Voltage-gated sodium （Nav） channels are indispensable membrane elements for the generation and propagation of electric signals in excitable cells. The successes in the crystallographic studies on prokaryotic Nay cha...Voltage-gated sodium （Nav） channels are indispensable membrane elements for the generation and propagation of electric signals in excitable cells. The successes in the crystallographic studies on prokaryotic Nay chan- nels in recent years greatly promote the mechanistic investigation of these proteins and their eukaryotic counterparts. In this paper, we mainly review the pro- gress in computational studies, especially the simula- tion studies, on these proteins in the past years.展开更多
基金We gratefully thank Mengdie Xia for her contribution in preparing the figures. This work was supported by the National Natural Science Foundation of China （Grant Nos. 31470033 and 31321062）.
文摘Voltage-gated sodium （Nav） channels are indispensable membrane elements for the generation and propagation of electric signals in excitable cells. The successes in the crystallographic studies on prokaryotic Nay chan- nels in recent years greatly promote the mechanistic investigation of these proteins and their eukaryotic counterparts. In this paper, we mainly review the pro- gress in computational studies, especially the simula- tion studies, on these proteins in the past years.
