This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the correspo...This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the corresponding ester[Fe_(2)(CO)_(6)(μ‑tedt)](2),where tedt=SCH_(2)CH(CH_(2)OOC(5‑C_(3)HNSCH_(3)))S.Further reactions of complex 2 with tri(ptolyl)phosphine(tp)or tris(4‑fluorophenyl)phosphine(fp)gave the phosphine‑substituted derivatives[Fe_(2)(CO)_(5)(tp)(μ‑tedt)](3)and[Fe_(2)(CO)_(5)(fp)(μ‑tedt)](4).The structures of the newly prepared complexes were elucidated by elemental analysis,NMR,IR,and X‑ray photoelectron spectroscopy.Moreover,single‑crystal X‑ray diffraction analysis confirmed their molecular structures,showing that they contain a di‑iron core ligated by a bridged dithiolate bearing a thiazole moiety and terminal carbonyls.The electrochemical and electrocatalytic proton reduction were probed by cyclic voltammetry,revealing that three complexes can catalyze the reduction of protons to H_(2) under the electrochemical conditions.For comparison,complex 4 possessed the best efficiency with a turnover frequency of 23.5 s^(-1)at 10 mmol·L^(-1)HOAc concentration.In addition,the fungicidal activity of these complexes was also investigated in this study.CCDC:2477511,2;2477512,3;2477513,4.展开更多
Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical t...Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex(AAPIC)compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks.AAPIC achieved comparable hemoglobin improvements(from 98.3±8.7 to 126.5±9.2 g/L)to heme iron(from 97.8±9.1 to 128.3±8.6 g/L)and was significantly superior to ferrous glycinate(from 98.6±8.9 to 119.7±10.3 g/L;p<0.001).Iron absorption efficiency showed AAPIC at 23.7±4.2%,heme iron at 25.1±3.8%,and ferrous glycinate at 18.4±5.1%.Toxicological assessments revealed no hepatotoxicity,nephrotoxicity,or mutagenicity.Gastrointestinal adverse events occurred in 8.3%of AAPIC recipients versus 15.0%with ferrous glycinate and 10.0%with heme iron.The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms.AAPIC represents a promising,well-tolerated alternative with clinical efficacy comparable to established iron formulations.展开更多
The complexes 1-4 of cyclobutanocucurbit[5]uril(CyB5Q[5])with Na^(+)/K^(+)have been synthesized and characterized by single-crystal X-ray diffraction.The results show that although the inorganic salts are used when th...The complexes 1-4 of cyclobutanocucurbit[5]uril(CyB5Q[5])with Na^(+)/K^(+)have been synthesized and characterized by single-crystal X-ray diffraction.The results show that although the inorganic salts are used when the cations are the same and the anions are different,in complex 1,Na^(+)closes one port of CyB5Q[5]through Na—O seven coordination bonds to form a molecular bowl;in complex 3,Na^(+)completely closes the two ports of CyB5Q[5]to form a molecular capsule with six Na—O coordination bonds;in complexes 2 and 4,the two ports of CyB5Q[5]are completely closed to form K—O coordinated molecular capsules,but the K^(+)of complex 2 is six-coordinated and that of complex 4 is eight-/nine-coordinated.and complex 4 are connected by three oxygen bridges to form a 1D molecular chain.CCDC:2457122,1;2457121,2;2457400,3;2457120,4.展开更多
In modern industrial production,foreign object detection in complex environments is crucial to ensure product quality and production safety.Detection systems based on deep-learning image processing algorithms often fa...In modern industrial production,foreign object detection in complex environments is crucial to ensure product quality and production safety.Detection systems based on deep-learning image processing algorithms often face challenges with handling high-resolution images and achieving accurate detection against complex backgrounds.To address these issues,this study employs the PatchCore unsupervised anomaly detection algorithm combined with data augmentation techniques to enhance the system’s generalization capability across varying lighting conditions,viewing angles,and object scales.The proposed method is evaluated in a complex industrial detection scenario involving the bogie of an electric multiple unit(EMU).A dataset consisting of complex backgrounds,diverse lighting conditions,and multiple viewing angles is constructed to validate the performance of the detection system in real industrial environments.Experimental results show that the proposed model achieves an average area under the receiver operating characteristic curve(AUROC)of 0.92 and an average F1 score of 0.85.Combined with data augmentation,the proposed model exhibits improvements in AUROC by 0.06 and F1 score by 0.03,demonstrating enhanced accuracy and robustness for foreign object detection in complex industrial settings.In addition,the effects of key factors on detection performance are systematically analyzed,providing practical guidance for parameter selection in real industrial applications.展开更多
Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(...Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid),phen(1,10-phenanthroline),bpb(1,4-bis(pyrid-4-yl)benzene),bpa(bis(4-pyridyl)amine),and copper,nickel and cadmium chlorides at 160℃.The products were isolated as stable crystalline solids and were characterized by IR spectra,elemental analyses,thermogravimetric analyses,and singlecrystal X-ray diffraction analyses.Single-crystal X-ray diffraction analyses revealed that three complexes crystallize in the monoclinic P21/n,tetragonal I42d,and orthorhombic P21212 space groups.The complexes exhibit molecular dimers(1)or 2D metal-organic networks(2 and 3).The catalytic performances in the Knoevenagel reaction of these complexes were investigated.Complex 1 exhibits an effective catalytic activity and excellent reusability as a heterogeneous catalyst in the Knoevenagel reaction at room temperature.CCDC:2463800,1;2463801,2;2463802,3.展开更多
Investigating the biological processes of iron(Fe)homeostasis is crucial for comprehending crop genetic improvement,which in turn helps address human malnutrition.This study utilized phenotyping,ionomics,and transcrip...Investigating the biological processes of iron(Fe)homeostasis is crucial for comprehending crop genetic improvement,which in turn helps address human malnutrition.This study utilized phenotyping,ionomics,and transcriptome analysis to uncover the regulatory mechanism of Fe homeostasis in rice under different Fe concentrations and during Fe supplementation.Our results showed both Fe deficiency and excess impede rice growth,with Fe excess exerting a more severe impact,particularly on the roots.The decrease in crown roots under excessive Fe conditions likely serves as an adaptive mechanism to counteract Fe toxicity.Transcriptomic analysis identified 4652 differentially expressed genes affected by Fe stress and supplementation.When Fe is supplemented to Fe-deficient rice,there are upregulations in the expression of genes related to Fe ion concentration and Fe homeostasis at 10 min and 2 h after supplementation,respectively,along with a brief downregulation at 30 min.This indicated a protective mechanism in the roots during Fe uptake.Notably,shoots with a lack of Fe accumulation did not show re-entry of Fe after supplementation,and there was a sustained downregulation of Fe-regulated genes.This suggests that the signaling from roots to shoots influences the response of shoots to Fe supplementation in rice.The molecular changes in Fe homeostasis discovered in this study can contribute to the improvement of rice.展开更多
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'...Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.展开更多
Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mech...Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mechanisms underlying these processes remain incompletely understood.Iron is an essential trace element in the human body,playing a crucial role in various biological processes.The maintenance of iron homeostasis relies on the body's intricate and nuanced regulatory mechanisms.In recent years,considerable attention has been directed toward the relationship between dysregulated iron homeostasis and neurodegenerative diseases.The regulation of iron homeostasis within cells is crucial for maintaining proper nervous system function.Research has already revealed that disruptions in iron homeostasis may lead to ferroptosis and oxidative stress,which,in turn,can impact neuronal health and contribute to the development of neurodegenerative diseases.This article primarily explores the intimate relationship between iron homeostasis and neurodegenerative diseases,aiming to provide novel insights and strategies for treating these debilitating conditions.展开更多
Three zinc(Ⅱ),nickel(Ⅱ),and cadmium(Ⅱ)complexes,namely[Zn(μ-Htpta)(py)_(2)]n(1),[Ni(H_(2)biim)2(H_(2)O)2][Ni(tpta)(H_(2)biim)2(H_(2)O)]2·3H_(2)O(2),and[Cd_(3)(μ4-tpta)2(μ-dpe)_(3)]_(n)(3),have been construc...Three zinc(Ⅱ),nickel(Ⅱ),and cadmium(Ⅱ)complexes,namely[Zn(μ-Htpta)(py)_(2)]n(1),[Ni(H_(2)biim)2(H_(2)O)2][Ni(tpta)(H_(2)biim)2(H_(2)O)]2·3H_(2)O(2),and[Cd_(3)(μ4-tpta)2(μ-dpe)_(3)]_(n)(3),have been constructed hydrothermally at 160℃ using H_(3)tpta([1,1':3',1″-terphenyl]-4,4',5'-tricarboxylic acid),py(pyridine),H_(2)biim(2,2'-biimidazole),dpe(1,2-di(4-pyridyl)ethylene),and zinc,nickel and cadmium chlorides,resulting in the formation of stable crystalline solids which were subsequently analyzed using infrared spectroscopy,element analysis,thermogravimetric analysis,as well as structural analyses conducted via single-crystal X-ray diffraction.The findings from these single-crystal Xray diffraction studies indicate that complexes 1-3 form crystals within the monoclinic system P2_(1)/c space group(1)or triclinic system P1 space group(2 and 3),and possess 1D,0D,and 3D structures,respectively.Complex 1 demonstrated substantial catalytic efficiency and excellent reusability as a heterogeneous catalyst in the reaction of Knoevenagel condensation under ambient temperature conditions.In addition,complex 1 also showcased notable anti-wear performance when used in polyalphaolefin synthetic lubricants.CCDC:2449810,1;2449811,2;2449812,3.展开更多
Journal of Iron and Steel Research International(中文刊名:钢铁研究学报(英文版),下文简称JISRI)是由中国钢铁工业协会主管、中国钢研科技集团有限公司主办的冶金领域学术期刊(CN 11-3678/TF,ISSN 1006-706X)。JISRI于1994年创刊,月...Journal of Iron and Steel Research International(中文刊名:钢铁研究学报(英文版),下文简称JISRI)是由中国钢铁工业协会主管、中国钢研科技集团有限公司主办的冶金领域学术期刊(CN 11-3678/TF,ISSN 1006-706X)。JISRI于1994年创刊,月刊,主编为赵栋梁教授和Hongbiao Dong教授。展开更多
The hydrated tricyclohexyltin theophylline-7-acetic acid(tpH)complex[Sn(C_(6)H_(11))_(3)(tp)(H_(2)O)]was synthesized via an ethanol solvothermal method using tricyclohexyltin hydroxide and tpH in a 1∶1 molar ratio.Th...The hydrated tricyclohexyltin theophylline-7-acetic acid(tpH)complex[Sn(C_(6)H_(11))_(3)(tp)(H_(2)O)]was synthesized via an ethanol solvothermal method using tricyclohexyltin hydroxide and tpH in a 1∶1 molar ratio.The complex was characterized by IR,^(1)H(^(13)C)NMR,elemental analysis,and powder X-ray diffraction,and the crystal structure was determined by single-crystal X-ray diffraction.The crystal belongs to the orthorhombic system with space group Iba2,and the central tin atom is in a five-coordinated trigonal bipyramidal configuration.Quantum chemistry ab initio calculations were performed to investigate the stability,molecular orbital energy,and frontier molecular orbital characteristics of the complex.Additionally,its thermal stability,electrochemical properties,and in vitro anticancer activity were evaluated.CCDC:2380308.展开更多
Iron is an essential mineral element that plays important roles in plant growth,development,and human health.Peanut is a valuable source of iron for human nutrition.Improving iron content in peanut seeds can enhance b...Iron is an essential mineral element that plays important roles in plant growth,development,and human health.Peanut is a valuable source of iron for human nutrition.Improving iron content in peanut seeds can enhance both yield potential and nutritional value.In this study,the seed iron content of the 401 peanut germplasm accessions was estimated and substantial variation among these accessions was observed,ranging from 9.02 to 50.60 mg/kg.The seed iron content of valencia type accessions was significantly higher than that of Peruvian,Virginia,and Irregular types.Landraces showed the highest average iron content,followed by advanced cultivars,breeding lines and interspecific hybrid cultivars.Accessions with red seed coat exhibited significantly higher iron content compared with those with pink seed coat.Correlation analysis revealed that the seed iron content significantly negatively correlated with hundred seed weight(HSW),resveratrol and oleic acid.Eight accessions with high iron content were identified with an average iron content of 32.46 mg/kg,including two elite genotypes that Zh.h4280 showed high resveratrol levels(1057.34μg/kg)and Zh.h1976 exhibited large seeds(HSW over 90g).Association analysis identified four markers,one of which,AHGS2053 stably explained with 5.75%–5.84%phenotypic variation.Accessions containing the favorable allele AHGS2053-250bp exhibited significantly higher iron content compared to those with alternative alleles.The results provide valuable germplasm resources and associated markers for breeding programs targeting high iron content in peanuts.展开更多
The liver,a critical metabolic organ,is particularly vulnerable to damage upon aluminum exposure.However,the precise molecular mechanisms through which aluminum induces hepatotoxicity remain to be fully elucidated.Thi...The liver,a critical metabolic organ,is particularly vulnerable to damage upon aluminum exposure.However,the precise molecular mechanisms through which aluminum induces hepatotoxicity remain to be fully elucidated.This study aimed to investigate the adverse effects of aluminum exposure on mouse liver tissue.The results indicated that AlCl_(3) exposure induced significant liver dysfunction,characterized by reduced adenosine triphosphate levels,elevated plasma alanine aminotransferase and aspartate aminotransferase.Histopathological analysis of liver tissue revealed marked histological damage,accompanied by substantial iron deposition.Further examinations demonstrated elevated hepatic levels of malondialdehyde,4-hydroxynonenal,and reactive oxygen species,decreased levels of glutathione(GSH)and superoxide dismutase,increased levels of oxidized glutathione(GSSG),and a reduced GSH/GSSG ratio.The mRNA and protein expression of ferroptosis-related molecules,including downregulated glutathione peroxidase 4 and solute carrier family 7 member 11,were significantly downregulated,while acyl-CoA synthetase long-chain family member 4,ferritin heavy chain 1,and iron regulatory protein 1 levels were significantly upregulated.Treatment with Ferrostatin-1 markedly ameliorated liver dysfunction and histopathological damage,attenuating signs of ferroptosis.These findings highlight the potential of ferroptosis-targeted therapies as a viable treatment strategy for aluminum exposure-induced hepatocyte injury.展开更多
Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presen...Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presents significant challenges.In this study,a novel research method was introduced for investigating the solidification process of ductile iron pipe,namely thermal simulation of ductile iron pipe.Comparative research was conducted on the microstructure and properties of the thermal simulation sample and the ductile iron pipe.The findings indicate that the thermal simulation sample and ductile iron pipe exhibit good heat transfer similarity and microstructure similarity.The difference of cooling rate between thermal simulation sample and ductile pipe is less than 0.24℃·s^(-1),and the difference of microstructure content of free cementite,ferrite,and pearlite is less than 5%.The tensile strength of annealed ductile iron pipe is 466 MPa,with an elongation of 16.1%and a Brinell hardness of 156.5 HBW.In comparison,the tensile strength of annealed thermal simulation sample is 482.0 MPa,with an elongation of 15.5%and a Brinell hardness of 159.0 HBW.These results suggest that the thermal simulation experimental research method is both scientific and feasible,offering an objective,reliable,and cost-effective approach to laboratory research on ductile iron pipe.展开更多
Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity an...Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T_(2)-weighted MRI contrast agent.展开更多
The methylene-selective oxidation of simple alkanes catalyzed by a nonheme iron(Ⅲ)-monoamidate complex using H_(2)O_(2)as the terminal oxidant is reported.Mechanistic studies suggest that iron(V)-oxo species is the a...The methylene-selective oxidation of simple alkanes catalyzed by a nonheme iron(Ⅲ)-monoamidate complex using H_(2)O_(2)as the terminal oxidant is reported.Mechanistic studies suggest that iron(V)-oxo species is the active intermediate,undergoing hydrogen atom abstraction(HAA)as the rate-determining step to initiate C-H bond activation.展开更多
Single-pixel imaging(SPI)receives widespread attention due to its superior anti-interference capabilities,and image segmentation technology can effectively facilitate its recognition and information extraction.However...Single-pixel imaging(SPI)receives widespread attention due to its superior anti-interference capabilities,and image segmentation technology can effectively facilitate its recognition and information extraction.However,the complexity of the target scene and plenty of imaging time in SPI make it challenging to achieve high-quality and concise segmentation.In this paper,we investigate the image-free intricate scene semantic segmentation in SPI.Using“learned”illumination patterns allows for the full extraction of the object's spatial information,thereby enabling pixel-level segmentation results through the decoding of the received measurements.Simulation and experimentation show that,in the absence of image reconstruction,the mean intersection over union(MIoU)of segmented image can reach higher than 85%,and the Dice coefficient(DICE)close to 90%even at the sampling ratio of 5%.Our approach may be favorable to applications in medical image segmentation and autonomous driving field.展开更多
Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for mor...Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for more than 3y.She was diagnosed with ASs and choroiditis at a local hospital.She has a seven-year history of bilateral high myopia.A fundus examination confirmed the presence of ASs and myopic fundus changes in both eyes.Multimodal imaging revealed an AZOOR complex in the left eye.展开更多
Cancer has been recognized as one of the leading causes of mortality for decades.Magnetic resonance imaging(MRI)is a powerful imaging technology that has been widely applied in tumor diagnosis.Herein,we report the syn...Cancer has been recognized as one of the leading causes of mortality for decades.Magnetic resonance imaging(MRI)is a powerful imaging technology that has been widely applied in tumor diagnosis.Herein,we report the synthesis of magnetic iron oxide nanoparticles(MIONs)functionalized with multidentate thioether polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(methacrylic acid)(PTMPPMAA).Cytotoxicity assessment via the CCK-8 assay confirmed the low toxicity of the nanoparticles.MRI results showed excellent negative contrast enhancement.Bio-distribution study indicated gradual excretion of the nanoparticles.These MIONs@PTMP-PMAA exhibit strong negative contrast enhancement and present great potential as T_(2)-weighted contrast agents for MRI.展开更多
文摘This paper reports the preparation of three di‑iron complexes containing a thiazole moiety.Esterification of complex[Fe_(2)(CO)_(6)(μ‑SCH_(2)CH(CH_(2)OH)S)](1)with 4‑methylthiazole‑5‑carboxylic acid gave the corresponding ester[Fe_(2)(CO)_(6)(μ‑tedt)](2),where tedt=SCH_(2)CH(CH_(2)OOC(5‑C_(3)HNSCH_(3)))S.Further reactions of complex 2 with tri(ptolyl)phosphine(tp)or tris(4‑fluorophenyl)phosphine(fp)gave the phosphine‑substituted derivatives[Fe_(2)(CO)_(5)(tp)(μ‑tedt)](3)and[Fe_(2)(CO)_(5)(fp)(μ‑tedt)](4).The structures of the newly prepared complexes were elucidated by elemental analysis,NMR,IR,and X‑ray photoelectron spectroscopy.Moreover,single‑crystal X‑ray diffraction analysis confirmed their molecular structures,showing that they contain a di‑iron core ligated by a bridged dithiolate bearing a thiazole moiety and terminal carbonyls.The electrochemical and electrocatalytic proton reduction were probed by cyclic voltammetry,revealing that three complexes can catalyze the reduction of protons to H_(2) under the electrochemical conditions.For comparison,complex 4 possessed the best efficiency with a turnover frequency of 23.5 s^(-1)at 10 mmol·L^(-1)HOAc concentration.In addition,the fungicidal activity of these complexes was also investigated in this study.CCDC:2477511,2;2477512,3;2477513,4.
文摘Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex(AAPIC)compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks.AAPIC achieved comparable hemoglobin improvements(from 98.3±8.7 to 126.5±9.2 g/L)to heme iron(from 97.8±9.1 to 128.3±8.6 g/L)and was significantly superior to ferrous glycinate(from 98.6±8.9 to 119.7±10.3 g/L;p<0.001).Iron absorption efficiency showed AAPIC at 23.7±4.2%,heme iron at 25.1±3.8%,and ferrous glycinate at 18.4±5.1%.Toxicological assessments revealed no hepatotoxicity,nephrotoxicity,or mutagenicity.Gastrointestinal adverse events occurred in 8.3%of AAPIC recipients versus 15.0%with ferrous glycinate and 10.0%with heme iron.The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms.AAPIC represents a promising,well-tolerated alternative with clinical efficacy comparable to established iron formulations.
文摘The complexes 1-4 of cyclobutanocucurbit[5]uril(CyB5Q[5])with Na^(+)/K^(+)have been synthesized and characterized by single-crystal X-ray diffraction.The results show that although the inorganic salts are used when the cations are the same and the anions are different,in complex 1,Na^(+)closes one port of CyB5Q[5]through Na—O seven coordination bonds to form a molecular bowl;in complex 3,Na^(+)completely closes the two ports of CyB5Q[5]to form a molecular capsule with six Na—O coordination bonds;in complexes 2 and 4,the two ports of CyB5Q[5]are completely closed to form K—O coordinated molecular capsules,but the K^(+)of complex 2 is six-coordinated and that of complex 4 is eight-/nine-coordinated.and complex 4 are connected by three oxygen bridges to form a 1D molecular chain.CCDC:2457122,1;2457121,2;2457400,3;2457120,4.
文摘In modern industrial production,foreign object detection in complex environments is crucial to ensure product quality and production safety.Detection systems based on deep-learning image processing algorithms often face challenges with handling high-resolution images and achieving accurate detection against complex backgrounds.To address these issues,this study employs the PatchCore unsupervised anomaly detection algorithm combined with data augmentation techniques to enhance the system’s generalization capability across varying lighting conditions,viewing angles,and object scales.The proposed method is evaluated in a complex industrial detection scenario involving the bogie of an electric multiple unit(EMU).A dataset consisting of complex backgrounds,diverse lighting conditions,and multiple viewing angles is constructed to validate the performance of the detection system in real industrial environments.Experimental results show that the proposed model achieves an average area under the receiver operating characteristic curve(AUROC)of 0.92 and an average F1 score of 0.85.Combined with data augmentation,the proposed model exhibits improvements in AUROC by 0.06 and F1 score by 0.03,demonstrating enhanced accuracy and robustness for foreign object detection in complex industrial settings.In addition,the effects of key factors on detection performance are systematically analyzed,providing practical guidance for parameter selection in real industrial applications.
文摘Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid),phen(1,10-phenanthroline),bpb(1,4-bis(pyrid-4-yl)benzene),bpa(bis(4-pyridyl)amine),and copper,nickel and cadmium chlorides at 160℃.The products were isolated as stable crystalline solids and were characterized by IR spectra,elemental analyses,thermogravimetric analyses,and singlecrystal X-ray diffraction analyses.Single-crystal X-ray diffraction analyses revealed that three complexes crystallize in the monoclinic P21/n,tetragonal I42d,and orthorhombic P21212 space groups.The complexes exhibit molecular dimers(1)or 2D metal-organic networks(2 and 3).The catalytic performances in the Knoevenagel reaction of these complexes were investigated.Complex 1 exhibits an effective catalytic activity and excellent reusability as a heterogeneous catalyst in the Knoevenagel reaction at room temperature.CCDC:2463800,1;2463801,2;2463802,3.
基金supported by the National Key Research and Development Program,China(Grant No.2023YFD2301900)the Natural Science Foundation of Sichuan Province,China(Grant No.23NSFSC0055).
文摘Investigating the biological processes of iron(Fe)homeostasis is crucial for comprehending crop genetic improvement,which in turn helps address human malnutrition.This study utilized phenotyping,ionomics,and transcriptome analysis to uncover the regulatory mechanism of Fe homeostasis in rice under different Fe concentrations and during Fe supplementation.Our results showed both Fe deficiency and excess impede rice growth,with Fe excess exerting a more severe impact,particularly on the roots.The decrease in crown roots under excessive Fe conditions likely serves as an adaptive mechanism to counteract Fe toxicity.Transcriptomic analysis identified 4652 differentially expressed genes affected by Fe stress and supplementation.When Fe is supplemented to Fe-deficient rice,there are upregulations in the expression of genes related to Fe ion concentration and Fe homeostasis at 10 min and 2 h after supplementation,respectively,along with a brief downregulation at 30 min.This indicated a protective mechanism in the roots during Fe uptake.Notably,shoots with a lack of Fe accumulation did not show re-entry of Fe after supplementation,and there was a sustained downregulation of Fe-regulated genes.This suggests that the signaling from roots to shoots influences the response of shoots to Fe supplementation in rice.The molecular changes in Fe homeostasis discovered in this study can contribute to the improvement of rice.
文摘Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.
基金supported in part by the National Natural Science Foundation of China,No.82371153(to YS)the Natural Science Foundation of Shandong Province,Nos.ZR2021MH378,ZR2022QH073(to LC)+1 种基金the Shandong Society of Geriatric Science and Technology Project,No.LKJGG2021Z020(to YS)the Yantai Science and Technology Innovation Development Project,Nos.2022YD009,2023YD050。
文摘Neurodegenerative diseases are prevalent conditions that greatly impact human health.These diseases are primarily characterized by the progressive loss and eventual death of neuronal function,although the precise mechanisms underlying these processes remain incompletely understood.Iron is an essential trace element in the human body,playing a crucial role in various biological processes.The maintenance of iron homeostasis relies on the body's intricate and nuanced regulatory mechanisms.In recent years,considerable attention has been directed toward the relationship between dysregulated iron homeostasis and neurodegenerative diseases.The regulation of iron homeostasis within cells is crucial for maintaining proper nervous system function.Research has already revealed that disruptions in iron homeostasis may lead to ferroptosis and oxidative stress,which,in turn,can impact neuronal health and contribute to the development of neurodegenerative diseases.This article primarily explores the intimate relationship between iron homeostasis and neurodegenerative diseases,aiming to provide novel insights and strategies for treating these debilitating conditions.
文摘Three zinc(Ⅱ),nickel(Ⅱ),and cadmium(Ⅱ)complexes,namely[Zn(μ-Htpta)(py)_(2)]n(1),[Ni(H_(2)biim)2(H_(2)O)2][Ni(tpta)(H_(2)biim)2(H_(2)O)]2·3H_(2)O(2),and[Cd_(3)(μ4-tpta)2(μ-dpe)_(3)]_(n)(3),have been constructed hydrothermally at 160℃ using H_(3)tpta([1,1':3',1″-terphenyl]-4,4',5'-tricarboxylic acid),py(pyridine),H_(2)biim(2,2'-biimidazole),dpe(1,2-di(4-pyridyl)ethylene),and zinc,nickel and cadmium chlorides,resulting in the formation of stable crystalline solids which were subsequently analyzed using infrared spectroscopy,element analysis,thermogravimetric analysis,as well as structural analyses conducted via single-crystal X-ray diffraction.The findings from these single-crystal Xray diffraction studies indicate that complexes 1-3 form crystals within the monoclinic system P2_(1)/c space group(1)or triclinic system P1 space group(2 and 3),and possess 1D,0D,and 3D structures,respectively.Complex 1 demonstrated substantial catalytic efficiency and excellent reusability as a heterogeneous catalyst in the reaction of Knoevenagel condensation under ambient temperature conditions.In addition,complex 1 also showcased notable anti-wear performance when used in polyalphaolefin synthetic lubricants.CCDC:2449810,1;2449811,2;2449812,3.
文摘Journal of Iron and Steel Research International(中文刊名:钢铁研究学报(英文版),下文简称JISRI)是由中国钢铁工业协会主管、中国钢研科技集团有限公司主办的冶金领域学术期刊(CN 11-3678/TF,ISSN 1006-706X)。JISRI于1994年创刊,月刊,主编为赵栋梁教授和Hongbiao Dong教授。
文摘The hydrated tricyclohexyltin theophylline-7-acetic acid(tpH)complex[Sn(C_(6)H_(11))_(3)(tp)(H_(2)O)]was synthesized via an ethanol solvothermal method using tricyclohexyltin hydroxide and tpH in a 1∶1 molar ratio.The complex was characterized by IR,^(1)H(^(13)C)NMR,elemental analysis,and powder X-ray diffraction,and the crystal structure was determined by single-crystal X-ray diffraction.The crystal belongs to the orthorhombic system with space group Iba2,and the central tin atom is in a five-coordinated trigonal bipyramidal configuration.Quantum chemistry ab initio calculations were performed to investigate the stability,molecular orbital energy,and frontier molecular orbital characteristics of the complex.Additionally,its thermal stability,electrochemical properties,and in vitro anticancer activity were evaluated.CCDC:2380308.
基金supported by the National Key Research and Development Program of China(2023YFD1200200)the earmarked funds for CARS(No.CARS-13)+2 种基金the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2025-OCRI)the National Program for Crop Germplasm Protection of China(22250402)the National Crop Germplasm Resources Center(NCGRC-2025-036)。
文摘Iron is an essential mineral element that plays important roles in plant growth,development,and human health.Peanut is a valuable source of iron for human nutrition.Improving iron content in peanut seeds can enhance both yield potential and nutritional value.In this study,the seed iron content of the 401 peanut germplasm accessions was estimated and substantial variation among these accessions was observed,ranging from 9.02 to 50.60 mg/kg.The seed iron content of valencia type accessions was significantly higher than that of Peruvian,Virginia,and Irregular types.Landraces showed the highest average iron content,followed by advanced cultivars,breeding lines and interspecific hybrid cultivars.Accessions with red seed coat exhibited significantly higher iron content compared with those with pink seed coat.Correlation analysis revealed that the seed iron content significantly negatively correlated with hundred seed weight(HSW),resveratrol and oleic acid.Eight accessions with high iron content were identified with an average iron content of 32.46 mg/kg,including two elite genotypes that Zh.h4280 showed high resveratrol levels(1057.34μg/kg)and Zh.h1976 exhibited large seeds(HSW over 90g).Association analysis identified four markers,one of which,AHGS2053 stably explained with 5.75%–5.84%phenotypic variation.Accessions containing the favorable allele AHGS2053-250bp exhibited significantly higher iron content compared to those with alternative alleles.The results provide valuable germplasm resources and associated markers for breeding programs targeting high iron content in peanuts.
基金supported by the Central Guided Local Development Fund Special Project(No.ZY23055039)the Natural Science Foundation of Guangxi Province(No.2025GXNSFHA069061)+5 种基金Baise City Scientific Research and Technology Development Plan Self-Funded Project(No.Encyclopedia 20241590)Baise City Scientific Research and Technol-ogy Development Plan Project(No.Encyclopedia 20232083)Guangxi Zhuang Autonomous Region Traditional Chinese Medicine Management Bureau Self-Funded Scientific Research Project(No.GZZC2020248)Guangxi Zhuang Autonomous Region Health Commission Self-Funded Scientific Research Project(No.Z20201416)2024 Innovation Project of Youjiang Medical University for Nationalities Graduate Education(No.YXCXJH2024004)the Natural Science Foundation of Guangxi Province(No.GUIKEAB24010060).
文摘The liver,a critical metabolic organ,is particularly vulnerable to damage upon aluminum exposure.However,the precise molecular mechanisms through which aluminum induces hepatotoxicity remain to be fully elucidated.This study aimed to investigate the adverse effects of aluminum exposure on mouse liver tissue.The results indicated that AlCl_(3) exposure induced significant liver dysfunction,characterized by reduced adenosine triphosphate levels,elevated plasma alanine aminotransferase and aspartate aminotransferase.Histopathological analysis of liver tissue revealed marked histological damage,accompanied by substantial iron deposition.Further examinations demonstrated elevated hepatic levels of malondialdehyde,4-hydroxynonenal,and reactive oxygen species,decreased levels of glutathione(GSH)and superoxide dismutase,increased levels of oxidized glutathione(GSSG),and a reduced GSH/GSSG ratio.The mRNA and protein expression of ferroptosis-related molecules,including downregulated glutathione peroxidase 4 and solute carrier family 7 member 11,were significantly downregulated,while acyl-CoA synthetase long-chain family member 4,ferritin heavy chain 1,and iron regulatory protein 1 levels were significantly upregulated.Treatment with Ferrostatin-1 markedly ameliorated liver dysfunction and histopathological damage,attenuating signs of ferroptosis.These findings highlight the potential of ferroptosis-targeted therapies as a viable treatment strategy for aluminum exposure-induced hepatocyte injury.
基金financially supported by the National Natural Science Foundation of China(52130109)。
文摘Centrifugal casting of ductile iron pipe is a high-temperature,semi-continuous production process.However,conducting laboratory research on the solidification process of centrifugal casting of ductile iron pipe presents significant challenges.In this study,a novel research method was introduced for investigating the solidification process of ductile iron pipe,namely thermal simulation of ductile iron pipe.Comparative research was conducted on the microstructure and properties of the thermal simulation sample and the ductile iron pipe.The findings indicate that the thermal simulation sample and ductile iron pipe exhibit good heat transfer similarity and microstructure similarity.The difference of cooling rate between thermal simulation sample and ductile pipe is less than 0.24℃·s^(-1),and the difference of microstructure content of free cementite,ferrite,and pearlite is less than 5%.The tensile strength of annealed ductile iron pipe is 466 MPa,with an elongation of 16.1%and a Brinell hardness of 156.5 HBW.In comparison,the tensile strength of annealed thermal simulation sample is 482.0 MPa,with an elongation of 15.5%and a Brinell hardness of 159.0 HBW.These results suggest that the thermal simulation experimental research method is both scientific and feasible,offering an objective,reliable,and cost-effective approach to laboratory research on ductile iron pipe.
基金financially supported by the International Cooperation Program from the Ministry of Science and Technology of Hubei Province(No.2023EHA069)Shenzhen Science and Technology Program(No.JCYJ20230807143702005)National Foreign Experts Program(No.G2022027015L)。
文摘Magnetic resonance imaging(MRI)is one of the most widely used diagnostic techniques.Iron oxide nanoparticles,as a promising kind of contrast agents,have attracted intense research interest due to their low toxicity and superparamagnetism.However,it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity,excellent water solubility and biocompatibility.In this paper,a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone)(PTMP-PVP)was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100℃.The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution,and they were found to be biocompatible as determined through CCK-8 assay and histology analysis.In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T_(2)-weighted MRI contrast agent.
文摘The methylene-selective oxidation of simple alkanes catalyzed by a nonheme iron(Ⅲ)-monoamidate complex using H_(2)O_(2)as the terminal oxidant is reported.Mechanistic studies suggest that iron(V)-oxo species is the active intermediate,undergoing hydrogen atom abstraction(HAA)as the rate-determining step to initiate C-H bond activation.
基金Project supported by the Fundamental Research Funds for the Central Universities of China(Grant No.531118010757)。
文摘Single-pixel imaging(SPI)receives widespread attention due to its superior anti-interference capabilities,and image segmentation technology can effectively facilitate its recognition and information extraction.However,the complexity of the target scene and plenty of imaging time in SPI make it challenging to achieve high-quality and concise segmentation.In this paper,we investigate the image-free intricate scene semantic segmentation in SPI.Using“learned”illumination patterns allows for the full extraction of the object's spatial information,thereby enabling pixel-level segmentation results through the decoding of the received measurements.Simulation and experimentation show that,in the absence of image reconstruction,the mean intersection over union(MIoU)of segmented image can reach higher than 85%,and the Dice coefficient(DICE)close to 90%even at the sampling ratio of 5%.Our approach may be favorable to applications in medical image segmentation and autonomous driving field.
基金Supported by the National Natural Science Foundation of China(No.82171073).
文摘Dear Editor,We present a case of acute zonal occult outer retinopathy(AZOOR)complex in a myopic patient with angioid streaks(ASs).A 19-year-old female has been experiencing visual field defects in her left eye for more than 3y.She was diagnosed with ASs and choroiditis at a local hospital.She has a seven-year history of bilateral high myopia.A fundus examination confirmed the presence of ASs and myopic fundus changes in both eyes.Multimodal imaging revealed an AZOOR complex in the left eye.
基金financially supported by the International Cooperation Program of the Ministry of Science and Technology of Hubei Province(No.2023EHA069)Shenzhen Science and Technology Program(No.JCYJ20230807143702005)+1 种基金National Foreign Experts Program(No.G2022027015L)the National Natural Science Foundation of China(No.82302265).
文摘Cancer has been recognized as one of the leading causes of mortality for decades.Magnetic resonance imaging(MRI)is a powerful imaging technology that has been widely applied in tumor diagnosis.Herein,we report the synthesis of magnetic iron oxide nanoparticles(MIONs)functionalized with multidentate thioether polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(methacrylic acid)(PTMPPMAA).Cytotoxicity assessment via the CCK-8 assay confirmed the low toxicity of the nanoparticles.MRI results showed excellent negative contrast enhancement.Bio-distribution study indicated gradual excretion of the nanoparticles.These MIONs@PTMP-PMAA exhibit strong negative contrast enhancement and present great potential as T_(2)-weighted contrast agents for MRI.
