Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that ...Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer＇s disease. Calcium channel blockers are effective therapeutics for treating Alzheimer＇s disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer＇s disease theraov.展开更多
Verticillium wilt diseases caused by the soil-borne fungus Verticillium dahliae result in devastating yield losses in many economically important crops annually. Here, we identified a novel ethyleneinducing xylanase(E...Verticillium wilt diseases caused by the soil-borne fungus Verticillium dahliae result in devastating yield losses in many economically important crops annually. Here, we identified a novel ethyleneinducing xylanase(EIX)-like protein, VdEIX3, from V. dahliae, which exhibits immunity-inducing activity in Nicotiana benthamiana. In vitro-purified VdEIX3 can induce strong oxidative burst, activate the expression of defense-related genes, and increase resistance against oomycete and fungal pathogens in N. benthamiana. VdEIX3 orthologs of other Verticillium pathogens also induce cell death in N. benthamiana, which form a new type of EIX protein family that is distinct from the known EIX proteins. A leucine-rich repeat receptor-like protein, NbEIX2, regulates the perception of VdEIX3 in N. benthamiana. Our results demonstrate that VdEIX3 is a novel EIX-like protein that can be recognized by N. benthamiana NbEIX2, and also suggest that NbEIX2 is a promising receptor-like protein that is potentially applicable to transgenic breeding for improving resistance to Verticillium wilt diseases.展开更多
A novel PEO-based composite polymer electro-lyte by using organic-inorganic hybrid EO20PO70EO20-em- mesoporous silica (P123-em-SBA15) as the filler has been developed. The experiment results show that P123-em- SBA15 c...A novel PEO-based composite polymer electro-lyte by using organic-inorganic hybrid EO20PO70EO20-em- mesoporous silica (P123-em-SBA15) as the filler has been developed. The experiment results show that P123-em- SBA15 can enhance the lithium-ion transference number of the composite polymer electrolyte, which is induced by the special topology structure of P123 in P123-em-SBA15 hybrid. In addition, room temperature ionic conductivity of the composite polymer electrolyte can also be increased by about two orders of magnitude. The excellent lithium transport properties suggest that PEO-LiClO4-P123-em-SBA15 com-posite polymer electrolyte can be used as electrolyte materi-als for all solid-state rechargeable lithium polymer batteries.展开更多
基金supported by the National Natural Science Foundation of China, No. 81171206
文摘Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer＇s disease. Calcium channel blockers are effective therapeutics for treating Alzheimer＇s disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer＇s disease theraov.
基金This study was supported by the Fundamental Research Funds for the Central Universities(KYLH201703)the National Natural Science Foundation of China(31625023)。
文摘Verticillium wilt diseases caused by the soil-borne fungus Verticillium dahliae result in devastating yield losses in many economically important crops annually. Here, we identified a novel ethyleneinducing xylanase(EIX)-like protein, VdEIX3, from V. dahliae, which exhibits immunity-inducing activity in Nicotiana benthamiana. In vitro-purified VdEIX3 can induce strong oxidative burst, activate the expression of defense-related genes, and increase resistance against oomycete and fungal pathogens in N. benthamiana. VdEIX3 orthologs of other Verticillium pathogens also induce cell death in N. benthamiana, which form a new type of EIX protein family that is distinct from the known EIX proteins. A leucine-rich repeat receptor-like protein, NbEIX2, regulates the perception of VdEIX3 in N. benthamiana. Our results demonstrate that VdEIX3 is a novel EIX-like protein that can be recognized by N. benthamiana NbEIX2, and also suggest that NbEIX2 is a promising receptor-like protein that is potentially applicable to transgenic breeding for improving resistance to Verticillium wilt diseases.
文摘A novel PEO-based composite polymer electro-lyte by using organic-inorganic hybrid EO20PO70EO20-em- mesoporous silica (P123-em-SBA15) as the filler has been developed. The experiment results show that P123-em- SBA15 can enhance the lithium-ion transference number of the composite polymer electrolyte, which is induced by the special topology structure of P123 in P123-em-SBA15 hybrid. In addition, room temperature ionic conductivity of the composite polymer electrolyte can also be increased by about two orders of magnitude. The excellent lithium transport properties suggest that PEO-LiClO4-P123-em-SBA15 com-posite polymer electrolyte can be used as electrolyte materi-als for all solid-state rechargeable lithium polymer batteries.
