Two new isochroman derivatives(1 and 2)were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp.33#.Their structures were characterized by IR,~1 H NMR,H RMS,and single-crystal X-ray crys...Two new isochroman derivatives(1 and 2)were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp.33#.Their structures were characterized by IR,~1 H NMR,H RMS,and single-crystal X-ray crystallography.The anticancer activity of the two compounds was investigated against four human lung cancer cells(NCI-H292,NCI-H460,LTEP-A-2 and MSTO-211)by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay.Furthermore,molecular docking studies supported the biological assay data,showing that compared with 1,compound 2 has stronger interaction with protein.展开更多
基金supported by the Project of Inner Mongolia University for the Nationalities(No.NMDYB15064)Science Research Project of Inner Mongolia Education Department(No.NJZY20114)。
文摘Two new isochroman derivatives(1 and 2)were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp.33#.Their structures were characterized by IR,~1 H NMR,H RMS,and single-crystal X-ray crystallography.The anticancer activity of the two compounds was investigated against four human lung cancer cells(NCI-H292,NCI-H460,LTEP-A-2 and MSTO-211)by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay.Furthermore,molecular docking studies supported the biological assay data,showing that compared with 1,compound 2 has stronger interaction with protein.
