A successful pregnancy requires the maternal immune system to recognize and tolerate the allogeneic fetus while maintaining defense against infection both systemically and in placental tissues.At the maternal–fetal i...A successful pregnancy requires the maternal immune system to recognize and tolerate the allogeneic fetus while maintaining defense against infection both systemically and in placental tissues.At the maternal–fetal interface,the trophoblasts in the placenta play an essential role in the suppression of maternal immune rejection of the fetus.To ensure maternal–fetal tolerance and successful placentation,delicate crosstalk is established among fetus-derived trophoblasts,maternal immune cells,and decidual stromal cells(DSCs)during normal pregnancy.Decidual immune cells not only participate in the maintenance of immune tolerance but also regulate the function of trophoblasts to promote fetal growth.An imbalance in this crosstalk may lead to adverse pregnancy outcomes,such as recurrent spontaneous abortion,preeclampsia,preterm birth,intrauterine growth restriction,and infection.Here we outline some of the important discoveries in recent years related to the mechanisms by which trophoblast-derived molecules induce maternal–fetal immune tolerance.展开更多
基金supported by grant number MOST 2017YFC1001400 awarded to D.-J.L.grants from the National Natural Science Foundation of China,numbers 81971456 and 81200425 awarded to X.-Q.W.grants from the National Natural Science Foundation of China,numbers 81471548 and 81490744 awarded to D.-J.L.
文摘A successful pregnancy requires the maternal immune system to recognize and tolerate the allogeneic fetus while maintaining defense against infection both systemically and in placental tissues.At the maternal–fetal interface,the trophoblasts in the placenta play an essential role in the suppression of maternal immune rejection of the fetus.To ensure maternal–fetal tolerance and successful placentation,delicate crosstalk is established among fetus-derived trophoblasts,maternal immune cells,and decidual stromal cells(DSCs)during normal pregnancy.Decidual immune cells not only participate in the maintenance of immune tolerance but also regulate the function of trophoblasts to promote fetal growth.An imbalance in this crosstalk may lead to adverse pregnancy outcomes,such as recurrent spontaneous abortion,preeclampsia,preterm birth,intrauterine growth restriction,and infection.Here we outline some of the important discoveries in recent years related to the mechanisms by which trophoblast-derived molecules induce maternal–fetal immune tolerance.
