Artificial intelligence(AI)is undergoing unprecedented changes,significantly impacting the translation industry.In 2024,UNESCO released the AI Competency Framework for Students,which establishes a comprehensive dimens...Artificial intelligence(AI)is undergoing unprecedented changes,significantly impacting the translation industry.In 2024,UNESCO released the AI Competency Framework for Students,which establishes a comprehensive dimension based on a two-dimensional content structure,four levels of competencies,and three levels of proficiency,promoting a positive interaction between humans and machines.Students in the Master of Translation and Interpreting Program represent the future talent pool of the translation industry.A key issue for every translator in the current era is how to maintain the subjectivity of the translator amid the AI wave,cultivating new opportunities in times of crisis and leveraging the translator’s subjective initiative.展开更多
Active endogenous metabolites regulate the viability of cells. This process is controlled by a series ofinteractions between small metabolites and large proteins. Previously, several studies had reported thatmetabolit...Active endogenous metabolites regulate the viability of cells. This process is controlled by a series ofinteractions between small metabolites and large proteins. Previously, several studies had reported thatmetabolite regulates the protein functions, such as diacylglycerol to protein kinase C, lactose regulationof the lac repressor, and HIF-1α stabilization by 2-hydroxyglutarate. However, decades old traditionalbiochemical methods are insufficient to systematically investigate the bio-molecular reactions for a high-throughput discovery. Here, we have reviewed an update on the recently developed chemical proteomicscalled activity-based protein profiling （ABPP）. ABPP is able to identify proteins interacted eithercovalently or non-covalently with metabolites significantly. Thus, ABPP will facilitate the characteriza-tion of specific metabolite regulating; proteins in human disease progression.展开更多
文摘Artificial intelligence(AI)is undergoing unprecedented changes,significantly impacting the translation industry.In 2024,UNESCO released the AI Competency Framework for Students,which establishes a comprehensive dimension based on a two-dimensional content structure,four levels of competencies,and three levels of proficiency,promoting a positive interaction between humans and machines.Students in the Master of Translation and Interpreting Program represent the future talent pool of the translation industry.A key issue for every translator in the current era is how to maintain the subjectivity of the translator amid the AI wave,cultivating new opportunities in times of crisis and leveraging the translator’s subjective initiative.
基金supported by the National Natural Science Foundation of China(No.81672440)Innovation Program of Science and Research from the DICP,CAS(No.DICP TMSR201601)the 100 Talents Program of Chinese Academy of Sciences
文摘Active endogenous metabolites regulate the viability of cells. This process is controlled by a series ofinteractions between small metabolites and large proteins. Previously, several studies had reported thatmetabolite regulates the protein functions, such as diacylglycerol to protein kinase C, lactose regulationof the lac repressor, and HIF-1α stabilization by 2-hydroxyglutarate. However, decades old traditionalbiochemical methods are insufficient to systematically investigate the bio-molecular reactions for a high-throughput discovery. Here, we have reviewed an update on the recently developed chemical proteomicscalled activity-based protein profiling （ABPP）. ABPP is able to identify proteins interacted eithercovalently or non-covalently with metabolites significantly. Thus, ABPP will facilitate the characteriza-tion of specific metabolite regulating; proteins in human disease progression.
