Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network con...Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network connectivity and predictors of iTBS treatment outcomes in adolescents and young adults with depression.Aim This study aimed to identify default mode network(DMN)-based connectivity patterns associated with varying iTBS treatment outcomes in depression.Methods Data from a randomised controlled trial of iTBS in depression(n=82)were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN.Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment.Furthermore,the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.Results Two distinct subgroups were identified.Subgroup 1 exhibited high heterogeneity and greater centrality in the posterior cingulate cortex and retrosplenial cortex,while subgroup 2 showed more homogeneous connectivity patterns and greater centrality in the temporoparietal junction and posterior inferior parietal lobule.No main effect for subgroup,treatment or subgroup×treatment interaction was revealed in the improvement of depressive symptoms.A significant subgroup×treatment interaction related to symbol coding improvement was detected(F=5.22,p=0.026).Within subgroup 1,the active group showed significantly greater improvement in symbol coding compared with the sham group(t=2.30,p=0.028),while baseline levels of interleukin-6 and C-reactive protein emerged as significant indicators for predicting improvements in symbolic coding(R2=0.35,RMSE(root-mean-square error)=5.72,p=0.013).Subgroup 2 showed no significant findings in terms of cognitive improvement or inflammatory cytokines predictions.展开更多
2025年10月,亚太地区旅游行业的目光聚焦于新加坡金沙会展中心,ITB Asia 2025在此盛大举行。这场旅游贸易盛会以其广泛的国际参与度、破纪录的商务会议数量以及对创新、可持续发展与战略合作的前瞻性关注,再次巩固了其在塑造亚太旅游业...2025年10月,亚太地区旅游行业的目光聚焦于新加坡金沙会展中心,ITB Asia 2025在此盛大举行。这场旅游贸易盛会以其广泛的国际参与度、破纪录的商务会议数量以及对创新、可持续发展与战略合作的前瞻性关注,再次巩固了其在塑造亚太旅游业未来中的核心地位。众多行业前沿动态和创新成果纷纷亮相,为亚太旅游业的未来发展勾勒出充满活力与希望的图景。展开更多
Objective:to observe the clinical effect of acupuncture by mángzhen huid(relaxing needling with sharp long needle) on iliotibial band friction syndrome(ITBS).Design:this was a two-arm randomized controlled trial ...Objective:to observe the clinical effect of acupuncture by mángzhen huid(relaxing needling with sharp long needle) on iliotibial band friction syndrome(ITBS).Design:this was a two-arm randomized controlled trial with blinding of participants,outcome assessment and statistician.Setting:acupuncture-Moxibustion,Tuina and Orthopedics Department and the Orthopedics Department of Shanghai the Sixth People’s Hospital,June 2018 to January 2021.Participants:a total of 64 patients with iliotibial band friction syndrome(ITBS).Interventions:with a 1:1 ratio the patients were randomly assigned to either the conventional acupuncture group(CA,n=32) or the Relaxing Needling with Sharp Long Needle group(RNSLN,n=32).The CA group was treated by applying acupuncture at Jūliáo(居髎GB 29),Fēngshì(风市GB 31),Liángqiū(梁丘ST34),Yánglingquán(阳陵泉GB 34),and Ashi points(阿是穴)of the affected side,and the RNSLN group was treated by applying relaxing needling with sharp long needle at GB 29,ST 34,and Ashi points of the affected side.Both groups were treated once every other day,10 times as one course of treatment.Outcome measures:the treatment effect was evaluated after one course of treatment by comparing their KSS scores and VAS scores,as well as overall response rate.Results:Sixty-four patients were included in the final data analysis.There was no difference in KSS and VAS scores between the two groups before treatment(P>0.05).After treatment,the KSS score of the two groups was higher than that before treatment,the VAS score of the two groups was lower than that before treatment(P<0.05).The KSS score of the RNSLN group was higher than that of the CA group,and the VAS score of the RNSLN group was lower than that of the CA group(P<0.05).The overall response rate of the RNSLN group was 93.75%,higher than 75% of the control group(P<0.05).Each group has 1case of subcutaneous bleeding as adverse event.Conclusion:Relaxing Needling with Sharp Long Needle could be more beneficial for iliotibial band friction syndrome(ITBS) compared with conventional acupuncture,and more evidence is required for its effectiveness before introducing the approach widely to clinical practice.展开更多
目的探讨说话瓣膜联合间歇性θ爆发刺激(intermittent theta burst stimulation,iTBS)对脑卒中吞咽障碍患者的疗效。方法选取住院治疗的120例脑卒中吞咽障碍患者作为观察对象,采用随机数字表法分为对照组和观察组,每组60例。对照组接受...目的探讨说话瓣膜联合间歇性θ爆发刺激(intermittent theta burst stimulation,iTBS)对脑卒中吞咽障碍患者的疗效。方法选取住院治疗的120例脑卒中吞咽障碍患者作为观察对象,采用随机数字表法分为对照组和观察组,每组60例。对照组接受常规吞咽功能训练,观察组在对照组基础上应用说话瓣膜联合iTBS治疗。观察两组疗效和不良反应发生情况,并对比两组治疗前后神经功能指标、吞咽功能指标和血清神经损伤指标水平差异进行对比。结果与对照组相比,观察组临床疗效更佳,不良反应发生率更低(均P<0.05)。观察组治疗后标准吞咽功能评价量表(standardized swallowing assessment,SSA)、洼田饮水试验分级,美国国立卫生研究院卒中量表(National institute of Health stroke scale,NIHSS)评分和中国脑卒中临床神经功能缺损程度评分量表(Chinese Stroke Scale of Clinical Neurological Deficit Grade,CSS)均低于对照组,功能性经口摄食量表(functional Oral intake scale,FOIS)评分高于对照组(均P<0.05)。与对照组相比,观察组治疗后血清视锥蛋白样蛋白1(visinin like protein-1,VILIP-1)、神经肽Y(neuropeptide Y,NPY)、扣针蛋白5(fibulin-5,FBLN-5)和神经元特异性烯醇化酶(neuron specific enolase,NSE)水平显著降低(均P<0.05)。结论说话瓣膜联合iTBS治疗可有效调节血清神经损伤指标水平,并显著改善脑卒中吞咽障碍患者吞咽功能和神经功能,且具有较高安全性。展开更多
Reverse-sheared Alfv6n eigenmodes （RSAEs） have been observed by using an interferometer and ECE diagnostics in NBI heated ELMy H-mode plasma on EAST tokamak. A typical feature of these modes is a fast frequency swee...Reverse-sheared Alfv6n eigenmodes （RSAEs） have been observed by using an interferometer and ECE diagnostics in NBI heated ELMy H-mode plasma on EAST tokamak. A typical feature of these modes is a fast frequency sweeping upward from -80 kHz to -110 kHz in hundred milliseconds during which the plasma temperature, density and rotation keeps no change. Only core channels of the interferometer can observe these modes, implying a core localized mode. The ECE measurement further showed that these modes located at about ρ = 0.37-0.46, just around the position of qmin with ρ -0.4. These core localized modes are very weak in the magnetic fluctuations measured by mirnov probes mounted at the machine vacuum vessel. A multiple frequency fluctuation component, seemingly the so-called ＇grand cascades＇, was also clearly observed on the ECE signal at ρ = 0.46. During the phase, a transient internal transport barrier （ITB） in ion temperature and toroidal rotation was observed and the ITB foot was just close to the position of qmin. A modulation of RSAE frequency by ELM event was observed and this modulation could be attributed to rotation decrease or qmin increase due to ELM. Further study of these modes in EAST can provide valuable constraints for the q profile measurement and will be important for the long pulse operation.展开更多
基金supported by the Guangzhou Municipal Key Discipline in Medicine(2021-2023)the Guangzhou High-level Clinical Key Specialty,the Guangzhou Research-oriented Hospital,the Innovative Clinical Technique of Guangzhou(2024-2026)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(grant number 2022A1515011567,2020A1515110565)the Guangzhou Science,Technology Planning Project(grant number 202201010714,202103000032)the National Natural Science Foundation of China(grant number 82471546)the Guangdong College Students Innovation and Entrepreneurship Training Project(grant number S202310570038)the Guangzhou Health Science and Technology Project(grant number 20231A010038)the Guangzhou Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine Technology Project(grant number:20232A010013)the Science and Technology Plan Project of Guangzhou(2023A03J0842).
文摘Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network connectivity and predictors of iTBS treatment outcomes in adolescents and young adults with depression.Aim This study aimed to identify default mode network(DMN)-based connectivity patterns associated with varying iTBS treatment outcomes in depression.Methods Data from a randomised controlled trial of iTBS in depression(n=82)were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN.Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment.Furthermore,the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.Results Two distinct subgroups were identified.Subgroup 1 exhibited high heterogeneity and greater centrality in the posterior cingulate cortex and retrosplenial cortex,while subgroup 2 showed more homogeneous connectivity patterns and greater centrality in the temporoparietal junction and posterior inferior parietal lobule.No main effect for subgroup,treatment or subgroup×treatment interaction was revealed in the improvement of depressive symptoms.A significant subgroup×treatment interaction related to symbol coding improvement was detected(F=5.22,p=0.026).Within subgroup 1,the active group showed significantly greater improvement in symbol coding compared with the sham group(t=2.30,p=0.028),while baseline levels of interleukin-6 and C-reactive protein emerged as significant indicators for predicting improvements in symbolic coding(R2=0.35,RMSE(root-mean-square error)=5.72,p=0.013).Subgroup 2 showed no significant findings in terms of cognitive improvement or inflammatory cytokines predictions.
文摘2025年10月,亚太地区旅游行业的目光聚焦于新加坡金沙会展中心,ITB Asia 2025在此盛大举行。这场旅游贸易盛会以其广泛的国际参与度、破纪录的商务会议数量以及对创新、可持续发展与战略合作的前瞻性关注,再次巩固了其在塑造亚太旅游业未来中的核心地位。众多行业前沿动态和创新成果纷纷亮相,为亚太旅游业的未来发展勾勒出充满活力与希望的图景。
基金Supported by Shanghai Three-year Action Plan for Further Accelerating the Development of Traditional Chinese Medicine (2018-2020):ZY (2018-2020)-ZYJS-09Shanghai Three-year Action Plan for Further Accelerating the Development of Traditional Chinese Medicine (2018-2020):No.ZY(2018-2020)-FWTX-4020Shanghai Three-year Action Plan for Further Accelerating the Inheritance,Innovation,Development of Traditional Chinese Medicine (2021-2023):No.ZY (2021-2023)-0205-04。
文摘Objective:to observe the clinical effect of acupuncture by mángzhen huid(relaxing needling with sharp long needle) on iliotibial band friction syndrome(ITBS).Design:this was a two-arm randomized controlled trial with blinding of participants,outcome assessment and statistician.Setting:acupuncture-Moxibustion,Tuina and Orthopedics Department and the Orthopedics Department of Shanghai the Sixth People’s Hospital,June 2018 to January 2021.Participants:a total of 64 patients with iliotibial band friction syndrome(ITBS).Interventions:with a 1:1 ratio the patients were randomly assigned to either the conventional acupuncture group(CA,n=32) or the Relaxing Needling with Sharp Long Needle group(RNSLN,n=32).The CA group was treated by applying acupuncture at Jūliáo(居髎GB 29),Fēngshì(风市GB 31),Liángqiū(梁丘ST34),Yánglingquán(阳陵泉GB 34),and Ashi points(阿是穴)of the affected side,and the RNSLN group was treated by applying relaxing needling with sharp long needle at GB 29,ST 34,and Ashi points of the affected side.Both groups were treated once every other day,10 times as one course of treatment.Outcome measures:the treatment effect was evaluated after one course of treatment by comparing their KSS scores and VAS scores,as well as overall response rate.Results:Sixty-four patients were included in the final data analysis.There was no difference in KSS and VAS scores between the two groups before treatment(P>0.05).After treatment,the KSS score of the two groups was higher than that before treatment,the VAS score of the two groups was lower than that before treatment(P<0.05).The KSS score of the RNSLN group was higher than that of the CA group,and the VAS score of the RNSLN group was lower than that of the CA group(P<0.05).The overall response rate of the RNSLN group was 93.75%,higher than 75% of the control group(P<0.05).Each group has 1case of subcutaneous bleeding as adverse event.Conclusion:Relaxing Needling with Sharp Long Needle could be more beneficial for iliotibial band friction syndrome(ITBS) compared with conventional acupuncture,and more evidence is required for its effectiveness before introducing the approach widely to clinical practice.
文摘目的探讨说话瓣膜联合间歇性θ爆发刺激(intermittent theta burst stimulation,iTBS)对脑卒中吞咽障碍患者的疗效。方法选取住院治疗的120例脑卒中吞咽障碍患者作为观察对象,采用随机数字表法分为对照组和观察组,每组60例。对照组接受常规吞咽功能训练,观察组在对照组基础上应用说话瓣膜联合iTBS治疗。观察两组疗效和不良反应发生情况,并对比两组治疗前后神经功能指标、吞咽功能指标和血清神经损伤指标水平差异进行对比。结果与对照组相比,观察组临床疗效更佳,不良反应发生率更低(均P<0.05)。观察组治疗后标准吞咽功能评价量表(standardized swallowing assessment,SSA)、洼田饮水试验分级,美国国立卫生研究院卒中量表(National institute of Health stroke scale,NIHSS)评分和中国脑卒中临床神经功能缺损程度评分量表(Chinese Stroke Scale of Clinical Neurological Deficit Grade,CSS)均低于对照组,功能性经口摄食量表(functional Oral intake scale,FOIS)评分高于对照组(均P<0.05)。与对照组相比,观察组治疗后血清视锥蛋白样蛋白1(visinin like protein-1,VILIP-1)、神经肽Y(neuropeptide Y,NPY)、扣针蛋白5(fibulin-5,FBLN-5)和神经元特异性烯醇化酶(neuron specific enolase,NSE)水平显著降低(均P<0.05)。结论说话瓣膜联合iTBS治疗可有效调节血清神经损伤指标水平,并显著改善脑卒中吞咽障碍患者吞咽功能和神经功能,且具有较高安全性。
基金supported by the National Key R&D Program of China (No. 2014GB106004)National Natural Science Foundation of China (Nos. 11605235, 11675211, 11505221)Scientific Research Grant of Hefei Science Center of CAS (No. 2015SRG-HSC010)
文摘Reverse-sheared Alfv6n eigenmodes （RSAEs） have been observed by using an interferometer and ECE diagnostics in NBI heated ELMy H-mode plasma on EAST tokamak. A typical feature of these modes is a fast frequency sweeping upward from -80 kHz to -110 kHz in hundred milliseconds during which the plasma temperature, density and rotation keeps no change. Only core channels of the interferometer can observe these modes, implying a core localized mode. The ECE measurement further showed that these modes located at about ρ = 0.37-0.46, just around the position of qmin with ρ -0.4. These core localized modes are very weak in the magnetic fluctuations measured by mirnov probes mounted at the machine vacuum vessel. A multiple frequency fluctuation component, seemingly the so-called ＇grand cascades＇, was also clearly observed on the ECE signal at ρ = 0.46. During the phase, a transient internal transport barrier （ITB） in ion temperature and toroidal rotation was observed and the ITB foot was just close to the position of qmin. A modulation of RSAE frequency by ELM event was observed and this modulation could be attributed to rotation decrease or qmin increase due to ELM. Further study of these modes in EAST can provide valuable constraints for the q profile measurement and will be important for the long pulse operation.
