A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that th...A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior.展开更多
An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease prog...An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in PD.Repetitive transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's disease.However,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain unknown.The purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated signaling.Animals with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod test.Immunoblot,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate putamen.Prolonged intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate putamen.Treatment with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor symptoms.After treatment with prolonged intermittent theta burst stimulation,complete motor recovery was observed.This improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst stimulation.Our results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)R.Intermittent theta burst stimulation reversed these effects by restoring the abundances of A_(1)R and A_(2A)R to control levels.The shift in ARs expression likely restored the balance between dopamine-adenosine signaling,ultimately leading to the recovery of motor control.展开更多
BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To e...BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To evaluate the outcomes of 5-ASA withdrawal due to non-adherence in UC patients while in remission on monotherapy.METHODS Adult patients with UC who were followed up between July 2019 and April 2025 were screened.Patients in remission receiving 5-ASA monotherapy who experienced treatment withdrawal due to non-adherence were included in this study.RESULTS Among 880 patients with UC,30(3.4%)had 5-ASA withdrawal due to nonadherence while in remission on monotherapy.Twelve patients(40%)had disease relapse after a median of 20 months.The rate of patients in remission was 89%in the first year,decreasing to 73%in the second year,and to 64%in the third year.There were no significant differences between patients with and without relapse in terms of demographics,disease extent,remission duration before 5-ASA withdrawal,previous medications,steroid dependence,5-ASA formulation,baseline inflammatory markers,or partial and endoscopic Mayo scores.Most patients(75%)who experienced relapse were successfully treated with 5-ASA monotherapy,while one-fourth of them required corticosteroids.No patients required biologic agents,hospitalization,or surgical intervention.CONCLUSION Intermittent therapy may be safe and feasible for UC patients,especially those in long-term remission,with treatment interruption up to one year considered acceptable.展开更多
In this work, we address the codiagnosability analysis problem of a networked discrete event system under malicious attacks. The considered system is modeled by a labeled Petri net and is monitored by a series of site...In this work, we address the codiagnosability analysis problem of a networked discrete event system under malicious attacks. The considered system is modeled by a labeled Petri net and is monitored by a series of sites, in which each site possesses its own set of sensors, without requiring communication among sites or to any coordinators. A net is said to be codiagnosable with respect to a fault if at least one site could deduce the occurrence of this fault within finite steps. In this context, we focus on a type of malicious attack that is called stealthy intermittent replacement attack. The stealthiness demands that the corrupted observations should be consistent with the system's normal behavior, while the intermittent replacement setting entails that the replaced transition labels must be recovered within a bounded of consecutive corrupted observations(called as K-corruption intermittent attack). Particularly, there exists a coordination between attackers that are separately effected on different sites, which holds the same corrupted observation for each common transition under attacks. From an attacker viewpoint, this work aims to design Kcorruption intermittent attacks for violating the codiagnosability of systems. For this purpose, we propose an attack automaton to analyze K-corruption intermittent attack for each site, and build a new structure called complete attack graph that is used to analyze all the potential attacked paths. Finally, an algorithm is inferred to obtain the K-corruption intermittent attacks, and examples are given to show the proposed attack strategy.展开更多
To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective dis...To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective disorders in children and adolescents,with major depressive disorder(MDD)at 2.00%and bipolar disorder at 0.86%.展开更多
BACKGROUND Intermittent fasting(IF),particularly time-restricted feeding(TRF),is increasingly popular has gained popularity for weight loss,yet management,but its effects impact on gut health remain unclear.Remains in...BACKGROUND Intermittent fasting(IF),particularly time-restricted feeding(TRF),is increasingly popular has gained popularity for weight loss,yet management,but its effects impact on gut health remain unclear.Remains inadequately understood.This study explores how investigated the effects of TRF effects on intestinal health and explored the underlying mechanisms.AIM To assess the effects of IF on intestinal health,elucidate the mechanisms involved.METHODS Mice were divided into two groups:Normal control(NC)and IF.The IF group underwent TRF,while the NC group had unrestricted access to food.Body weight,fecal characteristics,and intestinal morphology were analyzed.Colon tissue,serum,and fecal samples were collected for histological analysis,enzymelinked immunosorbent assay,flow cytometry,16S rRNA sequencing,and metabolomic profiling.RESULTS IF significantly affected body weight and intestinal morphology,compromised the intestinal barrier,increased pro-inflammatory cytokines,and heightened gut immune activation(P<0.05).It also disrupted the gut microbiota,promoting proinflammatory bacteria,reducing anti-inflammatory metabolites,and elevating pro-inflammatory metabolites(P<0.05).Indoleacrylic acid(IAA)supplementation notably alleviated intestinal inflammation and reversed immune dysfunction induced by IF(P<0.05).CONCLUSION Prolonged IF exacerbates intestinal inflammation by impairing gut barrier integrity and disrupting microbial homeostasis.However,IAA supplementation effectively mitigates fasting-induced intestinal inflammation and immune imbalance,suggesting its potential as a therapeutic agent.展开更多
Objective:A complex relationship exists between obstructive sleep apnea syndrome and diabetes mellitus(DM).Chronic intermittent hypoxia(CIH),which is a core pathological feature of obstructive sleep apnea syndrome,may...Objective:A complex relationship exists between obstructive sleep apnea syndrome and diabetes mellitus(DM).Chronic intermittent hypoxia(CIH),which is a core pathological feature of obstructive sleep apnea syndrome,may play an important role in the onset and development of DM-related atherosclerosis(DM-AS).This study aimed to investigate the mechanism of action of tetramethylpyrazine(TMP)in CIH-associated DM-AS.Methods:In vivo,a DM-AS mouse model was established by intraperitoneal injection of streptozotocin combined with a high-fat diet.They were exposed to CIH or normoxic conditions for 8 weeks and received different doses of TMP,rosuvastatin,toyocamycin,and purified water.Glycolipid metabolism,inflammation levels,degree of aortic AS,and expression levels of endoplasmic reticulum stress(ERS)and autophagy proteins were examined in mice.In vitro,human umbilical vein endothelial cells(HUVECs)were treated with high glucose and fat in combination with insulin to establish an insulin-resistant cell model(HUVEC-IR).After pretreatment with 4μ8C(IRE1 inhibitor)and different doses of TMP,intermittent hypoxic intervention was performed.Changes in cell morphology,proliferative activity,glucose consumption,and ability to migrate were observed,and the expression levels of ERS and autophagy proteins were detected.Results:In vivo experiments showed that CIH significantly increased blood glucose levels and Homeostasis Model Assessment of Insulin Resistance(HOMA-IR)(P<0.001 or P<0.05),low-density lipoprotein cholesterol(LDL-C)content(P<0.001),and the levels of three inflammatory factors[interleukin-1 beta(IL-1β),IL-6,and tumor necrosis factor-alpha(TNF-α)]in the mice(P<0.001)compared with those of the mice with DM alone;moreover,the aortic atherosclerotic(AS)plaque area in CIH mice was significantly enlarged(P<0.001).Western blotting results showed that the expressions of aortic IRE1α,XBP1s,Beclin1,and LC3A proteins were significantly increased in CIH mice compared with DM mice(P<0.05).After treatment with different doses of TMP,rosuvastatin calcium,and toyocamycin,serum inflammation and lipid levels and plaque area were significantly reduced in mice(P<0.001 and P<0.001,respectively).The expression levels of aortic XBP1s,Beclin1,and LC3A were reduced in TMP-and toyocamycin-treated mice(P<0.05).In the in vitro experiments,compared with normoxic cells,the cells treated with intermittent hypoxia(IH)showed a significant decrease in cell migration distance(P<0.05),a significant increase in apoptosis rate(P<0.001),a substantial increase in proliferation inhibition rate(P<0.001),a significant increase in the levels of XBP1s and LC3A proteins(P<0.05),and an increase in the number of autophagic vesicles/lysosomes,as observed under transmission electron microscopy.After treatment with different doses of TMP and 4μ8C,cell morphology was significantly restored,apoptosis rate significantly reduced(P<0.001),and XBP1s,Beclin1,and LC3A expressions significantly inhibited(P<0.05).Conclusion:CIH promoted the onset of DM-AS,whereas TMP attenuated ERS and excessive autophagy by modulating the IRE1α-XBP1 signaling pathway and inhibiting XBP1 splicing,thereby ameliorating DM-AS exacerbated by CIH.展开更多
Red clay,widely used as a subgrade material in southern China,requires a reliable evaluation of its dynamic behavior to ensure infrastructure safety.Long-term cyclic triaxial tests were conducted on red clay from typi...Red clay,widely used as a subgrade material in southern China,requires a reliable evaluation of its dynamic behavior to ensure infrastructure safety.Long-term cyclic triaxial tests were conducted on red clay from typical,complex subway subgrades to investigate its dynamic properties and shakedown behavior under intermittent cyclic loading.Results show that intermittent cyclic loading,especially with multiple amplitudes,causes greater axial plastic strain and lower post-cyclic strength than continuous loading.These effects diminish with increasing confining pressure.Notably,axial strain partially recovers during loading intervals,with recovery ratios depending on the number and sequence of pauses.Based on the rules of cumulative plastic strain rates and cumulative plastic strain increments,shakedown behavior for red clay under intermittent cyclic loading is divided into three categories:plastic shakedown,critical shakedown,and plastic creep.A quantitative shakedown limit criterion is proposed using the Boltzmann function.Shakedown behavior significantly influences the post-cyclic strengths,and the influence diminishes as confining pressure increases.Samples exhibiting plastic creep and plastic shakedown behavior have the lowest and highest strengths,and those with critical shakedown behaviors have medium strengths.Cyclic loading with relatively low-stress amplitude causes a hardening effect,while cyclic loading intermittence or cyclic loading with relatively high-stress amplitude causes a degradation effect,and both effects are mitigated by higher confining pressures.展开更多
Electrochemical nitrite(NO_(2)^(−))reduction offers a sustainable route for ammonia(NH_(3))synthesis while simultaneously removing contaminants in wastewater.However,its efficiency is often limited by low catalytic ef...Electrochemical nitrite(NO_(2)^(−))reduction offers a sustainable route for ammonia(NH_(3))synthesis while simultaneously removing contaminants in wastewater.However,its efficiency is often limited by low catalytic efficiency and the competitive hydrogen evolution reaction at low NO_(2)^(−)concentrations.Herein,we report an intermittent pulsed electrolysis(IPE)strategy using copper oxide(Cu_(x)O)nanowires,which significantly enhances the NH3 yield rate and Faradaic efficiency(FE)at lower reactant concentrations.In situ experiments and theoretical calculations reveal that alternating between open-circuit and cathodic potentials modulates the copper oxidation states,stabilizing the catalytically active cuprous oxide(Cu_(2)O).Consequently,the IPE approach provides an outstanding NH3 yield rate of 115.10 mg·h^(−1)·cm^(−2)and FE of 91.14%in the presence of 25 mM NO_(2)^(−),markedly outperforming conventional constant potential electrolysis.展开更多
In this study,we consider a single-link flexible manipulator in the presence of an unknown Bouc-Wen type of hysteresis and intermittent actuator faults.First,an inverse hysteresis dynamics model is introduced,and then...In this study,we consider a single-link flexible manipulator in the presence of an unknown Bouc-Wen type of hysteresis and intermittent actuator faults.First,an inverse hysteresis dynamics model is introduced,and then the control input is divided into an expected input and an error compensator.Second,a novel adaptive neural network-based control scheme is proposed to cancel the unknown input hysteresis.Subsequently,by modifying the adaptive laws and local control laws,a fault-tolerant control strategy is applied to address uncertain intermittent actuator faults in a flexible manipulator system.Through the direct Lyapunov theory,the proposed scheme allows the state errors to asymptotically converge to a specified interval.Finally,the effectiveness of the proposed scheme is verified through numerical simulations and experiments.展开更多
This paper examines the role of traumatic bonding in Anita Brookner’s novel Providence.Through the perspective of traumatic bonding theory,this paper explores the true nature of the relationship between Kitty Maule a...This paper examines the role of traumatic bonding in Anita Brookner’s novel Providence.Through the perspective of traumatic bonding theory,this paper explores the true nature of the relationship between Kitty Maule and Maurice Bishop.The paper analyzes the intermittent cycles of affection and neglect that characterize their interactions,highlighting how Bishop’s emotional detachment and sporadic gestures of warmth create a power imbalance that traps Kitty in a cycle of idealization and disillusionment.Drawing on the work of Dutton and Painter(1981)on traumatic bonding,the paper explores how Kitty’s emotional dependence on Maurice mirrors the patterns found in emotionally abusive relationships,revealing how the traumatic bond between Kitty and Bishop shapes her journey toward self-growth.展开更多
Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present so...Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.展开更多
The potentiostatic intermittent titration technique(PITT)is widely used to determine the diffusion coefficient of ions in electrode materials for rechargeable batteries such as lithium-ion or sodium-ion batteries,pred...The potentiostatic intermittent titration technique(PITT)is widely used to determine the diffusion coefficient of ions in electrode materials for rechargeable batteries such as lithium-ion or sodium-ion batteries,predicated on the assumption that the insertion/extraction of ions in the host materials is governed by diffusion.However,in practical scenarios,the electrochemical process might be dominated by interfacial reaction kinetics rather than diffusion.The present work derives analytical equations for electric current by considering the finite interfacial reaction kinetics and small overpotentials during PITT measurements and further studies the chemical stress field induced by the interfacial reaction-controlled ion insertion.The exchange current density(j_(0))can be ascertained using the analytical equation,which dictates the magnitude and decay rate of the electric current during a PITT process.The electric current decays more rapidly,and consequently,the lithium concentration reaches equilibrium faster for larger values of j_(0).The magnitude of the chemical stress is independent of j_(0) but depends on the overpotential.展开更多
Continuous control protocols are extensively utilized in traditional MASs,in which information needs to be transmitted among agents consecutively,therefore resulting in excessive consumption of limited resources.To de...Continuous control protocols are extensively utilized in traditional MASs,in which information needs to be transmitted among agents consecutively,therefore resulting in excessive consumption of limited resources.To decrease the control cost,based on ISC,several LFC problems are investigated for second-order MASs without and with time delay,respectively.Firstly,an intermittent sampled controller is designed,and a sufficient and necessary condition is derived,under which state errors between the leader and all the followers approach zero asymptotically.Considering that time delay is inevitable,a new protocol is proposed to deal with the time-delay situation.The error system’s stability is analyzed using the Schur stability theorem,and sufficient and necessary conditions for LFC are obtained,which are closely associated with the coupling gain,the system parameters,and the network structure.Furthermore,for the case where the current position and velocity information are not available,a distributed protocol is designed that depends only on the sampled position information.The sufficient and necessary conditions for LFC are also given.The results show that second-order MASs can achieve the LFC if and only if the system parameters satisfy the inequalities proposed in the paper.Finally,the correctness of the obtained results is verified by numerical simulations.展开更多
A recent article highlighted the hepatic benefits of intermittent fasting,particularly during Ramadan.However,the rising use of glucagon-like peptide-1(GLP-1)/glucose-dependent insulinotropic polypeptide(GIP)receptor ...A recent article highlighted the hepatic benefits of intermittent fasting,particularly during Ramadan.However,the rising use of glucagon-like peptide-1(GLP-1)/glucose-dependent insulinotropic polypeptide(GIP)receptor agonists(RAs)is altering public behavior,leading to decreased interest in diet and exercise.With a focus on hepatic health,we analyzed global search trends using Google Trends™data from January 1,2022 to December 31,2024,focusing on the keywords"fasting","intermittent fasting","diet","nutrition","liver",Semaglutide("Ozempic"™,the most widely known GLP-1 RA)and Tirzepatide("Mounjaro"™,a newer dual GLP-1 and GIP RA).Search interest for"intermittent fasting"and"diet"showed a significant decline over time(Spearman's rho:-0.582 and-0.605,respectively,both P<0.001),while interest in"fasting"and"nutrition"remained stable.Search interest for Semaglutide,Tirzepatide,"fasting and liver","diet and liver"and Semaglutide and"liver"increased(Spearman's rho:+0.914,+0.936,+0.369,+0.297 and+0.808,respectively,all P<0.001).These findings suggest a trend of shifting away from traditional dieting toward broader health concerns,likely influenced by the increasing use of GLP-1/GIP RAs.展开更多
With the proposed carbon-neutrality targets,intermittent renewable energy will become increasingly significant for the power sector in the future.It is vital to study its development paths,particularly for wind power ...With the proposed carbon-neutrality targets,intermittent renewable energy will become increasingly significant for the power sector in the future.It is vital to study its development paths,particularly for wind power and photovoltaics,while considering constraints on diffusion potential.Using learning curves,dynamic programming,and Bass models,this study analyzes technological diffusion trends to determine the most cost-effective development route for intermittent renewable energy power generation in China by 2060.This study simplifies reality by examining the individual diffusion processes of wind and photovoltaic power,focusing on the self-diffusion characteristics of the two technologies.The study assumes that self-diffusion is the primary driver of future development and describe the influence of multiple factors.The study finds that supportive policies are key drivers of development in the early stages of intermittent renewable energy deployment,especially for photovoltaics.The current diffusion scale of photovoltaics has a greater positive impact on its future development than that of wind power due to lower costs.In the long term,the phased goal for 2030 is projected to be met ahead of schedule,and the majority of future intermittent renewable energy output is expected to come from photovoltaics.The rapid development phases of photovoltaic and wind power conclude at similar times,but the maximum diffusion potential of photovoltaics is higher than that of wind power.Investment constraints and technological levels affect the initial and middle phases of the development path,but their effects are limited.The capacity of the power grid remains the key constraint in the entire research field.展开更多
This paper study the finite time internal synchronization and the external synchronization(hybrid synchronization)for duplex heterogeneous complex networks by time-varying intermittent control.There few study hybrid s...This paper study the finite time internal synchronization and the external synchronization(hybrid synchronization)for duplex heterogeneous complex networks by time-varying intermittent control.There few study hybrid synchronization of heterogeneous duplex complex networks.Therefore,we study the finite time hybrid synchronization of heterogeneous duplex networks,which employs the time-varying intermittent control to drive the duplex heterogeneous complex networks to achieve hybrid synchronization in finite time.To be specific,the switch frequency of the controllers can be changed with time by devise Lyapunov function and boundary function,the internal synchronization and external synchronization are achieved simultaneously in finite time.Finally,numerical examples are presented to illustrate the validness of theoretical results.展开更多
AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions.METHODS:This was a prospective observational study.We evaluated the control ab...AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions.METHODS:This was a prospective observational study.We evaluated the control ability of intermittent exotropia(IXT)patients in three conditions:natural 2D optotype viewing,2D optotype viewing with polarized glasses,and 3D optotype viewing with polarized glasses.Recording with a smartphone,we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking fusion.Additionally,the correlation of stereopsis were also analyzed.RESULTS:A total of 48 patients(age range:4-33y;54.17%male)participated in the study.When viewing 3D optotypes with polarized glasses,their median control scores were 1(interquartile range,0-4)at distance and 0(0-1)at near.These scores were significantly better than those observed under natural viewing conditions,which were 2.5(1-5)at a distance and 1(0-3)at near(Friedman test,P=0.049).Furthermore,those subjects who exhibited exophoria(realignment within 2 seconds)while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision(Kendall’sτb=-0.344,P=0.018).CONCLUSION:IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes,notably improving realignment capabilities.This expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.展开更多
Four-Wheel Independent Steering(4WIS)Vehicles can independently control the angle of each wheel,demonstrating superior trajectory tracking performance under normal conditions.However,on intermittent icy and snowy road...Four-Wheel Independent Steering(4WIS)Vehicles can independently control the angle of each wheel,demonstrating superior trajectory tracking performance under normal conditions.However,on intermittent icy and snowy roads,the presence of time-varying adhesion coefficients,time-varying cornering stiffness,and the irregularities due to ice and snow accumulation introduce multiple uncertainties into the steering system,significantly degrading the trajectory tracking performance of 4WIS vehicles.In response,this paper proposes a robust Tube Model Predictive Control(Tube-MPC)trajectory tracking control method for 4WIS.In this method,a Bi-directional Long Short-Term Memory neural network is established for online estimation of tire cornering stiffness under different road adhesion coefficients,providing accurate estimation of time-varying cornering stiffness for each wheel to mitigate the uncertainties of time-varying adhesion coefficients and cornering stiffness.Additionally,considering the road irregularities caused by snow accumulation on intermittent icy and snowy roads,a trajectory tracking controller that integrates Tube-MPC and robust Sliding Mode Control is proposed.The nominal MPC model,developed from the estimated tire cornering stiffness,utilizes the sliding surface and the optimal auxiliary control unit law for the tube is derived from the reaching law in Tube-MPC,aiming to minimize the trajectory tracking error while enhancing the controller’s robustness against road uncertainties.The experiments show that the proposed method outperforms the Tube-MPC algorithm in terms of trajectory accuracy and robustness.This method demonstrates excellent trajectory tracking accuracy under intermittent icy and snowy road conditions,and it lays a theoretical foundation for future studies on vehicle stability and trajectory tracking under such road conditions.展开更多
In the field of railway traction drive systems,voltage sensor intermittent faults can significantly impact the reliability and safety of the entire system.This paper proposes an online diagnosis method for detecting s...In the field of railway traction drive systems,voltage sensor intermittent faults can significantly impact the reliability and safety of the entire system.This paper proposes an online diagnosis method for detecting such faults using an Artificial Intelligence(AI)predictor based on a Nonlinear Autoregressive with eXogenous inputs(NARX)data structure.The model is trained efficiently using the Extreme Learning Machine(ELM)algorithm.The NARX model captures the dynamic characteristics of the voltage sensor data,enabling the AI predictor to learn complex nonlinear relationships.The ELM training method ensures rapid convergence and high accuracy.Through extensive experimental validation,the proposed method demonstrates high sensitivity to voltage sensor intermittent faults and robust performance under varying operating conditions.This approach offers a promising solution for enhancing the diagnostic capabilities of railway traction systems,ensuring timely fault detection and improving overall system reliability.展开更多
基金financially supported by the National Natural Science Foundation of China(Grant No.42172292)Taishan Scholars Project Special Funding,and Shandong Energy Group(Grant No.SNKJ 2022A01-R26).
文摘A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior.
基金supported by a grant from Ministry of Science,Technological Development and Innovation,Serbia,No.451-03-68/2022-14/200178(to NN)University of Defence,No.MFVMA/02/22-24(to MN)。
文摘An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in PD.Repetitive transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's disease.However,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain unknown.The purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated signaling.Animals with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod test.Immunoblot,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate putamen.Prolonged intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate putamen.Treatment with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor symptoms.After treatment with prolonged intermittent theta burst stimulation,complete motor recovery was observed.This improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst stimulation.Our results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)R.Intermittent theta burst stimulation reversed these effects by restoring the abundances of A_(1)R and A_(2A)R to control levels.The shift in ARs expression likely restored the balance between dopamine-adenosine signaling,ultimately leading to the recovery of motor control.
文摘BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To evaluate the outcomes of 5-ASA withdrawal due to non-adherence in UC patients while in remission on monotherapy.METHODS Adult patients with UC who were followed up between July 2019 and April 2025 were screened.Patients in remission receiving 5-ASA monotherapy who experienced treatment withdrawal due to non-adherence were included in this study.RESULTS Among 880 patients with UC,30(3.4%)had 5-ASA withdrawal due to nonadherence while in remission on monotherapy.Twelve patients(40%)had disease relapse after a median of 20 months.The rate of patients in remission was 89%in the first year,decreasing to 73%in the second year,and to 64%in the third year.There were no significant differences between patients with and without relapse in terms of demographics,disease extent,remission duration before 5-ASA withdrawal,previous medications,steroid dependence,5-ASA formulation,baseline inflammatory markers,or partial and endoscopic Mayo scores.Most patients(75%)who experienced relapse were successfully treated with 5-ASA monotherapy,while one-fourth of them required corticosteroids.No patients required biologic agents,hospitalization,or surgical intervention.CONCLUSION Intermittent therapy may be safe and feasible for UC patients,especially those in long-term remission,with treatment interruption up to one year considered acceptable.
基金supported in part by the IN2CCAM project that has received funding from the European Union's Horizon Europe research and innovation programme(101076791)the National Natural Science Foundation of China(62403378)the Natural Science Basic Research Program of Shaanxi Province(2024JC-YBQN-0669)
文摘In this work, we address the codiagnosability analysis problem of a networked discrete event system under malicious attacks. The considered system is modeled by a labeled Petri net and is monitored by a series of sites, in which each site possesses its own set of sensors, without requiring communication among sites or to any coordinators. A net is said to be codiagnosable with respect to a fault if at least one site could deduce the occurrence of this fault within finite steps. In this context, we focus on a type of malicious attack that is called stealthy intermittent replacement attack. The stealthiness demands that the corrupted observations should be consistent with the system's normal behavior, while the intermittent replacement setting entails that the replaced transition labels must be recovered within a bounded of consecutive corrupted observations(called as K-corruption intermittent attack). Particularly, there exists a coordination between attackers that are separately effected on different sites, which holds the same corrupted observation for each common transition under attacks. From an attacker viewpoint, this work aims to design Kcorruption intermittent attacks for violating the codiagnosability of systems. For this purpose, we propose an attack automaton to analyze K-corruption intermittent attack for each site, and build a new structure called complete attack graph that is used to analyze all the potential attacked paths. Finally, an algorithm is inferred to obtain the K-corruption intermittent attacks, and examples are given to show the proposed attack strategy.
基金the Tianjin Health Research Project(Grant No.TJWJ2023MS038)Tianjin Education Commission Research Project(Grant No.2023KJ044)S&T Program of Hebei(SG2021189)。
文摘To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective disorders in children and adolescents,with major depressive disorder(MDD)at 2.00%and bipolar disorder at 0.86%.
基金Supported by the Anhui University Research Project,No.2022AH051171Natural Science Foundation Project of Anhui Province,No.2408085QH271+6 种基金Anhui Medical University Scientific Research Level Improvement Plan,No.2022xkjT028Health Research Project of Anhui Province,No.AHWJ2023A30047the Anhui Provincial Natural Science Foundation,No.2208085MH240the Scientific Research Project of Anhui Provincial Department of Education,No.2022AH051167the Anhui Quality Engineering Project,No.2023sx200,No.2023jyjxggyjY087 and No.2023zyxwjxalk046the Anhui Provincial Postgraduate Education Quality Project,No.2024cxcysj062and Anhui Medical University Graduate Research and Practice Innovation Project,No.YJS20240095.
文摘BACKGROUND Intermittent fasting(IF),particularly time-restricted feeding(TRF),is increasingly popular has gained popularity for weight loss,yet management,but its effects impact on gut health remain unclear.Remains inadequately understood.This study explores how investigated the effects of TRF effects on intestinal health and explored the underlying mechanisms.AIM To assess the effects of IF on intestinal health,elucidate the mechanisms involved.METHODS Mice were divided into two groups:Normal control(NC)and IF.The IF group underwent TRF,while the NC group had unrestricted access to food.Body weight,fecal characteristics,and intestinal morphology were analyzed.Colon tissue,serum,and fecal samples were collected for histological analysis,enzymelinked immunosorbent assay,flow cytometry,16S rRNA sequencing,and metabolomic profiling.RESULTS IF significantly affected body weight and intestinal morphology,compromised the intestinal barrier,increased pro-inflammatory cytokines,and heightened gut immune activation(P<0.05).It also disrupted the gut microbiota,promoting proinflammatory bacteria,reducing anti-inflammatory metabolites,and elevating pro-inflammatory metabolites(P<0.05).Indoleacrylic acid(IAA)supplementation notably alleviated intestinal inflammation and reversed immune dysfunction induced by IF(P<0.05).CONCLUSION Prolonged IF exacerbates intestinal inflammation by impairing gut barrier integrity and disrupting microbial homeostasis.However,IAA supplementation effectively mitigates fasting-induced intestinal inflammation and immune imbalance,suggesting its potential as a therapeutic agent.
基金the National Natural Science Foundation of China(82074264)。
文摘Objective:A complex relationship exists between obstructive sleep apnea syndrome and diabetes mellitus(DM).Chronic intermittent hypoxia(CIH),which is a core pathological feature of obstructive sleep apnea syndrome,may play an important role in the onset and development of DM-related atherosclerosis(DM-AS).This study aimed to investigate the mechanism of action of tetramethylpyrazine(TMP)in CIH-associated DM-AS.Methods:In vivo,a DM-AS mouse model was established by intraperitoneal injection of streptozotocin combined with a high-fat diet.They were exposed to CIH or normoxic conditions for 8 weeks and received different doses of TMP,rosuvastatin,toyocamycin,and purified water.Glycolipid metabolism,inflammation levels,degree of aortic AS,and expression levels of endoplasmic reticulum stress(ERS)and autophagy proteins were examined in mice.In vitro,human umbilical vein endothelial cells(HUVECs)were treated with high glucose and fat in combination with insulin to establish an insulin-resistant cell model(HUVEC-IR).After pretreatment with 4μ8C(IRE1 inhibitor)and different doses of TMP,intermittent hypoxic intervention was performed.Changes in cell morphology,proliferative activity,glucose consumption,and ability to migrate were observed,and the expression levels of ERS and autophagy proteins were detected.Results:In vivo experiments showed that CIH significantly increased blood glucose levels and Homeostasis Model Assessment of Insulin Resistance(HOMA-IR)(P<0.001 or P<0.05),low-density lipoprotein cholesterol(LDL-C)content(P<0.001),and the levels of three inflammatory factors[interleukin-1 beta(IL-1β),IL-6,and tumor necrosis factor-alpha(TNF-α)]in the mice(P<0.001)compared with those of the mice with DM alone;moreover,the aortic atherosclerotic(AS)plaque area in CIH mice was significantly enlarged(P<0.001).Western blotting results showed that the expressions of aortic IRE1α,XBP1s,Beclin1,and LC3A proteins were significantly increased in CIH mice compared with DM mice(P<0.05).After treatment with different doses of TMP,rosuvastatin calcium,and toyocamycin,serum inflammation and lipid levels and plaque area were significantly reduced in mice(P<0.001 and P<0.001,respectively).The expression levels of aortic XBP1s,Beclin1,and LC3A were reduced in TMP-and toyocamycin-treated mice(P<0.05).In the in vitro experiments,compared with normoxic cells,the cells treated with intermittent hypoxia(IH)showed a significant decrease in cell migration distance(P<0.05),a significant increase in apoptosis rate(P<0.001),a substantial increase in proliferation inhibition rate(P<0.001),a significant increase in the levels of XBP1s and LC3A proteins(P<0.05),and an increase in the number of autophagic vesicles/lysosomes,as observed under transmission electron microscopy.After treatment with different doses of TMP and 4μ8C,cell morphology was significantly restored,apoptosis rate significantly reduced(P<0.001),and XBP1s,Beclin1,and LC3A expressions significantly inhibited(P<0.05).Conclusion:CIH promoted the onset of DM-AS,whereas TMP attenuated ERS and excessive autophagy by modulating the IRE1α-XBP1 signaling pathway and inhibiting XBP1 splicing,thereby ameliorating DM-AS exacerbated by CIH.
基金the support of the National Natural Science Foundation of China(Grant No.52108319)the Natural Science Foundation of Jiangxi Province(20224BAB214069)。
文摘Red clay,widely used as a subgrade material in southern China,requires a reliable evaluation of its dynamic behavior to ensure infrastructure safety.Long-term cyclic triaxial tests were conducted on red clay from typical,complex subway subgrades to investigate its dynamic properties and shakedown behavior under intermittent cyclic loading.Results show that intermittent cyclic loading,especially with multiple amplitudes,causes greater axial plastic strain and lower post-cyclic strength than continuous loading.These effects diminish with increasing confining pressure.Notably,axial strain partially recovers during loading intervals,with recovery ratios depending on the number and sequence of pauses.Based on the rules of cumulative plastic strain rates and cumulative plastic strain increments,shakedown behavior for red clay under intermittent cyclic loading is divided into three categories:plastic shakedown,critical shakedown,and plastic creep.A quantitative shakedown limit criterion is proposed using the Boltzmann function.Shakedown behavior significantly influences the post-cyclic strengths,and the influence diminishes as confining pressure increases.Samples exhibiting plastic creep and plastic shakedown behavior have the lowest and highest strengths,and those with critical shakedown behaviors have medium strengths.Cyclic loading with relatively low-stress amplitude causes a hardening effect,while cyclic loading intermittence or cyclic loading with relatively high-stress amplitude causes a degradation effect,and both effects are mitigated by higher confining pressures.
基金supported in part by the National Key R&D Program of China(No.2024YFA1509400)the National Natural Science Foundation of China(No.52302094)Natural Science Foundation of Jiangxi,China(No.20232ACB203002).
文摘Electrochemical nitrite(NO_(2)^(−))reduction offers a sustainable route for ammonia(NH_(3))synthesis while simultaneously removing contaminants in wastewater.However,its efficiency is often limited by low catalytic efficiency and the competitive hydrogen evolution reaction at low NO_(2)^(−)concentrations.Herein,we report an intermittent pulsed electrolysis(IPE)strategy using copper oxide(Cu_(x)O)nanowires,which significantly enhances the NH3 yield rate and Faradaic efficiency(FE)at lower reactant concentrations.In situ experiments and theoretical calculations reveal that alternating between open-circuit and cathodic potentials modulates the copper oxidation states,stabilizing the catalytically active cuprous oxide(Cu_(2)O).Consequently,the IPE approach provides an outstanding NH3 yield rate of 115.10 mg·h^(−1)·cm^(−2)and FE of 91.14%in the presence of 25 mM NO_(2)^(−),markedly outperforming conventional constant potential electrolysis.
基金supported in part by the National Key Research and Development Program of China(2023YFB4706400)the National Natural Science Foundation of China(62273112,62073030,62203161)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(2023B1515120018,2023B1515120019)the Open Project of Xiangjiang Laboratory(23XJ03012)the Natural Science Foundation of Hunan Province(2024JJ5087)the Natural Science Foundation of Jiangxi Province(20232BAB212024)the National Research Foundation of Korea funded by the Ministry of Science and ICT,South Korea(IRIS-2023-00207954)the Science and Technology Planning Project of Guangzhou,China(2023A03J0120)the Guangzhou University Research Project(RC2023037)
文摘In this study,we consider a single-link flexible manipulator in the presence of an unknown Bouc-Wen type of hysteresis and intermittent actuator faults.First,an inverse hysteresis dynamics model is introduced,and then the control input is divided into an expected input and an error compensator.Second,a novel adaptive neural network-based control scheme is proposed to cancel the unknown input hysteresis.Subsequently,by modifying the adaptive laws and local control laws,a fault-tolerant control strategy is applied to address uncertain intermittent actuator faults in a flexible manipulator system.Through the direct Lyapunov theory,the proposed scheme allows the state errors to asymptotically converge to a specified interval.Finally,the effectiveness of the proposed scheme is verified through numerical simulations and experiments.
文摘This paper examines the role of traumatic bonding in Anita Brookner’s novel Providence.Through the perspective of traumatic bonding theory,this paper explores the true nature of the relationship between Kitty Maule and Maurice Bishop.The paper analyzes the intermittent cycles of affection and neglect that characterize their interactions,highlighting how Bishop’s emotional detachment and sporadic gestures of warmth create a power imbalance that traps Kitty in a cycle of idealization and disillusionment.Drawing on the work of Dutton and Painter(1981)on traumatic bonding,the paper explores how Kitty’s emotional dependence on Maurice mirrors the patterns found in emotionally abusive relationships,revealing how the traumatic bond between Kitty and Bishop shapes her journey toward self-growth.
基金supported in part by the National Natural Science Foundation of China(62273255,62350003,62088101)the Shanghai Science and Technology Cooperation Project(22510712000,21550760900)+1 种基金the Shanghai Municipal Science and Technology Major Project(2021SHZDZX0100)the Fundamental Research Funds for the Central Universities
文摘Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.
基金supported by the National Natural Science Foundation of China(No.12374003)the Guangdong Basic and Applied Basic Research Foundation(No.2024A1515030256)the Shenzhen Science and Technology Program(Grant Nos.JCYJ20220531095208019 and GXWD20231129103124001).
文摘The potentiostatic intermittent titration technique(PITT)is widely used to determine the diffusion coefficient of ions in electrode materials for rechargeable batteries such as lithium-ion or sodium-ion batteries,predicated on the assumption that the insertion/extraction of ions in the host materials is governed by diffusion.However,in practical scenarios,the electrochemical process might be dominated by interfacial reaction kinetics rather than diffusion.The present work derives analytical equations for electric current by considering the finite interfacial reaction kinetics and small overpotentials during PITT measurements and further studies the chemical stress field induced by the interfacial reaction-controlled ion insertion.The exchange current density(j_(0))can be ascertained using the analytical equation,which dictates the magnitude and decay rate of the electric current during a PITT process.The electric current decays more rapidly,and consequently,the lithium concentration reaches equilibrium faster for larger values of j_(0).The magnitude of the chemical stress is independent of j_(0) but depends on the overpotential.
基金supported by the National Natural Science Foundation of China under Grants 62476138 and 42375016.
文摘Continuous control protocols are extensively utilized in traditional MASs,in which information needs to be transmitted among agents consecutively,therefore resulting in excessive consumption of limited resources.To decrease the control cost,based on ISC,several LFC problems are investigated for second-order MASs without and with time delay,respectively.Firstly,an intermittent sampled controller is designed,and a sufficient and necessary condition is derived,under which state errors between the leader and all the followers approach zero asymptotically.Considering that time delay is inevitable,a new protocol is proposed to deal with the time-delay situation.The error system’s stability is analyzed using the Schur stability theorem,and sufficient and necessary conditions for LFC are obtained,which are closely associated with the coupling gain,the system parameters,and the network structure.Furthermore,for the case where the current position and velocity information are not available,a distributed protocol is designed that depends only on the sampled position information.The sufficient and necessary conditions for LFC are also given.The results show that second-order MASs can achieve the LFC if and only if the system parameters satisfy the inequalities proposed in the paper.Finally,the correctness of the obtained results is verified by numerical simulations.
文摘A recent article highlighted the hepatic benefits of intermittent fasting,particularly during Ramadan.However,the rising use of glucagon-like peptide-1(GLP-1)/glucose-dependent insulinotropic polypeptide(GIP)receptor agonists(RAs)is altering public behavior,leading to decreased interest in diet and exercise.With a focus on hepatic health,we analyzed global search trends using Google Trends™data from January 1,2022 to December 31,2024,focusing on the keywords"fasting","intermittent fasting","diet","nutrition","liver",Semaglutide("Ozempic"™,the most widely known GLP-1 RA)and Tirzepatide("Mounjaro"™,a newer dual GLP-1 and GIP RA).Search interest for"intermittent fasting"and"diet"showed a significant decline over time(Spearman's rho:-0.582 and-0.605,respectively,both P<0.001),while interest in"fasting"and"nutrition"remained stable.Search interest for Semaglutide,Tirzepatide,"fasting and liver","diet and liver"and Semaglutide and"liver"increased(Spearman's rho:+0.914,+0.936,+0.369,+0.297 and+0.808,respectively,all P<0.001).These findings suggest a trend of shifting away from traditional dieting toward broader health concerns,likely influenced by the increasing use of GLP-1/GIP RAs.
基金support from the National Natural Science Foundation of China[Grant No.71874121,No.71671121 and No.71431005]the support from the National Key R&D Programme of China[Grant No.2018YFC0704400]+1 种基金the support from Major Projects of the National Social Science Fund of China[Grant No.17ZDA065]the support from the General Project of the Humanities and Social Science Fund of the Chinese Ministry of Education[Grant No.21YJA630023].
文摘With the proposed carbon-neutrality targets,intermittent renewable energy will become increasingly significant for the power sector in the future.It is vital to study its development paths,particularly for wind power and photovoltaics,while considering constraints on diffusion potential.Using learning curves,dynamic programming,and Bass models,this study analyzes technological diffusion trends to determine the most cost-effective development route for intermittent renewable energy power generation in China by 2060.This study simplifies reality by examining the individual diffusion processes of wind and photovoltaic power,focusing on the self-diffusion characteristics of the two technologies.The study assumes that self-diffusion is the primary driver of future development and describe the influence of multiple factors.The study finds that supportive policies are key drivers of development in the early stages of intermittent renewable energy deployment,especially for photovoltaics.The current diffusion scale of photovoltaics has a greater positive impact on its future development than that of wind power due to lower costs.In the long term,the phased goal for 2030 is projected to be met ahead of schedule,and the majority of future intermittent renewable energy output is expected to come from photovoltaics.The rapid development phases of photovoltaic and wind power conclude at similar times,but the maximum diffusion potential of photovoltaics is higher than that of wind power.Investment constraints and technological levels affect the initial and middle phases of the development path,but their effects are limited.The capacity of the power grid remains the key constraint in the entire research field.
基金Project supported by Jilin Provincial Science and Technology Development Plan(Grant No.20220101137JC).
文摘This paper study the finite time internal synchronization and the external synchronization(hybrid synchronization)for duplex heterogeneous complex networks by time-varying intermittent control.There few study hybrid synchronization of heterogeneous duplex complex networks.Therefore,we study the finite time hybrid synchronization of heterogeneous duplex networks,which employs the time-varying intermittent control to drive the duplex heterogeneous complex networks to achieve hybrid synchronization in finite time.To be specific,the switch frequency of the controllers can be changed with time by devise Lyapunov function and boundary function,the internal synchronization and external synchronization are achieved simultaneously in finite time.Finally,numerical examples are presented to illustrate the validness of theoretical results.
基金Supported by the National Natural Science Foundation of China(No.82070995,No.82301256)Youth S&T Talent Support Programme of Guangdong Provincial Association for Science and Technology.
文摘AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions.METHODS:This was a prospective observational study.We evaluated the control ability of intermittent exotropia(IXT)patients in three conditions:natural 2D optotype viewing,2D optotype viewing with polarized glasses,and 3D optotype viewing with polarized glasses.Recording with a smartphone,we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking fusion.Additionally,the correlation of stereopsis were also analyzed.RESULTS:A total of 48 patients(age range:4-33y;54.17%male)participated in the study.When viewing 3D optotypes with polarized glasses,their median control scores were 1(interquartile range,0-4)at distance and 0(0-1)at near.These scores were significantly better than those observed under natural viewing conditions,which were 2.5(1-5)at a distance and 1(0-3)at near(Friedman test,P=0.049).Furthermore,those subjects who exhibited exophoria(realignment within 2 seconds)while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision(Kendall’sτb=-0.344,P=0.018).CONCLUSION:IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes,notably improving realignment capabilities.This expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.
基金Supported by National Natural Science Foundation of China(Grant Nos.52405112,U24A20199)the Postdoctoral Fellowship Program of CPSF(Grant No.GZB20240973).
文摘Four-Wheel Independent Steering(4WIS)Vehicles can independently control the angle of each wheel,demonstrating superior trajectory tracking performance under normal conditions.However,on intermittent icy and snowy roads,the presence of time-varying adhesion coefficients,time-varying cornering stiffness,and the irregularities due to ice and snow accumulation introduce multiple uncertainties into the steering system,significantly degrading the trajectory tracking performance of 4WIS vehicles.In response,this paper proposes a robust Tube Model Predictive Control(Tube-MPC)trajectory tracking control method for 4WIS.In this method,a Bi-directional Long Short-Term Memory neural network is established for online estimation of tire cornering stiffness under different road adhesion coefficients,providing accurate estimation of time-varying cornering stiffness for each wheel to mitigate the uncertainties of time-varying adhesion coefficients and cornering stiffness.Additionally,considering the road irregularities caused by snow accumulation on intermittent icy and snowy roads,a trajectory tracking controller that integrates Tube-MPC and robust Sliding Mode Control is proposed.The nominal MPC model,developed from the estimated tire cornering stiffness,utilizes the sliding surface and the optimal auxiliary control unit law for the tube is derived from the reaching law in Tube-MPC,aiming to minimize the trajectory tracking error while enhancing the controller’s robustness against road uncertainties.The experiments show that the proposed method outperforms the Tube-MPC algorithm in terms of trajectory accuracy and robustness.This method demonstrates excellent trajectory tracking accuracy under intermittent icy and snowy road conditions,and it lays a theoretical foundation for future studies on vehicle stability and trajectory tracking under such road conditions.
文摘In the field of railway traction drive systems,voltage sensor intermittent faults can significantly impact the reliability and safety of the entire system.This paper proposes an online diagnosis method for detecting such faults using an Artificial Intelligence(AI)predictor based on a Nonlinear Autoregressive with eXogenous inputs(NARX)data structure.The model is trained efficiently using the Extreme Learning Machine(ELM)algorithm.The NARX model captures the dynamic characteristics of the voltage sensor data,enabling the AI predictor to learn complex nonlinear relationships.The ELM training method ensures rapid convergence and high accuracy.Through extensive experimental validation,the proposed method demonstrates high sensitivity to voltage sensor intermittent faults and robust performance under varying operating conditions.This approach offers a promising solution for enhancing the diagnostic capabilities of railway traction systems,ensuring timely fault detection and improving overall system reliability.
