Phospholipids are the major building blocks of the biological membranes. Additionally, phospholipids modulate membrane trafficking and metabolites derived from their
While industrial wastewater discharge causes pollution,it also contains abundant neglected energy.However,establishing effective methods for energy harvesting and real-time monitoring of pollution sources is a serious...While industrial wastewater discharge causes pollution,it also contains abundant neglected energy.However,establishing effective methods for energy harvesting and real-time monitoring of pollution sources is a serious challenge,and includes high-salt solution accompanying nickel ions(Ni(II))in the electroplating industry.Here,a nanoconfinement channel design strategy was adopted to custombuild a three-dimensional(3D)interpenetrating ion channel of metal–organic frameworks(MOFs).By introducing specific functional groups,the charge density of the ion channels could be adjusted.Osmotic energy harvesting achieved a maximumoutput power density of 9.1 W/m^(2),which was 6-fold greater than that of the typical commercial material,UiO-67,known to possess enhanced water stability and methane adsorption capacity.Benefiting from the spatial distribution design of functional groups in the nanoconfinement channels enabled excellent ion selectivity and optimal energy harvesting.Meanwhile,the nanoconfinement channels and functional groups collaborate to create a sensitive ion concentration detection space,presenting a well-designed modified ion channel for emission standards.When Ni(II)appeared,the current signal decreased by∼20-fold.The tripartite cooperation of functional groups,nanoconfinement,and Ni(II)-enabled stable and accurate detection ensured smooth working progress.This study not only provides a design strategy for energy harvesting and detection but also inspires the future design of integrated devices.展开更多
Effective annotation of in vivo drug metabolites using liquid chromatography-mass spectrometry(LCeMS)remains a formidable challenge.Herein,a metabolic reaction-based molecular networking(MRMN)strategy is introduced,wh...Effective annotation of in vivo drug metabolites using liquid chromatography-mass spectrometry(LCeMS)remains a formidable challenge.Herein,a metabolic reaction-based molecular networking(MRMN)strategy is introduced,which enables the“one-pot”discovery of prototype drugs and their metabolites.MRMN constructs networks by matching metabolic reactions and evaluating MS^(2)spectral similarity,incorporating innovations and improvements in feature degradation of MS^(2)spectra,exclusion of endogenous interference,and recognition of redundant nodes.A minimum 75%correlation between structural similarity and MS^(2)similarity of neighboring metabolites was ensured,mitigating false negatives due to spectral feature degradation.At least 79%of nodes,49%of edges,and 97%of subnetworks were reduced by an exclusion strategy of endogenous ions compared to the Global Natural Products Social Molecular Networking(GNPS)platform.Furthermore,an approach of redundant ions identification was refined,achieving a 10%-40%recognition rate across different samples.The effectiveness ofMRMN was validated through a single compound,plant extract,and mixtures of multiple plant extracts.Notably,MRMN is freely accessible online at https://yaolab.network,broadening its applications.展开更多
文摘Phospholipids are the major building blocks of the biological membranes. Additionally, phospholipids modulate membrane trafficking and metabolites derived from their
基金National Natural Science Foundation of China(grant nos.22373042 and 22341301)the Excellent Young Scientific and Technological Talents of Jilin Province Project(grant no.20240602013RC)+1 种基金the Science and Technology Major Project of Jilin Province(grant no.20240208001JH)the Fundamental Research Funds for the Central Universities.
文摘While industrial wastewater discharge causes pollution,it also contains abundant neglected energy.However,establishing effective methods for energy harvesting and real-time monitoring of pollution sources is a serious challenge,and includes high-salt solution accompanying nickel ions(Ni(II))in the electroplating industry.Here,a nanoconfinement channel design strategy was adopted to custombuild a three-dimensional(3D)interpenetrating ion channel of metal–organic frameworks(MOFs).By introducing specific functional groups,the charge density of the ion channels could be adjusted.Osmotic energy harvesting achieved a maximumoutput power density of 9.1 W/m^(2),which was 6-fold greater than that of the typical commercial material,UiO-67,known to possess enhanced water stability and methane adsorption capacity.Benefiting from the spatial distribution design of functional groups in the nanoconfinement channels enabled excellent ion selectivity and optimal energy harvesting.Meanwhile,the nanoconfinement channels and functional groups collaborate to create a sensitive ion concentration detection space,presenting a well-designed modified ion channel for emission standards.When Ni(II)appeared,the current signal decreased by∼20-fold.The tripartite cooperation of functional groups,nanoconfinement,and Ni(II)-enabled stable and accurate detection ensured smooth working progress.This study not only provides a design strategy for energy harvesting and detection but also inspires the future design of integrated devices.
基金was financially supported by the National Natural Science Foundation of China(U23A20500,82374011,82474050,82404818)the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTU-D-202203,China)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(2025A1515011795,2023A1515011144,2024A1515012714,2024A1515011699,China)the Guangzhou Basic and Applied Basic Research Foundation(2024A04J3398,China)the China Postdoctoral Science Foundation(2023M741395)the Postdoctoral Fellowship Program of CPSF(GZB20240274,China)the Natural Science Foundation of Guangxi(2025GXNSFBA069293,China)the Scientific Research Start-up Funding Project of Guangxi University(ZX01080033724006,China)supported by the Fundamental Research Funds for the Central Universities(China).
文摘Effective annotation of in vivo drug metabolites using liquid chromatography-mass spectrometry(LCeMS)remains a formidable challenge.Herein,a metabolic reaction-based molecular networking(MRMN)strategy is introduced,which enables the“one-pot”discovery of prototype drugs and their metabolites.MRMN constructs networks by matching metabolic reactions and evaluating MS^(2)spectral similarity,incorporating innovations and improvements in feature degradation of MS^(2)spectra,exclusion of endogenous interference,and recognition of redundant nodes.A minimum 75%correlation between structural similarity and MS^(2)similarity of neighboring metabolites was ensured,mitigating false negatives due to spectral feature degradation.At least 79%of nodes,49%of edges,and 97%of subnetworks were reduced by an exclusion strategy of endogenous ions compared to the Global Natural Products Social Molecular Networking(GNPS)platform.Furthermore,an approach of redundant ions identification was refined,achieving a 10%-40%recognition rate across different samples.The effectiveness ofMRMN was validated through a single compound,plant extract,and mixtures of multiple plant extracts.Notably,MRMN is freely accessible online at https://yaolab.network,broadening its applications.
