This study investigates the presence and health implications of per-and polyfluoroalkyl substances(PFAS)in human serum samples collected from white-collar workers in an industrialized region of China.Our research offe...This study investigates the presence and health implications of per-and polyfluoroalkyl substances(PFAS)in human serum samples collected from white-collar workers in an industrialized region of China.Our research offers fresh insights into the underexplored area of nonoccupational PFAS exposure among white-collar workers,shedding light on health risks linked to industrial PFAS pollution.Seven PFAS compounds were measured.Perfluorooctanoic acid(PFOA)and perfluorooctanesulfonate(PFOS)emerged as predominant pollutants,withΣ_(7)PFAS concentrations averaging 65.486 ng/mL.Gender differences showed higher serumΣ_(7)PFAS levels in males,and age-related analyses suggested PFAS accumulation over time,with higher concentrations in older groups.Additionally,significant correlations were found between PFAS concentrations and biomarkers of oxidative stress and immune interference,specifically malondialdehyde(MDA)and immunoglobulin M(IgM),indicating that PFAS exposure may contribute to oxidative damage and potential immunosuppression.The study highlights regional and international variations in PFAS serum concentrations,underscoring the influence of industrial activities on PFAS exposure and expanding on the established links between PFAS exposure and health outcomes.These findings call for targeted strategies to mitigate PFAS exposure in high-risk regions and warrant further research on PFAS health impacts,especially in regard to immune interference.展开更多
基金supported by the National Natural Science Foundation of China(nos.42407577,42322707,and 42325702)the Guangdong Basic and Applied Basic Research Foundation(no.2023A1515140118)+4 种基金the Shenzhen Science and Technology Innovation Committee(KCXFZ20240903093700002,JCYJ20241202130703005)the Ningbo key research and development planand“reveal the list”project(2023Z176)the Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control(no.2023B1212060002)the Guangdong-Hong Kong Joint Laboratory for Soil and Groundwater Pollution Control(no.2023B1212120001)the State Environ-mental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control.
文摘This study investigates the presence and health implications of per-and polyfluoroalkyl substances(PFAS)in human serum samples collected from white-collar workers in an industrialized region of China.Our research offers fresh insights into the underexplored area of nonoccupational PFAS exposure among white-collar workers,shedding light on health risks linked to industrial PFAS pollution.Seven PFAS compounds were measured.Perfluorooctanoic acid(PFOA)and perfluorooctanesulfonate(PFOS)emerged as predominant pollutants,withΣ_(7)PFAS concentrations averaging 65.486 ng/mL.Gender differences showed higher serumΣ_(7)PFAS levels in males,and age-related analyses suggested PFAS accumulation over time,with higher concentrations in older groups.Additionally,significant correlations were found between PFAS concentrations and biomarkers of oxidative stress and immune interference,specifically malondialdehyde(MDA)and immunoglobulin M(IgM),indicating that PFAS exposure may contribute to oxidative damage and potential immunosuppression.The study highlights regional and international variations in PFAS serum concentrations,underscoring the influence of industrial activities on PFAS exposure and expanding on the established links between PFAS exposure and health outcomes.These findings call for targeted strategies to mitigate PFAS exposure in high-risk regions and warrant further research on PFAS health impacts,especially in regard to immune interference.
