BACKGROUND A case study of multiple distinct levels of skipped thoracolumbar spine infection was reported in which 13 successful vacuum sealing drainage(VSD)surgeries were treated.CASE SUMMARY The patient underwent a ...BACKGROUND A case study of multiple distinct levels of skipped thoracolumbar spine infection was reported in which 13 successful vacuum sealing drainage(VSD)surgeries were treated.CASE SUMMARY The patient underwent a total of 13 procedures within our medical facility,including five performed under local anesthesia and eight performed under general anesthesia.The source of the ailment was ultimately identified as Enterobacter cloacae.After the last procedure,the patient's symptoms were alleviated,and the recovery process was satisfactory.Three months post-operation,the Japanese Orthopaedic Association scores had improved to 100%.Imageological examination revealed a satisfactory position of internal fixation,and the abnormal signals in the vertebral body and intervertebral space had been eliminated when compared to the pre-operative results.CONCLUSION The study demonstrates that the extreme lateral approach debridement combined with multiple VSD operations is a secure and successful method of treatment for recurrent spinal infection,providing an alternative to traditional surgery.展开更多
Intervertebral disc degeneration(IvDD)is a complex mechanobiological process driven by abnormal mechanical loading,resulting in structural failure,inflammatory activation,and cellular dysfunction.Understanding these m...Intervertebral disc degeneration(IvDD)is a complex mechanobiological process driven by abnormal mechanical loading,resulting in structural failure,inflammatory activation,and cellular dysfunction.Understanding these mechanobiological interactions offers novel therapeutic targets to interrupt the degenerative cascade and improve clinical outcomes in IVDD treatment.This review summarizes the fundamental characteristics of the mechanobiological microenvironment in IVDD,detailing mechanosensitive spinal components and providing evidence for mechanobiology-based therapies.By enhancing insight into disc degeneration from a mechano-biological perspective,researchers can develop innovative therapeutic strategies to restore a healthy disc microenvironment and spinal stability clinically,offering a promising outlook for patients with IvDD.However,current studies primarily focus on in vitro models and in vivo animal studies,limiting clinical translation.Therefore,effectively translating these research findings into practical clinical treatments remains a notable future challenge.展开更多
基金Supported by Natural Science Foundation of Shandong Province,No.ZR2023MH331.
文摘BACKGROUND A case study of multiple distinct levels of skipped thoracolumbar spine infection was reported in which 13 successful vacuum sealing drainage(VSD)surgeries were treated.CASE SUMMARY The patient underwent a total of 13 procedures within our medical facility,including five performed under local anesthesia and eight performed under general anesthesia.The source of the ailment was ultimately identified as Enterobacter cloacae.After the last procedure,the patient's symptoms were alleviated,and the recovery process was satisfactory.Three months post-operation,the Japanese Orthopaedic Association scores had improved to 100%.Imageological examination revealed a satisfactory position of internal fixation,and the abnormal signals in the vertebral body and intervertebral space had been eliminated when compared to the pre-operative results.CONCLUSION The study demonstrates that the extreme lateral approach debridement combined with multiple VSD operations is a secure and successful method of treatment for recurrent spinal infection,providing an alternative to traditional surgery.
基金supported by the National Natural Science Founda-tion of China(NSFC)(No.82130073)Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System+1 种基金Shanghai Science and Technology Committee(Nos.24410710600 and 23ZR1447400)Biomaterials and Regenerative Medicine Institute Cooperative Research Project,Shanghai Jiao Tong University School of Medicine(No.2022LHA01).
文摘Intervertebral disc degeneration(IvDD)is a complex mechanobiological process driven by abnormal mechanical loading,resulting in structural failure,inflammatory activation,and cellular dysfunction.Understanding these mechanobiological interactions offers novel therapeutic targets to interrupt the degenerative cascade and improve clinical outcomes in IVDD treatment.This review summarizes the fundamental characteristics of the mechanobiological microenvironment in IVDD,detailing mechanosensitive spinal components and providing evidence for mechanobiology-based therapies.By enhancing insight into disc degeneration from a mechano-biological perspective,researchers can develop innovative therapeutic strategies to restore a healthy disc microenvironment and spinal stability clinically,offering a promising outlook for patients with IvDD.However,current studies primarily focus on in vitro models and in vivo animal studies,limiting clinical translation.Therefore,effectively translating these research findings into practical clinical treatments remains a notable future challenge.
