Soft bioelectronics hold immense potential across diverse applications,notably in healthcare,human-machine interfaces,and conformal neural interfaces.A core driving force is the pursuit of high-fidelity,seamless integ...Soft bioelectronics hold immense potential across diverse applications,notably in healthcare,human-machine interfaces,and conformal neural interfaces.A core driving force is the pursuit of high-fidelity,seamless integration between electronic systems and biological tissues,enabling the long-term stable monitoring of biosignals and precise diagnosis and therapy within closed-loop configurations.The past decade has seen transformative growth in this field,yielding numerous novel conformal integration strategies.These include seminal developments such as ultra-thin epidermal electronics[1,2],conformal bioelectronics fabrication or encapsulation using viscoplastic effect[3,4],and a“drop-printing”strategy for damage-free,conformal wrapping of bioelectronic interfaces through dynamic stress release[5].However,a fundamental trade-off in the clinical translation of bioelectronics lies between practical handleability ex vivo(pre-implantation)and the demand for mechanical conformability in vivo[6].To realize imperceptible biointerfaces-platforms avoiding mechanical stress or chronic tissue compression-devices must be nanoscale-thin and ultrasoft.Yet,such nanofilms are fragile and difficult to manipulate during conventional microfabrication and transfer steps,impeding their clinical translation and scalability.展开更多
Flexible deep brain neural interfaces,as an important research direction in the field of neural engineering,have broad application prospects in areas such as neural signal detection,treatment of neurological diseases,...Flexible deep brain neural interfaces,as an important research direction in the field of neural engineering,have broad application prospects in areas such as neural signal detection,treatment of neurological diseases,and intelligent control systems.However,chronic inflammatory responses caused by longterm implantation and the resulting electrode failure seriously hinder the clinical development of this technology.This review systematically explores the long-term stability issues of flexible deep brain neural interfaces,with a focus on analyzing the synergistic optimization of electrode geometric morphology and implantation strategies in regulating inflammatory responses.Additionally,this paper delves into innovative strategies,such as passive enhancement of biocompatibility through electrode surface functionalization and active inhibition of inflammation through drug-controlled release systems,offering new technical paths to extend electrode lifespan.By integrating and reviewing existing innovative methods for deep brain flexible electrodes,this study provides an important theoretical foundation and technical guidance for the development of high-stability neural interface devices.展开更多
文摘Soft bioelectronics hold immense potential across diverse applications,notably in healthcare,human-machine interfaces,and conformal neural interfaces.A core driving force is the pursuit of high-fidelity,seamless integration between electronic systems and biological tissues,enabling the long-term stable monitoring of biosignals and precise diagnosis and therapy within closed-loop configurations.The past decade has seen transformative growth in this field,yielding numerous novel conformal integration strategies.These include seminal developments such as ultra-thin epidermal electronics[1,2],conformal bioelectronics fabrication or encapsulation using viscoplastic effect[3,4],and a“drop-printing”strategy for damage-free,conformal wrapping of bioelectronic interfaces through dynamic stress release[5].However,a fundamental trade-off in the clinical translation of bioelectronics lies between practical handleability ex vivo(pre-implantation)and the demand for mechanical conformability in vivo[6].To realize imperceptible biointerfaces-platforms avoiding mechanical stress or chronic tissue compression-devices must be nanoscale-thin and ultrasoft.Yet,such nanofilms are fragile and difficult to manipulate during conventional microfabrication and transfer steps,impeding their clinical translation and scalability.
基金supported by the National Key Research and Development Program of China(2022YFC2402501,2022YFB3205602)the National Natural Science Foundation of China(Nos.62121003,T2293730,T2293731,62333020,62171434,and 62471291)+3 种基金the Major Program of Scientific and Technical Innovation 2030(2021ZD02016030)the Joint Foundation Program of the Chinese Academy of Sciences(No.8091A170201)the Scientific Instrument Developing Project of the Chinese Academy of Sciences(No.PTYQ2024BJ0009)the National Natural Science Foundation of Beijing(F252069)。
文摘Flexible deep brain neural interfaces,as an important research direction in the field of neural engineering,have broad application prospects in areas such as neural signal detection,treatment of neurological diseases,and intelligent control systems.However,chronic inflammatory responses caused by longterm implantation and the resulting electrode failure seriously hinder the clinical development of this technology.This review systematically explores the long-term stability issues of flexible deep brain neural interfaces,with a focus on analyzing the synergistic optimization of electrode geometric morphology and implantation strategies in regulating inflammatory responses.Additionally,this paper delves into innovative strategies,such as passive enhancement of biocompatibility through electrode surface functionalization and active inhibition of inflammation through drug-controlled release systems,offering new technical paths to extend electrode lifespan.By integrating and reviewing existing innovative methods for deep brain flexible electrodes,this study provides an important theoretical foundation and technical guidance for the development of high-stability neural interface devices.
