To improve the treatment outcomes for large bone defects and osteoporosis,researchers have been committed to reducing bone loss and accelerating bone regeneration through cell transplantation,biomaterial intervention,...To improve the treatment outcomes for large bone defects and osteoporosis,researchers have been committed to reducing bone loss and accelerating bone regeneration through cell transplantation,biomaterial intervention,and biophysical stimulation over the past few decades.Magnetism,as a noninvasive biophysical stimulus,has been employed in the repair of the musculoskeletal system,achieving a series of promising results.In this review,we provide a retrospective analysis and perspective of research on magnetic-driven bone regeneration and functional reconstruction.This review aims to delineate safe and efficient magnetic application modalities and to summarize the potential mechanisms by which magnetism regulates the behavior of skeletal lineage cells,thereby providing insights for the expansion and translational application of magnetic-driven regenerative medicine.展开更多
基金supported by a grant from the National Natural Science Foundation of China(grant no.82272442)the Innovation Capability Support Program of Shaanxi Province(grant no.2024SF-LCZX-16)+1 种基金the Shaanxi Province Health Scientific Research Innovation Ability Promotion Plan(no.2024PT-12)the Key Research and Development Program of Shaanxi(2024SF-YBXM-375).
文摘To improve the treatment outcomes for large bone defects and osteoporosis,researchers have been committed to reducing bone loss and accelerating bone regeneration through cell transplantation,biomaterial intervention,and biophysical stimulation over the past few decades.Magnetism,as a noninvasive biophysical stimulus,has been employed in the repair of the musculoskeletal system,achieving a series of promising results.In this review,we provide a retrospective analysis and perspective of research on magnetic-driven bone regeneration and functional reconstruction.This review aims to delineate safe and efficient magnetic application modalities and to summarize the potential mechanisms by which magnetism regulates the behavior of skeletal lineage cells,thereby providing insights for the expansion and translational application of magnetic-driven regenerative medicine.
