To the Editor,Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by multisystem involvement.In addition to butterfly erythema,photosensitivity,arthritis,and other clinical manifestations,SLE can a...To the Editor,Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by multisystem involvement.In addition to butterfly erythema,photosensitivity,arthritis,and other clinical manifestations,SLE can also result in hematological complications,such as coagulopathy.Acquired hemophilia has been documented in patients with SLE,attributed to the presence of inhibitors against coagulation factors in the circulating blood.1 Furthermore,deficiency of factor XII(FXII)has been reported in patient with SLE in the absence of FXII inhibitors.2,3 However,there have been no reports of a deficiency of FIX without the presence of FIX inhibitors in patients with SLE.In this report,we present a case of a patient with SLE who exhibited recurrent mucosal bleeding attributed to reduced activity of FIX without detectable inhibitors.展开更多
基金supported by a grant from Peking University Shougang Hospital Research Funds,Grant/Award Number:SGYYZ202403.
文摘To the Editor,Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by multisystem involvement.In addition to butterfly erythema,photosensitivity,arthritis,and other clinical manifestations,SLE can also result in hematological complications,such as coagulopathy.Acquired hemophilia has been documented in patients with SLE,attributed to the presence of inhibitors against coagulation factors in the circulating blood.1 Furthermore,deficiency of factor XII(FXII)has been reported in patient with SLE in the absence of FXII inhibitors.2,3 However,there have been no reports of a deficiency of FIX without the presence of FIX inhibitors in patients with SLE.In this report,we present a case of a patient with SLE who exhibited recurrent mucosal bleeding attributed to reduced activity of FIX without detectable inhibitors.
