With the isomorphous difference Fourier method and the restrained least-squares re-finement technique, the crystal structure of 4- zinc bovine insulin in space group R_3 wasdetermined. The final crystallographic resid...With the isomorphous difference Fourier method and the restrained least-squares re-finement technique, the crystal structure of 4- zinc bovine insulin in space group R_3 wasdetermined. The final crystallographic residual is 0. 19 at 1. 9A resolution. Based on therefined model, the structural mechanism for prolonged action of 4- zinc insulin is discussed.展开更多
基金Project supported by the National Natural Science Foundation of China.
文摘With the isomorphous difference Fourier method and the restrained least-squares re-finement technique, the crystal structure of 4- zinc bovine insulin in space group R_3 wasdetermined. The final crystallographic residual is 0. 19 at 1. 9A resolution. Based on therefined model, the structural mechanism for prolonged action of 4- zinc insulin is discussed.
