Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the under...Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the underground parts of Ligularia intermedia. Their structures were elucidated by spectroscopic methods.展开更多
文摘利用Gibberella intermedia CA3-1对甾体化合物去氢表雄酮(DHEA)进行C7α-羟基化反应研究。用单因素实验的方法考察接种量、装液量、转速、有机溶剂助溶、投料浓度以及底物投加时间对产物7α-羟基去氢表雄酮(7α-OH-DHEA)生成的影响。最终确定最适工艺条件:接种量6%,装液量30 m L(250 m L三角瓶),转速220 r/min,体积分数6%丙二醇助溶,接种时即添加底物,底物DHEA质量浓度1 g/L,转化时间36 h。采用优化后的转化条件,7α-OH-DHEA摩尔得率为72.34%。
基金This work was financially supported by the National Natural Science Foundation of China for outstanding young scientists to Z. T. Wang (No. 39825129).
文摘Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the underground parts of Ligularia intermedia. Their structures were elucidated by spectroscopic methods.
