A randomized double-blind intervention trial was carried determine whether oral calcium supplementation could lower the proliferation of epithelial cells of the esophagus. 41 subjects identified with precancerous lesi...A randomized double-blind intervention trial was carried determine whether oral calcium supplementation could lower the proliferation of epithelial cells of the esophagus. 41 subjects identified with precancerous lesions by histopathology were randomized to receive oral supplementation of their conventional diets with 0.6 g of calcium as calcium carbonate or placebo. Both at the entry to the study and at the end of the treatment, seven months later, the subjects were examined, with an emphasis on the frequency and distribution of proliferating epithelial cells of the esophagus. Patterns of cell proliferation was defined by dividing the esophageal epithelium into cell columns oriented perpendicularly to the basal cell layer and by comparing the numbers and fractions of tritiated thymidine-labeled epithelial cells in the various cell columns and cell compartments.Before dietary supplementation with calcium, the profile of proliferating epithelial cells in the esophageal compartments in calcium group is similar to that in the placebo group, which is comparable to that previously observed in subjects with high risk for esophageal cancer. Seven months after supplementation having been started, in calcium group, proliferation was significantly reduced and the profile of the esophageal columns approached to that previously observed in subjects at low risk for esophageal cancer, however, in the placebo group, the proliferation and profile maintain at the same level as that before supplementation. Our findings indicate that oral calcium supplementation induces a more quiescent equilibrium in epithelial-cell proliferation in the esophageal mucosa of the subjects at high-risk for esophageal cancer, similar to that observed in subjects at low risk.展开更多
性接触传播已成为我国艾滋病的最主要传播途径,针对这一点,国内各地都对女性性工作者(female sex workers,FSWs)的高危行为进行了各种形式的干预调查。主要干预途径有:发放宣传材料、进行艾滋病相关知识培训、为FSWs提供就医便利、开展...性接触传播已成为我国艾滋病的最主要传播途径,针对这一点,国内各地都对女性性工作者(female sex workers,FSWs)的高危行为进行了各种形式的干预调查。主要干预途径有:发放宣传材料、进行艾滋病相关知识培训、为FSWs提供就医便利、开展同伴教育等。各种途径的干预都有一定效果,但也都存在一定的局限性。在干预过程中还发现了一些值得注意的问题,如暗娼实际行为与相关知识知晓率的脱离,性行为方式多样化带来的隐患,暗娼人群中存在吸毒者等。本文就近年来国内针对FSWs所进行的调查、干预及其相关工作中所遇到的问题进行综述,为该人群的艾滋病防治提供依据。展开更多
文摘A randomized double-blind intervention trial was carried determine whether oral calcium supplementation could lower the proliferation of epithelial cells of the esophagus. 41 subjects identified with precancerous lesions by histopathology were randomized to receive oral supplementation of their conventional diets with 0.6 g of calcium as calcium carbonate or placebo. Both at the entry to the study and at the end of the treatment, seven months later, the subjects were examined, with an emphasis on the frequency and distribution of proliferating epithelial cells of the esophagus. Patterns of cell proliferation was defined by dividing the esophageal epithelium into cell columns oriented perpendicularly to the basal cell layer and by comparing the numbers and fractions of tritiated thymidine-labeled epithelial cells in the various cell columns and cell compartments.Before dietary supplementation with calcium, the profile of proliferating epithelial cells in the esophageal compartments in calcium group is similar to that in the placebo group, which is comparable to that previously observed in subjects with high risk for esophageal cancer. Seven months after supplementation having been started, in calcium group, proliferation was significantly reduced and the profile of the esophageal columns approached to that previously observed in subjects at low risk for esophageal cancer, however, in the placebo group, the proliferation and profile maintain at the same level as that before supplementation. Our findings indicate that oral calcium supplementation induces a more quiescent equilibrium in epithelial-cell proliferation in the esophageal mucosa of the subjects at high-risk for esophageal cancer, similar to that observed in subjects at low risk.
文摘性接触传播已成为我国艾滋病的最主要传播途径,针对这一点,国内各地都对女性性工作者(female sex workers,FSWs)的高危行为进行了各种形式的干预调查。主要干预途径有:发放宣传材料、进行艾滋病相关知识培训、为FSWs提供就医便利、开展同伴教育等。各种途径的干预都有一定效果,但也都存在一定的局限性。在干预过程中还发现了一些值得注意的问题,如暗娼实际行为与相关知识知晓率的脱离,性行为方式多样化带来的隐患,暗娼人群中存在吸毒者等。本文就近年来国内针对FSWs所进行的调查、干预及其相关工作中所遇到的问题进行综述,为该人群的艾滋病防治提供依据。
