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Simulation of Atmospheric Wave-Fronts with Turbulence Intermittency
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作者 Giorgio Sedmak 《International Journal of Astronomy and Astrophysics》 2014年第1期155-164,共10页
A new extendable method for the simulation of atmospheric wave-fronts with turbulence intermittency is reported. The purpose is to generate simulations consistent with the distributions observed for the turbulence par... A new extendable method for the simulation of atmospheric wave-fronts with turbulence intermittency is reported. The purpose is to generate simulations consistent with the distributions observed for the turbulence parameters and the seeing, not available with standard methods. The intermittency is included by entering log-normal distributed arrays for the Fried parameter and the spatial coherence outer scale length into an extended form of the phase spectrum. The method is tested on large samples of simulated long-exposure point-source images. The tests show the agreement of the simulations with literature data. The simulations show that the intermittency affects negligibly the long-term median image size but breaks the symmetry of the wave-front phase spectrum, scatters the phase structure function and changes the image profile. 展开更多
关键词 Wave-fronts SIMULATION intermittency SEEING ATMOSPHERIC TURBULENCE
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A bibliometric analysis of publication trends in strabismus over the past 30y
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作者 Yi-Han Zhang Ying Guo +1 位作者 Shu-Jie Zhang Chen Zhao 《International Journal of Ophthalmology(English edition)》 2026年第1期149-159,共11页
AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 ... AIM:To summarize publication trends in the field of strabismus over the past 30y and predict future research hotspots.METHODS:A total of 2915 English-language articles and reviews on strabismus,published between 1993 and 2022,were retrieved from the Web of Science Core Collection.Bibliometric analyses were performed using VOSviewer and CiteSpace software to explore publication trends,as well as the contributions and collaborative networks of countries/regions,authors,institutions,and journals.RESULTS:The annual number of publications on strabismus showed a consistent upward trend.The United States(USA)maintained a leading position in this research field while Republic of Korea and China emerged as rapidly advancing contributors over the last decade.The University of California,Los Angeles ranked as the most productive institution,and Jonathan M.Holmes from USA was the most productive author.Journal of AAPOS was the leading journal with the most strabismus publications,whereas the two most highly cited articles were both published in Ophthalmology.Co-occurrence analysis identified pivotal keywords and burst terms,including intermittent exotropia(IXT),acute acquired comitant esotropia(AACE),functional magnetic resonance imaging(fMRI),and surgical treatment,which were confirmed as predominant and frontier topics.CONCLUSION:This study provides a comprehensive bibliometric analysis of strabismus research,revealing the evolution of research hotspots over the past 30y and outlining several cutting-edge directions for future investigation. 展开更多
关键词 bibliometric analysis STRABISMUS intermittent exotropia strabismus surgery functional magnetic resonance imaging research trends
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On-Off Intermittency Route to Chaos Synchronization and Spatial Periodic Synchronization of Chaos in Coupled Arrays of Chaotic Systems
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作者 邓晓龙 袁春华 +1 位作者 具睿 黄洪斌 《Journal of Southeast University(English Edition)》 EI CAS 2002年第1期95-98,共4页
Chaos synchronization of coupled nonlinear systems is ubiquitous in nature and science. Dynamic behaviors of coupled ring and linear arrays of unidirectionally coupled Lorenz oscillators are studied numerically. We fi... Chaos synchronization of coupled nonlinear systems is ubiquitous in nature and science. Dynamic behaviors of coupled ring and linear arrays of unidirectionally coupled Lorenz oscillators are studied numerically. We find that chaos synchronization in circular arrays of chaotic systems can occur through the on off intermittent synchronization with a power law distribution of laminar phases. And in the coupled ring and linear array it is found that the chaotic rotating waves generated from the ring propagate with spatial periodic synchronization along the linear array. 展开更多
关键词 Lorenz oscillator chaos synchronization intermittency chaos spatio periodic chaos
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Intermittency and bifurcation in SEPICs under voltage-mode control 被引量:2
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作者 刘芳 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第8期205-215,共11页
A stroboscopic map for voltage-controlled single ended primary inductor converter (SEPIC) with pulse width modulation (PWM) is presented, where low-frequency oscillating phenomena such as quasi-periodic and interm... A stroboscopic map for voltage-controlled single ended primary inductor converter (SEPIC) with pulse width modulation (PWM) is presented, where low-frequency oscillating phenomena such as quasi-periodic and intermittent quasi-periodic bifurcations occurring in the system are captured by numerical and experimental methods. According to bifurcation diagrams and nonlinear dynamical theory, the characteristics of the low-frequency oscillation and the mechanism for the appearance of the low-frequency oscillation are investigated. It is shown that as the controller parameter varies, the change in the conduction mode takes place from the continuous conduction mode (CCM) under the originally stable period one and high periodic orbits to the intermittent changes between CCM and discontinuous conduction mode (DCM), which may be related to the losing stability of the system and brought the system to exhibiting low-frequency oscillating behaviour in the time domain. Moreover, the occurrence of the intermittent quasi-periodic oscillation reflects that the system undergoes a Neimark-Sacker bifurcation. 展开更多
关键词 low-frequency oscillation intermittency single ended primary inductor converter Neimark-Sacker bifurcation
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A Prelude Staircase to a Type V Intermittency in Two—Dimensional Discontinuous Maps 被引量:2
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作者 WANGXU-Ming ZHAOJin-Gang HEDa-Ren 《Communications in Theoretical Physics》 SCIE CAS CSCD 2003年第6期657-662,共6页
A sequence of periodic attractors has been observed in a two-dimensional discontinuous map, which canbe considered as a model of impact oscillator. The so-called 'transfer number', which is defined as the mean... A sequence of periodic attractors has been observed in a two-dimensional discontinuous map, which canbe considered as a model of impact oscillator. The so-called 'transfer number', which is defined as the mean numberof transfer from non-impact state to impact state per iteration, is locked onto a lot of rational values to form a curveconsisting of many steps. Our numerical investigation confirms that every step is confined by conditions created by thecollision between the periodic orbit and the discontinuous boundary of the system. After the last collision the systemshows a chaotic motion with intermittent characteristics. Therefore the staircase can be addressed as a 'prelude staircaseto type V intermittency'. The similar phenomenon has also been observed in a model of electric circuit. These resultsof our study suggest that this kind of staircases is common in two (or even higher) dimensional discontinuous maps. 展开更多
关键词 two-dimensional map type V intermittency prelude staircase
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NONLINEAR STOCHASTIC HEAT EQUATION DRIVEN BY SPATIALLY COLORED NOISE:MOMENTS AND INTERMITTENCY 被引量:1
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作者 Le CHEN Kunwoo KIM 《Acta Mathematica Scientia》 SCIE CSCD 2019年第3期645-668,共24页
In this article, we study the nonlinear stochastic heat equation in the spatial domain R^d subject to a Gaussian noise which is white in time and colored in space. The spatial correlation can be any symmetric, nonnega... In this article, we study the nonlinear stochastic heat equation in the spatial domain R^d subject to a Gaussian noise which is white in time and colored in space. The spatial correlation can be any symmetric, nonnegative and nonnegative-definite function that satisfies Dalang's condition. We establish the existence and uniqueness of a random field solution starting from measure-valued initial data. We find the upper and lower bounds for the second moment. With these moment bounds, we first establish some necessary and sufficient conditions for the phase transition of the moment Lyapunov exponents, which extends the classical results from the stochastic heat equation on Z^d to that on R^d.Then, we prove a localization result for the intermittency fronts, which extends results by Conus and Khoshnevisan [9] from one space dimension to higher space dimension. The linear case has been recently proved by Huang et al [17] using different techniques. 展开更多
关键词 Stochastic heat equation MOMENT ESTIMATES phase transition intermittency intermittency front measure-valued initial data MOMENT LYAPUNOV EXPONENTS
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Circuit implementation and multiform intermittency in a hyper-chaotic model extended from the Lorenz system 被引量:1
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作者 仓诗建 陈增强 吴文娟 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第5期1792-1800,共9页
This paper presents a non-autonomous hyper-chaotic system, which is formed by adding a periodic driving signal to a four-dimensional chaotic model extended from the Lorenz system. The resulting non-autonomous hyper-ch... This paper presents a non-autonomous hyper-chaotic system, which is formed by adding a periodic driving signal to a four-dimensional chaotic model extended from the Lorenz system. The resulting non-autonomous hyper-chaotic system can display any dynamic behaviour among the periodic orbits, intermittency, chaos and hyper-chaos by controlling the frequency of the periodic signal. The phenomenon has been well demonstrated by numerical simulations, bifurcation analysis and electronic circuit realization. Moreover, the system is concrete evidence for the presence of Pomeau- Manneville Type-I intermittency and crisis-induced intermittency. The emergence of a different type of intermittency is similarly subjected to the frequency of periodic forcing. By statistical analysis, power scaling laws consisting in different intermittency are obtained for the lifetime in the laminar state between burst states. 展开更多
关键词 CHAOS circuit implementation type-I intermittency crisis-induced intermittency
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INTERMITTENCY AND SCALING IN TURBULENT CONVECTION 被引量:1
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作者 EmilyS.C.CHING 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2003年第5期385-393,共9页
Both the velocity and temperature measurements taken in turbulent Rayleigh-B'enard convection experiments have been analyzed. It is found that both the velocity and temperature fluctuations are intermittent and ca... Both the velocity and temperature measurements taken in turbulent Rayleigh-B'enard convection experiments have been analyzed. It is found that both the velocity and temperature fluctuations are intermittent and can be well-described by the She-Leveque hierarchical structure. A positive correlation between the vertical velocity and the temperature differences is found both at the center, near the sidewall and near the bottom of the convection cell, supporting that buoyancy is significant in the Bolgiano regime. Moreover, the intermittent nature of the temperature fluctuations in the Bolgiano regime can be attributted to the variations in the temperature dissipation rate. However, the relations between the velocity and temperature structure functions and their correlations implied by the Bolgiano-Obukhov scaling are not supported by experimental measurements. 展开更多
关键词 turbulent convection intermittency SCALING
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Intermittency in 3.7 A GeV ^16O-emulsion interactions 被引量:1
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作者 张东海 赵惠华 +5 位作者 刘芳 何春乐 贾会明 李雪琴 李振宇 李俊生 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第9期2689-2700,共12页
The intermittency effect has been studied for an interaction of 3.7 A GeV ^16O with emulsion using the distributions of both the pseudorapidity intervals and the azimuthal angle intervals of the shower particles emitt... The intermittency effect has been studied for an interaction of 3.7 A GeV ^16O with emulsion using the distributions of both the pseudorapidity intervals and the azimuthal angle intervals of the shower particles emitted in a central rapidity region. The scaled factorial moments, reduced scaled factorial moments and multifractal moments as functions of the bin size in pseudorapidity and in azimuthal angle have been calculated and have revealed the presence of an intermittent behaviour which may be due to the random cascading property of the reaction. The anomalous fractal dimension has been found to increase with the increase of rank of the moment. 展开更多
关键词 relativistic heavy-ion collision intermittency nuclear emulsion
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The theoretical study on intermittency and propagation of geodesic acoustic mode in L-mode discharge near tokamak edge
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作者 Zhaoyang LIU Yangzhong ZHANG +8 位作者 Swadesh Mitter MAHAJAN Adi LIU Tao XIE Chu ZHOU Tao LAN Jinlin XIE Hong LI Ge ZHUANG Wandong LIU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2021年第3期30-50,共21页
Through a systematically developed theory,we demonstrate that the motion of Instanton identified in Zhang et al(2017 Phys.Plasmas 24122304)is highly correlated to the intermittent excitation and propagation of geodesi... Through a systematically developed theory,we demonstrate that the motion of Instanton identified in Zhang et al(2017 Phys.Plasmas 24122304)is highly correlated to the intermittent excitation and propagation of geodesic acoustic mode(GAM)that is observed in tokamaks.While many numerical simulations have observed the phenomena,it is the first theory that reveals the physical mechanism behind GAM intermittent excitation and propagation.The preceding work is based on the micro-turbulence associated with toroidal ion temperature gradient mode,and slab-based phenomenological model of zonal flow.When full toroidal effect is introduced into the system,two branches of zonal flow emerge:the torus-modified low frequency zonal flow(TLFZF),and GAM,necessitating a unified exploration of GAM and TLFZF.Indeed,we observe that the transition from the Caviton to Instanton is triggered by a rapid zero-crossing of radial group velocity of drift wave and is found to be strongly correlated with the GAM onset.Many features peculiar to intermittent GAMs,observed in real machines,are thus identified in the numerical experiment.The results will be displayed in figures and in a movie;first for single central rational surface,and then with coupled multiple central rational surfaces.The periodic bursting first shown disappears as being replaced by irregular one,more similar to the intermittent characteristics observed in GAM experiments. 展开更多
关键词 zonal flow drift wave intermittency GAM L–H mode
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Generation of on-off intermittency based on RSssler chaotic system
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作者 周茜 陈增强 袁著祉 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第9期2616-2626,共11页
In this paper, one-state on-off intermittency and two-state on-off intermittency are generated in two five- dimensional continuum systems respectively. In each system, a two-dimensional subsystem is driven by the Ross... In this paper, one-state on-off intermittency and two-state on-off intermittency are generated in two five- dimensional continuum systems respectively. In each system, a two-dimensional subsystem is driven by the Rossler chaotic system. The parameter conditions under which the on-off intermittency occurs are discussed in detail. The statistical property of the intermittency is investigated. It is shown that the distribution of the laminar phase duration time follows a power law with an exponent of -3/2, which is a signature of on-off intermittency. Moreover, the phenomenon of intermingled basins is observed when attractors in the two symmetric invariant subspaces are stable. We provide an effective way to generate on-off intermittency based on a chaotic system, which is important for application and theoretical study. 展开更多
关键词 chaotic system on-off intermittency transverse Lyapunov exponent blowout bifurcation intermingled basins
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Intermittency of the density fluctuations and its influence on the radial transport in the boundary of J-TEXT
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作者 朱孟周 庄革 +1 位作者 王之江 潘垣 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第2期353-359,共7页
To improve the understanding of the turbulence intermittency, a detailed investigation of the intermittency of the density fluctuations has been performed in the boundary of J-TEXT. The intermittency of the density fl... To improve the understanding of the turbulence intermittency, a detailed investigation of the intermittency of the density fluctuations has been performed in the boundary of J-TEXT. The intermittency of the density fluctuations and its influence on the radial transport are reported. The probability distribution functions of the density fluctuations are not scale-invariant, being inconsistent with the self-organized criticality hypothesis. The underlying dynamics of the intermittency are detected using the quiet-time statistical method. The probability distribution function of the quiet times shows double-power-law regions, indicating the existence of correlations between the successive burst events. 展开更多
关键词 intermittency radial transport J-TEXT
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Impact of the Intermittency of Photovoltaic Power Plants on the Frequency Management: Case of the Senegalese Electricity Grid
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作者 Mahamat Adoum Abdoulaye Gabriel Jean Philippe Tevi +1 位作者 Djicknoum Diouf Amadou Seidou Maiga 《Journal of Power and Energy Engineering》 2020年第7期55-70,共16页
This paper investigates the impact of the intermittency of the photovoltaic (PV) power plants on the electric grid frequency management and the consequences that can occur. To meet these purposes, three years data of ... This paper investigates the impact of the intermittency of the photovoltaic (PV) power plants on the electric grid frequency management and the consequences that can occur. To meet these purposes, three years data of the Senegalese grid frequency are used, combined with three PV power plants data since their starting-up. Using these data, we analyzed two days of heavily disturbed operation of the Senegalese grid in order to emphasize the real impact of the presence of PV power plants on the electrical grid. Our study has highlighted that how the intermittency of photovoltaic power plants affects frequency management. It obviously appears that the PV production curves follow the irradiation variations. Instantaneous variations of PV production make it difficult to manage the grid frequency leading to more frequent load shedding as we have shown with the data after the commissioning of the PV power plants. We also estimate the power then energy losses during the load shedding induced by the PV integration on the power grid by comparing a period corresponding to one month before (February 2017) and one month after (February 2018) the integration of variable PV production. 展开更多
关键词 intermittency Frequency Fluctuation Energy Loss Power Loss Fluctuating Power
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Fluorescence Intermittency in Monolayer WSe_2
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作者 叶艳霞 窦秀明 +3 位作者 丁琨 杨富华 江德生 孙宝权 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第7期258-261,共4页
Fluorescence intermittent dynamics of single quantum emitters in monolayer WSe2 are investigated via measuring speetrally resolved time traces and time-dependent fluorescence intensity trajectories. Analysis of fluore... Fluorescence intermittent dynamics of single quantum emitters in monolayer WSe2 are investigated via measuring speetrally resolved time traces and time-dependent fluorescence intensity trajectories. Analysis of fluorescence trajectories and spectral shifting reveal a correlation between A model of an inverse power law can be used to understand the fluorescence intermittency and spectral diffusion the observed blinking dynamics. 展开更多
关键词 Fluorescence intermittency in Monolayer WSe2
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Intermittency in the Heavy Ion Collisions at Intermediate and High Energies
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作者 Zhang Xiao-dong Ge Ling-xiao Zhu Quan-ling (Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000) 《Chinese journal of nuclear physics》 1994年第4期303-307,共5页
The method of scaled factorial moments is used to study the fluctuations offragment-size distribution based on the quantum molecular dynamics model.From thecalculation of <sup>197</sup>Au(200 MeV/nucleon... The method of scaled factorial moments is used to study the fluctuations offragment-size distribution based on the quantum molecular dynamics model.From thecalculation of <sup>197</sup>Au(200 MeV/nucleon)+<sup>197</sup>Au central collision system,an intermit-tent pattern of fluctuations is found.In particular,the critical behavior is preliminarilydiscussed. 展开更多
关键词 FLUCTUATIONS intermittency HEAVY ION COLLISIONS
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Shear behaviors of intermittent joints subjected to shearing cycles under constant normal stiffness conditions:Effects of loading parameters 被引量:1
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作者 Bin Wang Yujing Jiang +1 位作者 Qiangyong Zhang Hongbin Chen 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第5期2695-2712,共18页
A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that th... A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior. 展开更多
关键词 Intermittent joint Cyclic shear Loading parameter Constant normal stiffness(CNS)
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The Supplementary Motor Area as a Flexible Hub Mediating Behavioral and Neuroplastic Changes in Motor Sequence Learning:A TMS and TMS-EEG Study 被引量:1
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作者 Jing Chen Yanzi Fan +6 位作者 Xize Jia Fengmei Fan Jinhui Wang Qihong Zou Bing Chen Xianwei Che Yating Lv 《Neuroscience Bulletin》 2025年第5期837-852,共16页
Attempts have been made to modulate motor sequence learning(MSL)through repetitive transcranial magnetic stimulation,targeting different sites within the sensorimotor network.However,the target with the optimum modula... Attempts have been made to modulate motor sequence learning(MSL)through repetitive transcranial magnetic stimulation,targeting different sites within the sensorimotor network.However,the target with the optimum modulatory effect on neural plasticity associated with MSL remains unclarified.This study was therefore designed to compare the role of the left primary motor cortex and the left supplementary motor area proper(SMAp)in modulating MSL across different complexity levels and for both hands,as well as the associated neuroplasticity by applying intermittent theta burst stimulation together with the electroencephalogram and concurrent transcranial magnetic stimulation.Our data demonstrated the role of SMAp stimulation in modulating neural communication to support MSL,which is achieved by facilitating regional activation and orchestrating neural coupling across distributed brain regions,particularly in interhemispheric connections.These findings may have important clinical implications,particularly for motor rehabilitation in populations such as post-stroke patients. 展开更多
关键词 Motor sequence learning Intermittent theta burst stimulation Concurrent transcranial magnetic stimulation and electroencephalogram NEUROPLASTICITY Functional connectivity
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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease
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作者 Milica Zeljkovic Jovanovic Jelena Stanojevic +4 位作者 Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic 《Neural Regeneration Research》 SCIE CAS 2025年第7期2053-2067,共15页
An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease prog... An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in PD.Repetitive transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's disease.However,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain unknown.The purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated signaling.Animals with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod test.Immunoblot,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate putamen.Prolonged intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate putamen.Treatment with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor symptoms.After treatment with prolonged intermittent theta burst stimulation,complete motor recovery was observed.This improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst stimulation.Our results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)R.Intermittent theta burst stimulation reversed these effects by restoring the abundances of A_(1)R and A_(2A)R to control levels.The shift in ARs expression likely restored the balance between dopamine-adenosine signaling,ultimately leading to the recovery of motor control. 展开更多
关键词 A_(1)R A_(2A)R adenosine receptors ADENOSINE ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling
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Acrolein-induced atherosclerosis via AMPK/SIRT1-CLOCK/BMAL1 pathway and the protection from intermittent fasting
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作者 Qianfeng Chen Yuxia Zhong +7 位作者 Bohan Li Yucong Feng Yuandie Zhang Tao Wei Margaret Zaitoun Shuang Rong Hua Wan Qing Feng 《Journal of Biomedical Research》 2025年第6期549-563,I0001,I0002,共17页
The circadian clock is crucial for the progression of cardiovascular diseases.Our previous studies showed that acrolein,an environmental pollutant,exacerbated atherosclerosis by reducing CLOCK/BMAL1 levels and disrupt... The circadian clock is crucial for the progression of cardiovascular diseases.Our previous studies showed that acrolein,an environmental pollutant,exacerbated atherosclerosis by reducing CLOCK/BMAL1 levels and disrupting circadian rhythm;in contrast,intermittent fasting(IF),a dietary regimen,ameliorated acrolein-induced atherosclerosis.In the current study,mice were administered acrolein at a dose of 3 mg/(kg·day)via drinking water and subjected to IF for 18 h(from 0:00 to 18:00).We observed that IF reduced the formation of aortic lesions accelerated by acrolein in Apo E-/-mice.Upon exposure to acrolein,the expression of Rel A,Il1b,and Tnf increased in the liver and heart tissues,but these changes were reversed by IF treatment.Notably,IF treatment upregulated the expression of adenosine monophosphate(AMP)-activated protein kinase catalytic subunit alpha-1(AMPKα1),p-AMPKα1,and sirtuin 1(SIRT1),while inhibiting acrolein-induced mitogen-activated protein kinase(MAPK)activation.Additionally,the expression of circadian genes Clock/Bmal1 was suppressed and disrupted by acrolein,whereas IF restored their expression.Moreover,consistent with the in vivo findings,shortterm starvation in vitro,as a fasting cell model,alleviated the dysregulation of CLOCK/BMAL1 and upregulated SIRT1 expression by modulating the AMPK and reactive oxygen species(ROS)-MAPK pathways activated by acrolein.In summary,we demonstrated that IF suppressed the ROS-MAPK pathway but activated the AMPK pathway to enhance the expression of circadian clock genes,thereby ameliorating acrolein-induced atherogenesis,which may shed light on strategies for preventing cardiovascular diseases. 展开更多
关键词 intermittent fasting ACROLEIN circadian rhythm AMPK SIRT1 MAPK
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K-Corruption Intermittent Attacks for Violating the Codiagnosability
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作者 Ruotian Liu Yihui Hu +1 位作者 Agostino Marcello Mangini Maria Pia Fanti 《IEEE/CAA Journal of Automatica Sinica》 2025年第1期159-172,共14页
In this work, we address the codiagnosability analysis problem of a networked discrete event system under malicious attacks. The considered system is modeled by a labeled Petri net and is monitored by a series of site... In this work, we address the codiagnosability analysis problem of a networked discrete event system under malicious attacks. The considered system is modeled by a labeled Petri net and is monitored by a series of sites, in which each site possesses its own set of sensors, without requiring communication among sites or to any coordinators. A net is said to be codiagnosable with respect to a fault if at least one site could deduce the occurrence of this fault within finite steps. In this context, we focus on a type of malicious attack that is called stealthy intermittent replacement attack. The stealthiness demands that the corrupted observations should be consistent with the system's normal behavior, while the intermittent replacement setting entails that the replaced transition labels must be recovered within a bounded of consecutive corrupted observations(called as K-corruption intermittent attack). Particularly, there exists a coordination between attackers that are separately effected on different sites, which holds the same corrupted observation for each common transition under attacks. From an attacker viewpoint, this work aims to design Kcorruption intermittent attacks for violating the codiagnosability of systems. For this purpose, we propose an attack automaton to analyze K-corruption intermittent attack for each site, and build a new structure called complete attack graph that is used to analyze all the potential attacked paths. Finally, an algorithm is inferred to obtain the K-corruption intermittent attacks, and examples are given to show the proposed attack strategy. 展开更多
关键词 Codiagnosability decentralized structure discrete event system intermittent attack Petri net
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