There have been several developments in determining the spontaneous combustion liability of coal. Most of the methods of concern have purely been based on the internal properties of the coal itself. The relation betwe...There have been several developments in determining the spontaneous combustion liability of coal. Most of the methods of concern have purely been based on the internal properties of the coal itself. The relation between the crossing-point method and the electrical resistance of coal was examined here to outline the spontaneous combustion tendency of coal, The electrical resistance property of coal was looked into as a decision-making parameter of the interaction matrix concept for the final decision on the spontaneous combustion tendency.展开更多
Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substant...Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substantial concern associated with this technology. This study introduces an innovative approach for establishing OCGS leakage scenarios, involving four pivotal stages, namely, interactive matrix establishment, risk matrix evaluation, cause–effect analysis, and scenario development, which has been implemented in the Pearl River Estuary Basin in China. The initial phase encompassed the establishment of an interaction matrix for OCGS systems based on features, events, and processes. Subsequent risk matrix evaluation and cause–effect analysis identified key system components, specifically CO_(2) injection and faults/features. Building upon this analysis, two leakage risk scenarios were successfully developed, accompanied by the corresponding mitigation measures. In addition, this study introduces the application of scenario development to risk assessment, including scenario numerical simulation and quantitative assessment. Overall, this research positively contributes to the sustainable development and safe operation of OCGS projects and holds potential for further refinement and broader application to diverse geographical environments and project requirements. This comprehensive study provides valuable insights into the establishment of OCGS leakage scenarios and demonstrates their practical application to risk assessment, laying the foundation for promoting the sustainable development and safe operation of ocean CO_(2) geological storage projects while proposing possibilities for future improvements and broader applications to different contexts.展开更多
Three-dimensional(3D)printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and organs.These tissue-en...Three-dimensional(3D)printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and organs.These tissue-engineered structures are intended to integrate with the patient’s body.Vascular tissue engineering(TE)is relevant in TE because it supports the sustained oxygenization and nutrition of all tissue-engineered constructs.Bioinks have a specific role,representingthenecessarymedium for printability and vascular cell growth.This review aims to understand the requirements for the design of vascular bioinks.First,an in-depth analysis of vascular cell interaction with their native environment must be gained.A physiological bioink suitable for a tissue-engineered vascular graft(TEVG)must not only ensure good printability but also induce cells to behave like in a native vascular vessel,including self-regenerative and growth functions.This review describes the general structure of vascular walls with wall-specific cell and extracellular matrix(ECM)components and biomechanical properties and functions.Furthermore,the physiological role of vascular ECM components for their interaction with vascular cells and the mode of interaction is introduced.Diverse currently available or imaginable bioinks are described from physiological matrix proteins to nonphysiologically occurring but natural chemical compounds useful for vascular bioprinting.The physiological performance of these bioinks is evaluated with regard to biomechanical properties postprinting,with a view to current animal studies of 3D printed vascular structures.Finally,the main challenges for further bioink development,suitable bioink components to create a self-assembly bioink concept,and future bioprinting strategies are outlined.These concepts are discussed in terms of their suitability to be part of a TEVG with a high potential for later clinical use.展开更多
CONSPECTUS:The vascular system,encompassing blood and lymphatic vessels,is essential for nutrient transport,waste elimination,and homeostasis regulation.Composed of endothelial cells and mural cells,such as smooth mus...CONSPECTUS:The vascular system,encompassing blood and lymphatic vessels,is essential for nutrient transport,waste elimination,and homeostasis regulation.Composed of endothelial cells and mural cells,such as smooth muscle cells and pericytes,the vasculature is critical for various physiological processes,including development,organogenesis,wound healing,and tumor metastasis.The interplay between the biophysical properties of the extracellular matrix and its biochemical composition significantly influences vascular function and integrity.However,studying these complex interactions in vivo presents considerable challenges,underscoring the need for innovative research methodologies.For example,traditional 2D cell culture fails to account for the complex,multifaceted environment that cells are exposed to in vivo.Vascular tissue engineering has emerged as a promising approach,aiming to replicate the architecture and functionality of blood vessels to enhance understanding of vascular development and pathology.A central facet of vascular tissue engineering is biomaterial design,in which natural or synthetic polymers are assembled into water-swollen networks,or hydrogels,for 3D cell cultures that can last days or weeks.By utilizing hydrogel biomaterials,researchers can create tunable model systems that closely mimic the natural vascular environment,such as by modifying polymer backbone functionalization and the local biochemical environment or altering the resultant physical properties of the hydrogel.These customizable microenvironments facilitate critical cell-matrix interactions,enabling investigations into key vascular mechanisms such as adhesion,migration,proliferation,and differentiation.This Account explores key aspects of cell-matrix interactions in vascular tissue engineering and the biomaterials designed to study them.We begin with advancements in material design that replicate the spatial and mechanical properties of vascular tissues:matrix stiffness can be tuned to mimic the stiffness of in vivo tissues,viscoelasticity is introduced to replicate the time-dependent strain associated with biologic fluids and tissues,spatial orientation is designed to mimic the architecture common to naturally occurring extracellular matrix,and degradation is an inherent feature of these materials to facilitate cell-caused microenvironment remodeling.We then examine how the biochemical properties of materials influence vascular function:matrix composition can replicate the factors expected in the vascular extracellular matrix,bioactive cues are presented to match the complex gradients formed by paracrine signaling,and hypoxia can be introduced via material design to understand how angiogenesis occurs at the edges of existing vascular networks.Finally,we identify major challenges in the field,highlighting current obstacles and proposing future strategies to enhance the characterization of vascular tissue constructs.These insights aim to advance effective methods in vascular tissue engineering and characterize the biological mechanisms responsible for endothelial cell vascularization.展开更多
Floor water inrush is one of the main types of coal mine water hazards.With the development of deep mining,the prediction and evaluation of floor water inrush is particularly significant.This paper proposes a variable...Floor water inrush is one of the main types of coal mine water hazards.With the development of deep mining,the prediction and evaluation of floor water inrush is particularly significant.This paper proposes a variable weight model,which combines a multi-factor interaction matrix(MFIM)and the technique for order performance by similarity to ideal solution(TOPSIS)to implement the risk assessment of floor water inrush in coal mines.Based on the MFIM,the interaction between seven evaluation indices,including the confined water pressure,water supply condition and aquifer water yield property,floor aquifuge thickness,fault water transmitting ability,fracture development degree,mining depth and thickness and their influence on floor water inrush were considered.After calculating the constant weights,the active degree evaluation was used to assign a variable weight to the indices.The values of the middle layer and final risk level were obtained by TOPSIS.The presented model was successfully applied in the 9901 working face in the Taoyang Mine and four additional coal mines and the results were highly consistent with the engineering situations.Compared with the existing nonlinear evaluation methods,the proposed model had advantages in terms of the weighting,principle explanation,and algorithm structure.展开更多
The new Austrian tunneling method （NATM） is widely applied in design and construction of underground engineering projects. When the type and distribution of unfavorable geological bodies （UGBs） associated with the...The new Austrian tunneling method （NATM） is widely applied in design and construction of underground engineering projects. When the type and distribution of unfavorable geological bodies （UGBs） associated with their influences on geoengineering are complicated or unfortunately are overlooked, we should pay more attentions to internal features of rocks grades IV and V （even in local but mostly controlling zones）. With increasing attentions to the characteristics, mechanism and influences of engineering construction-triggered geohazards, it is crucial to fully understand the disturbance of these geohazards on project construction. A reasonable determination method in construction procedure, i.e. the shape of working face, the type of engineering support and the choice of feasible procedure, should be considered in order to mitigate the construction-triggered geohazards. Due to their high sensitivity to groundwater and in-situ stress, various UGBs exhibit hysteretic nature and failure modes. To give a complete understanding on the internal causes, the emphasis on advanced comprehensive geological forecasting and overall reinforcement treatment is therefore of more practical significance. Compre- hensive evaluation of influential factors, identification of UGB, and measures of discontinuity dynamic controlling comprises the geoengineering condition evaluation and dynamic controlling method. In a case of a cut slope, the variations of UGBs and the impacts of key environmental factors are presented, where more severe construction-triggered geohazards emerged in construction stage than those predicted in design and field investigation stages. As a result, the weight ratios of different influential factors with respect to field investigation, design and construction are obtained.展开更多
This research describes a quantitative,rapid,and low-cost methodology for debris flow susceptibility evaluation at the basin scale using open-access data and geodatabases.The proposed approach can aid decision makers ...This research describes a quantitative,rapid,and low-cost methodology for debris flow susceptibility evaluation at the basin scale using open-access data and geodatabases.The proposed approach can aid decision makers in land management and territorial planning,by first screening for areas with a higher debris flow susceptibility.Five environmental predisposing factors,namely,bedrock lithology,fracture network,quaternary deposits,slope inclination,and hydrographic network,were selected as independent parameters and their mutual interactions were described and quantified using the Rock Engineering System(RES)methodology.For each parameter,specific indexes were proposed,aiming to provide a final synthetic and representative index of debris flow susceptibility at the basin scale.The methodology was tested in four basins located in the Upper Susa Valley(NW Italian Alps)where debris flow events are the predominant natural hazard.The proposed matrix can represent a useful standardized tool,universally applicable,since it is independent of type and characteristic of the basin.展开更多
Pumpkin (Cucurbita moschata ) is one of the well-known edible plants that contains several phytoconstituents,including polyphenols.The properties of medicinal values in pumpkin have been demonstrated,such as anti-diab...Pumpkin (Cucurbita moschata ) is one of the well-known edible plants that contains several phytoconstituents,including polyphenols.The properties of medicinal values in pumpkin have been demonstrated,such as anti-diabetic,antioxidant,anti-carcinogenic,anti-inflammatory,hypolipidemic,and hypoglycemic.As functional compounds in pumpkins and the secondary metabolites in plants,the positive effects of polyphenols have been studied,including high antioxidant capacities and the mitigation potential of chronic diseases and certain cancers.This review is proposed to comprehensively investigate the interactions between phenolic compounds and pumpkin matrix constituents,including carbohydrates,proteins,lipids,minerals,vitamins,and other polyphenols,which will significantly impact the bioaccessibility and bioavailability of bioactive compounds in pumpkins,especially phenolics.Meanwhile,the effect on the nutritional properties of bioactive compounds has also been reported.Furthermore,this review includes the assessments for the food processing strategies to demonstrate the impact on phenolic intake capacity and changes in the content and properties of active compounds.展开更多
文摘There have been several developments in determining the spontaneous combustion liability of coal. Most of the methods of concern have purely been based on the internal properties of the coal itself. The relation between the crossing-point method and the electrical resistance of coal was examined here to outline the spontaneous combustion tendency of coal, The electrical resistance property of coal was looked into as a decision-making parameter of the interaction matrix concept for the final decision on the spontaneous combustion tendency.
文摘Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substantial concern associated with this technology. This study introduces an innovative approach for establishing OCGS leakage scenarios, involving four pivotal stages, namely, interactive matrix establishment, risk matrix evaluation, cause–effect analysis, and scenario development, which has been implemented in the Pearl River Estuary Basin in China. The initial phase encompassed the establishment of an interaction matrix for OCGS systems based on features, events, and processes. Subsequent risk matrix evaluation and cause–effect analysis identified key system components, specifically CO_(2) injection and faults/features. Building upon this analysis, two leakage risk scenarios were successfully developed, accompanied by the corresponding mitigation measures. In addition, this study introduces the application of scenario development to risk assessment, including scenario numerical simulation and quantitative assessment. Overall, this research positively contributes to the sustainable development and safe operation of OCGS projects and holds potential for further refinement and broader application to diverse geographical environments and project requirements. This comprehensive study provides valuable insights into the establishment of OCGS leakage scenarios and demonstrates their practical application to risk assessment, laying the foundation for promoting the sustainable development and safe operation of ocean CO_(2) geological storage projects while proposing possibilities for future improvements and broader applications to different contexts.
文摘Three-dimensional(3D)printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and organs.These tissue-engineered structures are intended to integrate with the patient’s body.Vascular tissue engineering(TE)is relevant in TE because it supports the sustained oxygenization and nutrition of all tissue-engineered constructs.Bioinks have a specific role,representingthenecessarymedium for printability and vascular cell growth.This review aims to understand the requirements for the design of vascular bioinks.First,an in-depth analysis of vascular cell interaction with their native environment must be gained.A physiological bioink suitable for a tissue-engineered vascular graft(TEVG)must not only ensure good printability but also induce cells to behave like in a native vascular vessel,including self-regenerative and growth functions.This review describes the general structure of vascular walls with wall-specific cell and extracellular matrix(ECM)components and biomechanical properties and functions.Furthermore,the physiological role of vascular ECM components for their interaction with vascular cells and the mode of interaction is introduced.Diverse currently available or imaginable bioinks are described from physiological matrix proteins to nonphysiologically occurring but natural chemical compounds useful for vascular bioprinting.The physiological performance of these bioinks is evaluated with regard to biomechanical properties postprinting,with a view to current animal studies of 3D printed vascular structures.Finally,the main challenges for further bioink development,suitable bioink components to create a self-assembly bioink concept,and future bioprinting strategies are outlined.These concepts are discussed in terms of their suitability to be part of a TEVG with a high potential for later clinical use.
基金supported by the National Science Foundation GRFP DGS 2139754.
文摘CONSPECTUS:The vascular system,encompassing blood and lymphatic vessels,is essential for nutrient transport,waste elimination,and homeostasis regulation.Composed of endothelial cells and mural cells,such as smooth muscle cells and pericytes,the vasculature is critical for various physiological processes,including development,organogenesis,wound healing,and tumor metastasis.The interplay between the biophysical properties of the extracellular matrix and its biochemical composition significantly influences vascular function and integrity.However,studying these complex interactions in vivo presents considerable challenges,underscoring the need for innovative research methodologies.For example,traditional 2D cell culture fails to account for the complex,multifaceted environment that cells are exposed to in vivo.Vascular tissue engineering has emerged as a promising approach,aiming to replicate the architecture and functionality of blood vessels to enhance understanding of vascular development and pathology.A central facet of vascular tissue engineering is biomaterial design,in which natural or synthetic polymers are assembled into water-swollen networks,or hydrogels,for 3D cell cultures that can last days or weeks.By utilizing hydrogel biomaterials,researchers can create tunable model systems that closely mimic the natural vascular environment,such as by modifying polymer backbone functionalization and the local biochemical environment or altering the resultant physical properties of the hydrogel.These customizable microenvironments facilitate critical cell-matrix interactions,enabling investigations into key vascular mechanisms such as adhesion,migration,proliferation,and differentiation.This Account explores key aspects of cell-matrix interactions in vascular tissue engineering and the biomaterials designed to study them.We begin with advancements in material design that replicate the spatial and mechanical properties of vascular tissues:matrix stiffness can be tuned to mimic the stiffness of in vivo tissues,viscoelasticity is introduced to replicate the time-dependent strain associated with biologic fluids and tissues,spatial orientation is designed to mimic the architecture common to naturally occurring extracellular matrix,and degradation is an inherent feature of these materials to facilitate cell-caused microenvironment remodeling.We then examine how the biochemical properties of materials influence vascular function:matrix composition can replicate the factors expected in the vascular extracellular matrix,bioactive cues are presented to match the complex gradients formed by paracrine signaling,and hypoxia can be introduced via material design to understand how angiogenesis occurs at the edges of existing vascular networks.Finally,we identify major challenges in the field,highlighting current obstacles and proposing future strategies to enhance the characterization of vascular tissue constructs.These insights aim to advance effective methods in vascular tissue engineering and characterize the biological mechanisms responsible for endothelial cell vascularization.
基金Projects(41877239,51379112,51422904,40902084,41772298)supported by the National Natural Science Foundation of ChinaProject(2019GSF111028)supported by the Key Technology Research and Development Program of Shandong Province,China+1 种基金Project(2018JC044)supported by the Fundamental Research Funds of Shandong University,ChinaProject(JQ201513)supported by the Natural Science Foundation of Shandong Province,China。
文摘Floor water inrush is one of the main types of coal mine water hazards.With the development of deep mining,the prediction and evaluation of floor water inrush is particularly significant.This paper proposes a variable weight model,which combines a multi-factor interaction matrix(MFIM)and the technique for order performance by similarity to ideal solution(TOPSIS)to implement the risk assessment of floor water inrush in coal mines.Based on the MFIM,the interaction between seven evaluation indices,including the confined water pressure,water supply condition and aquifer water yield property,floor aquifuge thickness,fault water transmitting ability,fracture development degree,mining depth and thickness and their influence on floor water inrush were considered.After calculating the constant weights,the active degree evaluation was used to assign a variable weight to the indices.The values of the middle layer and final risk level were obtained by TOPSIS.The presented model was successfully applied in the 9901 working face in the Taoyang Mine and four additional coal mines and the results were highly consistent with the engineering situations.Compared with the existing nonlinear evaluation methods,the proposed model had advantages in terms of the weighting,principle explanation,and algorithm structure.
基金support by the National Natural Science Foundation of China (No. 41372324)support from the Chinese Special Funds for Major State Basic Research Project under Grant No. 2010CB732001
文摘The new Austrian tunneling method （NATM） is widely applied in design and construction of underground engineering projects. When the type and distribution of unfavorable geological bodies （UGBs） associated with their influences on geoengineering are complicated or unfortunately are overlooked, we should pay more attentions to internal features of rocks grades IV and V （even in local but mostly controlling zones）. With increasing attentions to the characteristics, mechanism and influences of engineering construction-triggered geohazards, it is crucial to fully understand the disturbance of these geohazards on project construction. A reasonable determination method in construction procedure, i.e. the shape of working face, the type of engineering support and the choice of feasible procedure, should be considered in order to mitigate the construction-triggered geohazards. Due to their high sensitivity to groundwater and in-situ stress, various UGBs exhibit hysteretic nature and failure modes. To give a complete understanding on the internal causes, the emphasis on advanced comprehensive geological forecasting and overall reinforcement treatment is therefore of more practical significance. Compre- hensive evaluation of influential factors, identification of UGB, and measures of discontinuity dynamic controlling comprises the geoengineering condition evaluation and dynamic controlling method. In a case of a cut slope, the variations of UGBs and the impacts of key environmental factors are presented, where more severe construction-triggered geohazards emerged in construction stage than those predicted in design and field investigation stages. As a result, the weight ratios of different influential factors with respect to field investigation, design and construction are obtained.
文摘This research describes a quantitative,rapid,and low-cost methodology for debris flow susceptibility evaluation at the basin scale using open-access data and geodatabases.The proposed approach can aid decision makers in land management and territorial planning,by first screening for areas with a higher debris flow susceptibility.Five environmental predisposing factors,namely,bedrock lithology,fracture network,quaternary deposits,slope inclination,and hydrographic network,were selected as independent parameters and their mutual interactions were described and quantified using the Rock Engineering System(RES)methodology.For each parameter,specific indexes were proposed,aiming to provide a final synthetic and representative index of debris flow susceptibility at the basin scale.The methodology was tested in four basins located in the Upper Susa Valley(NW Italian Alps)where debris flow events are the predominant natural hazard.The proposed matrix can represent a useful standardized tool,universally applicable,since it is independent of type and characteristic of the basin.
基金funded by Ezy Chef Pty Ltd,Australia under the project theme of“In vitro digestion model for plant proteinsblended food product analysis”and supported by the AusIndustry Entrepreneurs’Programme“Innovation Connections Grant(TCG00175)”+2 种基金Also,supported by the University of Melbourne under the“McKenzie Fellowship Scheme”(Grant No.UoM-18/21)“Collaborative Research Development Grant(Grant No.UoM-21/23)”funded by the Faculty of Veterinary and Agricultural Sciencesthe University of Melbourne,Australia.Dr Hafiz Suleria is the recipient of an“Australian Research Council-Discovery Early Career Award”(ARC-DECRA-DE220100055)funded by the Australian Government.
文摘Pumpkin (Cucurbita moschata ) is one of the well-known edible plants that contains several phytoconstituents,including polyphenols.The properties of medicinal values in pumpkin have been demonstrated,such as anti-diabetic,antioxidant,anti-carcinogenic,anti-inflammatory,hypolipidemic,and hypoglycemic.As functional compounds in pumpkins and the secondary metabolites in plants,the positive effects of polyphenols have been studied,including high antioxidant capacities and the mitigation potential of chronic diseases and certain cancers.This review is proposed to comprehensively investigate the interactions between phenolic compounds and pumpkin matrix constituents,including carbohydrates,proteins,lipids,minerals,vitamins,and other polyphenols,which will significantly impact the bioaccessibility and bioavailability of bioactive compounds in pumpkins,especially phenolics.Meanwhile,the effect on the nutritional properties of bioactive compounds has also been reported.Furthermore,this review includes the assessments for the food processing strategies to demonstrate the impact on phenolic intake capacity and changes in the content and properties of active compounds.
