A quinine-derived thiourea-catalyzed inter-/intramolecular Michael cycloaddition of chromoneoxindole/benzofuranone synthons with 3-substituted methylenebenzofuranones has been established,which constructed enantiomeri...A quinine-derived thiourea-catalyzed inter-/intramolecular Michael cycloaddition of chromoneoxindole/benzofuranone synthons with 3-substituted methylenebenzofuranones has been established,which constructed enantiomerically pure bispiro[benzofuran-oxindole/benzofuran-chromanone]s bearing five consecutive stereocenters including two spiro quaternary carton centers in good yields(up to 93%) with high diastereoselectivities(up to>20:1 dr) and good enantioselectivities(up to>99% ee).Moreover,this is the first example of bifunctional chromone-benzofuranone synthon directed organocatalytic tandem reaction,and also the first example of the bispiro[benzofuran-oxindole] and bispirobenzofuranone,potentially useful in medicinal chemistry.展开更多
Objective:The inter-α-trypsin inhibitor heavy chain 4(ITIH4)protein is involved in the development of tumors.However,the relationship between ITIH4 and ovarian cancer(OC)has not been extensively examined.This study a...Objective:The inter-α-trypsin inhibitor heavy chain 4(ITIH4)protein is involved in the development of tumors.However,the relationship between ITIH4 and ovarian cancer(OC)has not been extensively examined.This study aimed to explore the effect of ITIH4 on OC and to identify its underlying mechanism.Methods:Expressions of ITIH4 in OC tissues and cells were determined using quantitative reverse transcription polymerase chain reaction(RT-qPCR)and western blots.The function of ITIH4 in the OC cell line HO8910 pm was tested via ITIH4 knockdown.The cell growth rate was measured using MTT and colony formation assays.Flow cytometry was performed to evaluate cell cycle progression.Cell migration and invasion abilities were observed using the transwell migration assay.Results:ITIH4 was downregulated in OC tissues and cells.ITIH4 knockdown promoted cell growth and cell cycle progression.Consistent with these results,inhibition of ITIH4 in OC cells significantly increased cell migration and invasion abilities.Cox regression analysis suggests that ITIH4 expression alone is not a good predictor of the prognosis of malignant ovarian tumors in patients.Conclusions:ITIH4 inhibits the progression of OC,suggesting that ITIH4 may be a useful biomarker for OC.This study may provide a potential novel target for the treatment of OC.展开更多
本文基于Brown语料库的100万词的数据,考察科技英语的篇际词汇增长模型,以篇章为计量单位,描述科技英语文本中词汇量V(N)与累积文本容量N之间的函数关系。通过对幂函数和对数函数的比较分析,构建了新的词汇增长模型,并应用此模型推导出...本文基于Brown语料库的100万词的数据,考察科技英语的篇际词汇增长模型,以篇章为计量单位,描述科技英语文本中词汇量V(N)与累积文本容量N之间的函数关系。通过对幂函数和对数函数的比较分析,构建了新的词汇增长模型,并应用此模型推导出科技英语的理论词汇增长曲线及其95%双向置信区间。本研究属于计算语言学的基础理论研究,反映了语言的经济律,有深刻的理论价值;另外,本文对英语作为外语的教学(English as Foreign Language,简称EFL),特别是词汇教学和教材编写,也有一定的指导意义。展开更多
Soil salinization is a common phenomenon that affects both the environment and the socio-economy in arid and semi-arid regions; it is also an important aspect of land cover change. In this study, we integrated multi-s...Soil salinization is a common phenomenon that affects both the environment and the socio-economy in arid and semi-arid regions; it is also an important aspect of land cover change. In this study, we integrated multi-sensor remote sensing data with a field survey to analyze processes of soil salinization in a semi-arid area in China from 1979 to 2009. Generally, the area of salt-affected soils increased by 0.28% per year with remarkable acceleration from 1999 to 2009 （0.42% increase per year）. In contrast, the area of surface water bodies showed a decreasing trend （-0.08% per year） in the same period. Decreases in precipitation and increases in aridity due to annual （especially summer） warming provided a favorable condition for soil salinization. The relatively flat terrain favored waterlogging at the surface, and continuous drought facilitated upward movement of soil water and accumulation of surface saline and calcium. Meanwhile, land-use practices also played a crucial role in accelerating soil salinization. The conversion to cropland from natural vegetation greatly increased the demand for groundwater irrigation and aggravated the process of soil salinization. Furthermore, there are potential feedbacks of soil salinization to regional climate. The salinization of soils can limit the efficiency of plant water use as well as photosynthesis; therefore, it reduces the amount of carbon sequestrated by terrestrial ecosystem. Soil salinization also reduces the absorbed solar radiation by increasing land surface albedo. Such conversions of land cover significantly change the energy and water balance between land and atmosphere.展开更多
We tested the use of otolith shape analysis to discriminate between species and stocks of five goby species( Ctenotrypauchen chinensis, Odontamblyopus lacepedii, Amblychaeturichthys hexanema, Chaeturichthys stigmatias...We tested the use of otolith shape analysis to discriminate between species and stocks of five goby species( Ctenotrypauchen chinensis, Odontamblyopus lacepedii, Amblychaeturichthys hexanema, Chaeturichthys stigmatias, and Acanthogobius hasta) found in northern Chinese coastal waters. The five species were well differentiated with high overall classification success using shape indices(83.7%), elliptic Fourier coefficients(98.6%), or the combination of both methods(94.9%). However, shape analysis alone was only moderately successful at discriminating among the four stocks(Liaodong Bay, LD; Bohai Bay, BH; Huanghe(Yellow) River estuary HRE, and Jiaozhou Bay, JZ stocks) of A. hasta(50%–54%) and C. stigmatias(65.7%–75.8%). For these two species, shape analysis was moderately successful at discriminating the HRE or JZ stocks from other stocks, but failed to effectively identify the LD and BH stocks. A large number of otoliths were misclassified between the HRE and JZ stocks, which are geographically well separated. The classification success for stock discrimination was higher using elliptic Fourier coefficients alone(70.2%) or in combination with shape indices(75.8%) than using only shape indices(65.7%) in C. stigmatias whereas there was little difference among the three methods for A. hasta. Our results supported the common belief that otolith shape analysis is generally more effective for interspecific identification than intraspecific discrimination. Moreover, compared with shape indices analysis, Fourier analysis improves classification success during inter- and intra-species discrimination by otolith shape analysis, although this did not necessarily always occur in all fish species.展开更多
In this article, we establish some atomic decomposition theorems for martin- gale Hardy-Lorentz spaces. As applications, with the help of weak atomic decompositions, some interpolation theorems for martingale Hardy-Lo...In this article, we establish some atomic decomposition theorems for martin- gale Hardy-Lorentz spaces. As applications, with the help of weak atomic decompositions, some interpolation theorems for martingale Hardy-Lorentz spaces are proved.展开更多
基金financial support from the National Nature Science Foundation of China(Nos.81760625,81660576 and81560563)Projects of Guizhou Province(Nos.[2016]5623,JG[2016]06,[2019]1402,[2017]5609 and[2018]5781)。
文摘A quinine-derived thiourea-catalyzed inter-/intramolecular Michael cycloaddition of chromoneoxindole/benzofuranone synthons with 3-substituted methylenebenzofuranones has been established,which constructed enantiomerically pure bispiro[benzofuran-oxindole/benzofuran-chromanone]s bearing five consecutive stereocenters including two spiro quaternary carton centers in good yields(up to 93%) with high diastereoselectivities(up to>20:1 dr) and good enantioselectivities(up to>99% ee).Moreover,this is the first example of bifunctional chromone-benzofuranone synthon directed organocatalytic tandem reaction,and also the first example of the bispiro[benzofuran-oxindole] and bispirobenzofuranone,potentially useful in medicinal chemistry.
基金supported by Guangxi Scientific Research and Technology Development Project (No. 14124004-1-24)
文摘Objective:The inter-α-trypsin inhibitor heavy chain 4(ITIH4)protein is involved in the development of tumors.However,the relationship between ITIH4 and ovarian cancer(OC)has not been extensively examined.This study aimed to explore the effect of ITIH4 on OC and to identify its underlying mechanism.Methods:Expressions of ITIH4 in OC tissues and cells were determined using quantitative reverse transcription polymerase chain reaction(RT-qPCR)and western blots.The function of ITIH4 in the OC cell line HO8910 pm was tested via ITIH4 knockdown.The cell growth rate was measured using MTT and colony formation assays.Flow cytometry was performed to evaluate cell cycle progression.Cell migration and invasion abilities were observed using the transwell migration assay.Results:ITIH4 was downregulated in OC tissues and cells.ITIH4 knockdown promoted cell growth and cell cycle progression.Consistent with these results,inhibition of ITIH4 in OC cells significantly increased cell migration and invasion abilities.Cox regression analysis suggests that ITIH4 expression alone is not a good predictor of the prognosis of malignant ovarian tumors in patients.Conclusions:ITIH4 inhibits the progression of OC,suggesting that ITIH4 may be a useful biomarker for OC.This study may provide a potential novel target for the treatment of OC.
文摘本文基于Brown语料库的100万词的数据,考察科技英语的篇际词汇增长模型,以篇章为计量单位,描述科技英语文本中词汇量V(N)与累积文本容量N之间的函数关系。通过对幂函数和对数函数的比较分析,构建了新的词汇增长模型,并应用此模型推导出科技英语的理论词汇增长曲线及其95%双向置信区间。本研究属于计算语言学的基础理论研究,反映了语言的经济律,有深刻的理论价值;另外,本文对英语作为外语的教学(English as Foreign Language,简称EFL),特别是词汇教学和教材编写,也有一定的指导意义。
基金supported by the National Basic Research Program of China (Grant No.2009CB723904)the National Natural Science Foundation of China (Grant No. 41105076)+1 种基金the National Key technology R & D program (Grant No. 2012BAC22B04)the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA05090201)
文摘Soil salinization is a common phenomenon that affects both the environment and the socio-economy in arid and semi-arid regions; it is also an important aspect of land cover change. In this study, we integrated multi-sensor remote sensing data with a field survey to analyze processes of soil salinization in a semi-arid area in China from 1979 to 2009. Generally, the area of salt-affected soils increased by 0.28% per year with remarkable acceleration from 1999 to 2009 （0.42% increase per year）. In contrast, the area of surface water bodies showed a decreasing trend （-0.08% per year） in the same period. Decreases in precipitation and increases in aridity due to annual （especially summer） warming provided a favorable condition for soil salinization. The relatively flat terrain favored waterlogging at the surface, and continuous drought facilitated upward movement of soil water and accumulation of surface saline and calcium. Meanwhile, land-use practices also played a crucial role in accelerating soil salinization. The conversion to cropland from natural vegetation greatly increased the demand for groundwater irrigation and aggravated the process of soil salinization. Furthermore, there are potential feedbacks of soil salinization to regional climate. The salinization of soils can limit the efficiency of plant water use as well as photosynthesis; therefore, it reduces the amount of carbon sequestrated by terrestrial ecosystem. Soil salinization also reduces the absorbed solar radiation by increasing land surface albedo. Such conversions of land cover significantly change the energy and water balance between land and atmosphere.
基金Supported by the National Natural Science Foundation of China(NSFC)(Nos.40976084,U1406403,41121064)
文摘We tested the use of otolith shape analysis to discriminate between species and stocks of five goby species( Ctenotrypauchen chinensis, Odontamblyopus lacepedii, Amblychaeturichthys hexanema, Chaeturichthys stigmatias, and Acanthogobius hasta) found in northern Chinese coastal waters. The five species were well differentiated with high overall classification success using shape indices(83.7%), elliptic Fourier coefficients(98.6%), or the combination of both methods(94.9%). However, shape analysis alone was only moderately successful at discriminating among the four stocks(Liaodong Bay, LD; Bohai Bay, BH; Huanghe(Yellow) River estuary HRE, and Jiaozhou Bay, JZ stocks) of A. hasta(50%–54%) and C. stigmatias(65.7%–75.8%). For these two species, shape analysis was moderately successful at discriminating the HRE or JZ stocks from other stocks, but failed to effectively identify the LD and BH stocks. A large number of otoliths were misclassified between the HRE and JZ stocks, which are geographically well separated. The classification success for stock discrimination was higher using elliptic Fourier coefficients alone(70.2%) or in combination with shape indices(75.8%) than using only shape indices(65.7%) in C. stigmatias whereas there was little difference among the three methods for A. hasta. Our results supported the common belief that otolith shape analysis is generally more effective for interspecific identification than intraspecific discrimination. Moreover, compared with shape indices analysis, Fourier analysis improves classification success during inter- and intra-species discrimination by otolith shape analysis, although this did not necessarily always occur in all fish species.
基金supported by the National Natural Science Foundation of China(10871016)
文摘In this article, we establish some atomic decomposition theorems for martin- gale Hardy-Lorentz spaces. As applications, with the help of weak atomic decompositions, some interpolation theorems for martingale Hardy-Lorentz spaces are proved.
