Doxorubicin（DOX） loaded poly（lactic-co-glycolic acid）（PLGA） microparticles with internal pores（MP-D） were developed for long-acting release in pulmonary inhalation treatment. The PLGA microparticles exhibited ...Doxorubicin（DOX） loaded poly（lactic-co-glycolic acid）（PLGA） microparticles with internal pores（MP-D） were developed for long-acting release in pulmonary inhalation treatment. The PLGA microparticles exhibited favorable aerodynamic properties for pulmonary delivery. In vitro drug release profile suggested that MP-D have the advantage of long-term maintenance of drug concentrations. MTT assay demonstrated the in vitro anti-tumor efficiency of the DOX loaded PLGA microparticles. Furthermore, melanoma lung metastasis model was established to determine the in vivo antitumor efficiency. The mice treated with MP-D showed significantly fewer lesions than the untreated ones. The survival analysis indicated that MP-D prolonged the survival time of tumor-bearing mice. These results suggested that DOX loaded PLGA microparticles with internal pores have the potential to be used as long-acting release carriers in clinical lung cancer treatment.展开更多
Calcareous sand is typically known as a problematic marine sediment because of its diverse morphology and complex inner pore structure.However,the coupling effects of morphology and inner pores on the mechanical prope...Calcareous sand is typically known as a problematic marine sediment because of its diverse morphology and complex inner pore structure.However,the coupling effects of morphology and inner pores on the mechanical properties of calcareous sand particles have rarely been investigated and understood.In this study,apparent contours and internal pore distributions of calcareous sand particles were obtained by three-dimensional(3D)scanning imaging and X-ray micro-computed tomography(X-mCT),respectively.It was revealed that calcareous sand particles with different outer morphologies have different porosities and inner pore distributions because of their original sources and particle transport processes.In addition,a total of 120 photo-related compression tests and 4923D discrete element simulations of four specific shaped particles,i.e.bulky,angular,dendritic and flaky,with variations in the inner pore distribution were conducted.The macroscopic particle strength and Weibull modulus obtained from the physical tests are not positively correlated with the porosity or regularity in shape,indicating the existence of coupling effect of particle shape and pore distribution.The shape effect on the particle strength first increases with the porosity and then decreases.The particle crushing of relatively regular particles is governed by the porosity,but that of extremely irregular particles is governed by the particle shape.The particle strength increases with the uniformity of the pore distribution.Particle fragmentation is mainly dependant on tensile bond strength,and the degree of tensile failure is considerably impacted by the particle shape but limited by the pore distribution.展开更多
The wave-seabed interaction issue is of great importance for the design of foundation around marine infrastructures. Most previous investigations for such a problem have been limited to uncoupled or one- way coupled m...The wave-seabed interaction issue is of great importance for the design of foundation around marine infrastructures. Most previous investigations for such a problem have been limited to uncoupled or one- way coupled methods connecting two separated wave and seabed sub models with the continuity of pressures at the seabed surface. In this study, a strongly coupled model was proposed to realize both wave and seabed processes in a same program and to calculate the wave fields and seabed response simultaneously. The information between wave fields and seabed fields were strongly shared and thus results in a more profound investigation of the mechanism of the wave-seabed interaction. In this letter, the wave and seabed models were validated with previous experimental tests. Then, a set of application of present model were discussed in prediction of the wave-induced seabed response. Numerical results show the wave-induced liquefaction area of coupled model is smaller than that of uncoupled model.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.51222307,51303173,51390480,21474104 and 51403205)the Ministry of Science and Technology of China(International cooperation and communication program 2011DFR51090)Jilin Province Science and Technology Development Program(Nos.20120306,20130521011JH)
文摘Doxorubicin（DOX） loaded poly（lactic-co-glycolic acid）（PLGA） microparticles with internal pores（MP-D） were developed for long-acting release in pulmonary inhalation treatment. The PLGA microparticles exhibited favorable aerodynamic properties for pulmonary delivery. In vitro drug release profile suggested that MP-D have the advantage of long-term maintenance of drug concentrations. MTT assay demonstrated the in vitro anti-tumor efficiency of the DOX loaded PLGA microparticles. Furthermore, melanoma lung metastasis model was established to determine the in vivo antitumor efficiency. The mice treated with MP-D showed significantly fewer lesions than the untreated ones. The survival analysis indicated that MP-D prolonged the survival time of tumor-bearing mice. These results suggested that DOX loaded PLGA microparticles with internal pores have the potential to be used as long-acting release carriers in clinical lung cancer treatment.
基金the Fundamental Research Funds for the Central Universities,China(Grant No.B210203032)the National Natural Science Foundation of China(Grant No.52279097)the Green and Blue Project of Jiangsu Province,China.
文摘Calcareous sand is typically known as a problematic marine sediment because of its diverse morphology and complex inner pore structure.However,the coupling effects of morphology and inner pores on the mechanical properties of calcareous sand particles have rarely been investigated and understood.In this study,apparent contours and internal pore distributions of calcareous sand particles were obtained by three-dimensional(3D)scanning imaging and X-ray micro-computed tomography(X-mCT),respectively.It was revealed that calcareous sand particles with different outer morphologies have different porosities and inner pore distributions because of their original sources and particle transport processes.In addition,a total of 120 photo-related compression tests and 4923D discrete element simulations of four specific shaped particles,i.e.bulky,angular,dendritic and flaky,with variations in the inner pore distribution were conducted.The macroscopic particle strength and Weibull modulus obtained from the physical tests are not positively correlated with the porosity or regularity in shape,indicating the existence of coupling effect of particle shape and pore distribution.The shape effect on the particle strength first increases with the porosity and then decreases.The particle crushing of relatively regular particles is governed by the porosity,but that of extremely irregular particles is governed by the particle shape.The particle strength increases with the uniformity of the pore distribution.Particle fragmentation is mainly dependant on tensile bond strength,and the degree of tensile failure is considerably impacted by the particle shape but limited by the pore distribution.
基金supported by the National Natural Science Foundation of China(41176073)
文摘The wave-seabed interaction issue is of great importance for the design of foundation around marine infrastructures. Most previous investigations for such a problem have been limited to uncoupled or one- way coupled methods connecting two separated wave and seabed sub models with the continuity of pressures at the seabed surface. In this study, a strongly coupled model was proposed to realize both wave and seabed processes in a same program and to calculate the wave fields and seabed response simultaneously. The information between wave fields and seabed fields were strongly shared and thus results in a more profound investigation of the mechanism of the wave-seabed interaction. In this letter, the wave and seabed models were validated with previous experimental tests. Then, a set of application of present model were discussed in prediction of the wave-induced seabed response. Numerical results show the wave-induced liquefaction area of coupled model is smaller than that of uncoupled model.
