AIM:To preliminary explore the safety and effectiveness of artificial iris implantation.METHODS:Fourteen patients with iris defects who underwent artificial iris implantation at Hainan Boao Super Hospital from June 20...AIM:To preliminary explore the safety and effectiveness of artificial iris implantation.METHODS:Fourteen patients with iris defects who underwent artificial iris implantation at Hainan Boao Super Hospital from June 2020 to September 2021 were retrospectively analyzed for safety and effectiveness of the surgery by comparing the preoperative and postoperative best-corrected visual acuity(BCVA),intraocular pressure(IOP),corneal endothelial cell density(ECD),ocular axial length(AL),anterior chamber depth(ACD),patient satisfaction of photophobia and appearance improvement,and postoperative complications.RESULTS:The mean age was 37.21±14.85(7-60)y,including 13 males and 1 female.The mean follow-up period was 4.64±2.32(1-10)mo.The mean AL was 24.00±1.06(21.68-25.58)mm.The postoperative mean anterior chamber depth measured was 4.07±0.75(2.61-5.07)mm.The mean BCVA was 0.69±0.65 logMAR preoperatively and 0.46±0.60 logMAR at the last follow-up time(P=0.36).There was no significant differences in the IOP preoperative and postoperative(14.14±3.10 and 13.65±3.08 mm Hg,respectively,P=0.69).The preoperative ECD was 1674.09±566.11 per 1 mm^(2),and the postoperative ECD was 1439.45±425.15 per 1 mm^(2)(P=0.21).No obvious corneal opacity or corneal decompensation was observed in all patients.The preoperative and postoperative photophobia scores were 8.50±1.55 and 4.50±1.94,respectively(P<0.05),and the preoperative and postoperative appearance defect scores were 6.58±2.98 and 2.75±1.69,respectively(P<0.05).Among the 14 patients,one had artificial iris displacement,two had a transient IOP rise after treatment of antiglaucomatous eyedrops.No complications were observed during surgery.CONCLUSION:The novel artificial iris material is safe,which can significantly improve the appearance defects and photophobia,improve the postoperative visual acuity to a certain extent.This surgery had a high patient satisfaction rate with few and controllable postoperative complications.At the same time,the artificial iris,with its diverse configurations,variable colors,arbitrary cutting,and various surgical procedures,fully realizes personalized treatment,which solves the clinical problem of iris defect.展开更多
The mutualistic symbiotic system formed by clumping arbuscular mycorrhizal fungi(AMF)and plants can remediate heavy metal-contaminated soils.However,the specific mechanisms underlying the interaction between AMF and i...The mutualistic symbiotic system formed by clumping arbuscular mycorrhizal fungi(AMF)and plants can remediate heavy metal-contaminated soils.However,the specific mechanisms underlying the interaction between AMF and inter-root microbial communities,particularly their impact on organic phosphorus(P)cycling,remain unclear.This study investigated the gene regulation processes involved in inter-root soil phosphorus cycling in wetland plants,specifically Iris tectorum,following inoculation with AMF under varying concentrations of chromium(Cr)stress.Through macro-genome sequencing,we analyzed the composition and structure of the inter-root soil microbial community associated with Iris tectorum under greenhouse pot conditions.The results demonstrated significant changes in the diversity and composition of the inter-root soil microbial community following AMF inoculation,with Proteobacteria,Actinobacteria,Chloroflexi,Acidobacteria,and Bacteroidetes being the dominant taxa.Under Cr stress,species and gene co-occurrence network analysis revealed that AMF promoted the transformation process of organic phosphorus mineralization and facilitated inorganic phosphorus uptake.Additionally,network analysis of functional genes indicated strong aggregation of(pstS,pstA,pstC,TC.PIT,phoR,pp-gppA)genes,which collectively enhanced phosphorus uptake by plants.These findings shed light on the inter-root soil phosphorus cycling process during the co-remediation of Cr-contaminated soil by AMF-Iris tectorum symbiosis,providing valuable theoretical support for the application of AMF-wetland plant symbiosis systems to remediate heavy metal-contaminated soil.展开更多
Iris sanguinea Donn ex Horn.is a common perennial ornamental herb in Northeast China due to its strong cold-resistance capacity.In this study,integrative analyses of metabolomics and transcriptomics data were performe...Iris sanguinea Donn ex Horn.is a common perennial ornamental herb in Northeast China due to its strong cold-resistance capacity.In this study,integrative analyses of metabolomics and transcriptomics data were performed on five cultivars of I.sanguinea with varying petal colors to elucidate the molecular basis underlying petal pigmentation.The metabolomics data revealed that a total of five major anthocyanins were responsible for petal pigmentation in I.sanguinea.While two delphinidin-3-O-glucoside derivatives contributed to blue coloration in petals,two petunidin-3-O-glucoside and cyanidin-3-O-rutinoside derivatives exhibited significantly higher abundances in the deep pink petals.In addition,transcriptomics revealed a gradual increase in the expression of a large set of genes involved in flavonoid and anthocyanin biosynthesis pathways,corresponding to the varying levels of anthocyanin content among cultivar petals.Integrated metabolomics and transcriptomics analysis further led to the discovery of molecular modules controlling petal pigmentation,in which an R2R3 MYB transcription factor IsMYBL1 was found to be associated with the accumulation of key anthocyanin derivatives,it localized to the nucleus.The regulatory role of IsMYBL1 in anthocyanin accumulation has been validated through overexpressing in tobacco and knockdown in I.sanguinea using an improved virusinduced gene silencing(VIGS)approach.Finally,BiFC and Y2H showed that IsMYBL1 interacts with IsEGL3 and IsTTG1 to activate the expression of genes involved in anthocyanin biosynthesis,Yeast one-hybrid,dual-luciferase assays,showed that IsMYBL1 significantly increased anthocyanin contents in I.sanguinea by promoting the expression of IsANS,thereby promoting anthocyanin accumulation.Taken together,our study has provided a comprehensive molecular profiling of petal coloration in I.sanguinea and revealed key gene/metabolite networks that determine petal pigmentation.展开更多
AIM:To compare the efficacy of different administration regimens of compound tropicamide eyedrops(CTE)for pupil dilation for children with dark iris.METHODS:A prospective,comparative,randomized interventional study wa...AIM:To compare the efficacy of different administration regimens of compound tropicamide eyedrops(CTE)for pupil dilation for children with dark iris.METHODS:A prospective,comparative,randomized interventional study was conducted.Children in Group 1 received CTE 3 times with a 3min interval between each application.Children in Group 2 received CTE 4 times with a 5min interval between each application.We measured their pupil diameters at baseline(pre-drug instillation)and 30min and 60min post-drug instillation and assessed the pupillary light reflex at 60min post-drug instillation.RESULTS:In total,194 eyes of 101 children were enrolled.The changes of pupil diameter at 30min and 60min post-drug instillation were 1.2±0.6 mm and 2.3±1.0 mm in Group 1,and 2.3±0.9 mm and 3.7±1.0 mm in Group 2,respectively.Group 2 showed a larger change in pupil size than Group 1 at 30min(P<0.01)and 60min(P<0.01).The effect of pupil dilation in Group 2 was 1.25 times that in Group 1.The change in pupil size was positively associated with age.A higher proportion of children in Group 1 had smaller pupil diameter and reactive pupils at the final time point,with only 33 children(33.7%)had final pupil size≥6.5 mm,and only 9 children(9.2%)had non-reactive pupils.Children in Group 2 achieved larger pupil diameter and more nonreactive pupils at the final time point,with 84 children(87.5%)had final pupil size≥6.5 mm,and only 22 children(22.9%)had reactive pupils.CONCLUSION:Increasing the frequency of compound tropicamide and lengthening the interval between eye drop applications can produce stronger mydriatic effects.展开更多
In northern China,light and temperature are major limiting factors for plant growth,particularly during seed production and seedling establishment.While previous studies suggested a possible role for the MYB97 gene in...In northern China,light and temperature are major limiting factors for plant growth,particularly during seed production and seedling establishment.While previous studies suggested a possible role for the MYB97 gene in cold-stress,confirmation through documented evidence was lacking.In this study,we transformed the MYB97 gene from Iris laevigata into tobacco,and discovered that the gene boosted photosynthesis,photoprotection and resilience to cold.The transgenic tobacco seeds exhibited enhanced germination and accelerated seedling growth.Moreover,these plants had decreased levels of MDA(Malondialdehyde)and relative conductance,coupled with elevated concentrations of proline and soluble sugars.This response was accompanied by heightened activity of antioxidant enzymes during periods of cold stress(4 and−2℃).Exposure to low temperatures(0–15℃)also reduced heights but accentuated primary root growth in transgenic tobacco plants.Additionally,tobacco leaves showed an increased growth along with higher chlorophyll levels,net photosynthetic rates,stomatal conductance,transpiration rates and non-photochemical quenching coefficient.This study shows that IlMYB97(The MYB97 genes in I.laevigata)improves cold-resistance,and enhances photosynthesis and photoprotective ability,and thus overall growth and development.These findings would offer the genetic resources to further study cold resistance and photosynthesis.展开更多
Phakic intraocular lens implantation has become one of the important means of correcting refractive errors today.Among them,the implantable collamer lens(ICL)is favored for its wide range of correction,excellent optic...Phakic intraocular lens implantation has become one of the important means of correcting refractive errors today.Among them,the implantable collamer lens(ICL)is favored for its wide range of correction,excellent optical quality,and high safety,but the risks of postoperative complications such as glaucoma and anterior subcapsular opacification still exist.Vault is an important indicator for evaluating the safety after ICL implantation,and its ideal state is crucial for preventing complications.Studies have shown that iris morphology has a significant impact on vault.In order to further optimize surgical outcomes and improve surgical safety,this review comprehensively reviews the research progress of iris-related parameters in ICL implantation and discusses the importance of various parameters in preoperative evaluation and postoperative follow-up.展开更多
Urbanization has resulted in a significant degra-dation of soil quality,subjecting plants to persistent abiotic stressors such as heavy metal pollution,salinization,and drought.UDP-glycosyltransferases(UGTs)participat...Urbanization has resulted in a significant degra-dation of soil quality,subjecting plants to persistent abiotic stressors such as heavy metal pollution,salinization,and drought.UDP-glycosyltransferases(UGTs)participate in protein glycosylation,secondary metabolite synthesis,and detoxification of exogenous toxic substances.Iris sanguinea Donn ex Hornem exhibits a high degree of resistance to various abiotic stressors.To enhance the plant’s response to adversity,a novel glycosyltransferase belonging to the UGT78 family,encoding flavonoid 3-O-glucosyltransferase(UF3GT),was cloned from the monocot species I.san-guinea.Compared with the control group,overexpression of IsUGT78 enhanced sensitivity to cadmium stress,while showing no significant impact under NaCl and d-sorbitol treatments.Under cadmium treatment,arabidopsis exoge-nously transformed with the IsUGT78 gene possessed lower germination,fresh weight,root length,and chlorophyll con-tent and increased malondialdehyde content than the wild type arabidopsis.In addition,metabolomics in leaves led to the identification of 299 flavonoid metabolites,eight and 127 which were significantly up-and down-regulated,respec-tively,in the transgenic plants.Of note,all eight upregulated flavonoid compounds were glycosylated.Given that arabi-dopsis,which exogenously expresses the IsUGT78 gene,has reduced resistance to cadmium,IsUGT78 may lead to a reduced ability to cope with cadmium stress.展开更多
This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocul...This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocular metastatic malignancies.Positron emission tomographycomputed tomography played a crucial role in identifying primary sites and systemic metastases.Local treatment combined with systemic therapy effectively reduced tumor size,preserved useful vision,and improved the patient’s survival rate.A comparison was made of the characteristics of iris metastases from esophageal cancer and lung cancer,including age,gender,tumor characteristics,and treatment.The challenges associated with diagnosis and treatment are discussed,highlighting the implications for clinical practice.展开更多
Iris recognition technology(IRT)-based authentication is a biometric financial technology(FinTech)application used to automate user recognition and verification.In addition to being a controversial technology with var...Iris recognition technology(IRT)-based authentication is a biometric financial technology(FinTech)application used to automate user recognition and verification.In addition to being a controversial technology with various facilitators and inhibitors,the adoption of IRT-based FinTech is driven by contextual factors,such as customer perceptions,deployed biometric technology,and financial transaction settings.Due to its controversial and contextual properties,analyzing IRT-based FinTech acceptance is challenging.This study uses a net valence framework to investigate the salient positive and negative factors influencing the intention to use IRT-based FinTech in automated teller machines(ATMs)in Jordan.This study is pertinent because there is a dearth of research on IRT-based FinTech in the relevant literature;most previous research has taken purely engineering and technical approaches.Furthermore,despite considerable investments by banks and other financial institutions in this FinTech,target user adoption is minimal,and only 6% of Jordan’s ATM transactions are currently IRT-enabled.This study employs mixed methods.In the first qualitative study,17 Jordanian customers were interviewed regarding the benefits and risks of IRT-based FinTech in ATMs.Content analyses determined the most important concepts or themes.The advantages include financial security,convenience,and FinTech-enabled hygiene,whereas the concerns include performance,financial,privacy,and physical risks.The research model is constructed based on the qualitative study and theoretical underpinnings,wherein 631 Jordanian bank customers with active ATM accounts were surveyed to validate the research model.The findings indicate that IRT-based FinTech usage in ATMs is proportional to its perceived value.In descending order of effect,financial security,FinTech-enabled hygiene,and convenience benefits positively impact perceived value.Privacy,financial,and physical risks have negative impacts on perceived value,whereas performance risk has no effect.This study contributes to the relatively untapped domain of biometric technology in information systems,with important theoretical and practical implications.展开更多
In a brand new era,with chaotic scenario that exists within the world,people are undermined with diverse psychological assaults.There have been numerous sensible approaches on the way to understand and lessen those at...In a brand new era,with chaotic scenario that exists within the world,people are undermined with diverse psychological assaults.There have been numerous sensible approaches on the way to understand and lessen those attacks.Bioscrypt developments have verified to be one of the beneficial approaches for intercepting these troubles.Identifying recognition through human iris organ is said as one of the well-known biometric strategies because of its reliability and higher accurate return in comparison to different developments.Reviewing beyond literatures,terrible imaging condition,low flexibility of version,and small length iris image dataset are the constraints desiring solutions.Among these kinds of developments,the iris popularity structures are suitable gear for the human identification.Iris popularity has been an energetic studies location for the duration of previous couple of decades,due to its extensive packages in the areas,from airports to native land protection border protection.In the past,various functions and methods for iris recognition have been presented.Despite of the very fact that there are many approaches published in this field,there are still liberal amount of problems in this methodology like tedious and computational intricacy.We suggest an all-encompassing deep learning architecture for iris recognition supported by a genetic algorithm and a wavelet transformation,which may jointly learn the feature representation and perform recognition to realize high efficiency.With just a few training photos from each class,we train our model on a well-known iris recognition dataset and demonstrate improvements over prior methods.We think that this architecture can be frequently employed for various biometric recognition jobs,assisting in the development of a more scalable and precise system.The exploratory aftereffects of the proposed technique uncover that the strategy is effective inside the iris acknowledgment.展开更多
AIM: To analyse previous literature and to formulate a management strategy for iris microhaemangiomas (IMH).METHODS:Areview of the literature in English language articles on IMH.RESULTS: Thirty five English language a...AIM: To analyse previous literature and to formulate a management strategy for iris microhaemangiomas (IMH).METHODS:Areview of the literature in English language articles on IMH.RESULTS: Thirty five English language articles fulfilled the criteria for inclusion to the study and based on the contents on these articles a management strategy was formulated. Age at presentation ranged from 42 to 80 years with no sex or racial predisposition. Most patients with IMH have no systemic disease but a higher incidence had been reported in patients with diabetes mellitus, myotonic dystrophy, chronic obstructive pulmonary disease (COPD) and several other systemic and ophthalmic co-morbidities. Most patients remained asymptomatic until they experienced a sudden blurring of vision due to a hyphaema. Some patients only develop a self-limiting single episode of hyphaema and therefore the laser or surgical photocoagulation of iris should be reserved for the cases complicated with recurrent hyphaema. In some patients, several laser photoco-agulation sessions may be needed and the recurrent iris vascular tufts may require more aggressive treatment. Iris fluorescein angiography (IFA) is useful in identifying the true extent of the disease and helps to improve the precision of the laser treatment. Surgical excision (iridectomy) should only be considered in patients who fail to respond to repeated laser treatment. In some cases IMHs has been initially misdiagnosed as amaurosis fugax, iritis and Posner-Schlossman syndrome.CONCLUSION: Owing to its scarcity, there is no good quality scientific evidence to support the management of IMH. The authors discuss the various treatment options and present a management strategy based on the previous literature for the management for this rare condition and its complications.展开更多
目的:探讨及评价不同准直器(Fixed/Iris)的选择对治疗计划剂量学特点的影响。方法:选取12例肝癌患者影像数据,统一给予靶区剂量50 Gy/5 F,在相同条件下分别对每例患者选择Fixed与Iris准直器进行治疗计划设计,通过靶区适形度指数(CI)、...目的:探讨及评价不同准直器(Fixed/Iris)的选择对治疗计划剂量学特点的影响。方法:选取12例肝癌患者影像数据,统一给予靶区剂量50 Gy/5 F,在相同条件下分别对每例患者选择Fixed与Iris准直器进行治疗计划设计,通过靶区适形度指数(CI)、均匀性指数(HI)、梯度指数(GI)、正常肝脏平均受量以及治疗时间等参数,分析评估计划优化质量及实施效率。结果:Iris组计划执行的平均治疗时间明显优于Fix组[(48.33±1.92)min vs(51.50±1.88)min,t=4.23,P=0.001],而CI(0.79±0.07 vs 0.80±0.08,t=0.52,P=0.613)、HI(0.42±0.14 vs 0.41±0.14,t=0.35,P=0.733)、GI(3.66±0.61 vs 3.60±0.50,t=1.15,P=0.273)、处方剂量归一值[(76.92±6.55)%vs(77.00±6.34)%,t=0.18,P=0.857]以及正常肝脏平均受量[(5.15±1.25)Gy vs(5.16±1.27)Gy,t=0.63,P=0.542]则无统计学差异。结论:CyberKnife系统中使用Iris相对Fixed准直器而言,除治疗时间明显缩短外,没有显著的剂量学差异。而对于其他部位肿瘤患者的治疗计划有无差异,还需进一步探讨和研究。展开更多
文摘AIM:To preliminary explore the safety and effectiveness of artificial iris implantation.METHODS:Fourteen patients with iris defects who underwent artificial iris implantation at Hainan Boao Super Hospital from June 2020 to September 2021 were retrospectively analyzed for safety and effectiveness of the surgery by comparing the preoperative and postoperative best-corrected visual acuity(BCVA),intraocular pressure(IOP),corneal endothelial cell density(ECD),ocular axial length(AL),anterior chamber depth(ACD),patient satisfaction of photophobia and appearance improvement,and postoperative complications.RESULTS:The mean age was 37.21±14.85(7-60)y,including 13 males and 1 female.The mean follow-up period was 4.64±2.32(1-10)mo.The mean AL was 24.00±1.06(21.68-25.58)mm.The postoperative mean anterior chamber depth measured was 4.07±0.75(2.61-5.07)mm.The mean BCVA was 0.69±0.65 logMAR preoperatively and 0.46±0.60 logMAR at the last follow-up time(P=0.36).There was no significant differences in the IOP preoperative and postoperative(14.14±3.10 and 13.65±3.08 mm Hg,respectively,P=0.69).The preoperative ECD was 1674.09±566.11 per 1 mm^(2),and the postoperative ECD was 1439.45±425.15 per 1 mm^(2)(P=0.21).No obvious corneal opacity or corneal decompensation was observed in all patients.The preoperative and postoperative photophobia scores were 8.50±1.55 and 4.50±1.94,respectively(P<0.05),and the preoperative and postoperative appearance defect scores were 6.58±2.98 and 2.75±1.69,respectively(P<0.05).Among the 14 patients,one had artificial iris displacement,two had a transient IOP rise after treatment of antiglaucomatous eyedrops.No complications were observed during surgery.CONCLUSION:The novel artificial iris material is safe,which can significantly improve the appearance defects and photophobia,improve the postoperative visual acuity to a certain extent.This surgery had a high patient satisfaction rate with few and controllable postoperative complications.At the same time,the artificial iris,with its diverse configurations,variable colors,arbitrary cutting,and various surgical procedures,fully realizes personalized treatment,which solves the clinical problem of iris defect.
基金supported by 2024 Guizhou Basic Research Plan(Natural Science)Project,China(Foundation of Guizhou science cooperation-ZK[2024]General 490)the National Natural Science Foundation of China(No.31560107).
文摘The mutualistic symbiotic system formed by clumping arbuscular mycorrhizal fungi(AMF)and plants can remediate heavy metal-contaminated soils.However,the specific mechanisms underlying the interaction between AMF and inter-root microbial communities,particularly their impact on organic phosphorus(P)cycling,remain unclear.This study investigated the gene regulation processes involved in inter-root soil phosphorus cycling in wetland plants,specifically Iris tectorum,following inoculation with AMF under varying concentrations of chromium(Cr)stress.Through macro-genome sequencing,we analyzed the composition and structure of the inter-root soil microbial community associated with Iris tectorum under greenhouse pot conditions.The results demonstrated significant changes in the diversity and composition of the inter-root soil microbial community following AMF inoculation,with Proteobacteria,Actinobacteria,Chloroflexi,Acidobacteria,and Bacteroidetes being the dominant taxa.Under Cr stress,species and gene co-occurrence network analysis revealed that AMF promoted the transformation process of organic phosphorus mineralization and facilitated inorganic phosphorus uptake.Additionally,network analysis of functional genes indicated strong aggregation of(pstS,pstA,pstC,TC.PIT,phoR,pp-gppA)genes,which collectively enhanced phosphorus uptake by plants.These findings shed light on the inter-root soil phosphorus cycling process during the co-remediation of Cr-contaminated soil by AMF-Iris tectorum symbiosis,providing valuable theoretical support for the application of AMF-wetland plant symbiosis systems to remediate heavy metal-contaminated soil.
基金supported by the National Science Foundation(Grant No.31670344)the Fundamental Research Funds for the Central Universities(Grant No.2572023CT18)the Natural Fund Project of Heilongjiang Province(Grant No.LH2020C044).
文摘Iris sanguinea Donn ex Horn.is a common perennial ornamental herb in Northeast China due to its strong cold-resistance capacity.In this study,integrative analyses of metabolomics and transcriptomics data were performed on five cultivars of I.sanguinea with varying petal colors to elucidate the molecular basis underlying petal pigmentation.The metabolomics data revealed that a total of five major anthocyanins were responsible for petal pigmentation in I.sanguinea.While two delphinidin-3-O-glucoside derivatives contributed to blue coloration in petals,two petunidin-3-O-glucoside and cyanidin-3-O-rutinoside derivatives exhibited significantly higher abundances in the deep pink petals.In addition,transcriptomics revealed a gradual increase in the expression of a large set of genes involved in flavonoid and anthocyanin biosynthesis pathways,corresponding to the varying levels of anthocyanin content among cultivar petals.Integrated metabolomics and transcriptomics analysis further led to the discovery of molecular modules controlling petal pigmentation,in which an R2R3 MYB transcription factor IsMYBL1 was found to be associated with the accumulation of key anthocyanin derivatives,it localized to the nucleus.The regulatory role of IsMYBL1 in anthocyanin accumulation has been validated through overexpressing in tobacco and knockdown in I.sanguinea using an improved virusinduced gene silencing(VIGS)approach.Finally,BiFC and Y2H showed that IsMYBL1 interacts with IsEGL3 and IsTTG1 to activate the expression of genes involved in anthocyanin biosynthesis,Yeast one-hybrid,dual-luciferase assays,showed that IsMYBL1 significantly increased anthocyanin contents in I.sanguinea by promoting the expression of IsANS,thereby promoting anthocyanin accumulation.Taken together,our study has provided a comprehensive molecular profiling of petal coloration in I.sanguinea and revealed key gene/metabolite networks that determine petal pigmentation.
基金Supported by the National Natural Science Foundation of China(No.82371093,No.72342015)R&D Program of Beijing Municipal Education Commission(No.KZ202110025039).
文摘AIM:To compare the efficacy of different administration regimens of compound tropicamide eyedrops(CTE)for pupil dilation for children with dark iris.METHODS:A prospective,comparative,randomized interventional study was conducted.Children in Group 1 received CTE 3 times with a 3min interval between each application.Children in Group 2 received CTE 4 times with a 5min interval between each application.We measured their pupil diameters at baseline(pre-drug instillation)and 30min and 60min post-drug instillation and assessed the pupillary light reflex at 60min post-drug instillation.RESULTS:In total,194 eyes of 101 children were enrolled.The changes of pupil diameter at 30min and 60min post-drug instillation were 1.2±0.6 mm and 2.3±1.0 mm in Group 1,and 2.3±0.9 mm and 3.7±1.0 mm in Group 2,respectively.Group 2 showed a larger change in pupil size than Group 1 at 30min(P<0.01)and 60min(P<0.01).The effect of pupil dilation in Group 2 was 1.25 times that in Group 1.The change in pupil size was positively associated with age.A higher proportion of children in Group 1 had smaller pupil diameter and reactive pupils at the final time point,with only 33 children(33.7%)had final pupil size≥6.5 mm,and only 9 children(9.2%)had non-reactive pupils.Children in Group 2 achieved larger pupil diameter and more nonreactive pupils at the final time point,with 84 children(87.5%)had final pupil size≥6.5 mm,and only 22 children(22.9%)had reactive pupils.CONCLUSION:Increasing the frequency of compound tropicamide and lengthening the interval between eye drop applications can produce stronger mydriatic effects.
基金supported by the Science and Technology Basic Resources Investigation Program of China(2019FY100500)the Fun-damental Research Funds for the Central Universities(2572023CT18)the Natural Fund Project of Heilongjiang Province(LH 2020C 044).
文摘In northern China,light and temperature are major limiting factors for plant growth,particularly during seed production and seedling establishment.While previous studies suggested a possible role for the MYB97 gene in cold-stress,confirmation through documented evidence was lacking.In this study,we transformed the MYB97 gene from Iris laevigata into tobacco,and discovered that the gene boosted photosynthesis,photoprotection and resilience to cold.The transgenic tobacco seeds exhibited enhanced germination and accelerated seedling growth.Moreover,these plants had decreased levels of MDA(Malondialdehyde)and relative conductance,coupled with elevated concentrations of proline and soluble sugars.This response was accompanied by heightened activity of antioxidant enzymes during periods of cold stress(4 and−2℃).Exposure to low temperatures(0–15℃)also reduced heights but accentuated primary root growth in transgenic tobacco plants.Additionally,tobacco leaves showed an increased growth along with higher chlorophyll levels,net photosynthetic rates,stomatal conductance,transpiration rates and non-photochemical quenching coefficient.This study shows that IlMYB97(The MYB97 genes in I.laevigata)improves cold-resistance,and enhances photosynthesis and photoprotective ability,and thus overall growth and development.These findings would offer the genetic resources to further study cold resistance and photosynthesis.
基金Key Research and Development Projects of Zhejiang Science and Technology Plan(No.2021C03103)Research and Development Plan of Zhejiang Science and Technology Department(No.2023C03089)Scientific Research Project of Zhejiang Provincial Department of Education(No.Y202456401)。
文摘Phakic intraocular lens implantation has become one of the important means of correcting refractive errors today.Among them,the implantable collamer lens(ICL)is favored for its wide range of correction,excellent optical quality,and high safety,but the risks of postoperative complications such as glaucoma and anterior subcapsular opacification still exist.Vault is an important indicator for evaluating the safety after ICL implantation,and its ideal state is crucial for preventing complications.Studies have shown that iris morphology has a significant impact on vault.In order to further optimize surgical outcomes and improve surgical safety,this review comprehensively reviews the research progress of iris-related parameters in ICL implantation and discusses the importance of various parameters in preoperative evaluation and postoperative follow-up.
基金supported by the Science and Technology Basic Resources Investigation Program of China(2019FY100500)the Fundamental Research Funds for the Central Universities(2572023CT18)the National Science Foundation(31670344).
文摘Urbanization has resulted in a significant degra-dation of soil quality,subjecting plants to persistent abiotic stressors such as heavy metal pollution,salinization,and drought.UDP-glycosyltransferases(UGTs)participate in protein glycosylation,secondary metabolite synthesis,and detoxification of exogenous toxic substances.Iris sanguinea Donn ex Hornem exhibits a high degree of resistance to various abiotic stressors.To enhance the plant’s response to adversity,a novel glycosyltransferase belonging to the UGT78 family,encoding flavonoid 3-O-glucosyltransferase(UF3GT),was cloned from the monocot species I.san-guinea.Compared with the control group,overexpression of IsUGT78 enhanced sensitivity to cadmium stress,while showing no significant impact under NaCl and d-sorbitol treatments.Under cadmium treatment,arabidopsis exoge-nously transformed with the IsUGT78 gene possessed lower germination,fresh weight,root length,and chlorophyll con-tent and increased malondialdehyde content than the wild type arabidopsis.In addition,metabolomics in leaves led to the identification of 299 flavonoid metabolites,eight and 127 which were significantly up-and down-regulated,respec-tively,in the transgenic plants.Of note,all eight upregulated flavonoid compounds were glycosylated.Given that arabi-dopsis,which exogenously expresses the IsUGT78 gene,has reduced resistance to cadmium,IsUGT78 may lead to a reduced ability to cope with cadmium stress.
基金Supported by the National Natural Science Foundation of China (No.81900912)Fundamental Research Funds for the Central Universities (No.YCJJ20230109).
文摘This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocular metastatic malignancies.Positron emission tomographycomputed tomography played a crucial role in identifying primary sites and systemic metastases.Local treatment combined with systemic therapy effectively reduced tumor size,preserved useful vision,and improved the patient’s survival rate.A comparison was made of the characteristics of iris metastases from esophageal cancer and lung cancer,including age,gender,tumor characteristics,and treatment.The challenges associated with diagnosis and treatment are discussed,highlighting the implications for clinical practice.
文摘Iris recognition technology(IRT)-based authentication is a biometric financial technology(FinTech)application used to automate user recognition and verification.In addition to being a controversial technology with various facilitators and inhibitors,the adoption of IRT-based FinTech is driven by contextual factors,such as customer perceptions,deployed biometric technology,and financial transaction settings.Due to its controversial and contextual properties,analyzing IRT-based FinTech acceptance is challenging.This study uses a net valence framework to investigate the salient positive and negative factors influencing the intention to use IRT-based FinTech in automated teller machines(ATMs)in Jordan.This study is pertinent because there is a dearth of research on IRT-based FinTech in the relevant literature;most previous research has taken purely engineering and technical approaches.Furthermore,despite considerable investments by banks and other financial institutions in this FinTech,target user adoption is minimal,and only 6% of Jordan’s ATM transactions are currently IRT-enabled.This study employs mixed methods.In the first qualitative study,17 Jordanian customers were interviewed regarding the benefits and risks of IRT-based FinTech in ATMs.Content analyses determined the most important concepts or themes.The advantages include financial security,convenience,and FinTech-enabled hygiene,whereas the concerns include performance,financial,privacy,and physical risks.The research model is constructed based on the qualitative study and theoretical underpinnings,wherein 631 Jordanian bank customers with active ATM accounts were surveyed to validate the research model.The findings indicate that IRT-based FinTech usage in ATMs is proportional to its perceived value.In descending order of effect,financial security,FinTech-enabled hygiene,and convenience benefits positively impact perceived value.Privacy,financial,and physical risks have negative impacts on perceived value,whereas performance risk has no effect.This study contributes to the relatively untapped domain of biometric technology in information systems,with important theoretical and practical implications.
文摘In a brand new era,with chaotic scenario that exists within the world,people are undermined with diverse psychological assaults.There have been numerous sensible approaches on the way to understand and lessen those attacks.Bioscrypt developments have verified to be one of the beneficial approaches for intercepting these troubles.Identifying recognition through human iris organ is said as one of the well-known biometric strategies because of its reliability and higher accurate return in comparison to different developments.Reviewing beyond literatures,terrible imaging condition,low flexibility of version,and small length iris image dataset are the constraints desiring solutions.Among these kinds of developments,the iris popularity structures are suitable gear for the human identification.Iris popularity has been an energetic studies location for the duration of previous couple of decades,due to its extensive packages in the areas,from airports to native land protection border protection.In the past,various functions and methods for iris recognition have been presented.Despite of the very fact that there are many approaches published in this field,there are still liberal amount of problems in this methodology like tedious and computational intricacy.We suggest an all-encompassing deep learning architecture for iris recognition supported by a genetic algorithm and a wavelet transformation,which may jointly learn the feature representation and perform recognition to realize high efficiency.With just a few training photos from each class,we train our model on a well-known iris recognition dataset and demonstrate improvements over prior methods.We think that this architecture can be frequently employed for various biometric recognition jobs,assisting in the development of a more scalable and precise system.The exploratory aftereffects of the proposed technique uncover that the strategy is effective inside the iris acknowledgment.
文摘AIM: To analyse previous literature and to formulate a management strategy for iris microhaemangiomas (IMH).METHODS:Areview of the literature in English language articles on IMH.RESULTS: Thirty five English language articles fulfilled the criteria for inclusion to the study and based on the contents on these articles a management strategy was formulated. Age at presentation ranged from 42 to 80 years with no sex or racial predisposition. Most patients with IMH have no systemic disease but a higher incidence had been reported in patients with diabetes mellitus, myotonic dystrophy, chronic obstructive pulmonary disease (COPD) and several other systemic and ophthalmic co-morbidities. Most patients remained asymptomatic until they experienced a sudden blurring of vision due to a hyphaema. Some patients only develop a self-limiting single episode of hyphaema and therefore the laser or surgical photocoagulation of iris should be reserved for the cases complicated with recurrent hyphaema. In some patients, several laser photoco-agulation sessions may be needed and the recurrent iris vascular tufts may require more aggressive treatment. Iris fluorescein angiography (IFA) is useful in identifying the true extent of the disease and helps to improve the precision of the laser treatment. Surgical excision (iridectomy) should only be considered in patients who fail to respond to repeated laser treatment. In some cases IMHs has been initially misdiagnosed as amaurosis fugax, iritis and Posner-Schlossman syndrome.CONCLUSION: Owing to its scarcity, there is no good quality scientific evidence to support the management of IMH. The authors discuss the various treatment options and present a management strategy based on the previous literature for the management for this rare condition and its complications.
文摘目的:探讨及评价不同准直器(Fixed/Iris)的选择对治疗计划剂量学特点的影响。方法:选取12例肝癌患者影像数据,统一给予靶区剂量50 Gy/5 F,在相同条件下分别对每例患者选择Fixed与Iris准直器进行治疗计划设计,通过靶区适形度指数(CI)、均匀性指数(HI)、梯度指数(GI)、正常肝脏平均受量以及治疗时间等参数,分析评估计划优化质量及实施效率。结果:Iris组计划执行的平均治疗时间明显优于Fix组[(48.33±1.92)min vs(51.50±1.88)min,t=4.23,P=0.001],而CI(0.79±0.07 vs 0.80±0.08,t=0.52,P=0.613)、HI(0.42±0.14 vs 0.41±0.14,t=0.35,P=0.733)、GI(3.66±0.61 vs 3.60±0.50,t=1.15,P=0.273)、处方剂量归一值[(76.92±6.55)%vs(77.00±6.34)%,t=0.18,P=0.857]以及正常肝脏平均受量[(5.15±1.25)Gy vs(5.16±1.27)Gy,t=0.63,P=0.542]则无统计学差异。结论:CyberKnife系统中使用Iris相对Fixed准直器而言,除治疗时间明显缩短外,没有显著的剂量学差异。而对于其他部位肿瘤患者的治疗计划有无差异,还需进一步探讨和研究。
