This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the correspo...This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the corresponding ester[Fe_(2)(CO)_(6)(μ‑tedt)](2),where tedt=SCH_(2)CH(CH_(2)OOC(5‑C_(3)HNSCH_(3)))S.Further reactions of complex 2 with tri(ptolyl)phosphine(tp)or tris(4‑fluorophenyl)phosphine(fp)gave the phosphine‑substituted derivatives[Fe_(2)(CO)_(5)(tp)(μ‑tedt)](3)and[Fe_(2)(CO)_(5)(fp)(μ‑tedt)](4).The structures of the newly prepared complexes were elucidated by elemental analysis,NMR,IR,and X‑ray photoelectron spectroscopy.Moreover,single‑crystal X‑ray diffraction analysis confirmed their molecular structures,showing that they contain a di‑iron core ligated by a bridged dithiolate bearing a thiazole moiety and terminal carbonyls.The electrochemical and electrocatalytic proton reduction were probed by cyclic voltammetry,revealing that three complexes can catalyze the reduction of protons to H_(2) under the electrochemical conditions.For comparison,complex 4 possessed the best efficiency with a turnover frequency of 23.5 s^(-1)at 10 mmol·L^(-1)HOAc concentration.In addition,the fungicidal activity of these complexes was also investigated in this study.CCDC:2477511,2;2477512,3;2477513,4.展开更多
Journal of Iron and Steel Research International(中文刊名:钢铁研究学报(英文版),下文简称JISRI)是由中国钢铁工业协会主管、中国钢研科技集团有限公司主办的冶金领域学术期刊(CN 11-3678/TF,ISSN 1006-706X)。JISRI于1994年创刊,月...Journal of Iron and Steel Research International(中文刊名:钢铁研究学报(英文版),下文简称JISRI)是由中国钢铁工业协会主管、中国钢研科技集团有限公司主办的冶金领域学术期刊(CN 11-3678/TF,ISSN 1006-706X)。JISRI于1994年创刊,月刊,主编为赵栋梁教授和Hongbiao Dong教授。展开更多
Investigating the biological processes of iron(Fe)homeostasis is crucial for comprehending crop genetic improvement,which in turn helps address human malnutrition.This study utilized phenotyping,ionomics,and transcrip...Investigating the biological processes of iron(Fe)homeostasis is crucial for comprehending crop genetic improvement,which in turn helps address human malnutrition.This study utilized phenotyping,ionomics,and transcriptome analysis to uncover the regulatory mechanism of Fe homeostasis in rice under different Fe concentrations and during Fe supplementation.Our results showed both Fe deficiency and excess impede rice growth,with Fe excess exerting a more severe impact,particularly on the roots.The decrease in crown roots under excessive Fe conditions likely serves as an adaptive mechanism to counteract Fe toxicity.Transcriptomic analysis identified 4652 differentially expressed genes affected by Fe stress and supplementation.When Fe is supplemented to Fe-deficient rice,there are upregulations in the expression of genes related to Fe ion concentration and Fe homeostasis at 10 min and 2 h after supplementation,respectively,along with a brief downregulation at 30 min.This indicated a protective mechanism in the roots during Fe uptake.Notably,shoots with a lack of Fe accumulation did not show re-entry of Fe after supplementation,and there was a sustained downregulation of Fe-regulated genes.This suggests that the signaling from roots to shoots influences the response of shoots to Fe supplementation in rice.The molecular changes in Fe homeostasis discovered in this study can contribute to the improvement of rice.展开更多
Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical t...Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex(AAPIC)compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks.AAPIC achieved comparable hemoglobin improvements(from 98.3±8.7 to 126.5±9.2 g/L)to heme iron(from 97.8±9.1 to 128.3±8.6 g/L)and was significantly superior to ferrous glycinate(from 98.6±8.9 to 119.7±10.3 g/L;p<0.001).Iron absorption efficiency showed AAPIC at 23.7±4.2%,heme iron at 25.1±3.8%,and ferrous glycinate at 18.4±5.1%.Toxicological assessments revealed no hepatotoxicity,nephrotoxicity,or mutagenicity.Gastrointestinal adverse events occurred in 8.3%of AAPIC recipients versus 15.0%with ferrous glycinate and 10.0%with heme iron.The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms.AAPIC represents a promising,well-tolerated alternative with clinical efficacy comparable to established iron formulations.展开更多
Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mech...Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mechanisms underlying these processes remain incompletely understood.Iron is an essential trace element in the human body,playing a crucial role in various biological processes.The maintenance of iron homeostasis relies on the body's intricate and nuanced regulatory mechanisms.In recent years,considerable attention has been directed toward the relationship between dysregulated iron homeostasis and neurodegenerative diseases.The regulation of iron homeostasis within cells is crucial for maintaining proper nervous system function.Research has already revealed that disruptions in iron homeostasis may lead to ferroptosis and oxidative stress,which,in turn,can impact neuronal health and contribute to the development of neurodegenerative diseases.This article primarily explores the intimate relationship between iron homeostasis and neurodegenerative diseases,aiming to provide novel insights and strategies for treating these debilitating conditions.展开更多
The liver,a critical metabolic organ,is particularly vulnerable to damage upon aluminum exposure.However,the precise molecular mechanisms through which aluminum induces hepatotoxicity remain to be fully elucidated.Thi...The liver,a critical metabolic organ,is particularly vulnerable to damage upon aluminum exposure.However,the precise molecular mechanisms through which aluminum induces hepatotoxicity remain to be fully elucidated.This study aimed to investigate the adverse effects of aluminum exposure on mouse liver tissue.The results indicated that AlCl_(3) exposure induced significant liver dysfunction,characterized by reduced adenosine triphosphate levels,elevated plasma alanine aminotransferase and aspartate aminotransferase.Histopathological analysis of liver tissue revealed marked histological damage,accompanied by substantial iron deposition.Further examinations demonstrated elevated hepatic levels of malondialdehyde,4-hydroxynonenal,and reactive oxygen species,decreased levels of glutathione(GSH)and superoxide dismutase,increased levels of oxidized glutathione(GSSG),and a reduced GSH/GSSG ratio.The mRNA and protein expression of ferroptosis-related molecules,including downregulated glutathione peroxidase 4 and solute carrier family 7 member 11,were significantly downregulated,while acyl-CoA synthetase long-chain family member 4,ferritin heavy chain 1,and iron regulatory protein 1 levels were significantly upregulated.Treatment with Ferrostatin-1 markedly ameliorated liver dysfunction and histopathological damage,attenuating signs of ferroptosis.These findings highlight the potential of ferroptosis-targeted therapies as a viable treatment strategy for aluminum exposure-induced hepatocyte injury.展开更多
Iron is an essential mineral element that plays important roles in plant growth,development,and human health.Peanut is a valuable source of iron for human nutrition.Improving iron content in peanut seeds can enhance b...Iron is an essential mineral element that plays important roles in plant growth,development,and human health.Peanut is a valuable source of iron for human nutrition.Improving iron content in peanut seeds can enhance both yield potential and nutritional value.In this study,the seed iron content of the 401 peanut germplasm accessions was estimated and substantial variation among these accessions was observed,ranging from 9.02 to 50.60 mg/kg.The seed iron content of valencia type accessions was significantly higher than that of Peruvian,Virginia,and Irregular types.Landraces showed the highest average iron content,followed by advanced cultivars,breeding lines and interspecific hybrid cultivars.Accessions with red seed coat exhibited significantly higher iron content compared with those with pink seed coat.Correlation analysis revealed that the seed iron content significantly negatively correlated with hundred seed weight(HSW),resveratrol and oleic acid.Eight accessions with high iron content were identified with an average iron content of 32.46 mg/kg,including two elite genotypes that Zh.h4280 showed high resveratrol levels(1057.34μg/kg)and Zh.h1976 exhibited large seeds(HSW over 90g).Association analysis identified four markers,one of which,AHGS2053 stably explained with 5.75%–5.84%phenotypic variation.Accessions containing the favorable allele AHGS2053-250bp exhibited significantly higher iron content compared to those with alternative alleles.The results provide valuable germplasm resources and associated markers for breeding programs targeting high iron content in peanuts.展开更多
Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presen...Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presents significant challenges.In this study,a novel research method was introduced for investigating the solidification process of ductile iron pipe,namely thermal simulation of ductile iron pipe.Comparative research was conducted on the microstructure and properties of the thermal simulation sample and the ductile iron pipe.The findings indicate that the thermal simulation sample and ductile iron pipe exhibit good heat transfer similarity and microstructure similarity.The difference of cooling rate between thermal simulation sample and ductile pipe is less than 0.24℃·s^(-1),and the difference of microstructure content of free cementite,ferrite,and pearlite is less than 5%.The tensile strength of annealed ductile iron pipe is 466 MPa,with an elongation of 16.1%and a Brinell hardness of 156.5 HBW.In comparison,the tensile strength of annealed thermal simulation sample is 482.0 MPa,with an elongation of 15.5%and a Brinell hardness of 159.0 HBW.These results suggest that the thermal simulation experimental research method is both scientific and feasible,offering an objective,reliable,and cost-effective approach to laboratory research on ductile iron pipe.展开更多
With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely o...With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely obesity and neurodegeneration.展开更多
Practical,undirected and selective catalytic functionalization of unactivated arenes remains a challenging problem in organic synthesis.We herein report a bioinspired L-cystine-derived ligand BCPOM/Fe-enabled innate C...Practical,undirected and selective catalytic functionalization of unactivated arenes remains a challenging problem in organic synthesis.We herein report a bioinspired L-cystine-derived ligand BCPOM/Fe-enabled innate C-H difluoromethylation of unactivated arenes as limiting reagents with stable and inexpensive BrCF_(2)CO_(2)Et as the difluoromethylation source in high efficiency.Notably,this method uses environmentally benign H_(2)O_(2) as the sole oxidant,and enables late-stage functionalization and exceptionally functional-group tolerance,even including oxidation-labile aldehyde,phenolic hydroxy,primary amine,and boronic acid groups,which is difficult to access by current means.展开更多
Background and AimsHepatic iron deposition(HID)in the reticuloendothelial system(RES)is associated with histological severity in metabolic dysfunction-associated steatotic liver disease(MASLD).This study aimed to asse...Background and AimsHepatic iron deposition(HID)in the reticuloendothelial system(RES)is associated with histological severity in metabolic dysfunction-associated steatotic liver disease(MASLD).This study aimed to assess the interaction between the transferrin(TF)-rs1049296 C>T variant and HID patterns on the risk of significant liver fibrosis in MASLD.MethodsWe analyzed 406 adults with liver biopsy-confirmed MASLD.HID was categorized as hepatocellular,RES,or mixed,based on Perl's iron staining.The association between iron-related genetic variants and significant liver fibrosis(fibrosis stage≥F2)was analyzed,focusing on the interactions between single-nucleotide polymorphism genotypes and iron deposition patterns.Multivariable logistic regression analysis was used to adjust for potential confounders.ResultsHID was detected in 271(66.7%)patients,with hepatocellular,RES,and mixed patterns accounting for 11.1%,18.0%,and 37.7%,respectively.A significant interaction was observed between HID and the TF-rs1049296 genotype(P=0.035 for interaction).In multivariable analysis,male sex,hypertension,severe lobular inflammation,and mixed hepatocellular/RES iron deposition were independent predictors of significant liver fibrosis.RES deposition markedly increased the risk of significant liver fibrosis(adjusted odds ratio:6.65;95%confidence interval:1.84-23.97,p<0.05),particularly in men with isolated RES iron deposition(adjusted odds ratio:5.26;95%confidence interval:1.21-22.81,p<0.05).ConclusionsThe TF-rs1049296 T allele interacts with RES iron deposition to identify a MASLD subpopulation at elevated risk of progressive liver disease,providing opportunities for refined risk stratification and personalized management.展开更多
Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity an...Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T_(2)-weighted MRI contrast agent.展开更多
Cancer has been recognized as one of the leading causes of mortality for decades.Magnetic resonance imaging(MRI)is a powerful imaging technology that has been widely applied in tumor diagnosis.Herein,we report the syn...Cancer has been recognized as one of the leading causes of mortality for decades.Magnetic resonance imaging(MRI)is a powerful imaging technology that has been widely applied in tumor diagnosis.Herein,we report the synthesis of magnetic iron oxide nanoparticles(MIONs)functionalized with multidentate thioether polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(methacrylic acid)(PTMPPMAA).Cytotoxicity assessment via the CCK-8 assay confirmed the low toxicity of the nanoparticles.MRI results showed excellent negative contrast enhancement.Bio-distribution study indicated gradual excretion of the nanoparticles.These MIONs@PTMP-PMAA exhibit strong negative contrast enhancement and present great potential as T_(2)-weighted contrast agents for MRI.展开更多
Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in hu...Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.展开更多
Ironmaking process(IP)is indispensable to modern iron and steel industry,where real-time monitoring is crucial for achieving high molten iron quality(MIQ)with low energy consumption.While neural network-based models s...Ironmaking process(IP)is indispensable to modern iron and steel industry,where real-time monitoring is crucial for achieving high molten iron quality(MIQ)with low energy consumption.While neural network-based models show some promising results,they are generally limited by non-negligible drawbacks such as interpretability issues of feature learning.To address these issues,we propose a novel concept based on the shallow-to-deep correlation network representation regression(Sh-to-De CNRR).Our approach,shallow correlation network representation regression(ShCNRR),combines neural network and canonical correlation analysis thoughts to generate explainable features via shallow correlation network representation(CNR).A twin inverse network is then derived to obtain the explicit model output,leveraging the shallow CNR.To capture deeper nonlinear information,we extend ShCNRR into a hierarchical deep correlation network representation regression(DeCNRR)model that features stacked neural networks,enabling us to learn deeper CNR from process data.The feasibility and advantages of our proposals are validated by theoretical derivations and practical IP cases,which contain one MIQ regression and three MIQ-related fault detection tasks.The results reveal that highly fused statistical and neural network models yield superior monitoring performance compared to current state-of-the-art models,while statistical tests verify the convincing feature mining.展开更多
The utilization of iron coke provides a green pathway for low-carbon ironmaking.To uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the micro...The utilization of iron coke provides a green pathway for low-carbon ironmaking.To uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was investigated.Furthermore,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric method.The findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and interconnect.This provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron coke.Accelerating the heating rate in non-isothermal gasification can enhance the reactivity of iron coke.The metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon atoms.The kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore structure.Moreover,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.展开更多
The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion batteries.Lithium manganese iron phosphate(LiMn_(x)Fe_(1-x)PO_(4))has garnered...The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion batteries.Lithium manganese iron phosphate(LiMn_(x)Fe_(1-x)PO_(4))has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy density.Although LiMn_(x)Fe_(1-x)PO_(4)has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap density.This review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMn_(x)Fe_(1-x)PO_(4)to analyze reaction processes accurately and guide material preparation.Later,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMn_(x)Fe_(1-x)PO_(4),including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology design.Finally,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are anticipated.More importantly,it is expected to provide key insights into the development of high-performance and stable LiMn_(x)Fe_(1-x)PO_(4)materials,to achieve practical energy storage requirements.展开更多
The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost ...The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost toxic cyanotoxin,microcystin-LR(MC-LR)enter soil via runoff,irrigated surface water and sewage,and the application of cyanobacterial biofertilizers as part of the sustainable agricultural practice.Earthworms in such remediation systems must sustain the potential risk from both nZVI and MC-LR.In the present study,earthworms(Eisenia fetida)were exposed up to 14 days to MC-LR and nZVI(individually and inmixture),and the toxicity was investigated at both the organismal andmetabolic levels,including growth,tissue damage,oxidative stress,metabolic response and gut microbiota.Results showed that co-exposure of MC-LR and nZVI is less potent to earthworms than that of separate exposure.Histological observations in the co-exposure group revealed only minor epidermal brokenness,and KEGG enrichment analysis showed that co-exposure induced earthworms to regulate glutathione biosynthesis for detoxification and reduced adverse effects from MC-LR.The combined use of nZVI promoted the growth and reproduction of soil and earthworm gut bacteria(e.g.,Sphingobacterium and Acinetobacter)responsible for the degradation of MC-LR,whichmight explain the observed antagonism between nZVI and MC-LR in earthworm microcosm.Our study suggests the beneficial use of nZVI to detoxify pollutants in earthworm-based vermiremediation systems where freshwater containing cyanobacterial blooms is frequently used to irrigate soil and supply water for the growth and metabolism of earthworms.展开更多
Nano zero-valent iron(nZVI)is widely used in soil remediation due to its high reactivity.However,the easy agglomeration,poor antioxidant ability and passivation layer of Fe-Cr coprecipitates of nZVI have limited its a...Nano zero-valent iron(nZVI)is widely used in soil remediation due to its high reactivity.However,the easy agglomeration,poor antioxidant ability and passivation layer of Fe-Cr coprecipitates of nZVI have limited its application scale in Cr-contaminated soil remediation,especially in high concentration of Cr-contaminated soil.Herein,we found that the carboxymethyl cellulose on nZVI particles could increase the zeta potential value of soil and change the phase of nZVI.Along with the presence of biochar,97.0%and 96.6%Cr immobilization efficiency through CMC-nZVI/BC were respectively achieved in high and low concentrations of Cr-contaminated soils after 90-days remediation.In addition,the immobilization efficiency of Cr(VI)only decreased by 5.1%through CMC-nZVI/BC treatment after 10 weeks aging in air,attributing to the strong antioxidation ability.As for the surrounding Crcontaminated groundwater,the Cr(VI)removal capacity of CMC-nZVI/BC was evaluated under different reaction conditions through column experiments and COMSOL Multiphysics.CMC-nZVI/BC could efficiently remove 85%of Cr(VI)in about 400 hr when the initial Cr(VI)concentration was 40 mg/L and the flow rate was 0.5 mL/min.This study demonstrates that uniformly dispersed CMC-nZVI/BC has an excellent remediation effect on different concentrations of Cr-contaminated soils.展开更多
文摘This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the corresponding ester[Fe_(2)(CO)_(6)(μ‑tedt)](2),where tedt=SCH_(2)CH(CH_(2)OOC(5‑C_(3)HNSCH_(3)))S.Further reactions of complex 2 with tri(ptolyl)phosphine(tp)or tris(4‑fluorophenyl)phosphine(fp)gave the phosphine‑substituted derivatives[Fe_(2)(CO)_(5)(tp)(μ‑tedt)](3)and[Fe_(2)(CO)_(5)(fp)(μ‑tedt)](4).The structures of the newly prepared complexes were elucidated by elemental analysis,NMR,IR,and X‑ray photoelectron spectroscopy.Moreover,single‑crystal X‑ray diffraction analysis confirmed their molecular structures,showing that they contain a di‑iron core ligated by a bridged dithiolate bearing a thiazole moiety and terminal carbonyls.The electrochemical and electrocatalytic proton reduction were probed by cyclic voltammetry,revealing that three complexes can catalyze the reduction of protons to H_(2) under the electrochemical conditions.For comparison,complex 4 possessed the best efficiency with a turnover frequency of 23.5 s^(-1)at 10 mmol·L^(-1)HOAc concentration.In addition,the fungicidal activity of these complexes was also investigated in this study.CCDC:2477511,2;2477512,3;2477513,4.
文摘Journal of Iron and Steel Research International(中文刊名:钢铁研究学报(英文版),下文简称JISRI)是由中国钢铁工业协会主管、中国钢研科技集团有限公司主办的冶金领域学术期刊(CN 11-3678/TF,ISSN 1006-706X)。JISRI于1994年创刊,月刊,主编为赵栋梁教授和Hongbiao Dong教授。
基金supported by the National Key Research and Development Program,China(Grant No.2023YFD2301900)the Natural Science Foundation of Sichuan Province,China(Grant No.23NSFSC0055).
文摘Investigating the biological processes of iron(Fe)homeostasis is crucial for comprehending crop genetic improvement,which in turn helps address human malnutrition.This study utilized phenotyping,ionomics,and transcriptome analysis to uncover the regulatory mechanism of Fe homeostasis in rice under different Fe concentrations and during Fe supplementation.Our results showed both Fe deficiency and excess impede rice growth,with Fe excess exerting a more severe impact,particularly on the roots.The decrease in crown roots under excessive Fe conditions likely serves as an adaptive mechanism to counteract Fe toxicity.Transcriptomic analysis identified 4652 differentially expressed genes affected by Fe stress and supplementation.When Fe is supplemented to Fe-deficient rice,there are upregulations in the expression of genes related to Fe ion concentration and Fe homeostasis at 10 min and 2 h after supplementation,respectively,along with a brief downregulation at 30 min.This indicated a protective mechanism in the roots during Fe uptake.Notably,shoots with a lack of Fe accumulation did not show re-entry of Fe after supplementation,and there was a sustained downregulation of Fe-regulated genes.This suggests that the signaling from roots to shoots influences the response of shoots to Fe supplementation in rice.The molecular changes in Fe homeostasis discovered in this study can contribute to the improvement of rice.
文摘Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex(AAPIC)compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks.AAPIC achieved comparable hemoglobin improvements(from 98.3±8.7 to 126.5±9.2 g/L)to heme iron(from 97.8±9.1 to 128.3±8.6 g/L)and was significantly superior to ferrous glycinate(from 98.6±8.9 to 119.7±10.3 g/L;p<0.001).Iron absorption efficiency showed AAPIC at 23.7±4.2%,heme iron at 25.1±3.8%,and ferrous glycinate at 18.4±5.1%.Toxicological assessments revealed no hepatotoxicity,nephrotoxicity,or mutagenicity.Gastrointestinal adverse events occurred in 8.3%of AAPIC recipients versus 15.0%with ferrous glycinate and 10.0%with heme iron.The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms.AAPIC represents a promising,well-tolerated alternative with clinical efficacy comparable to established iron formulations.
基金supported in part by the National Natural Science Foundation of China,No.82371153(to YS)the Natural Science Foundation of Shandong Province,Nos.ZR2021MH378,ZR2022QH073(to LC)+1 种基金the Shandong Society of Geriatric Science and Technology Project,No.LKJGG2021Z020(to YS)the Yantai Science and Technology Innovation Development Project,Nos.2022YD009,2023YD050。
文摘Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mechanisms underlying these processes remain incompletely understood.Iron is an essential trace element in the human body,playing a crucial role in various biological processes.The maintenance of iron homeostasis relies on the body's intricate and nuanced regulatory mechanisms.In recent years,considerable attention has been directed toward the relationship between dysregulated iron homeostasis and neurodegenerative diseases.The regulation of iron homeostasis within cells is crucial for maintaining proper nervous system function.Research has already revealed that disruptions in iron homeostasis may lead to ferroptosis and oxidative stress,which,in turn,can impact neuronal health and contribute to the development of neurodegenerative diseases.This article primarily explores the intimate relationship between iron homeostasis and neurodegenerative diseases,aiming to provide novel insights and strategies for treating these debilitating conditions.
基金supported by the Central Guided Local Development Fund Special Project(No.ZY23055039)the Natural Science Foundation of Guangxi Province(No.2025GXNSFHA069061)+5 种基金Baise City Scientific Research and Technology Development Plan Self-Funded Project(No.Encyclopedia 20241590)Baise City Scientific Research and Technol-ogy Development Plan Project(No.Encyclopedia 20232083)Guangxi Zhuang Autonomous Region Traditional Chinese Medicine Management Bureau Self-Funded Scientific Research Project(No.GZZC2020248)Guangxi Zhuang Autonomous Region Health Commission Self-Funded Scientific Research Project(No.Z20201416)2024 Innovation Project of Youjiang Medical University for Nationalities Graduate Education(No.YXCXJH2024004)the Natural Science Foundation of Guangxi Province(No.GUIKEAB24010060).
文摘The liver,a critical metabolic organ,is particularly vulnerable to damage upon aluminum exposure.However,the precise molecular mechanisms through which aluminum induces hepatotoxicity remain to be fully elucidated.This study aimed to investigate the adverse effects of aluminum exposure on mouse liver tissue.The results indicated that AlCl_(3) exposure induced significant liver dysfunction,characterized by reduced adenosine triphosphate levels,elevated plasma alanine aminotransferase and aspartate aminotransferase.Histopathological analysis of liver tissue revealed marked histological damage,accompanied by substantial iron deposition.Further examinations demonstrated elevated hepatic levels of malondialdehyde,4-hydroxynonenal,and reactive oxygen species,decreased levels of glutathione(GSH)and superoxide dismutase,increased levels of oxidized glutathione(GSSG),and a reduced GSH/GSSG ratio.The mRNA and protein expression of ferroptosis-related molecules,including downregulated glutathione peroxidase 4 and solute carrier family 7 member 11,were significantly downregulated,while acyl-CoA synthetase long-chain family member 4,ferritin heavy chain 1,and iron regulatory protein 1 levels were significantly upregulated.Treatment with Ferrostatin-1 markedly ameliorated liver dysfunction and histopathological damage,attenuating signs of ferroptosis.These findings highlight the potential of ferroptosis-targeted therapies as a viable treatment strategy for aluminum exposure-induced hepatocyte injury.
基金supported by the National Key Research and Development Program of China(2023YFD1200200)the earmarked funds for CARS(No.CARS-13)+2 种基金the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2025-OCRI)the National Program for Crop Germplasm Protection of China(22250402)the National Crop Germplasm Resources Center(NCGRC-2025-036)。
文摘Iron is an essential mineral element that plays important roles in plant growth,development,and human health.Peanut is a valuable source of iron for human nutrition.Improving iron content in peanut seeds can enhance both yield potential and nutritional value.In this study,the seed iron content of the 401 peanut germplasm accessions was estimated and substantial variation among these accessions was observed,ranging from 9.02 to 50.60 mg/kg.The seed iron content of valencia type accessions was significantly higher than that of Peruvian,Virginia,and Irregular types.Landraces showed the highest average iron content,followed by advanced cultivars,breeding lines and interspecific hybrid cultivars.Accessions with red seed coat exhibited significantly higher iron content compared with those with pink seed coat.Correlation analysis revealed that the seed iron content significantly negatively correlated with hundred seed weight(HSW),resveratrol and oleic acid.Eight accessions with high iron content were identified with an average iron content of 32.46 mg/kg,including two elite genotypes that Zh.h4280 showed high resveratrol levels(1057.34μg/kg)and Zh.h1976 exhibited large seeds(HSW over 90g).Association analysis identified four markers,one of which,AHGS2053 stably explained with 5.75%–5.84%phenotypic variation.Accessions containing the favorable allele AHGS2053-250bp exhibited significantly higher iron content compared to those with alternative alleles.The results provide valuable germplasm resources and associated markers for breeding programs targeting high iron content in peanuts.
基金financially supported by the National Natural Science Foundation of China(52130109)。
文摘Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presents significant challenges.In this study,a novel research method was introduced for investigating the solidification process of ductile iron pipe,namely thermal simulation of ductile iron pipe.Comparative research was conducted on the microstructure and properties of the thermal simulation sample and the ductile iron pipe.The findings indicate that the thermal simulation sample and ductile iron pipe exhibit good heat transfer similarity and microstructure similarity.The difference of cooling rate between thermal simulation sample and ductile pipe is less than 0.24℃·s^(-1),and the difference of microstructure content of free cementite,ferrite,and pearlite is less than 5%.The tensile strength of annealed ductile iron pipe is 466 MPa,with an elongation of 16.1%and a Brinell hardness of 156.5 HBW.In comparison,the tensile strength of annealed thermal simulation sample is 482.0 MPa,with an elongation of 15.5%and a Brinell hardness of 159.0 HBW.These results suggest that the thermal simulation experimental research method is both scientific and feasible,offering an objective,reliable,and cost-effective approach to laboratory research on ductile iron pipe.
文摘With the industrialization of agriculture and the advancement of medical care,human life expectancy has increased considerably and continues to rise steadily.This results in novel and unprecedented challenges,namely obesity and neurodegeneration.
基金sponsored by the Natural Science Foundation of China(Nos.22371126,21776139 and 22072067)the“Qing Lan Project”Young and Middle-aged Academic Leaders of Jiangsu Provincial Colleges and Universities,the Natural Science Foundation of Jiangsu Province(No.BK20161553)the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Practical,undirected and selective catalytic functionalization of unactivated arenes remains a challenging problem in organic synthesis.We herein report a bioinspired L-cystine-derived ligand BCPOM/Fe-enabled innate C-H difluoromethylation of unactivated arenes as limiting reagents with stable and inexpensive BrCF_(2)CO_(2)Et as the difluoromethylation source in high efficiency.Notably,this method uses environmentally benign H_(2)O_(2) as the sole oxidant,and enables late-stage functionalization and exceptionally functional-group tolerance,even including oxidation-labile aldehyde,phenolic hydroxy,primary amine,and boronic acid groups,which is difficult to access by current means.
基金funded by grants from the National Natural Science Foundation of China(82070588)High-Level Creative Talents from the Department of Public Health in Zhejiang Province(S2032102600032)+2 种基金the Project of New Century 551 Talent Nurturing in WenzhouGT is supported in part by grants from the School of Medicine,University of Verona,Verona,Italy.CDB is supported in part by the Southampton NIHR Biomedical Research Centre(NIHR203319),UKCDB has received research grant support from Echosens,the manufacturer of the Fibroscan device used to assess liver fat and fibrosis in chronic liver diseases.
文摘Background and AimsHepatic iron deposition(HID)in the reticuloendothelial system(RES)is associated with histological severity in metabolic dysfunction-associated steatotic liver disease(MASLD).This study aimed to assess the interaction between the transferrin(TF)-rs1049296 C>T variant and HID patterns on the risk of significant liver fibrosis in MASLD.MethodsWe analyzed 406 adults with liver biopsy-confirmed MASLD.HID was categorized as hepatocellular,RES,or mixed,based on Perl's iron staining.The association between iron-related genetic variants and significant liver fibrosis(fibrosis stage≥F2)was analyzed,focusing on the interactions between single-nucleotide polymorphism genotypes and iron deposition patterns.Multivariable logistic regression analysis was used to adjust for potential confounders.ResultsHID was detected in 271(66.7%)patients,with hepatocellular,RES,and mixed patterns accounting for 11.1%,18.0%,and 37.7%,respectively.A significant interaction was observed between HID and the TF-rs1049296 genotype(P=0.035 for interaction).In multivariable analysis,male sex,hypertension,severe lobular inflammation,and mixed hepatocellular/RES iron deposition were independent predictors of significant liver fibrosis.RES deposition markedly increased the risk of significant liver fibrosis(adjusted odds ratio:6.65;95%confidence interval:1.84-23.97,p<0.05),particularly in men with isolated RES iron deposition(adjusted odds ratio:5.26;95%confidence interval:1.21-22.81,p<0.05).ConclusionsThe TF-rs1049296 T allele interacts with RES iron deposition to identify a MASLD subpopulation at elevated risk of progressive liver disease,providing opportunities for refined risk stratification and personalized management.
基金financially supported by the International Cooperation Program from the Ministry of Science and Technology of Hubei Province(No.2023EHA069)Shenzhen Science and Technology Program(No.JCYJ20230807143702005)National Foreign Experts Program(No.G2022027015L)。
文摘Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T_(2)-weighted MRI contrast agent.
基金financially supported by the International Cooperation Program of the Ministry of Science and Technology of Hubei Province(No.2023EHA069)Shenzhen Science and Technology Program(No.JCYJ20230807143702005)+1 种基金National Foreign Experts Program(No.G2022027015L)the National Natural Science Foundation of China(No.82302265).
文摘Cancer has been recognized as one of the leading causes of mortality for decades.Magnetic resonance imaging(MRI)is a powerful imaging technology that has been widely applied in tumor diagnosis.Herein,we report the synthesis of magnetic iron oxide nanoparticles(MIONs)functionalized with multidentate thioether polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(methacrylic acid)(PTMPPMAA).Cytotoxicity assessment via the CCK-8 assay confirmed the low toxicity of the nanoparticles.MRI results showed excellent negative contrast enhancement.Bio-distribution study indicated gradual excretion of the nanoparticles.These MIONs@PTMP-PMAA exhibit strong negative contrast enhancement and present great potential as T_(2)-weighted contrast agents for MRI.
基金supported by the National Key R&D Program of China,Nos.2017YFA0104302(to NG and XM)and 2017YFA0104304(to BW and ZZ)
文摘Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.
基金supported in part by the Pioneer Research and Development Program of Zhejiang(2025C01021)Zhejiang Province Postdoctoral Research Project Selection Fund(ZJ2025061)+3 种基金the National Science and Technology Major Project-Intelligent Manufacturing Systems and Robotics of China(2025ZD1602000,2025ZD1601800)the National Natural Science Foundation of China(61933015,62273030,62573387)the Natural Science Foundation of Zhejiang province,China(LY24F030004)the Fundamental Research Funds of Zhejiang Sci-Tech University(25222139-Y)。
文摘Ironmaking process(IP)is indispensable to modern iron and steel industry,where real-time monitoring is crucial for achieving high molten iron quality(MIQ)with low energy consumption.While neural network-based models show some promising results,they are generally limited by non-negligible drawbacks such as interpretability issues of feature learning.To address these issues,we propose a novel concept based on the shallow-to-deep correlation network representation regression(Sh-to-De CNRR).Our approach,shallow correlation network representation regression(ShCNRR),combines neural network and canonical correlation analysis thoughts to generate explainable features via shallow correlation network representation(CNR).A twin inverse network is then derived to obtain the explicit model output,leveraging the shallow CNR.To capture deeper nonlinear information,we extend ShCNRR into a hierarchical deep correlation network representation regression(DeCNRR)model that features stacked neural networks,enabling us to learn deeper CNR from process data.The feasibility and advantages of our proposals are validated by theoretical derivations and practical IP cases,which contain one MIQ regression and three MIQ-related fault detection tasks.The results reveal that highly fused statistical and neural network models yield superior monitoring performance compared to current state-of-the-art models,while statistical tests verify the convincing feature mining.
基金financially supported by the National Science Foundation of China(Nos.51974212 and 52274316)the China Baowu Low Carbon Metallurgy Innovation Foundation(No.BWLCF202116)+1 种基金the Science and Technology Major Project of Wuhan(No.2023020302020572)the Foundation of Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education(No.FMRUlab23-04)。
文摘The utilization of iron coke provides a green pathway for low-carbon ironmaking.To uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was investigated.Furthermore,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric method.The findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and interconnect.This provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron coke.Accelerating the heating rate in non-isothermal gasification can enhance the reactivity of iron coke.The metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon atoms.The kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore structure.Moreover,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.
基金National Natural Science Foundation of China(52104294)Fundamental Research Funds for the Central Universities(FRF-TP-19-079A1)。
文摘The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion batteries.Lithium manganese iron phosphate(LiMn_(x)Fe_(1-x)PO_(4))has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy density.Although LiMn_(x)Fe_(1-x)PO_(4)has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap density.This review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMn_(x)Fe_(1-x)PO_(4)to analyze reaction processes accurately and guide material preparation.Later,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMn_(x)Fe_(1-x)PO_(4),including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology design.Finally,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are anticipated.More importantly,it is expected to provide key insights into the development of high-performance and stable LiMn_(x)Fe_(1-x)PO_(4)materials,to achieve practical energy storage requirements.
基金supported by the National Natural Science Foundation of China(No.21777139)the National Key Research and Development Program of China(No.2017YFA0207003).
文摘The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost toxic cyanotoxin,microcystin-LR(MC-LR)enter soil via runoff,irrigated surface water and sewage,and the application of cyanobacterial biofertilizers as part of the sustainable agricultural practice.Earthworms in such remediation systems must sustain the potential risk from both nZVI and MC-LR.In the present study,earthworms(Eisenia fetida)were exposed up to 14 days to MC-LR and nZVI(individually and inmixture),and the toxicity was investigated at both the organismal andmetabolic levels,including growth,tissue damage,oxidative stress,metabolic response and gut microbiota.Results showed that co-exposure of MC-LR and nZVI is less potent to earthworms than that of separate exposure.Histological observations in the co-exposure group revealed only minor epidermal brokenness,and KEGG enrichment analysis showed that co-exposure induced earthworms to regulate glutathione biosynthesis for detoxification and reduced adverse effects from MC-LR.The combined use of nZVI promoted the growth and reproduction of soil and earthworm gut bacteria(e.g.,Sphingobacterium and Acinetobacter)responsible for the degradation of MC-LR,whichmight explain the observed antagonism between nZVI and MC-LR in earthworm microcosm.Our study suggests the beneficial use of nZVI to detoxify pollutants in earthworm-based vermiremediation systems where freshwater containing cyanobacterial blooms is frequently used to irrigate soil and supply water for the growth and metabolism of earthworms.
基金supported by the National Key Research and Development Program of China(No.2020YFC1808701)the Fundamental Research Funds for the Central Universities(No.buctrc202232).
文摘Nano zero-valent iron(nZVI)is widely used in soil remediation due to its high reactivity.However,the easy agglomeration,poor antioxidant ability and passivation layer of Fe-Cr coprecipitates of nZVI have limited its application scale in Cr-contaminated soil remediation,especially in high concentration of Cr-contaminated soil.Herein,we found that the carboxymethyl cellulose on nZVI particles could increase the zeta potential value of soil and change the phase of nZVI.Along with the presence of biochar,97.0%and 96.6%Cr immobilization efficiency through CMC-nZVI/BC were respectively achieved in high and low concentrations of Cr-contaminated soils after 90-days remediation.In addition,the immobilization efficiency of Cr(VI)only decreased by 5.1%through CMC-nZVI/BC treatment after 10 weeks aging in air,attributing to the strong antioxidation ability.As for the surrounding Crcontaminated groundwater,the Cr(VI)removal capacity of CMC-nZVI/BC was evaluated under different reaction conditions through column experiments and COMSOL Multiphysics.CMC-nZVI/BC could efficiently remove 85%of Cr(VI)in about 400 hr when the initial Cr(VI)concentration was 40 mg/L and the flow rate was 0.5 mL/min.This study demonstrates that uniformly dispersed CMC-nZVI/BC has an excellent remediation effect on different concentrations of Cr-contaminated soils.
