange capacity for the selective separation of Pu(Ⅳ)in highly acidic conditions.Notably,in 8 mol/L nitric acid solution,COF-IHEP3-CH3NO3demonstrated the capability to eliminate plutonium within 20 min in 98%removal efficiency with a Kdvalue of 2450 m L/g.Experimental and theoretical analysis suggest that the ionized sp^(2)c-COFs exhibit exceptional stability,selectivity,and prevention of secondary contamination towards Pu(Ⅳ)in the presence of multiple ions environments.In short,this work provides an appropriate anion exchange strategy to design ionic sp^(2)c-COFs as a promising platform for Pu(Ⅳ)recovery from HLLW.展开更多
Microbial participation in biofortification can improve the availability of selenium(Se)in soil and contribute to the enrichment of Se in crops.In this study,a selenite(Se(IV))reducing strain was isolated from Se-rich...Microbial participation in biofortification can improve the availability of selenium(Se)in soil and contribute to the enrichment of Se in crops.In this study,a selenite(Se(IV))reducing strain was isolated from Se-rich soil,and its Se transformation and bio-enhancement ability were studied.The strain was identified as Bacillus pseudomycoides and could reduce more than 93.48%of 1.0 m M Se(IV)in 54 h.The results of scanning electron microscope(SEM)and energy dispersive Xray spectrometry(EDS)showed that Se(IV)was reduced to Se(0),and Se nanoparticles(Se NPs)were eventually formed.In pot experiments,B.pseudomycoides SA14 could promote the bioavailable Se in soils and the concentration of Se in Brassica chinensis L..The concentrations of watersoluble Se,ion exchange Se and carbonate-binding Se in soil were increased by 23.13%,22.05%and 30.89%,respectively.The Se concentration of Brassica chinensis L.in pot experiments was increased by 145.05%.The relative abundance of Bacillus in soil increased from 0.97%to 2.08%in the pot experiments.As far as we know,this is the first report of Se reduction by B.pseudomycoides.This study might provide a prospective strategy for microbial fortification of Se in crops.展开更多
The efficient recovery of silver(Ag)from retired photovoltaic(PV)panels is crucial for resource sustainability and envi-ronmental protection.This study developed an environmentally friendly leaching method using ammon...The efficient recovery of silver(Ag)from retired photovoltaic(PV)panels is crucial for resource sustainability and envi-ronmental protection.This study developed an environmentally friendly leaching method using ammonia(NH_(3)·H_(2)O)and hydrogen peroxide(H_(2)O_(2)),achieving the selective dissolution of Ag from retired crystalline silicon solar panels.Meanwhile,nonprecious metals such as aluminum(Al)and lead(Pb),which are commonly found in PV cells,were barely dissolved,dem-onstrating the excellent selectivity of this method for Ag.Light irradiation significantly improved the dissolution efficiency of Ag and reduced the amount of the reagent used.Ag dissolution occurred owing to a dual-pathway synergistic effect,which stemmed from the direct oxidation of Ag by H_(2)O_(2).The strongly oxidizing hydroxyl radicals generated by photocatalysis accelerated the oxidation and dissolution of Ag.In addition,NH 3·H_(2)O effectively promoted the dissolution and stabilization of oxidation products by forming soluble Ag–NH3·H2O complexes([Ag(NH3)2]+).This article reports an efficient,selective,and environmentally friendly strategy of Ag recovery and elucidates the radical-mediated dissolution mechanism under light-driven conditions,offering a feasible way for sustainably recovering valuable metals from retired PV panels.展开更多
文摘Inductively coupled plasma optical emission spectrometric approach（ICP-OES）is used to determine the magnesium and aluminum content as principal components in pyrotechnic compositions used for fireworks and firecrackers. Elements of magnesium and aluminum are commonly found in aluminum powder or magnesium-aluminum alloy powder in pyrotechnic compositions in fireworks and firecrackers. Statistical analysis shows that the magnesium content in pyrotechnics is between 8% to 30% and the aluminum content is between 8% to 35%（roughly）.Concept of this method： suppose the weight of the sample is 400rag,constant volume is IL and the concentlation of magnesium and aluminum is between 12mg/L to 160mg/L in sample solution, the determination scope of the method for magnesium and aluminum content would be between 3% to 40%.Further experiments proved that the fitting correlation coefficient of the magnesium calibration curve is 0.9999 or higher, recovery is 101.01% -101.96%.The fitting correlation coefficient of the aluminum calibration curve is 0.9999 or higher, recovery is 99.36%-103.07%. The allowable differential value is 0.4% between two single tests under repeatable conditions. This method can completely satisfy the requirements of the fireworks and firecrackers industry with high accuracy and good precision.
基金the University of Transport Technology under the project entitled“Application of Machine Learning Algorithms in Landslide Susceptibility Mapping in Mountainous Areas”with grant number DTTD2022-16.
文摘This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.
基金supported by the National Natural Science Foundation of China(Nos.22206050 and 52270047).
文摘Fenton and Fenton-like processes,which could produce highly reactive species to degrade organic contaminants,have been widely used in the field of wastewater treatment.Therein,the chemistry of Fenton process including the nature of active oxidants,the complicated reactions involved,and the behind reason for its strongly pH-dependent performance,is the basis for the application of Fenton and Fenton-like processes in wastewater treatment.Nevertheless,the conflicting views still exist about the mechanism of the Fenton process.For instance,reaching a unanimous consensus on the nature of active oxidants(hydroxyl radical or tetravalent iron)in this process remains challenging.This review comprehensively examined the mechanism of the Fenton process including the debate on the nature of active oxidants,reactions involved in the Fenton process,and the behind reason for the pH-dependent degradation of contaminants in the Fenton process.Then,we summarized several strategies that promote the Fe(Ⅱ)/Fe(Ⅲ)cycle,reduce the competitive consumption of active oxidants by side reactions,and replace the Fenton reagent,thus improving the performance of the Fenton process.Furthermore,advances for the future were proposed including the demand for the high-accuracy identification of active oxidants and taking advantages of the characteristic of target contaminants during the degradation of contaminants by the Fenton process.
基金supported by the Open Project of State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology(No.ES202306).
文摘Treatment of precious metals in electronic waste has attracted tremendous attention and is essential for both environmental protection and resource sustainable development.In this study,a novel adsorbent for precious metal ions,V_(2)O_(3)spiny hollow nanospheres(pV_(2)O_(3)SHN),was synthe sized through a one-step hydrothermal-as sis ted methodology for the adsorption of Au(Ⅲ),Ag(Ⅰ),Pd(Ⅱ),and Pt(Ⅳ) from the leaching solution of electronic waste.The results reveal that the p-V2O3SHN hierarchy was successfully constructed with a hollow structure and dense spiny morphology.The prepared p-V2O3SHN can effectively remove precious metal ions such as Au(Ⅲ),Ag(Ⅰ),Pd(Ⅱ),and Pt(Ⅳ),with the selective capture order being Au(Ⅲ)> Ag(Ⅰ)> Pt(Ⅳ)> Pd(Ⅱ)> other metal ions.This superior adsorption capability can be attributed to the multi-diffusible,intermingled composition,and numerous active sites decorating the p-V2O3SHN hierarchy,facilitating the uptake of Au(Ⅲ),Ag(Ⅰ),Pd(Ⅱ),and Pt(Ⅳ) ions from electronic waste.The Langmuir model provided a better fit for the uptake process,revealing maximum uptake capacities of 833.33 mg/g for Au(Ⅲ),370.37 mg/g for Ag(Ⅰ),42.01 mg/g for Pd(Ⅱ),and 77.51 mg/g for Pt(Ⅳ) on p-V_(2)O_(3)SHN.Remarkably,p-V_(2)O_(3)SHN exhibited a robust affinity for the adsorbate due to the presence of surface defects and reduction reactions.The new p-V2O3SHN also demonstrated good reusability for three sorption cycles,highlighting its potential for electronic waste treatment.Due to its facile synthesis and excellent efficiency,hierarchical p-V2O3SHN presents itself as a promising candidate for the selective uptake of Au(Ⅲ),Ag(Ⅰ),Pt(Ⅳ),and Pd(Ⅱ) from electronic waste.
文摘BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in childhood.AIM To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without DGBI.METHODS One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy controls.They filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of digital-ization.RESULTS Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.
文摘BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To provide fair organ distribution,predictive mortality scores have been developed.AIM To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of mortality.METHODS Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to 2018.RESULTS The transplant recipients were mainly male,with a mean age of 58.1 years.Donors were mostly male,with a mean age of 41.6 years.The median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 days.For APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD 24.2.The 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<0.008.At 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and survivors.As for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.
基金Zhejiang Medical Technology Project(No.2022RC009)Zhejiang Provincial Natural Science Foundation(No.LY23H050005)National Natural Science Foundation of China(No.81900692)。
文摘Objective:Peritoneal fibrosis(PF)is an adverse event that occurs during long-term peritoneal dialysis,significantly impairing treatment efficiency and adversely affecting patient outcomes.Astragaloside IV(AS-Ⅳ),a principal active component derived from Astragalus membranaceus(Fisch.)Bunge,has exhibited anti-inflammatory and antifibrotic effects in various settings.This study aims to investigate the potential therapeutic efficacy and mechanism of AS-Ⅳin the treatment of PF.Methods:The PF mouse model was established by intraperitoneal injection of 4.25%peritoneal dialysis fluid(100 mL/kg).The epithelial-mesenchymal transition(EMT)of HMrSV5 cells was induced by the addition of 10 ng/mL transforming growth factorβ(TGF-β).The differentially expressed genes in HMrSV5 cells treated with AS-Ⅳwere screened using transcriptome sequencing analysis.The potential targets of AS-Ⅳwere screened using network pharmacology and analyzed using molecular docking and molecular dynamics simulations.Results:Administration of AS-Ⅳat doses of 20,40,or 80 mg/kg effectively mitigated the increase in peritoneal thickness and the development of fibrosis in mice with PF.The expression of the fibrosis markerα-smooth muscle actin in the peritoneum was significantly decreased in AS-Ⅳ-treated mice.The treatment of AS-Ⅳ(10,20,and 40μmol/L)significantly delayed the EMT of HMrSV5 cells induced by TGF-β,as demonstrated by the decreased number of 5-ethynyl-2'-deox yuridine-positive cells,reduced migrated area,and decreased expression of fibrosis markers.A total of 460 differentially expressed genes were detected in AS-Ⅳ-treated HMrSV5 cells through transcriptome sequencing,with notable enrichment in the phosphatidylinositol-4,5-bisphosphate3-kinase(PI3K)-AKT serine/threonine kinase 1(AKT)signaling pathway.The reduced levels of phosphorylated PI3K(p-PI3K)and p-AKT were detected in HMrSV5 cells with AS-Ⅳtreatment.Epidermal growth factor receptor(EGFR)was predicted as a direct target of AS-Ⅳ,exhibiting strong hydrogen bond interactions.The activation of the PI3K-AKT pathway by the compound740Y-P,and the activation of the EGFR pathway by NSC 228155 each partially counteracted the inhibitory effect of AS-Ⅳon the EMT of HMrSV5 cells.Conclusion:AS-Ⅳdelayed the EMT process in peritoneal mesothelial cells and slowed the progression of PF,potentially serving as a therapeutic agent for the early prevention and treatment of PF.
基金supported by the National Natural Science Foundation of China(Nos.U2067212,22176191)the National Science Fund for Distinguished Young Scholars(No.21925603)。
文摘In the current era marked by energy shortages,the advancement of nuclear energy stands as an inevitable progression.The reprocessing of spent nuclear fuel plays a crucial role in determining the sustainability of nuclear energy as a viable energy source.Among these processes,the separation and recovery of Pu(Ⅳ)from high-level liquid waste(HLLW)hold paramount significance in terms of safety and strategic implications.Herein,this work focused on the synthesis of two acid-and radiation-resistant pyridine-based sp^(2)c-COFs(COF-IHEP3 and COF-IHEP4),followed by the creation of two pyridine-based ionized sp^(2)c-COFs named COF-IHEP3-CH_(3)NO_(3)and COF-IHEP4-CH3NO3through post-modification.These materials have potential anion exchange capacity for the selective separation of Pu(Ⅳ)in highly acidic conditions.Notably,in 8 mol/L nitric acid solution,COF-IHEP3-CH3NO3demonstrated the capability to eliminate plutonium within 20 min in 98%removal efficiency with a Kdvalue of 2450 m L/g.Experimental and theoretical analysis suggest that the ionized sp^(2)c-COFs exhibit exceptional stability,selectivity,and prevention of secondary contamination towards Pu(Ⅳ)in the presence of multiple ions environments.In short,this work provides an appropriate anion exchange strategy to design ionic sp^(2)c-COFs as a promising platform for Pu(Ⅳ)recovery from HLLW.
基金supported by the Open Project of Technology Innovation Center for Ecological Evaluation and Remediation of Agricultural Land in Plain Area,MNR(No.ZJGCJ202001)Basic Public Welfare Research Program of Zhejiang Province(No.LGF22D030001)Jiande City(No.HX2022B-011)。
文摘Microbial participation in biofortification can improve the availability of selenium(Se)in soil and contribute to the enrichment of Se in crops.In this study,a selenite(Se(IV))reducing strain was isolated from Se-rich soil,and its Se transformation and bio-enhancement ability were studied.The strain was identified as Bacillus pseudomycoides and could reduce more than 93.48%of 1.0 m M Se(IV)in 54 h.The results of scanning electron microscope(SEM)and energy dispersive Xray spectrometry(EDS)showed that Se(IV)was reduced to Se(0),and Se nanoparticles(Se NPs)were eventually formed.In pot experiments,B.pseudomycoides SA14 could promote the bioavailable Se in soils and the concentration of Se in Brassica chinensis L..The concentrations of watersoluble Se,ion exchange Se and carbonate-binding Se in soil were increased by 23.13%,22.05%and 30.89%,respectively.The Se concentration of Brassica chinensis L.in pot experiments was increased by 145.05%.The relative abundance of Bacillus in soil increased from 0.97%to 2.08%in the pot experiments.As far as we know,this is the first report of Se reduction by B.pseudomycoides.This study might provide a prospective strategy for microbial fortification of Se in crops.
基金supported by the National Science Foundation of China(Nos.22525606,22176128,22236005,22406131,22506126)the Innovation Program of Shanghai Municipal Education Commission(No.2023ZKZD50)+13 种基金Shanghai Leading Talent Program of Eastern Talent Plan(No.LJ2023002)Shanghai Government(Nos.22dz1205400,23520711100)Chinese Education Ministry Key Laboratory and International Joint Laboratory on Resource ChemistryShanghai Eastern Scholar ProgramThe authors also thank Fellowship of China National Postdoctoral Program for Innovative Talents(No.BX20240229)the China Postdoctoral Science(No.2024M762100)the Foundation the Shanghai Science and Technology Commission Project(No.24ZR1455700)Shanghai Post-doctoral Excellence Pro-gram(No.2024787)the Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Com-mission(No.24CGA49)the“111 Innovation and Talent Recruitment Base on Photochemical and Energy Materials”(No.D18020)Yunnan University Collaborative Innovation Center(Qujing Green Photovoltaic Industry Collaborative Innovation Center)Technology Talent and Platform Plan Project of Yunnan Provincial Department of Science and Technology(No.202305AF150088)Shanghai Engineering Research Center of Green Energy Chemical Engineering(No.18DZ2254200)Shanghai Frontiers Science Center of Biomimetic Catalysis.
文摘The efficient recovery of silver(Ag)from retired photovoltaic(PV)panels is crucial for resource sustainability and envi-ronmental protection.This study developed an environmentally friendly leaching method using ammonia(NH_(3)·H_(2)O)and hydrogen peroxide(H_(2)O_(2)),achieving the selective dissolution of Ag from retired crystalline silicon solar panels.Meanwhile,nonprecious metals such as aluminum(Al)and lead(Pb),which are commonly found in PV cells,were barely dissolved,dem-onstrating the excellent selectivity of this method for Ag.Light irradiation significantly improved the dissolution efficiency of Ag and reduced the amount of the reagent used.Ag dissolution occurred owing to a dual-pathway synergistic effect,which stemmed from the direct oxidation of Ag by H_(2)O_(2).The strongly oxidizing hydroxyl radicals generated by photocatalysis accelerated the oxidation and dissolution of Ag.In addition,NH 3·H_(2)O effectively promoted the dissolution and stabilization of oxidation products by forming soluble Ag–NH3·H2O complexes([Ag(NH3)2]+).This article reports an efficient,selective,and environmentally friendly strategy of Ag recovery and elucidates the radical-mediated dissolution mechanism under light-driven conditions,offering a feasible way for sustainably recovering valuable metals from retired PV panels.
