Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms,including anxiety,depression,psychosis,and other mental disorders.Non-invasive neuromodulation is an emerging clinic...Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms,including anxiety,depression,psychosis,and other mental disorders.Non-invasive neuromodulation is an emerging clinical intervention approach,and over the past decade,research on non-invasive neuromodulation aimed at regulating interoception has rapidly developed.This review first outlines the pathways of interoceptive signals and assessment methods,then summarizes the interoceptive abnormalities in psychiatric disorders and current studies for non-invasive neuromodulation targeting interoception,including intervention modes,target sites,interoceptive measures,and potential neurobiological mechanisms.Finally,we discuss significant research challenges and future directions.展开更多
BACKGROUND Interoception dysfunction has an important impact on the onset and development of major depressive disorder(MDD).Social support serves as a protective factor against MDD,and sociability also plays a signifi...BACKGROUND Interoception dysfunction has an important impact on the onset and development of major depressive disorder(MDD).Social support serves as a protective factor against MDD,and sociability also plays a significant role in this condition.These interconnected constructs-social support and sociability-play pivotal roles in MDD.However,no research on the mechanisms underlying the associations be-tween social support and sociability,particularly the potential role of interocep-tion,have been reported.ception,social support,and sociability,respectively.A mediation analysis model for the eight dimensions of intero-ception(noticing,not distracting,not worrying,attention regulation,emotional awareness,self-regulation,body listening,and trust),social support,and sociability were established to evaluate the mediating effects.RESULTS A partial correlation analysis of eight dimensions of the MAIA-2,SSRS,and TSBI scores,with demographic data as control variables,revealed pairwise correlations between the SSRS score and both the MAIA-2 score and TSBI score.In the major depression(MD)group,the SSRS score had a positive direct effect on the TSBI score,while the scores for body listening,emotional awareness,self-regulation,and trust in the MAIA-2C had indirect effects on the TSBI score.In the HC group,the SSRS score had a positive direct effect on the TSBI score,and the scores for attention regulation,emotional awareness,self-regulation,and trust in the MAIA-2C had indirect effects on the TSBI score.The proportion of mediators in the MD group was lower than that in the HC group.CONCLUSION Interoceptive awareness is a mediating factor in the association between social support and sociability in both HCs and depressed patients.Training in interoceptive awareness might not only help improve emotional regulation in depressed patients but also enhance their social skills and support networks.展开更多
Following the discovery of bone as an endocrine organ with systemic influence,bone-brain interaction has emerged as a research hotspot,unveiling complex bidirectional communication between bone and brain.Studies indic...Following the discovery of bone as an endocrine organ with systemic influence,bone-brain interaction has emerged as a research hotspot,unveiling complex bidirectional communication between bone and brain.Studies indicate that bone and brain can influence each other’s homeostasis via multiple pathways,yet there is a dearth of systematic reviews in this area.This review comprehensively examines interactions across three key areas:the influence of bone-derived factors on brain function,the effects of brain-related diseases or injuries(BRDI)on bone health,and the concept of skeletal interoception.Additionally,the review discusses innovative approaches in biomaterial design inspired by bone-brain interaction mechanisms,aiming to facilitate bonebrain interactions through materiobiological effects to aid in the treatment of neurodegenerative and bone-related diseases.Notably,the integration of artificial intelligence(AI)in biomaterial design is highlighted,showcasing AI’s role in expediting the formulation of effective and targeted treatment strategies.In conclusion,this review offers vital insights into the mechanisms of bone-brain interaction and suggests advanced approaches to harness these interactions in clinical practice.These insights offer promising avenues for preventing and treating complex diseases impacting the skeleton and brain,underscoring the potential of interdisciplinary approaches in enhancing human health.展开更多
The insula is a complex brain region central to the orchestration of taste perception,interoception,emotion,and decision-making.Recent research has shed light on the intricate connections between the insula and other ...The insula is a complex brain region central to the orchestration of taste perception,interoception,emotion,and decision-making.Recent research has shed light on the intricate connections between the insula and other brain regions,revealing the crucial role of this area in integrating sensory,emotional,and cognitive information.The unique anatomical position and extensive connectivity allow the insula to serve as a critical hub in the functional network of the brain.We summarize its role in interoceptive and exteroceptive sensory processing,illustrating insular function as a bridge connecting internal and external experiences.Drawing on recent research,we delineate the insular involvement in emotional processes,highlighting its implications in psychiatric conditions,such as anxiety,depression,and addiction.We further discuss the insular contributions to cognition,focusing on its significant roles in time perception and decision-making.Collectively,the evidence underscores the insular function as a dynamic interface that synthesizes diverse inputs into coherent subjective experiences and decision-making processes.Through this review,we hope to highlight the importance of the insula as an interface between sensation,emotion,and cognition,and to inspire further research into this fascinating brain region.展开更多
Objective: The purpose of this study was to elucidate clinical factors influencing quality of life (QOL) in anorexia nervosa (AN) patients. Methods: Twenty female patients with AN (median age = 30.0 years, quartile de...Objective: The purpose of this study was to elucidate clinical factors influencing quality of life (QOL) in anorexia nervosa (AN) patients. Methods: Twenty female patients with AN (median age = 30.0 years, quartile deviation = 6.8) and forty female healthy controls (HC) (median age = 30.0 years, quartile deviation = 8.6) participated in the study. QOL was assessed with the 36-Item Short Form Health Survey (SF-36) and social support was evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS). Clinical symptoms were evaluated with the Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D) and the Eating Disorder Inventory-2 (EDI-2). Results: Scores of the SF-36 Mental Component Summary (MCS) (U = 124.0, P U = 223.0, P = 0.006) and scores of total (U = 108.0, P < 0.0001) and subscales of the MSPSS were lower in AN group than HC group, and the SIGH-D score was higher (U = 46.0, P ρ = −0.565, P < 0.05) and subscales of the EDI-2 Interoceptive Confusion (ρ = −0.556, P ρ = −0.581, P ρ = −0.617, P < 0.05) were negatively correlated to MCS, and score of Interoceptive Confusion subscale showed a negative correlation to RCS (ρ = −0.672, P < 0.05). Moreover, stepwise regression analysis showed that the SIGH-D score was an independent predictor of MCS and Interoceptive Confusion score predicted RCS. Conclusion: These results suggest that among a variety of clinical symptoms and psychopathologies, depressive symptoms, poor emotional awareness and impaired sense of control are the most important influencing factors on AN patients’ QOL.展开更多
Bone tissue is richly innervated,and the influence of the nervous system on the physiological and pathological status of bone tissue has emerged as a significant research focus.The recent discovery of the skeletal int...Bone tissue is richly innervated,and the influence of the nervous system on the physiological and pathological status of bone tissue has emerged as a significant research focus.The recent discovery of the skeletal interoceptive circuits further emphasizes the crucial role of the central nervous system in the control of bone homeostasis.Skeletal interoception represents one of the most intricate mechanisms in the human body for maintaining bone homeostasis,as it involves the orchestrated efforts of skeletal,nervous,immune,and endocrine systems.In this review,we comprehensively introduce the three primary components of the skeletal interoceptive circuitry,including the ascending pathways that perceive and convey signals to the central nervous system,the central neural pathways that process and interpret these signals,and the descending pathways that mediate the regulatory effects on bone tissue.We also discuss how innovative therapeutic strategies can be developed to modulate bone homeostasis by leveraging the most updated findings on skeletal interoceptive circuitry.We anticipate that the application of knowledge on skeletal interoception will lead to a paradigm shift in the field of orthopaedics and biomaterials.展开更多
基金supported by grants from the National Natural Science Foundation of China(82101582)the Shanghai Science and Technology Committee(22Y11903600 and 23Y11906000)the Shanghai Municipal Health Commission(202240266).
文摘Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms,including anxiety,depression,psychosis,and other mental disorders.Non-invasive neuromodulation is an emerging clinical intervention approach,and over the past decade,research on non-invasive neuromodulation aimed at regulating interoception has rapidly developed.This review first outlines the pathways of interoceptive signals and assessment methods,then summarizes the interoceptive abnormalities in psychiatric disorders and current studies for non-invasive neuromodulation targeting interoception,including intervention modes,target sites,interoceptive measures,and potential neurobiological mechanisms.Finally,we discuss significant research challenges and future directions.
基金Supported by the Wuxi Municipal Health Commission Major Project,No.202107.
文摘BACKGROUND Interoception dysfunction has an important impact on the onset and development of major depressive disorder(MDD).Social support serves as a protective factor against MDD,and sociability also plays a significant role in this condition.These interconnected constructs-social support and sociability-play pivotal roles in MDD.However,no research on the mechanisms underlying the associations be-tween social support and sociability,particularly the potential role of interocep-tion,have been reported.ception,social support,and sociability,respectively.A mediation analysis model for the eight dimensions of intero-ception(noticing,not distracting,not worrying,attention regulation,emotional awareness,self-regulation,body listening,and trust),social support,and sociability were established to evaluate the mediating effects.RESULTS A partial correlation analysis of eight dimensions of the MAIA-2,SSRS,and TSBI scores,with demographic data as control variables,revealed pairwise correlations between the SSRS score and both the MAIA-2 score and TSBI score.In the major depression(MD)group,the SSRS score had a positive direct effect on the TSBI score,while the scores for body listening,emotional awareness,self-regulation,and trust in the MAIA-2C had indirect effects on the TSBI score.In the HC group,the SSRS score had a positive direct effect on the TSBI score,and the scores for attention regulation,emotional awareness,self-regulation,and trust in the MAIA-2C had indirect effects on the TSBI score.The proportion of mediators in the MD group was lower than that in the HC group.CONCLUSION Interoceptive awareness is a mediating factor in the association between social support and sociability in both HCs and depressed patients.Training in interoceptive awareness might not only help improve emotional regulation in depressed patients but also enhance their social skills and support networks.
基金financially supported by the Basic Science Center Program(T2288102)the Key Program of the National Natural Science Foundation of China(32230059)+3 种基金the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry(JKVD1211002)the Project supported by the Young Scientists Fund of the National Natural Science Foundation of China(32401128)Postdoctoral Fellowship Program of CPSF(GZC20230793)Shanghai Post-doctoral Excellence Program(2023251).
文摘Following the discovery of bone as an endocrine organ with systemic influence,bone-brain interaction has emerged as a research hotspot,unveiling complex bidirectional communication between bone and brain.Studies indicate that bone and brain can influence each other’s homeostasis via multiple pathways,yet there is a dearth of systematic reviews in this area.This review comprehensively examines interactions across three key areas:the influence of bone-derived factors on brain function,the effects of brain-related diseases or injuries(BRDI)on bone health,and the concept of skeletal interoception.Additionally,the review discusses innovative approaches in biomaterial design inspired by bone-brain interaction mechanisms,aiming to facilitate bonebrain interactions through materiobiological effects to aid in the treatment of neurodegenerative and bone-related diseases.Notably,the integration of artificial intelligence(AI)in biomaterial design is highlighted,showcasing AI’s role in expediting the formulation of effective and targeted treatment strategies.In conclusion,this review offers vital insights into the mechanisms of bone-brain interaction and suggests advanced approaches to harness these interactions in clinical practice.These insights offer promising avenues for preventing and treating complex diseases impacting the skeleton and brain,underscoring the potential of interdisciplinary approaches in enhancing human health.
基金supported by grants from the National Natural Science Foundation of China(32371060 and 32271065)the Lingang Laboratory(LG-QS-202203-06 and LG-QS-202203-02)the Chinese Academy of Sciences,and Benyuan Charity Foundation.
文摘The insula is a complex brain region central to the orchestration of taste perception,interoception,emotion,and decision-making.Recent research has shed light on the intricate connections between the insula and other brain regions,revealing the crucial role of this area in integrating sensory,emotional,and cognitive information.The unique anatomical position and extensive connectivity allow the insula to serve as a critical hub in the functional network of the brain.We summarize its role in interoceptive and exteroceptive sensory processing,illustrating insular function as a bridge connecting internal and external experiences.Drawing on recent research,we delineate the insular involvement in emotional processes,highlighting its implications in psychiatric conditions,such as anxiety,depression,and addiction.We further discuss the insular contributions to cognition,focusing on its significant roles in time perception and decision-making.Collectively,the evidence underscores the insular function as a dynamic interface that synthesizes diverse inputs into coherent subjective experiences and decision-making processes.Through this review,we hope to highlight the importance of the insula as an interface between sensation,emotion,and cognition,and to inspire further research into this fascinating brain region.
文摘Objective: The purpose of this study was to elucidate clinical factors influencing quality of life (QOL) in anorexia nervosa (AN) patients. Methods: Twenty female patients with AN (median age = 30.0 years, quartile deviation = 6.8) and forty female healthy controls (HC) (median age = 30.0 years, quartile deviation = 8.6) participated in the study. QOL was assessed with the 36-Item Short Form Health Survey (SF-36) and social support was evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS). Clinical symptoms were evaluated with the Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D) and the Eating Disorder Inventory-2 (EDI-2). Results: Scores of the SF-36 Mental Component Summary (MCS) (U = 124.0, P U = 223.0, P = 0.006) and scores of total (U = 108.0, P < 0.0001) and subscales of the MSPSS were lower in AN group than HC group, and the SIGH-D score was higher (U = 46.0, P ρ = −0.565, P < 0.05) and subscales of the EDI-2 Interoceptive Confusion (ρ = −0.556, P ρ = −0.581, P ρ = −0.617, P < 0.05) were negatively correlated to MCS, and score of Interoceptive Confusion subscale showed a negative correlation to RCS (ρ = −0.672, P < 0.05). Moreover, stepwise regression analysis showed that the SIGH-D score was an independent predictor of MCS and Interoceptive Confusion score predicted RCS. Conclusion: These results suggest that among a variety of clinical symptoms and psychopathologies, depressive symptoms, poor emotional awareness and impaired sense of control are the most important influencing factors on AN patients’ QOL.
基金Innovation and Technology Fund,Grant/Award Number:ITS/256/22,Shenzhenthe support fromthe Research Grants Council,the Government of the HongKong SAR(Collaborative Research Fund No.C7003-22Yto W.Q.)+5 种基金the Food and Health Bureau,the Government ofthe Hong Kong SAR(No.09201466 to W.Q.)NationalNatural Science Foundation of China(No.82201124to W.Q.)National Natural Science Foundation of China/Research Grants Council Joint Research Scheme(N_HKU721/23 to W.Q.)Hong Kong Innovation Tech-nology Fund(ITS/256/22 to W.Q.)Shenzhen Scienceand Technology Innovation Committee Projects(Nos.SGDX20220530111405038,W.Q.)Guangdong Basic andApplied Basic Research Foundation(2023A1515011963,W.Q.)。
文摘Bone tissue is richly innervated,and the influence of the nervous system on the physiological and pathological status of bone tissue has emerged as a significant research focus.The recent discovery of the skeletal interoceptive circuits further emphasizes the crucial role of the central nervous system in the control of bone homeostasis.Skeletal interoception represents one of the most intricate mechanisms in the human body for maintaining bone homeostasis,as it involves the orchestrated efforts of skeletal,nervous,immune,and endocrine systems.In this review,we comprehensively introduce the three primary components of the skeletal interoceptive circuitry,including the ascending pathways that perceive and convey signals to the central nervous system,the central neural pathways that process and interpret these signals,and the descending pathways that mediate the regulatory effects on bone tissue.We also discuss how innovative therapeutic strategies can be developed to modulate bone homeostasis by leveraging the most updated findings on skeletal interoceptive circuitry.We anticipate that the application of knowledge on skeletal interoception will lead to a paradigm shift in the field of orthopaedics and biomaterials.
