Flexible deep brain neural interfaces,as an important research direction in the field of neural engineering,have broad application prospects in areas such as neural signal detection,treatment of neurological diseases,...Flexible deep brain neural interfaces,as an important research direction in the field of neural engineering,have broad application prospects in areas such as neural signal detection,treatment of neurological diseases,and intelligent control systems.However,chronic inflammatory responses caused by longterm implantation and the resulting electrode failure seriously hinder the clinical development of this technology.This review systematically explores the long-term stability issues of flexible deep brain neural interfaces,with a focus on analyzing the synergistic optimization of electrode geometric morphology and implantation strategies in regulating inflammatory responses.Additionally,this paper delves into innovative strategies,such as passive enhancement of biocompatibility through electrode surface functionalization and active inhibition of inflammation through drug-controlled release systems,offering new technical paths to extend electrode lifespan.By integrating and reviewing existing innovative methods for deep brain flexible electrodes,this study provides an important theoretical foundation and technical guidance for the development of high-stability neural interface devices.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC2402501,2022YFB3205602)the National Natural Science Foundation of China(Nos.62121003,T2293730,T2293731,62333020,62171434,and 62471291)+3 种基金the Major Program of Scientific and Technical Innovation 2030(2021ZD02016030)the Joint Foundation Program of the Chinese Academy of Sciences(No.8091A170201)the Scientific Instrument Developing Project of the Chinese Academy of Sciences(No.PTYQ2024BJ0009)the National Natural Science Foundation of Beijing(F252069)。
文摘Flexible deep brain neural interfaces,as an important research direction in the field of neural engineering,have broad application prospects in areas such as neural signal detection,treatment of neurological diseases,and intelligent control systems.However,chronic inflammatory responses caused by longterm implantation and the resulting electrode failure seriously hinder the clinical development of this technology.This review systematically explores the long-term stability issues of flexible deep brain neural interfaces,with a focus on analyzing the synergistic optimization of electrode geometric morphology and implantation strategies in regulating inflammatory responses.Additionally,this paper delves into innovative strategies,such as passive enhancement of biocompatibility through electrode surface functionalization and active inhibition of inflammation through drug-controlled release systems,offering new technical paths to extend electrode lifespan.By integrating and reviewing existing innovative methods for deep brain flexible electrodes,this study provides an important theoretical foundation and technical guidance for the development of high-stability neural interface devices.
