Light and nitrogen(N)are two critically environmental factors essential for plant survival,as they constitute the fundamental molecular framework of plant cells and significantly influence patterns of plant growth and...Light and nitrogen(N)are two critically environmental factors essential for plant survival,as they constitute the fundamental molecular framework of plant cells and significantly influence patterns of plant growth and development.Light is the driving force behind photosynthesis,a process that converts light energy into chemical energy stored as sugars.Additionally,light acts as a direct signal that can modulate plant morphogenesis and structural development.Nitrogen,as the most crucial mineral nutrient for plants,is a component of numerous biomolecules.It also functions as a signaling molecule,regulating plant growth and development.Moreover,light and nitrogen directly regulate the balance of carbon(C)and N within plants,affecting numerous biochemical reactions and various physiological processes.This review focuses on the interactions between light and nitrogen in physiological,metabolic,and molecular levels.We will also discuss the regulatory networks and mechanisms through which light and nitrogen influence C and N absorption and metabolism in plants.展开更多
In optical metro-access networks,Access Points(APs)and Data Centers(DCs)are located on the fiber ring.In the cloud-centric solution,a large number of Internet of Things(IoT)data pose an enormous burden on DCs,so the V...In optical metro-access networks,Access Points(APs)and Data Centers(DCs)are located on the fiber ring.In the cloud-centric solution,a large number of Internet of Things(IoT)data pose an enormous burden on DCs,so the Virtual Machines(VMs)cannot be successfully launched due to the server overload.In addition,transferring the data from the AP to the remote DC may cause an undesirable delivery delay.For this end,we propose a promising solution considering the interplay between the cloud DC and edge APs.More specifically,bringing the partial capability of computing in APs close to things can reduce the pressure of DCs while guaranteeing the expected Quality of Service(QoS).In this work,when the cloud DC resource becomes limited,especially for delay sensitive but not computing-dependent IoT applications,we degrade their VMs and migrate them to edge APs instead of the remote DC.To avoid excessive VM degradation and computing offloading,we derive appropriate VM degradation coefficients based on classic microeconomic theory.Simulation results demonstrate that our algorithms improve the service providers'utility with the ratio from 34%to 89%over traditional cloud-centric solutions.展开更多
Beyond modern trade tensions and diplomatic milestones,Europe and China’s profound connection stems from a 3,000-year interplay of ideas,goods,and values,shaping their intertwined visions of governance,equality,and s...Beyond modern trade tensions and diplomatic milestones,Europe and China’s profound connection stems from a 3,000-year interplay of ideas,goods,and values,shaping their intertwined visions of governance,equality,and societal progress.展开更多
Salvia miltiorrhiza(Danshen)is a traditional Chinese herb that is commonly known for its cardiovascular and hepatoprotective benefits.Recent studies have confirmed that Danshen and its bioactive components can influen...Salvia miltiorrhiza(Danshen)is a traditional Chinese herb that is commonly known for its cardiovascular and hepatoprotective benefits.Recent studies have confirmed that Danshen and its bioactive components can influence gut microbial homeostasis,thereby affecting Helicobacter pylori(HP)colonization in the human stomach.HP is a bacterial pathogen associated with various gastrointestinal diseases.Current HP treatments mainly involve antibiotics and proton pump inhibitors.However,their efficacy is strongly compromised by the rapid emergence of antibiotic resistance in HP and genetic heterogeneity among patients.The interaction between Danshen and gut microbial status provides a novel perspective for HP treatment.Understanding the medical properties of Danshen in altering gut microbiota and eliminating HP,as well as the underlying mechanisms,is important for improving human gastrointestinal healthcare.This review investigates the interaction between Danshen and gut microbiota and its impact on HP infection using databases including Web of Science,PubMed,and Google Scholar.We explored the unconventional intersection between Danshen,gut microbiota,and HP infection,shedding light on their intricate interplay and potential therapeutic implications.A comprehensive understanding of this interaction provides valuable insights into developing novel therapeutic strategies that target the gut microbiota to mitigate HP-associated gastrointestinal disorders.展开更多
Large interfacial strains in particles are crucial for promoting bonding in cold spraying(CS),initiated either by adiabatic shear instability(ASI)due to softening prevailing over strain hardening or by hydrostatic pla...Large interfacial strains in particles are crucial for promoting bonding in cold spraying(CS),initiated either by adiabatic shear instability(ASI)due to softening prevailing over strain hardening or by hydrostatic plasticity,which is claimed to promote bonding even without ASI.A thorough microstructural analysis is vital to fully understand the bonding mechanisms at play during microparticle impacts and throughout the CS process.In this study,the HEA CoCrFeMnNi,known for its relatively high strain hardening and resistance to softening,was selected to investigate the microstructure characteristics and bonding mech-anisms in CS.This study used characterization techniques covering a range of length scales,including electron channeling contrast imaging(ECCI),electron backscatter diffraction(EBSD),and high-resolution transmission microscopy(HR-TEM),to explore the microstructure characteristics of bonding and overall structure development of CoCrFeMnNi microparticles after impact in CS.HR-TEM lamellae were prepared using focused ion beam milling.Additionally,the effects of deformation field variables on microstructure development were determined through finite element modeling(FEM)of microparticle impacts.The ECCI,EBSD,and HR-TEM analyses revealed an interplay between dislocation-driven processes and twinning,leading to the development of four distinct deformation microstructures.Significant grain refinement occurs at the interface through continuous dynamic recrystallization(CDRX)due to high strain and temperature rise from adiabatic deformation,signs of softening,and ASI.Near the interface,a necklace-like structure of refined grains forms around grain boundaries,along with elongated grains,resulting from the coexistence of dynamic recovery and discontinuous dynamic recrystallization(DDRX)due to lower temperature rise and strain.Towards the particle or substrate interior,concurrent twinning and dislocation-mediated mechanisms refine the structure,forming straight,curved,and intersected twins.At the top of the particles,only deformed grains with a low dislocation density are observed.Our results showed that DRX induces microstructure softening in highly strained interface areas,facilitating atomic bonding in CoCrFeMnNi.HR-TEM investigation confirms the formation of atomic bonds between particles and substrate,with a gradual change in crystal lattice orientation from the particle to the substrate and the occurrence of some misfit dislocations and vacancies at the interface.Finally,the findings of this research suggest that softening and ASI,even in materials resistant to softening,are required to establish bonding in CS.展开更多
Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and ...Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair.展开更多
Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain cells.The SOX t...Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain cells.The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis,such as maintaining the cell stemness,cell prolife ration,cell fate decisions,and terminal diffe rentiation into neurons and glial cells.MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression.Together with other gene regulatory factors,microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment.The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain.Deregulated SOX/mic roRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies,including neurodegenerative disorders,traumatic brain injury,and cancer.Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neuro restoration.N umerous studies have confirmed complex intera ctions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma.Keeping in mind the crucial roles of SOX genes and microRNAs in neural development,we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions.Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies.展开更多
In this paper we study the extraordinary optical transmission of one-dimensional multi-slits in an ideal metal film.The transmissivity is calculated as a function of various structural parameters.The transmissivity os...In this paper we study the extraordinary optical transmission of one-dimensional multi-slits in an ideal metal film.The transmissivity is calculated as a function of various structural parameters.The transmissivity oscillates,with the period being just the light wavelength,as a function of the spacing between slits.As the number of slits increases,the transmissivity varies in one of three ways.It can increase,attenuate,or remain basically unchanged,depending on the spacing between slits.Each way is in an oscillatory manner.The slit interaction responsible for the oscillating transmission strength that depends on slit spacing is the subject of more detailed investigation.The interaction most intuitively manifests as a current distribution in the metal surface between slits.We find that this current is attenuated in an oscillating fashion from the slit corners to the center of the region between two adjacent slits,and we present a mathematical expression for its waveform.展开更多
Dear Editor, Hepatitis C virus （HCV） is a major cause of chronic liver diseases and hepatocellular carcinoma （HCC） with about 71 million people globally infected. HCV encodes only 10 viral proteins and its replica...Dear Editor, Hepatitis C virus （HCV） is a major cause of chronic liver diseases and hepatocellular carcinoma （HCC） with about 71 million people globally infected. HCV encodes only 10 viral proteins and its replication relies on host proteins. Many host factors including ADP-ribosylation factors （ARFs） have been characterized （Tai et al., 2009; Matto et al., 2011; Zhang et al., 2012; Zhang et al., 2016; Zhou and Zhang, 2016）.展开更多
Neurotransmitter release from presynaptic cells can be recorded by postsynaptic potentials/currents in central nerve system. However, little is known about how to
基金supported by grants from Hainan Seed Laboratory(B21HJ0003)the National Natural Science Foundation of China(U23A20185)the Hainan Excellent Talent Team。
文摘Light and nitrogen(N)are two critically environmental factors essential for plant survival,as they constitute the fundamental molecular framework of plant cells and significantly influence patterns of plant growth and development.Light is the driving force behind photosynthesis,a process that converts light energy into chemical energy stored as sugars.Additionally,light acts as a direct signal that can modulate plant morphogenesis and structural development.Nitrogen,as the most crucial mineral nutrient for plants,is a component of numerous biomolecules.It also functions as a signaling molecule,regulating plant growth and development.Moreover,light and nitrogen directly regulate the balance of carbon(C)and N within plants,affecting numerous biochemical reactions and various physiological processes.This review focuses on the interactions between light and nitrogen in physiological,metabolic,and molecular levels.We will also discuss the regulatory networks and mechanisms through which light and nitrogen influence C and N absorption and metabolism in plants.
基金supported by the Researchers Supporting Project of King Saud University,Riyadh,Saudi Arabia,under Project RSPD2025R681。
文摘In optical metro-access networks,Access Points(APs)and Data Centers(DCs)are located on the fiber ring.In the cloud-centric solution,a large number of Internet of Things(IoT)data pose an enormous burden on DCs,so the Virtual Machines(VMs)cannot be successfully launched due to the server overload.In addition,transferring the data from the AP to the remote DC may cause an undesirable delivery delay.For this end,we propose a promising solution considering the interplay between the cloud DC and edge APs.More specifically,bringing the partial capability of computing in APs close to things can reduce the pressure of DCs while guaranteeing the expected Quality of Service(QoS).In this work,when the cloud DC resource becomes limited,especially for delay sensitive but not computing-dependent IoT applications,we degrade their VMs and migrate them to edge APs instead of the remote DC.To avoid excessive VM degradation and computing offloading,we derive appropriate VM degradation coefficients based on classic microeconomic theory.Simulation results demonstrate that our algorithms improve the service providers'utility with the ratio from 34%to 89%over traditional cloud-centric solutions.
文摘Beyond modern trade tensions and diplomatic milestones,Europe and China’s profound connection stems from a 3,000-year interplay of ideas,goods,and values,shaping their intertwined visions of governance,equality,and societal progress.
基金supported by Henan Province Science and Technology Research and Development(No.242102311176)China Agriculture Research System of MOF and MARA(No.CARS-21)+2 种基金Henan Modern Industrial Technology System of Chinese Herbal Medicine(No.HARS-22-11-Z1)Program for Science&Technology Innovation Talents in Universities of Henan Province(No.23HASTIT045)Henan Province Scientific and Technological Project(No.232102311059)。
文摘Salvia miltiorrhiza(Danshen)is a traditional Chinese herb that is commonly known for its cardiovascular and hepatoprotective benefits.Recent studies have confirmed that Danshen and its bioactive components can influence gut microbial homeostasis,thereby affecting Helicobacter pylori(HP)colonization in the human stomach.HP is a bacterial pathogen associated with various gastrointestinal diseases.Current HP treatments mainly involve antibiotics and proton pump inhibitors.However,their efficacy is strongly compromised by the rapid emergence of antibiotic resistance in HP and genetic heterogeneity among patients.The interaction between Danshen and gut microbial status provides a novel perspective for HP treatment.Understanding the medical properties of Danshen in altering gut microbiota and eliminating HP,as well as the underlying mechanisms,is important for improving human gastrointestinal healthcare.This review investigates the interaction between Danshen and gut microbiota and its impact on HP infection using databases including Web of Science,PubMed,and Google Scholar.We explored the unconventional intersection between Danshen,gut microbiota,and HP infection,shedding light on their intricate interplay and potential therapeutic implications.A comprehensive understanding of this interaction provides valuable insights into developing novel therapeutic strategies that target the gut microbiota to mitigate HP-associated gastrointestinal disorders.
文摘Large interfacial strains in particles are crucial for promoting bonding in cold spraying(CS),initiated either by adiabatic shear instability(ASI)due to softening prevailing over strain hardening or by hydrostatic plasticity,which is claimed to promote bonding even without ASI.A thorough microstructural analysis is vital to fully understand the bonding mechanisms at play during microparticle impacts and throughout the CS process.In this study,the HEA CoCrFeMnNi,known for its relatively high strain hardening and resistance to softening,was selected to investigate the microstructure characteristics and bonding mech-anisms in CS.This study used characterization techniques covering a range of length scales,including electron channeling contrast imaging(ECCI),electron backscatter diffraction(EBSD),and high-resolution transmission microscopy(HR-TEM),to explore the microstructure characteristics of bonding and overall structure development of CoCrFeMnNi microparticles after impact in CS.HR-TEM lamellae were prepared using focused ion beam milling.Additionally,the effects of deformation field variables on microstructure development were determined through finite element modeling(FEM)of microparticle impacts.The ECCI,EBSD,and HR-TEM analyses revealed an interplay between dislocation-driven processes and twinning,leading to the development of four distinct deformation microstructures.Significant grain refinement occurs at the interface through continuous dynamic recrystallization(CDRX)due to high strain and temperature rise from adiabatic deformation,signs of softening,and ASI.Near the interface,a necklace-like structure of refined grains forms around grain boundaries,along with elongated grains,resulting from the coexistence of dynamic recovery and discontinuous dynamic recrystallization(DDRX)due to lower temperature rise and strain.Towards the particle or substrate interior,concurrent twinning and dislocation-mediated mechanisms refine the structure,forming straight,curved,and intersected twins.At the top of the particles,only deformed grains with a low dislocation density are observed.Our results showed that DRX induces microstructure softening in highly strained interface areas,facilitating atomic bonding in CoCrFeMnNi.HR-TEM investigation confirms the formation of atomic bonds between particles and substrate,with a gradual change in crystal lattice orientation from the particle to the substrate and the occurrence of some misfit dislocations and vacancies at the interface.Finally,the findings of this research suggest that softening and ASI,even in materials resistant to softening,are required to establish bonding in CS.
基金supported by grants from the National Institute of Dental and Craniofacial Research, NIH (supported by R01 DE026339)
文摘Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair.
基金the Ministry of Education,Science and Technological Development of the Republic of Serbia(Agreement number 451-03-9/2021-14/200042,to MiS,DSN,MM,DD and MaS)the Serbian Academy of Sciences and Arts(Grant number F24,to MiS(PI),MM,DD and MaS)。
文摘Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain cells.The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis,such as maintaining the cell stemness,cell prolife ration,cell fate decisions,and terminal diffe rentiation into neurons and glial cells.MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression.Together with other gene regulatory factors,microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment.The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain.Deregulated SOX/mic roRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies,including neurodegenerative disorders,traumatic brain injury,and cancer.Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neuro restoration.N umerous studies have confirmed complex intera ctions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma.Keeping in mind the crucial roles of SOX genes and microRNAs in neural development,we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions.Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 11074145,10874124,and 61275028)
文摘In this paper we study the extraordinary optical transmission of one-dimensional multi-slits in an ideal metal film.The transmissivity is calculated as a function of various structural parameters.The transmissivity oscillates,with the period being just the light wavelength,as a function of the spacing between slits.As the number of slits increases,the transmissivity varies in one of three ways.It can increase,attenuate,or remain basically unchanged,depending on the spacing between slits.Each way is in an oscillatory manner.The slit interaction responsible for the oscillating transmission strength that depends on slit spacing is the subject of more detailed investigation.The interaction most intuitively manifests as a current distribution in the metal surface between slits.We find that this current is attenuated in an oscillating fashion from the slit corners to the center of the region between two adjacent slits,and we present a mathematical expression for its waveform.
文摘Dear Editor, Hepatitis C virus （HCV） is a major cause of chronic liver diseases and hepatocellular carcinoma （HCC） with about 71 million people globally infected. HCV encodes only 10 viral proteins and its replication relies on host proteins. Many host factors including ADP-ribosylation factors （ARFs） have been characterized （Tai et al., 2009; Matto et al., 2011; Zhang et al., 2012; Zhang et al., 2016; Zhou and Zhang, 2016）.
文摘Neurotransmitter release from presynaptic cells can be recorded by postsynaptic potentials/currents in central nerve system. However, little is known about how to
