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Hierarchical Manufacturing of Anisotropic and High-Efficiency Electromagnetic Interference Shielding Modules for Smart Electronics
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作者 Shaohong Shi Siwen Deng +6 位作者 Yuheng Jiang Jiabin Chen Lukas Sporrer Fangchao Cheng Quanquan Guo Jingjing Jing Yinghong Chen 《Nano-Micro Letters》 2026年第6期125-139,共15页
To shield electronics from complicated electromagnetic environments caused by wireless electromagnetic waves,achieving elaborately structural manufacturing while not sacrificing electromagnetic interference shielding ... To shield electronics from complicated electromagnetic environments caused by wireless electromagnetic waves,achieving elaborately structural manufacturing while not sacrificing electromagnetic interference shielding performances remains crucial challenges.Herein,we propose a hierarchical manufacturing method that combines the use of 3D printing shear flow field and layer-by-layer assembly for fabricating the structurally customizable and multifunctional polylactic acid@graphene nanoparticle(PLA@GNs)materials.The dynamic behavior of polymer fluids is firstly explored via computational fluid dynamic simulation,and a Weissenberg number is employed to quantitatively analyze the disordered-to-ordered structural evolution of molecular chains and nanoparticles,allowing to tailor the micro-scale ordered structures.Subsequently,the macro-scale 3D architectures of PLA@GNs modules are fabricated by layer-by-layer assembly.Owing to the aligned GNs,the shielding performance reaches 41.2 d B,simultaneously accompanied by a directional thermal conductivity of 3.2 W m^(-1)K^(-1).Moreover,the potential application of 3D-printed shielding modules in specific civilian frequency bands such as 4G(1800–2100 MHz),Bluetooth(2402–2480 MHz),and 5G(3300–3800 MHz)is fully demonstrated.Overall,this work not only establishes a universal methodology about 3D printing shear flow field-driven orientation of two-dimensional nanoparticles within polymer fluids,but also gives a scientific method for advanced manufacturing of the next-generation electromagnetic functional modules for smart electronics. 展开更多
关键词 3D printing Graphene nanoparticles Hierarchical manufacturing Electromagnetic interference shielding Thermal management
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Multistage microcellular waterborne polyurethane composite with optionally low-reflection behavior for ultra-efficient electromagnetic interference shielding 被引量:5
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作者 Jianming Yang Hu Wang +4 位作者 Hexin Zhang Peng Lin Hong Gao Youyi Xia Xia Liao 《Journal of Materials Science & Technology》 2025年第5期132-140,共9页
Electromagnetic interference(EMI)shielding materials with superior shielding efficiency and low-reflection properties hold promising potential for utilization across electronic components,precision instruments,and fif... Electromagnetic interference(EMI)shielding materials with superior shielding efficiency and low-reflection properties hold promising potential for utilization across electronic components,precision instruments,and fifth-generation communication equipment.In this study,multistage microcellular waterborne polyurethane(WPU)composites were constructed via gradient induction,layer-by-layer casting,and supercritical carbon dioxide foaming.The gradient-structured WPU/ironcobalt loaded reduced graphene oxide(FeCo@rGO)foam serves as an impedance-matched absorption layer,while the highly conductive WPU/silver loaded glass microspheres(Ag@GM)layer is employed as a reflection layer.Thanks to the incorporation of an asymmetric structure,as well as the introduction of gradient and porous configurations,the composite foam demonstrates excellent conductivity,outstanding EMI SE(74.9 dB),and minimal reflection characteristics(35.28%)in 8.2-12.4 GHz,implying that more than 99.99999%of electromagnetic(EM)waves were blocked and only 35.28%were reflected to the external environment.Interestingly,the reflectivity of the composite foam is reduced to 0.41%at 10.88 GHz due to the resonance for incident and reflected EM waves.Beyond that,the composite foam is characterized by low density(0.47 g/cm^(3))and great stability of EMI shielding properties.This work offers a viable approach for craft-ing lightweight,highly shielding,and minimally reflective EMI shielding composites. 展开更多
关键词 Electromagnetic interference shielding Supercritical carbon dioxide(ScCO_(2))foaming Low reflectivity Multilayered structure MICROCELLULAR
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Flexible multifunctional polydimethylsiloxane composites with segregated structure fabricated by hydrophobic interaction for efficient electromagnetic interference shielding
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作者 Weirui Zhang Zhongjie He +6 位作者 Jinliang Xie Fangfang Su Yangyang Xin Dongdong Yao Mingxiang Li Yudeng Wang Yaping Zheng 《Journal of Materials Science & Technology》 2025年第17期67-77,共11页
The formation of segregated structure has been demonstrated as an effective strategy for achieving ex-ceptional electromagnetic interference(EMI)shielding performance at low filler loadings.However,the acquisition of ... The formation of segregated structure has been demonstrated as an effective strategy for achieving ex-ceptional electromagnetic interference(EMI)shielding performance at low filler loadings.However,the acquisition of polymer particles and the formation of interactions with conductive fillers remain signifi-cant challenges for polydimethylsiloxane,which are crucial to the construction of a segregated structure.In this work,MXene sheets were functionalized and assembled onto the surface of polydimethylsilox-ane microspheres via hydrophobic interaction.Subsequently,functionalized MXene/polydimethylsiloxane(FMP)composites with a segregated structure were fabricated by filtration and hot-pressing.The FMP composite containing 8.22 wt.%MXene exhibited a high electrical conductivity of 99.4 S m^(−1)and a sat-isfactory EMI shielding effectiveness/thickness(EMI SE/d)of 31.3 dB mm^(−1).Furthermore,the FMP com-posite demonstrated excellent reliability with over 90%retention of EMI shielding effectiveness under harsh environments such as ultra-high/low temperatures and acidic/alkaline solutions.Additionally,the photothermal conversion performance of FMP composites and the capacitive sensing performance of the sensor based on FMP composites indicated their potential for managing body temperature and moni-toring human movement.Consequently,FMP composites show great promise in wearable electronics for effective electromagnetic interference shielding,thermal management and capacitive sensing. 展开更多
关键词 MXene POLYDIMETHYLSILOXANE Hydrophobic interaction Segregated structure Electromagnetic interference shielding
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Construction of rGO-MXene@FeNi/epoxy composites with regular honeycomb structures for high-efficiency electromagnetic interference shielding
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作者 Ping Song Zihang Cai +6 位作者 Jiaojiao Li Mukun He Hua Qiu Fang Ren Yali Zhang Hua Guo Penggang Ren 《Journal of Materials Science & Technology》 2025年第14期311-320,共10页
With the rapid development of 5G communication technology and wearable electronic devices,the demand for low-reflection electromagnetic interference(EMI)shielding materials is becoming increasingly urgent.In this work... With the rapid development of 5G communication technology and wearable electronic devices,the demand for low-reflection electromagnetic interference(EMI)shielding materials is becoming increasingly urgent.In this work,reduced graphene oxide-MXene(rGMH)@FeNi/epoxy EMI shielding composites with a regular honeycomb structure were successfully prepared by the combination of surface functionalization modification,sacrificial template,and freeze-drying.The effects of magnetic FeNi alloy particle loading mode and loading amount on the EMI shielding performance of composites were investigated.The results show that rGMH@FeNi/epoxy EMI shielding composites have the highest EMI shielding effectiveness(EMI SE)and the lowest reflection shielding effectiveness when magnetic FeNi alloy particles are loaded only on the graphene skeleton.In this composite,the EMI SE value of the composite is 61 dB when the rGMH@FeNi mass fraction is 5.4 wt%(f-FeNi mass fraction is 0.9 wt%),which is 4.7 times that of the blended rGO/MXene/FeNi/epoxy resin composite(13 dB)with the same mass fraction.At the same time,the rGMH@FeNi/epoxy composite has excellent thermal stability(heat-resistance index of 190.3℃)and mechanical properties(energy storage modulus of 8606.7 MPa).These polymer-based EMI shielding composites with excellent EMI shielding properties and low reflection effectiveness have great potential in the protection of high-power,portable and wearable electronic devices against electromagnetic pollution. 展开更多
关键词 Electromagnetic interference(EMI)shielding Reduced graphene oxide-MXene@FeNi Epoxy resins Honeycomb structures
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Multifunctional Asymmetric Bilayer Aerogels for Highly Efficient Electromagnetic Interference Shielding with Ultrahigh Electromagnetic Wave Absorption
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作者 Cheng‑Zhang Qi Peng Min +6 位作者 Xinfeng Zhou Meng Jin Xia Sun Jianjun Wu Yanjun Liu Hao‑Bin Zhang Zhong‑Zhen Yu 《Nano-Micro Letters》 2025年第11期680-697,共18页
Although multifunctional electromagnetic interference(EMI)shielding materials with ultrahigh electromagnetic wave absorption are highly required to solve increasingly serious electromagnetic radiation and pollution an... Although multifunctional electromagnetic interference(EMI)shielding materials with ultrahigh electromagnetic wave absorption are highly required to solve increasingly serious electromagnetic radiation and pollution and meet multi-scenario applications,EMI shielding materials usually cause a lot of reflection and have a single function.To realize the broadband absorption-dominated EMI shielding via absorption-reflection-reabsorption mechanisms and the interference cancelation effect,multifunctional asymmetric bilayer aerogels are designed by sequential printing of a MXene-graphene oxide(MG)layer with a MG emulsion ink and a conductive MXene layer with a MXene ink and subsequent freeze-drying for generating and solidifying numerous pores in the aerogels.The top MG layer of the asymmetric bilayer aerogel optimizes impedance matching and achieves re-absorption,while the bottom MXene layer enhances the reflection of the incident electromagnetic waves.As a result,the asymmetric bilayer aerogel achieves an average absorption coefficient of 0.95 in the X-band and shows the tunable absorption ability to electromagnetic wave in the ultrawide band from 8.2 to 40 GHz.Finite element simulations substantiate the effectiveness of the asymmetric bilayer aerogel for electromagnetic wave absorption.The multifunctional bilayer aerogels exhibit hydrophobicity,thermal insulation and Joule heating capacities and are efficient in solar-thermal/electric heating,infrared stealth,and clean-up of spilled oil. 展开更多
关键词 Multifunctional bilayer aerogels Electromagnetic interference shielding MXene sheets Graphene oxide Infrared stealth and camouflage
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Sparse graph neural network aided efficient decoder for polar codes under bursty interference
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作者 Shengyu Zhang Zhongxiu Feng +2 位作者 Zhe Peng Lixia Xiao Tao Jiang 《Digital Communications and Networks》 2025年第2期359-364,共6页
In this paper,a sparse graph neural network-aided(SGNN-aided)decoder is proposed for improving the decoding performance of polar codes under bursty interference.Firstly,a sparse factor graph is constructed using the e... In this paper,a sparse graph neural network-aided(SGNN-aided)decoder is proposed for improving the decoding performance of polar codes under bursty interference.Firstly,a sparse factor graph is constructed using the encoding characteristic to achieve high-throughput polar decoding.To further improve the decoding performance,a residual gated bipartite graph neural network is designed for updating embedding vectors of heterogeneous nodes based on a bidirectional message passing neural network.This framework exploits gated recurrent units and residual blocks to address the gradient disappearance in deep graph recurrent neural networks.Finally,predictions are generated by feeding the embedding vectors into a readout module.Simulation results show that the proposed decoder is more robust than the existing ones in the presence of bursty interference and exhibits high universality. 展开更多
关键词 Sparse graph neural network Polar codes Bursty interference Sparse factor graph Message passing neural network
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Numerical Simulation Study on Aerodynamic Interference Characteristics of Overlapping Rotors in Heavy⁃Load eVTOL Aircraft
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作者 DU Siliang DENG Kai WANG Bo 《Transactions of Nanjing University of Aeronautics and Astronautics》 2026年第1期40-54,共15页
Focusing on the unclear mechanism of aerodynamic interference in overlapping rotors of heavy-load electric vertical take-off and landing(eVTOL)aircraft,this paper aims to reveal the aerodynamic interference characteri... Focusing on the unclear mechanism of aerodynamic interference in overlapping rotors of heavy-load electric vertical take-off and landing(eVTOL)aircraft,this paper aims to reveal the aerodynamic interference characteristics and flow field evolution laws of overlapping rotor configurations in hovering conditions through numerical simulation methods.The research method involves constructing a computational model for rotor flow fields and aerodynamic characteristics based on the Reynolds-averaged Navier-Stokes(RANS)equations and the Spalart-Allmaras(S-A)turbulence model.The dynamic simulation of rotor rotational motion was achieved by using the moving nested grid technology.The reliability of the computational method was ensured through the grid independence verification and the comparison with experimental data.The research results indicate that in overlapping rotor systems,rotorⅡexperiences a decrease in thrust,significant power fluctuations,and reduced hovering efficiency due to continuous interference from the adjacent rotor’s wake and blade-vortex interactions.Blade-tip vortices undergo breakage,fusion,and secondary rolling in the overlapping region,forming large-scale turbulent structures that lead to attenuation of the induced velocity field and aerodynamic efficiency losses.Additionally,the interaction between the rotor downwash and the fuselage triggers a“fountain effect”and a sudden increase in surface pressure on the fuselage,exacerbating flow field distortion.Based on the aforementioned mechanisms,the safe flight of overlapping rotor configurations can be achieved by optimizing the configuration strategy of the rotational speed phase difference between adjacent blades.This study provides a theoretical basis for the rotor layout design and the aerodynamic performance enhancement of heavy-load eVTOL aircraft. 展开更多
关键词 electric vertical takeoff and landing(eVTOL)aircraft overlapping rotors aerodynamic interference numerical simulation rotor vortex interference
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Heterolayered Carbonized MXene/Polyimide Aerogel for Low-Reflection Electromagnetic Interference Shielding and Multi-Spectrum Compatible Protection
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作者 Shan Zhang Chen‑Ming Liang +5 位作者 Lu Zhou Juntao Wu Martin CKoo Zongxin Wu Yun‑Tian Chen Guang‑Sheng Wang 《Nano-Micro Letters》 2026年第6期702-716,共15页
The advancement of next-generation high-frequency communication systems and stealth detection technologies necessitate the development of efficient,multi-spectrum compatible shielding materials.However,the achievement... The advancement of next-generation high-frequency communication systems and stealth detection technologies necessitate the development of efficient,multi-spectrum compatible shielding materials.However,the achievement of simultaneous high efficiency and low reflectivity across microwave,terahertz,and infrared spectra remains a formidable challenge.Herein,a carbonized MXene/polyimide(C-MXene/PI)aerogel material integrating a spatially coupled hierarchically anisotropic structure with stepwise conductivity gradients was constructed.Electromagnetic waves propagate through the top-down vertical disordered horizontal architecture and progressive conductivity gradient of C-MXene/PI aerogel,undergoing stepwise absorption-dissipation-re-dissipation processes.The C-MXene/PI aerogel exhibits an average electromagnetic interference(EMI)shielding effectiveness of91.0 dB in X-band and a reflection coefficient of 0.40.In the terahertz frequency band,the average EMI shielding performance reaches66.2 dB with a reflection coefficient of 0.33.Furthermore,the heterolayered porous architecture of C-MXene/PI aerogels exhibits low thermal conductivity and reduced infrared emissivity,enabling exceptional infrared stealth capability across the 2-16μm wavelength spectrum.This study provides an feasible strategy for constructing low-reflectivity multi-spectrum compatible shielding materials. 展开更多
关键词 Heterolayered Electromagnetic interference shielding Multi-spectrum Low reflection High efficiency
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Second-order correlated interference with multi-wavelength thermal-light beams
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作者 De-Sheng Wang Yi-Ning Zhao +5 位作者 Lingxin Kong Su-Heng Zhang Chong Wang Cheng Ren Yuehua Su De-Zhong Cao 《Chinese Physics B》 2026年第2期374-382,共9页
A method for correlating thermal light over a wide spectral range is proposed.A multi-wavelength pseudothermal source,prepared by projecting laser beams of multiple wavelengths(650 nm,635 nm,532 nm,and 473 nm)onto a m... A method for correlating thermal light over a wide spectral range is proposed.A multi-wavelength pseudothermal source,prepared by projecting laser beams of multiple wavelengths(650 nm,635 nm,532 nm,and 473 nm)onto a moving thin ground glass plate,is employed in a double-slit interference experiment.The ground glass plate induces random phase differences between light beams of different wavelengths passing through it.This initial random phase difference significantly influences the high-order intensity correlation functions of multi-wavelength thermal beams.Experimentally,second-order correlated interference patterns,including subwavelength interference,of pseudothermal beams with different wavelengths are observed in the intensity correlation measurements.This method facilitates applications of correlated thermal photons in quantum information processing and quantum imaging. 展开更多
关键词 correlated interference multi-wavelength thermal light second-order correlation function
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Ultrahigh Electromagnetic Interference Shielding and Integrated Thermal Sensing-encryption Enabled by a Honeycomb-inspired Multifunctional Foam
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作者 Shao-Peng Yu Ya Liu +4 位作者 Ming-Yu Hao Xin Zhang Xu Zhang Yi-Cheng Yuan Zhen-Xiu Zhang 《Chinese Journal of Polymer Science》 2026年第2期513-524,I0016,共13页
With the rapid development of intelligent electronic and military equipment,multifunctional flexible materials that integrat electromagnetic interference(EMI)shielding,temperature sensing,and information encryption ar... With the rapid development of intelligent electronic and military equipment,multifunctional flexible materials that integrat electromagnetic interference(EMI)shielding,temperature sensing,and information encryption are urgently required.This study presents a bio-inspired hierarchical composite foam fabricated using supercritical nitrogen foaming technology.This material exhibits a honeycomb structure,with pore cell sizes controllable within a range of 30–92μm by regulating the filler.The carbon fiber felt(CFf)provides efficient reflection of electromagnetic waves,while the chloroprene rubber/carbon fiber/carbon black foam facilitates both wave absorption and temperature monitoring through its optimized conductive network.This synergistic mechanism results in an EMI shielding effectiveness(SE)of 60.06 d B with excellent temperature sensing performance(The temperature coefficient of resistance(TCR)is-2.642%/℃)in the 24–70℃ range.Notably,the material has a thermal conductivity of up to 0.159 W/(m·K),and the bio-inspired layered design enables information encryption,demonstrating the material's potential for secure communication applications.The foam also has tensile properties of up to 5.13 MPa and a tear strength of 33.02 N/mm.This biomimetic design overcomes the traditional limitations of flexible materials and provides a transformative solution for next-generation applications such as flexible electronics,aerospace systems and military equipment,which urgently need integrated electromagnetic protection,thermal management and information security. 展开更多
关键词 FLEXIBILITY Cellular structures Electromagnetic interference shielding Temperature sensor Message encryption
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Multifunctional CNT/cellulose-BN/PVA Composites Integrating Dual-continuous Network Structure with Gradient Conductivity for Electromagnetic Interference Shielding and Joule Heating
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作者 Xiao-Rui Wang Ting-Ting Liu +2 位作者 Cheng-Hua Cui Xin Xu Liang-Qing Zhang 《Chinese Journal of Polymer Science》 2026年第3期803-812,I0015,共11页
In this study,an architecture featuring a gradient conductive network structure and three-dimensional dual-continuous network structure is constructed in a carbon nanotubes/cellulose-boron nitride/poly(vinyl alcohol)(... In this study,an architecture featuring a gradient conductive network structure and three-dimensional dual-continuous network structure is constructed in a carbon nanotubes/cellulose-boron nitride/poly(vinyl alcohol)(CNT/cellulose-BN/PVA)composite.Using cellulose aerogel as a template,CNT were incorporated into the cellulose template by vertically impregnating the CNT suspension.Following the impregnation of BN/PVA and high-pressure compression,three-dimensional dual-continuous network structure was successfully constructed in the CNT/cellulose-BN/PVA composite.The comprehensive performance of the composite,including electromagnetic interference(EMI)shielding and Joule heating performance,was investigated.The results indicate that the total EMI shielding effectiveness(SE)for the CNT/cellulose-BN/PVA composite reveals similar values for electromagnetic waves incident from different directions,but totally different shielding mechanisms.For the CNT/cellulose-BN/PVA composite with three impregnation cycles of CNT,the EMI SE values exceeded 39 dB for electromagnetic waves incident from both the high-and low-CNT-content sides.93%of the microwaves were reflected when electromagnetic waves were incident from the high-CNT-content side,while the reflection coefficient decreased to 0.44 for the transverse direction.In addition,the construction of the dual-continuous network structure enabled the composite to exhibit both excellent electrical conductivity and good thermal conductivity simultaneously,endowing the material with good Joule heating performance.CNT/cellulose-BN/PVA composite films have significant potential for application as EMI shielding materials in extremely cold weather. 展开更多
关键词 Cellulose Dual-continuous network structure Gradient conductivity Electromagnetic interference shielding Joule heating
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Optical temporal interference model for investigation and manipulation of non-integer high-order harmonic generation
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作者 Zhao-Yue Meng Yun Pan +1 位作者 Jun-Ping Wang Xi Zhao 《Chinese Physics B》 2026年第2期433-441,共9页
High-precision optical frequency measurement serves as a cornerstone of modern science and technology,enabling advancements in fields ranging from fundamental physics to quantum information technologies.Obtaining prec... High-precision optical frequency measurement serves as a cornerstone of modern science and technology,enabling advancements in fields ranging from fundamental physics to quantum information technologies.Obtaining precise photon frequencies,especially in the ultraviolet or even extreme ultraviolet regimes,is a key goal in both light–matter interaction experiments and engineering applications.High-order harmonic generation(HHG)is an ideal light source for producing such photons.In this work,we propose an optical temporal interference model(OTIM)that establishes an analogy with multi-slit Fraunhofer diffraction(MSFD)to manipulate fine-frequency photon generation by exploiting the temporal coherence of HHG processes.Our model provides a unified physical framework for three distinct non-integer HHG generation schemes:single-pulse,shaped-pulse,and laser pulse train approaches,which correspond to single-MSFD-like,double-MSFD-like,and multi-MSFD-like processes,respectively.Arbitrary non-integer HHG photons can be obtained using our scheme.Our approach provides a new perspective for accurately measuring and controlling photon frequencies in fields such as frequency comb technology,interferometry,and atomic clocks. 展开更多
关键词 high-order harmonic generation optical temporal interference multi-slit Fraunhofer diffraction
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Beyond the surface:Advancing neurorehabilitation with transcranial temporal interference stimulation——clinical applications and future prospects
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作者 Camille E.Proulx Friedhelm C.Hummel 《Neural Regeneration Research》 2026年第5期1987-1988,共2页
Brain lesions,such as those caused by stroke or traumatic brain injury(TBI),frequently result in persistent motor and cognitive impairments that significantly affect the individual patient's quality of life.Despit... Brain lesions,such as those caused by stroke or traumatic brain injury(TBI),frequently result in persistent motor and cognitive impairments that significantly affect the individual patient's quality of life.Despite differences in the mechanisms of injury,both conditions share a high prevalence of motor and cognitive impairments.These deficits show only limited natural recovery. 展开更多
关键词 NEUROREHABILITATION STIMULATION TRANSCRANIAL TEMPORAL interference motor cognitive impairments brain lesionssuch motor cognitive impairmentsthese
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High-fidelity full-color self-interference incoherent digital holography via quarter-wave geometric phase optics
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作者 Jae-Won Lee Jin-Hyeok Seo +4 位作者 Jung-Yeop Shin Jing-Wen Bu Kihong Choi Keehoon Hong Hak-Rin Kim 《Opto-Electronic Advances》 2026年第1期49-64,共16页
We present a compact self-interference incoherent digital holography(SIDH)system that incorporates a quarter-waveplate(QWP)-based geometric phase(GP)lens to achieve high-fidelity,full-color holographic imaging under b... We present a compact self-interference incoherent digital holography(SIDH)system that incorporates a quarter-waveplate(QWP)-based geometric phase(GP)lens to achieve high-fidelity,full-color holographic imaging under broadband incoherent illumination.Traditional SIDH systems that utilize half-waveplate(HWP)-based GP lenses are hindered by unavoidable triple-wavefront polarization interference,stemming from chromatic dispersion in phase retardation.This interference introduces color-dependent artifacts in the reconstructed images.In contrast,our QWP-based design inherently suppresses such interference by using the non-diffracted beam as the reference,enabling stable dual-wavefront modulation.This approach produces phase-encoded polarization interference patterns that remain spectrally consistent across the red,green,and blue(RGB)channels.Experimental results demonstrate substantial noise suppression and significantly improved full-color image fidelity,supported by channelspecific noise analysis and structural similarity metrics.The system also preserves a simplified optical configuration without active polarization control,allowing for compact integration and cost-effective fabrication.These advantages position the proposed QWP-GP SIDH architecture as a promising solution for portable,real-time digital holographic 3D imaging,with scalable potential in applications such as augmented reality,optical diagnostics,and spectral holography. 展开更多
关键词 self-interference incoherent digital holography digital holography geometric phase lens polarization interference holographic imaging
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安罗替尼联合ICI一线治疗晚期肺鳞状细胞癌的疗效和安全性:37例单中心回顾性队列分析
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作者 林勇 肖春妹 +5 位作者 谢强 陈群 石琴 罗杨 胡颖 林恒 《中国肿瘤生物治疗杂志》 北大核心 2026年第2期155-162,共8页
目的:探讨安罗替尼联合免疫检查点抑制剂(ICI)作为一线方案治疗晚期肺鳞状细胞癌(LUSC)的有效性及安全性。方法:采用单中心回顾性队列设计,连续纳入2018年10月至2023年12月福建省福州肺科医院收治的37例初治晚期LUSC患者。所有患者接受... 目的:探讨安罗替尼联合免疫检查点抑制剂(ICI)作为一线方案治疗晚期肺鳞状细胞癌(LUSC)的有效性及安全性。方法:采用单中心回顾性队列设计,连续纳入2018年10月至2023年12月福建省福州肺科医院收治的37例初治晚期LUSC患者。所有患者接受安罗替尼(剂量为8、10或12 mg/d,用药2周/停药1周)联合ICI治疗。主要终点为无进展生存期(PFS),次要终点包括客观缓解率(ORR)、疾病控制率(DCR)及治疗相关不良事件(TRAE)。结果:全组患者中位随访15.2个月,ORR达54.1%(20/37),DCR为97.3%(36/37),中位PFS为11.8个月(95%CI:8.3~NA),12个月PFS率为48.6%。探索性亚组分析显示:安罗替尼12 mg剂量组的中位PFS(未达到vs 7.5个月,HR=0.09,95%CI:0.01~0.67,P<0.01)及ORR(100%vs 42.9%,P<0.01)均显著优于8/10 mg组。分期分层显示ⅢB/ⅢC期患者ORR显著优于Ⅳ期(84.6%vs 41.7%,P=0.02)。安全性方面,62.2%(23/37)的患者发生TRAE,以1~2级高血压[29.7%(11/37)]、手足综合征[21.6%(8/37)]为主,3例(8.1%)因3级TRAE终止治疗。结论:安罗替尼联合ICI作为晚期LUSC一线治疗方案具有良好的疗效前景和可管理的安全性。其中,12 mg剂量组在探索性分析中显示出更优疗效的潜在信号,早期分期患者ORR更高。该结果值得开展大规模前瞻性研究进行进一步验证。 展开更多
关键词 肺鳞状细胞癌 安罗替尼 免疫检查点抑制剂 免疫治疗 联合治疗 治疗相关不良事件
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Quantum Interference and Optical Tuning of Self-Trapped Exciton State in Double Halide Perovskite
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作者 Kai-Xuan Xu Xin-Bao Liu +9 位作者 Simin Pang Zhe Zhang Yubin Wang Haonan Chang Jiajun Luo Jiang Tang Qihua Xiong Sheng Meng Shiwu Gao Jun Zhang 《Chinese Physics Letters》 2026年第3期87-101,共15页
Self-trapped excitons(STEs),known for their unique radiative properties,have been harnessed in diverse photonic devices;however,their comprehensive understanding and manipulation remain elusive.In this study,we presen... Self-trapped excitons(STEs),known for their unique radiative properties,have been harnessed in diverse photonic devices;however,their comprehensive understanding and manipulation remain elusive.In this study,we present novel experimental and theoretical evidence revealing the hybrid nature and optical tunability of STE state in Cs_(2)Ag_(0.4)Na_(0.6)InCl_(6).The detection of the Fano resonance in laser energy-dependent Raman and photoluminescence spectra indicates the emergence of an exciton-phonon hybrid state,arising from robust quantum interference between the discrete phonon and continuum exciton states.Moreover,we demonstrate continuous tuning of this hybrid state with the energy and intensity of the laser field.These findings lay the foundation for a comprehensive understanding of the nature of STE and their potential for state control. 展开更多
关键词 photonic deviceshowevertheir self trapped exciton state optical tuning exciton phonon hybrid state fano resonance photoluminescence spectra quantum interference double halide perovskite
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Metal-based nanomedicines for cancer theranostics
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作者 Hai-Jia Yu Jian-Hua Liu +6 位作者 Wei Liu Rui Niu Bin Zhang Yuan Xiong Yang Liu Ying-Hui Wang Hong-Jie Zhang 《Military Medical Research》 2026年第1期78-128,共51页
The heterogeneity and invasiveness of cancer cells pose serious challenges in cancer diagnosis and treatment.Advancements and innovations in metal-based nanomedicines provide novel avenues for addressing these challen... The heterogeneity and invasiveness of cancer cells pose serious challenges in cancer diagnosis and treatment.Advancements and innovations in metal-based nanomedicines provide novel avenues for addressing these challenges.Metal-based nanomedicines possess unique physicochemical properties that enable their interaction with living organisms,thereby inducing complex biological responses.These nanomaterials have been extensively used to enhance the contrast and sensitivity of cancer imaging and to amplify the distinction between cancerous and healthy tissues.Moreover,these nanomaterials can effectively combat a wide spectrum of cancers through various methods,including drug delivery,radiotherapy,photothermal therapy(PTT),photodynamic therapy(PDT),sonodynamic therapy(SDT),biocatalytic therapy,ion interference therapy(IIT),and immunotherapy.Currently,there is still a need for a comprehensive summary on the metal-based nanomaterials for cancer diagnosis and treatment.Herein,we present a systematic and complete overview of action mechanisms and the applications of metal-based nanomaterials in cancer theranostics.A summary of common strategies for synthesizing and modifying metal-based nanomedicines is presented,and their biosafety is analyzed.Then,the latest developments in their applications for cancer imaging and anticancer treatment are provided.Finally,the key technical challenges and reasonable perspectives of metal-based nanomedicines for cancer theranostics in clinical applications are discussed. 展开更多
关键词 Metal-based nanomedicines Synthesis strategy Computed tomography(CT)imaging Nuclear imaging Magnetic resonance imaging(MRI) Fluorescence(FL)imaging Photoacoustic imaging(PAI) DRUG-DELIVERY Phototherapy Catalytic therapy Ion interference therapy(IIT) Immunotherapy
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Gene interference regulates aquaporin-4 expression in swollen tissue of rats with cerebral ischemic edema Correlation with variation in apparent diffusion coefficient 被引量:14
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作者 Hui Hu Hong Lu +3 位作者 Zhanping He Xiangjun Han Jing Chen Rong Tu 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第21期1659-1666,共8页
To investigate the effects of mRNA interference on aquaporin-4 expression in swollen tissue of rats with ischemic cerebral edema, and diagnose the significance of diffusion-weighted MRI, we injected 5 pL shRNA- aquapo... To investigate the effects of mRNA interference on aquaporin-4 expression in swollen tissue of rats with ischemic cerebral edema, and diagnose the significance of diffusion-weighted MRI, we injected 5 pL shRNA- aquaporin-4 (control group) or siRNA- aquaporin-4 solution (1:800) (RNA interference group) into the rat right basal ganglia immediately before occlusion of the middle cerebral artery. At 0.25 hours after occlusion of the middle cerebral artery, diffusion-weighted MRI displayed a high signal; within 2 hours, the relative apparent diffusion coefficient decreased markedly, aquaporin-4 expression increased rapidly, and intracellular edema was obviously aggravated; at 4 and 6 hours, the relative apparent diffusion coefficient slowly returned to control levels, aquaporin-4 expression slightly increased, and angioedema was observed. In the RNA interference group, during 0.25- 6 hours after injection of siRNA- aquaporin-4 solution, the relative apparent diffusion coefficient slightly fluctuated and aquaporin-4 expression was upregulated; during 0.5 4 hours, the relative apparent diffusion coefficient was significantly higher, while aquaporin-4 expression was significantly lower when compared with the control group, and intracellular edema was markedly reduced; at 0.25 and 6 hours, the relative apparent diffusion coefficient and aquaporin-4 expression were similar when compared with the control group; obvious angioedema remained at 6 hours. Pearson's correlation test results showed that aquaporin-4 expression was negatively correlated with the apparent diffusion coefficient (r = -0.806, P 〈 0.01). These findings suggest that upregulated aquaporin-4 expression is likely to be the main molecular mechanism of intracellular edema and may be the molecular basis for decreased relative apparent diffusion coefficient. Aquaporin-4 gene interference can effectively inhibit the upregulation of aquaporin-4 expression during the stage of intracelfular edema with time-effectiveness. Moreover, diffusion-weighted MRI can accurately detect intracellular edema. 展开更多
关键词 cerebral ischemic edema magnetic resonance imaging diffusion gene silencing AQUAPORIN-4 mRNA interference neural regeneration
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Towards Efficient Electromagnetic Interference Shielding Performance for Polyethylene Composites by Structuring Segregated Carbon Black/Graphite Networks 被引量:6
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作者 Cheng-hua Cui 鄢定祥 +4 位作者 Huan Pang Li-chuan Jia Yu Bao Xin Jiang Zhong-ming Li 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2016年第12期1490-1499,共10页
An electromagnetic interference (EMI) shielding composite based on ultrahigh molecular weight polyethylene (UHMWPE) loaded with economical graphite-carbon black (CB) hybrid fillers was prepared via a green and f... An electromagnetic interference (EMI) shielding composite based on ultrahigh molecular weight polyethylene (UHMWPE) loaded with economical graphite-carbon black (CB) hybrid fillers was prepared via a green and facile methodology, i.e., high-speed mechanical mixing combined with hot compression thus avoiding the assistance of the intensive ultrasound dispersion in volatile organic solvents. In this composite, the graphite-CB hybrid fillers were selectively distributed in the interfacial regions of UHMWPE domains resulting a typical segregated structure. Thanks to the specific morphology of segregated conductive networks along with the synergetic effect of large-sized graphite flakes and small-sized CB nanoparticles, a low filler loading of 7.7 vol% (15 wt%) yielded the graphite-CB/UHMWPE composites with a satisfactory electrical conductivity of 33.9 S/m and a superior shielding effectiveness of 40.2 dB, manifesting the comparable value of the pricey large-aspect-ratio carbon nanofillers (e.g., carbon nanotubes and graphene nanosheets) based polymer composites. More interestingly, with the addition of 15 wt% graphite-CB (1/3, W/W) hybrid fillers, the tensile strength and elongation at break of the composite reached 25.3 MPa and 126%, respectively; with a remarkable increase of 58.1% and 2420% over the conventional segregated graphite/UHMWPE composites. The mechanical reinforcement could be attributed to the favor of the small-sized CB particles in the polymer molecular diffusion between UHMWPE domains which in tuna provided a stronger interfacial adhesion. This work provides a facile, green and affordable strategy to obtain the polymer composites with high electrical conductivity, efficient EMI shielding, and balanced mechanical performance. 展开更多
关键词 GRAPHITE Carbon black Segregated structure Electromagnetic interference Synergistic effect.
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Efficient Subchannel Allocation Based on Clustered Interference Alignment in Ultra-Dense Femtocell Networks 被引量:3
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作者 Hao Zhang Hongyan Li Jung Hoon Lee 《China Communications》 SCIE CSCD 2017年第4期1-10,共10页
In this paper, we exploit clustered interference alignment(IA) for efficient subchannel allocation in ultra-dense orthogonal frequency division multiplexing access(OFDMA) based femtocell networks, which notably improv... In this paper, we exploit clustered interference alignment(IA) for efficient subchannel allocation in ultra-dense orthogonal frequency division multiplexing access(OFDMA) based femtocell networks, which notably improves the spectral efficiency as well as addresses the feasibility issue of IA. Our problem is formulated as a combinatorial optimization problem which is NP-hard. To avoid obtaining its optimal solution by exhaustive search, we propose a two-phases efficient solution with low-complexity. The first phase groups all the femtocell user equipments(FUEs) into disjoint clusters, and the second phase allocates subchannels to the formed clusters where IA is performed. By doing this, the intra-cluster and inter-cluster interferences are mitigated by clustered IA and subchannel allocation in ultra-dense femtocell networks, respectively.Also, low-complexity algorithm is proposed to solve the corresponding sub-problem in each phase. Simulation results demonstrate that the proposed scheme not only outperforms other related schemes, but also provides a close performance to the optimal solution. 展开更多
关键词 interference alignment CLUSTERING subchannel allocation ultra-dense femtocells
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