An O / W emulsion non-solvent addition method was used to prepare ethyleellulose (EC) microcapsules of water soluble pharmaceutical (theophylline). The solvent and non-solvent reagents used in this work were toluene a...An O / W emulsion non-solvent addition method was used to prepare ethyleellulose (EC) microcapsules of water soluble pharmaceutical (theophylline). The solvent and non-solvent reagents used in this work were toluene and cyclohexane. The effects of polymer concentration, core wall ratio and particle size on the kinetics as well as the dissolution rate of the drug were investigated. The results show that the dissolution rate increases with the increasing of polymer concentration and core wall ratio. The release of microcapsules prepared with different procedures can be selectively profiled with first order and Higuchi matrix kinetic models.展开更多
The microencapsulation of the extractant was studied by drying-in-liquid with a [(O_Ⅰ/W_Ⅰ)/O_Ⅱ]/W_Ⅱ multi-emulsion. The microcapsules were characterized by the release efficiency of the extractants to discuss the ...The microencapsulation of the extractant was studied by drying-in-liquid with a [(O_Ⅰ/W_Ⅰ)/O_Ⅱ]/W_Ⅱ multi-emulsion. The microcapsules were characterized by the release efficiency of the extractants to discuss the effect of Tween 60, gelatin, and EC on the experimental results. The size dispersity of microcapsules with the different concentrations of gelatin was also discussed. The results show that microcapsules with good membrane tension for several extractants can be obtained with this method.展开更多
To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats.The plasma concentrations were analyzed by ultra-performance liquid chrom...To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats.The plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection(UPLC-MS/MS)through a new validated method.The pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows:AUC_(0-t) 900.76±186.59 versus 687.08±66.24 ng h/ml,C_(max) 854.54±159.48 versus 610.59±235.99 ng/ml,t_(1/2)2.37±1.99 versus 2.80±2.69 h.The relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%.The developed methods could meet the requirements of bioanalysis.Compared to the solution injection,intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.展开更多
The method of mathematical model and further computer simulation is an effective way to the theoretical study of emulsion polymerization and the scale-up of the reactors. In this work, Monte Carlo method has been used...The method of mathematical model and further computer simulation is an effective way to the theoretical study of emulsion polymerization and the scale-up of the reactors. In this work, Monte Carlo method has been used to simulate the nucleation of emulsion polymerization. The effects of emulsifier concentration [S] and initiator concentration [I] on various parameters such as the number of the particles (N p), the average diameter of the latex particles (D p), monomer conversion (x) and average radical number per particle (n) have been studied. The quantitative equations between [S], [I] and N p are in accord absolutely with the classical theory of Smith-Ewart.展开更多
It was tried to prepare composite particles made of polymer and two kinds of solid powders by forming Pickeringemulsion followed by the drying-in-liquid method and to investigate how the stepwise addition of solid pow...It was tried to prepare composite particles made of polymer and two kinds of solid powders by forming Pickeringemulsion followed by the drying-in-liquid method and to investigate how the stepwise addition of solid powders affected the contained ratio and adhesion ratio of solid powders and the structure of composite particles. Limonene oil dissolving expanded polystyrene and ethylene glycol were adopted as the dispersed phase and the continuous phase, respectively. Magnetite and titanium dioxide were used as solid powders. Magnetite was added before or after formation of the (O/W) dispersion. Titanium dioxide was added at the various elapsed times from addition of magnetite. Titanium dioxide adhered only on the surface of composite particles irrespective of addition time. At the earlier addition of both solid powders, the surface-covering type composite particles were prepared. At the latter addition of titanium dioxide, a part of magnetite adhered on the surface and the remainder was dispersed into composite particle.展开更多
以Lactobacillus plantarum 330G4为被包埋菌株,选用天然食品级材料为水相和油相包埋材料,采用超声波辅助双乳化法,通过单因素和响应面优化试验,筛选油包水(Water-in-oil,W/O)和水包油包水(Water-in-oil-inwater,W/O/W)包埋乳液的最佳...以Lactobacillus plantarum 330G4为被包埋菌株,选用天然食品级材料为水相和油相包埋材料,采用超声波辅助双乳化法,通过单因素和响应面优化试验,筛选油包水(Water-in-oil,W/O)和水包油包水(Water-in-oil-inwater,W/O/W)包埋乳液的最佳条件。结果为菜籽油、果胶和乳清蛋白是双乳化法良好的油相和水相包埋材料;油相体积分数、乳化剂质量分数和功率对W/O乳液包埋率影响较大,响应面优化制备W/O乳液的最佳条件为乳清蛋白质量分数8%、菜籽油体积分数64%、聚甘油蓖麻醇酸酯质量分数3.30%、功率505 W、时间30 s;W/O乳液体积分数、功率和时间对W/O/W乳液包埋率影响较大,响应面优化制备W/O/W乳液的最佳条件为果胶质量分数0.25%、W/O乳液体积分数16.60%、功率75 W、时间3 min;被包埋菌中的活菌数10.34 lg CFU/mL、包埋率92.82%、稳定性99.06%、平均粒径10.53μm;与未包埋活菌数相比,经模拟消化后活菌数提高了7.34 lg CFU/mL;经50、70、90℃热处理30 min后,活菌数分别提高了4.17、3.20、4.58 lg CFU/mL;经25℃贮存30 d后,活菌数提高了6.05 lg CFU/mL。表明超声波辅助双乳化法包埋植物乳杆菌是提高益生菌活性的有效途径。研究结果可为其它益生菌的包埋和提高其活性提供参考,也可为开发研制新型高活性益生菌产品提供新途径。展开更多
文摘An O / W emulsion non-solvent addition method was used to prepare ethyleellulose (EC) microcapsules of water soluble pharmaceutical (theophylline). The solvent and non-solvent reagents used in this work were toluene and cyclohexane. The effects of polymer concentration, core wall ratio and particle size on the kinetics as well as the dissolution rate of the drug were investigated. The results show that the dissolution rate increases with the increasing of polymer concentration and core wall ratio. The release of microcapsules prepared with different procedures can be selectively profiled with first order and Higuchi matrix kinetic models.
文摘The microencapsulation of the extractant was studied by drying-in-liquid with a [(O_Ⅰ/W_Ⅰ)/O_Ⅱ]/W_Ⅱ multi-emulsion. The microcapsules were characterized by the release efficiency of the extractants to discuss the effect of Tween 60, gelatin, and EC on the experimental results. The size dispersity of microcapsules with the different concentrations of gelatin was also discussed. The results show that microcapsules with good membrane tension for several extractants can be obtained with this method.
文摘To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats.The plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection(UPLC-MS/MS)through a new validated method.The pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows:AUC_(0-t) 900.76±186.59 versus 687.08±66.24 ng h/ml,C_(max) 854.54±159.48 versus 610.59±235.99 ng/ml,t_(1/2)2.37±1.99 versus 2.80±2.69 h.The relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%.The developed methods could meet the requirements of bioanalysis.Compared to the solution injection,intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.
文摘The method of mathematical model and further computer simulation is an effective way to the theoretical study of emulsion polymerization and the scale-up of the reactors. In this work, Monte Carlo method has been used to simulate the nucleation of emulsion polymerization. The effects of emulsifier concentration [S] and initiator concentration [I] on various parameters such as the number of the particles (N p), the average diameter of the latex particles (D p), monomer conversion (x) and average radical number per particle (n) have been studied. The quantitative equations between [S], [I] and N p are in accord absolutely with the classical theory of Smith-Ewart.
文摘It was tried to prepare composite particles made of polymer and two kinds of solid powders by forming Pickeringemulsion followed by the drying-in-liquid method and to investigate how the stepwise addition of solid powders affected the contained ratio and adhesion ratio of solid powders and the structure of composite particles. Limonene oil dissolving expanded polystyrene and ethylene glycol were adopted as the dispersed phase and the continuous phase, respectively. Magnetite and titanium dioxide were used as solid powders. Magnetite was added before or after formation of the (O/W) dispersion. Titanium dioxide was added at the various elapsed times from addition of magnetite. Titanium dioxide adhered only on the surface of composite particles irrespective of addition time. At the earlier addition of both solid powders, the surface-covering type composite particles were prepared. At the latter addition of titanium dioxide, a part of magnetite adhered on the surface and the remainder was dispersed into composite particle.
文摘以Lactobacillus plantarum 330G4为被包埋菌株,选用天然食品级材料为水相和油相包埋材料,采用超声波辅助双乳化法,通过单因素和响应面优化试验,筛选油包水(Water-in-oil,W/O)和水包油包水(Water-in-oil-inwater,W/O/W)包埋乳液的最佳条件。结果为菜籽油、果胶和乳清蛋白是双乳化法良好的油相和水相包埋材料;油相体积分数、乳化剂质量分数和功率对W/O乳液包埋率影响较大,响应面优化制备W/O乳液的最佳条件为乳清蛋白质量分数8%、菜籽油体积分数64%、聚甘油蓖麻醇酸酯质量分数3.30%、功率505 W、时间30 s;W/O乳液体积分数、功率和时间对W/O/W乳液包埋率影响较大,响应面优化制备W/O/W乳液的最佳条件为果胶质量分数0.25%、W/O乳液体积分数16.60%、功率75 W、时间3 min;被包埋菌中的活菌数10.34 lg CFU/mL、包埋率92.82%、稳定性99.06%、平均粒径10.53μm;与未包埋活菌数相比,经模拟消化后活菌数提高了7.34 lg CFU/mL;经50、70、90℃热处理30 min后,活菌数分别提高了4.17、3.20、4.58 lg CFU/mL;经25℃贮存30 d后,活菌数提高了6.05 lg CFU/mL。表明超声波辅助双乳化法包埋植物乳杆菌是提高益生菌活性的有效途径。研究结果可为其它益生菌的包埋和提高其活性提供参考,也可为开发研制新型高活性益生菌产品提供新途径。
