Objective To determine the effects and toxicity of interstitial brachytherapy using iridium 192 on brain malignant gliomas.Methods Between January 1992 and January 1995, 56 patients with anaplastic astrocytoma and ...Objective To determine the effects and toxicity of interstitial brachytherapy using iridium 192 on brain malignant gliomas.Methods Between January 1992 and January 1995, 56 patients with anaplastic astrocytoma and glioblastoma multiforme were treated with stereotactic brachytherapy using temporary high activity iridium 192 sources.Results The median survival for patients receiving brachytherapy was 28 months. The survival rates at 1, 2, 3 years were 92.8%, 83.9% and 71.4% respectively.Conclusions Brachytherapy may improve the control of local tumor and prolong the survival, when used in deep malignant brain gliomas, by temporary implanted high doses of iridium 192 sources.展开更多
高剂量率(High Dose Rate,HDR)近距离放射治疗在现代临床近距离放疗中得到广泛应用,临床实践依赖于^(192)Ir源的精确剂量学参数。由于不同放射源设计各异,各型号放射源需特定的剂量学参数。尽管国际上已针对^(192)Ir源进行了广泛研究,...高剂量率(High Dose Rate,HDR)近距离放射治疗在现代临床近距离放疗中得到广泛应用,临床实践依赖于^(192)Ir源的精确剂量学参数。由于不同放射源设计各异,各型号放射源需特定的剂量学参数。尽管国际上已针对^(192)Ir源进行了广泛研究,但针对原子高科股份有限公司生产的HDR ^(192)Ir源的国内研究较少。为了计算国产HDR ^(192)Ir源的剂量学参数,依据美国医学物理师协会(American Association of Physicists in Medicine,AAPM)TG43-U1推荐的剂量学参数计算方法,使用蒙特卡罗模拟软件建立^(192)Ir源的详细结构模型进行模拟计算。模拟结果显示:剂量率常数为1.105 cGy·h^(-1)·U^(-1),与文献值差异小于1.2%;单位活度空气比释动能率为9.788×10^(-8) U·Bq^(-1),差异为0.23%;径向剂量函数和各向异性函数结果与文献一致。结果表明,该模型对于国产HDR ^(192)Ir源的临床应用,具有一定的指导意义。展开更多
文摘Objective To determine the effects and toxicity of interstitial brachytherapy using iridium 192 on brain malignant gliomas.Methods Between January 1992 and January 1995, 56 patients with anaplastic astrocytoma and glioblastoma multiforme were treated with stereotactic brachytherapy using temporary high activity iridium 192 sources.Results The median survival for patients receiving brachytherapy was 28 months. The survival rates at 1, 2, 3 years were 92.8%, 83.9% and 71.4% respectively.Conclusions Brachytherapy may improve the control of local tumor and prolong the survival, when used in deep malignant brain gliomas, by temporary implanted high doses of iridium 192 sources.
文摘高剂量率(High Dose Rate,HDR)近距离放射治疗在现代临床近距离放疗中得到广泛应用,临床实践依赖于^(192)Ir源的精确剂量学参数。由于不同放射源设计各异,各型号放射源需特定的剂量学参数。尽管国际上已针对^(192)Ir源进行了广泛研究,但针对原子高科股份有限公司生产的HDR ^(192)Ir源的国内研究较少。为了计算国产HDR ^(192)Ir源的剂量学参数,依据美国医学物理师协会(American Association of Physicists in Medicine,AAPM)TG43-U1推荐的剂量学参数计算方法,使用蒙特卡罗模拟软件建立^(192)Ir源的详细结构模型进行模拟计算。模拟结果显示:剂量率常数为1.105 cGy·h^(-1)·U^(-1),与文献值差异小于1.2%;单位活度空气比释动能率为9.788×10^(-8) U·Bq^(-1),差异为0.23%;径向剂量函数和各向异性函数结果与文献一致。结果表明,该模型对于国产HDR ^(192)Ir源的临床应用,具有一定的指导意义。
