Temporal relation computation is one of the tasks of the extraction of temporal arguments from event, and it is also the ultimate goal of temporal information processing. However, temporal relation computation based o...Temporal relation computation is one of the tasks of the extraction of temporal arguments from event, and it is also the ultimate goal of temporal information processing. However, temporal relation computation based on machine learning requires a lot of hand-marked work, and exploring more features from discourse. A method of two-stage machine learning based on temporal relation computation （TSMLTRC） is proposed in this paper for the shortcomings of current temporal relation computation between two events. The first stage is to get the main temporal attributes of event based on classification learning. The second stage is to compute the event temporal relation in the discourse through employing the result of the first stage as the basic features, and also employing some new linguistic characteristics. Experiments show that, compared with the artificial golden rule, the computational efficiency in the first stage is much higher, and the F1-Score of event temporal relation which is computed through combining multi-features may be increased at 85.8% in the second stage.展开更多
This study explored the possibility of using event-related potentials （ERP） for the measurement of picture-recognition memory and examined its correlation with the Chinese Wechsler Memory Scale-revised （WMS-RC） in...This study explored the possibility of using event-related potentials （ERP） for the measurement of picture-recognition memory and examined its correlation with the Chinese Wechsler Memory Scale-revised （WMS-RC） in patients with memory disorder caused by severe traumatic brain injury （sTBI）. The subjects included 20 sTBI patients with memory disorder and 22 healthy individuals. Memory function was measured by using WMS-RC. Behavioral and ERP responses were recorded on-line during performance on a battery of picture recognition and the responses were analyzed off-line for recognition memory effects. Mean memory quotient （MQ） of patients with sTBI was significantly lower than that of the control group. Mean reaction time （RT） was significantly longer and the mean correctness rate （CR） of picture recognition was significantly lower in sTBI group than that of the controls. In controls, the main components of average ERP of picture recognition includes two positive-going waves, designated as P170 and P500, that appear 170 ms and 500 ms after stimulation when the subject could later successfully recall and recognize the pictures. P500 amplitude of target stimulus was significantly higher than that of non-target stimulus. Compared to controls, P500 responses of sTBI group were significantly delayed in latency （P〈0.001） and lower in amplitude （P〈0.001）. P500 latency showed significant negative correlation with MQ and the scores of ＂addition＂, ＂visual recognition＂, ＂picture recall＂, ＂visual reproduction＂ and ＂tactile memory＂ in WMS-RC. ERP of picture recognition provides a neurophysiological approach to directly assess memory impairment, and P500 may serve as a helpful index for memory disorder caused by sTBI in forensic practice.展开更多
BACKGROUND Recent studies have indicated that triglyceride glucose(TyG)-waist height ratio(WHtR)and TyG-waist circumference(TyG-WC)are effective indicators for evaluating insulin resistance.However,research on the ass...BACKGROUND Recent studies have indicated that triglyceride glucose(TyG)-waist height ratio(WHtR)and TyG-waist circumference(TyG-WC)are effective indicators for evaluating insulin resistance.However,research on the association in TyG-WHtR,TyG-WC,and the risk and prognosis of major adverse cardiovascular events(MACEs)in type 2 diabetes mellitus(T2DM)cases are limited.AIM To clarify the relation in TyG-WHtR,TyG-WC,and the risk of MACEs and overall mortality in T2DM patients.METHODS Information for this investigation was obtained from Action to Control Cardiovascular Risk in Diabetes(ACCORD)/ACCORD Follow-On(ACCORDION)study database.The Cox regression model was applied to assess the relation among TyG-WHtR,TyG-WC and future MACEs risk and overall mortality in T2DM cases.The RCS analysis was utilized to explore the nonlinear correlation.Subgroup and interaction analyses were conducted to prove the robustness.The receiver operating characteristic curves were applied to analysis the additional predicting value of TyG-WHtR and TyG-WC.RESULTS After full adjustment for confounding variables,the highest baseline TyG-WHtR cohort respectively exhibited a 1.353-fold and 1.420-fold higher risk for MACEs and overall mortality,than the lowest quartile group.Similarly,the highest baseline TyG-WC cohort showed a 1.314-fold and 1.480-fold higher risk for MACEs and overall mortality,respectively.Each 1 SD increase in TyG-WHtR was significantly related to an 11.7%increase in MACEs and a 14.9%enhance in overall mortality.Each 1 SD increase in TyG-WC corresponded to an 11.5%in MACEs and a 16.6%increase in overall mortality.Including these two indexes in conventional models significantly improved the predictive power for MACEs and overall mortality.CONCLUSION TyG-WHtR and TyG-WC were promising predictors of MACEs and overall mortality risk in T2DM cases.展开更多
The present study investigated the relationships among event-related potentials (ERPs), memory, and schizophrenic symptoms in college students with schizotypal-traits. Scores on the Schizotypal Personality Questionnai...The present study investigated the relationships among event-related potentials (ERPs), memory, and schizophrenic symptoms in college students with schizotypal-traits. Scores on the Schizotypal Personality Questionnaire (SPQ) were used to categorize the participants into schizotypal-trait (n = 30) and normal control (n = 37) groups. ERPs were assessed using an auditory oddball paradigm, in which a series of standard tones (1000 Hz) and target tones (1500 Hz) were presented;participants were asked to count the number of presented target tones. The verbal memory and visual memory of the participants were evaluated using the Korean version of the California Verbal Learning Test (K-CVLT) and the Rey-Osterrieth Complex Figure Test (RCFT), respectively. The schizotypal-trait and control groups did not differ in terms of age, educational level, IQ score, accuracy on the auditory oddball task, or performance on the K-CVLT and RCFT measures. However, the schizotypal-trait group exhibited significantly smaller P300 amplitudes than the control group. Additionally, the P300 amplitudes measured at Cz and Pz were negatively correlated with the cognitive-perceptual factor scores on the SPQ. Thus, the present results indicate that reduced P300 amplitudes may represent a biological marker of schizophrenia.展开更多
Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupunctu...Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupuncture at Shenting（DU24）,Tianzhu（BL10）,Sishencong（Extra）,Yintang（Extra）,Renzhong（DU26）,Neiguan（PC6）,Shenmen（HT7）,Fengchi（GB20）,Wangu（GB12） and Baihui（DU20）（once a day for 56 days）.Compared with donepezil hydrochloride alone,P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture.Mini-Mental State Examination score was also higher.Moreover,these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture.These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia,and exerts neuroprotective effects against vascular dementia.展开更多
Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscien...Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscience.Methods: The experiments were designed as a 2(TCM terms vs. WM terms) × 2(correct terms vs.incorrect terms) × 2(analogical priming task vs. non-priming task) scheme. A total of 26 medical students completed a non-priming judgment task and an analogical priming judgment task on medical terms. During the tasks, the participants were asked to make correct/incorrect judgments on WM terms and TCM terms, and their behavioral data and event-related potentials(ERPs) were recorded.Results: Behaviorally, the response speed and accuracy of WM terms were higher than those of TCM terms(both P <.001), indicating a prominent concreteness effect. Analogical priming shortened the response time to medical terms(P <.001), and the response time to TCM terms was shortened more significantly(P =.001). For ERPs, WM terms induced a larger P200(an early positive ERP component), a smaller N400(a negative ERP component), and a higher late positive ERP component, indicating superiority of attention adjustment, smaller-scale semantic activation, and a higher cost of late semantic analysis and integration. However, the analogical priming eliminated the difference between WM and TCM terms in P200 and N400 while maintaining it in the LPC. This suggests that WM terms are sensitive to analogical attention adjustment, and TCM terms are susceptible to analogical semantic integration.Conclusion: Our findings suggest that WM and TCM disease behavior terms may initially differ in concreteness or the use of a verbal-linguistic system. Analogy is more conducive to understanding TCM terms. This research provides important neuroscientific evidence of the difference in thinking between TCM and WM.展开更多
Event relation extraction plays a crucial role in constructing an event knowledge graph.However,current models only extract trigger words as event ontology representations,and do not consider node type during informat...Event relation extraction plays a crucial role in constructing an event knowledge graph.However,current models only extract trigger words as event ontology representations,and do not consider node type during information aggregation,resulting in low accuracy in event relation extraction.To address these challenges,we propose an event relation extraction model based on heterogeneous graph attention networks and event ontology direction induction.To enhance the completeness of event information,we incorporate argument role information,in addition to trigger words,into the input text.A novel heterogeneous graph attention framework is proposed to reasonably allocate weights to trigger words,argument roles,and text information,and then perform two levels of aggregation,node-level and semantic-level,in sequence.To improve the accuracy of event direction discrimination,we construct an event ontology subgraph that includes trigger words and arguments to aggregate complete event structure information during direction induction.Finally,we evaluate our model on three datasets,TimeBank-Dense,MATRES,and HiEve,and demonstrate that our model outperforms state-of-the-art models by 1.2%,0.5%,and 0.8%,respectively,in terms of the Micro-F1 score.Our proposed model provides a promising solution for event relation extraction and can be applied in various natural language processing applications.展开更多
Purpose:The purpose of present study was to investigate the impact of sport experience on response inhibition and response re-engagement in expert badminton athletes during the stop-signal task and change-signal task....Purpose:The purpose of present study was to investigate the impact of sport experience on response inhibition and response re-engagement in expert badminton athletes during the stop-signal task and change-signal task.Methods:A total of 19 badminton athletes and 20 nonathletes performed both the stop-signal task and change-signal task.Reaction times(RTs)and event-related potentials were recorded and analyzed.Results:Behavioral results indicated that badminton athletes responded faster than nonathletes to go stimuli and to change signals,with faster change RTs and change-signal RTs,which take into consideration the variable stimulus onset time mean.During successful change trials in the change-signal task,the amplitudes of the event-related potential components N2 and P3 were smaller for badminton athletes than for nonathletes.Moreover,change-signal RTs and N2 amplitudes as well as change RTs and P3 amplitudes were significantly correlated in badminton athletes.A significant correlation was also found between the amplitude of the event-related potential component N1 and response accuracy to change signals in badminton athletes.Conclusion:Moderation of brain cortical activity in badminton athletes was more associated with their ability to rapidly inhibit a planned movement and re-engage with a new movement compared with nonathletes.The superior inhibitory control and more efficient neural mechanisms in badminton athletes compared with nonathletes might be a result of badminton athletes’ professional training experience.展开更多
BACKGROUND： Study results of event-refated potential in obsessive compulsive disorder （OCD） remain controversial, potentially as a result of different instruments utilized and their differing technical characterist...BACKGROUND： Study results of event-refated potential in obsessive compulsive disorder （OCD） remain controversial, potentially as a result of different instruments utilized and their differing technical characteristics. OBJECTIVE： To investigate the differences in several common event-related potentials, Le. contingent negative variations, P300, and mismatch negativity （MMN）, in OCD patients, depression patients, generalized anxiety disorder （GAD） patients, and healthy controls. DESIGN, TIME AND SETTING： A case-control study was performed in the Department of Electrophysiology, Shanghai Mental Health Center from May 2002 to December 2005. PARTICIPANTS： A total of 38 OCD patients, 20 depression patients, and 18 GAD patients, who were diagnosed according to the criteria of Chinese Classification of Mental Disorders （Version 3）, formulated by the Chinese Psychiatry Association, were selected from the Outpatient Department of Shanghai Mental Health Center. Patients with two or more the above diseases were excluded. In addition, 28 healthy people, gender and age matched, were selected as controls. METHODS： Contingent negative variations, P300, and MMN were recorded by a Nicolet Spirit Instrument. All electrodes were attached at Cz according to the Intemationa11020 system, with the mastoid leads as reference and Fpz as ground. MAIN OUTCOME MEASURES： Amplitude and latency of contingent negative variations, P300, and MMN. RESULTS： The contingent negative variations, P300, and MMN were different （P 〈 0.01）. OCD patients showed an increased MI amplitude compared with controls, depression, and GAD patients （P 〈 0.01）. Target P300 amplitudes were significantly lower in OCD, depression, and GAD patients compared with controls （P 〈 0.01）. Moreover, N2 latency and latency of MMN were prolonged in OCD and depression groups compared with controls （P 〈 0.05）. CONCLUSION： Event-related potentials were different in depression, GAD, and OCD patients and healthy controls. In particular, OCD patients exhibited unique characteristics.展开更多
Several investigations have shown that emotional events show superior recall than non-emotional ones. However, the cortical mechanisms underlying the episodic recall of emotional scenes are still poorly understood. Ou...Several investigations have shown that emotional events show superior recall than non-emotional ones. However, the cortical mechanisms underlying the episodic recall of emotional scenes are still poorly understood. Our main aim was to compare the magnitude of the Event-Related brain Potentials (ERP) old-new effect related to emotionally unpleasant, pleasant and neutral photographic images. As expected, correct recognition of all types of images elicited three topographically distinct ERP components sensitive to the classical old-new recognition effect. The results revealed that the behavioral performances were mainly sensitive to arousal, while the ERP old/new effect over posterior regions (300 - 1000 ms) was exclusively affected by unpleasantness. A later component (1000 - 1400 ms) showed an inverted old/ new effect at parietal sites, which was also sensitive to unpleasantness. These results imply that ERP reflecting episodic conscious recollection and post-retrieval monitoring are clearly affected both by valence and arousal.展开更多
Patients with major depressive disorder （MDD） develop a negative cognitive bias, but how they respond to information in Chinese emotional words is unclear. Here we used a Stroop paradigm with subliminal Chinese emot...Patients with major depressive disorder （MDD） develop a negative cognitive bias, but how they respond to information in Chinese emotional words is unclear. Here we used a Stroop paradigm with subliminal Chinese emotional words to explore the event-related potential components of abnormal emotional processing Jn patients with MDD. The correct rate was similar in MDD and normal control groups, but MDD reaction time was longer than the normal controls, especially to the negative and neutral stimuli. In N270, repeated-measure analysis of variance demonstrated a significant main effect of the relation electrode and valence on peak amplitude and interactions between valence and electrode site. The peak amplitudes of the three kinds of words were different in the two groups （positive 〉 negative 〉 neutral）. The topography of the difference waves indicated that the difference distributed in the frontal and left parietal-temporal sites across the scalp. In N400, there was a significant main effect of the relation electrode and valence on peak amplitude, and the latency showed a main effect of the electrode and an interaction between electrode and group. The amplitudes induced by type of words were significantly different from each other in both groups （positive 〉 negative 〉 neutral）. The topography of the difference waves indicated that the effect of relation type was primarily at left and right frontal and central and left parietal-temporal regions. Both MDD patients and normal controls exhibited significant emotional Stroop effects during the processing of positive/negative Chinese emotional words. MDD patients showed interference in emotional stimuli in early cognitive processing that induced psychological resource intervention during late emotional information processing.展开更多
Objective:To investigate the variations of contingent negative varisations(CNV),P300 and mismatch negativity (MMN) in patients with obsessive compulsive disorder(OCD),depressiopn and anxiety.MEthods:Event-related pote...Objective:To investigate the variations of contingent negative varisations(CNV),P300 and mismatch negativity (MMN) in patients with obsessive compulsive disorder(OCD),depressiopn and anxiety.MEthods:Event-related potentials CNV,P300 and MMN were recorded in 31 patients with OCD by Nicolet SPirit Instrument,and were compared with that of 20 depression controls(DC) and 17 anxiety controls(AC)and 28 normal controls(NC),Results:A significant difference of CNV among 4 sulbject groups was found in both post-imperative negative variation(PINV) and amplitudes(M1)(P<0.01)(emergence of PINV were 45%),60%,35%,and 4% in OCD,DC,AC and NC groups respectively),Compared with NC group,DC and AC groups showed decreased M1 amplitude(P<0.01).A significant difference of P300 among 4 groups was found in both latencies(Cz/N2) and P3 and nontarget-P2 amplitudes(P<0.05-0.01),The delayed MMN latencies of OCD and DC were similar to that of P300 changes,Conclusions:CNV,P300 and MMN are useful tools for assessing the brain malfunction of OCD,DC and AC,and its clinical application are suggested.The characteristics ERPs of those patients might be useful indexes in distinguishing OCD from DC and AC patients.展开更多
Attention allocation research frequently focuses on the valence of emotion. However, there is increasing evidence to indicate that arousal may be more relevant at some stages of affective processing. The present study...Attention allocation research frequently focuses on the valence of emotion. However, there is increasing evidence to indicate that arousal may be more relevant at some stages of affective processing. The present study employed a combined priming and cue-target paradigm and examined event-related potentials (ERPs) in order to explore the effects of emotional conflict of arousal on attention allocation. The background context of arousal was manipulated (using photos of facial expressions) while subjects performed a cognitive task in which a central arrow cue indicated the location of a peripheric target square, and a response was made according to the direction of the square. There was no main effect between incongruent emotion and congruent emotion in the response time, which means the resolution of the emotional conflict facilitate the participant behavioral response. There was a main effect of different emotional states on ERP component. In the present study, incongruent arousal also triggered greater positive potential compared with congruent arousal.展开更多
In this paper, the Lie-form invariance of a nonholonomic system of relative motion in event space is studied. Firstly, the definition and the criterion of the Lie-form invariance of the nonholonomic system of relative...In this paper, the Lie-form invariance of a nonholonomic system of relative motion in event space is studied. Firstly, the definition and the criterion of the Lie-form invariance of the nonholonomic system of relative motion in event space is given. Secondly, the Hojman conserved quantity and a new type of conserved quantity deduced from the Lie-form invariance are obtained. An example is given to illustrate the application of the results.展开更多
Immune checkpoint inhibitors have shown to be very effective when treating lung cancer. Nivolumab, a programmed death-1 (PD-1) inhibitor has been approved for the treatment of metastatic non-squamous and squamous NSCL...Immune checkpoint inhibitors have shown to be very effective when treating lung cancer. Nivolumab, a programmed death-1 (PD-1) inhibitor has been approved for the treatment of metastatic non-squamous and squamous NSCLC. Immunotherapy with checkpoint inhibitors are associated with toxicities defined as immune-related adverse events (irAEs). The most common irAEs are rash, colitis, hepatitis, pneumonitis, and endocrinopathies. Although any organ system can be affected, other rare irAEs can occur and affect the bone marrow, pancreas, and the neurologic and cardiac systems. Pericardial effusion induced by immunotherapy is uncommon and has been described only in a few case reports. Immune-related adverse events usually develop within the first weeks to months after treatment initiation. This is a case report of a 52-year-old male patient with metastatic squamous-cell lung cancer who had a massive pericardial effusion secondary to treatment with nivolumab as second line treatment. During his hospital stay, the patient underwent pericardiocentesis and treatment with corticosteroids. A CT scan after these treatments revealed complete tumor response and minimal pericardial effusion. Nivolumab was definitively ceased. The patient continues to show complete response for 16 months. In general, Nivolumab is well-tolerated and has an excellent safety profile. However, it is important to be aware of life-threatening immune-related adverse events, particularly cardiac toxicity. Consensus guidelines regarding the treatment of the most common irAEs have been established. The optimal management of irAEs is based on clinical experience. It’s crucial to report new or rare irAEs to conduct prospective trials to evaluate the best treatment strategy.展开更多
Owing to information asymmetry,evaluating the credit risk of small-and mediumsized enterprises(SMEs)is difficult.While previous studies evaluating the credit risk of SMEs have mostly focused on intrinsic risk generate...Owing to information asymmetry,evaluating the credit risk of small-and mediumsized enterprises(SMEs)is difficult.While previous studies evaluating the credit risk of SMEs have mostly focused on intrinsic risk generated by SMEs,our study considers both intrinsic and relational risks generated by neighbor firms’publicly available risk events.We propose a framework for quantifying relational risk based on publicly available risk events for SMEs’credit risk evaluation.Our proposed framework quantifies relational risk by weighting the impact of publicly available risk events of each firm in an interfirm network—considering the impact of interfirm network type,risk event type,and time dependence of risk events—and combines the relational risk score with financial and demographic features to evaluate SMEs credit risk.Our results reveal that relational risk score significantly improves both discrimination and granting performances of credit risk evaluation of SMEs,providing valuable managerial and practical implications for financial institutions.展开更多
The relative amplitude method （RAM） is more suitable for source inversion of low magnitude earthquakes because it avoids the modeling of short-period waveforms. We introduced an improved relative amplitude method （...The relative amplitude method （RAM） is more suitable for source inversion of low magnitude earthquakes because it avoids the modeling of short-period waveforms. We introduced an improved relative amplitude method （IRAM） which is more robust in practical cases. The IRAM uses a certain function to quantify the fitness between the observed and the predicted relative amplitudes among direct P wave, surface reflected pP and sP waves for a given focal mechanism. Using the IRAM, we got the fault-plane solutions of two earthquakes of mb4.9 and mb3.8, occurred in Issyk-Kul lake, Kyrgyzstan. For the larger event, its fault-plane solutions are consistent with the Harvard＇s CMT solutions. As to the smaller one, the strikes of the solution are consistent with those of the main faults near the epicenter. The synthetic long period waveforms and the predicted P wave first motions of the solutions are consistent with observations at some of regional stations. Finally, we demonstrated that fault-solutions cannot interpret the characteristics of teleseismic P waveforms of the underground nuclear explosion detonated in Democratic People＇s Republic of Korea （DPRK） on October 9, 2006.展开更多
BACKGROUND： Studies have shown that closed-class words, such as prepositions and conjunctions, induce a left anterior negativity （N280）, indicating that N280 should be a specific component of the word category. OBJ...BACKGROUND： Studies have shown that closed-class words, such as prepositions and conjunctions, induce a left anterior negativity （N280）, indicating that N280 should be a specific component of the word category. OBJECTIVE： To observe if Chinese prepositions and verbs exhibit different linguistic functions, to determine whether they are processed by different neural systems, and to verify that N280 is a specific component. DESIGN, TIME AND SETTING： The observed neurolinguistics experiment was performed at Xuzhou Normal University between November and December 2006. PARTICIPANTS： Sixteen undergraduate students, comprising 8 females and 8 males, with no mental or neuropathological history, were selected. METHODS： A total of 15 verbs and prepositions were used as linguistic stimuli, and each verb and preposition was combined to produce four correct phrase collocations and four incorrect ones. MAIN OUTCOME MEASURES： Event-related potentials were recorded in the subjects while they read correct or incorrect phases flashed upon a video screen. RESULTS： Both verbs and prepositions elicited negativity at the frontal site in a 230-330 ms window, as well as at the fronto-temporal and central sites in a 350-500 ms window. Neither exhibited significant differences in peak [F（1, 15） = 0.144, P = 0.710] and latency [F（1, 15） = 0.144, P= 0.710]. Both verbs and prepositions elicited negativity at the left and right hemisphere in a 270-400 ms window. CONCLUSION： There was no significant difference between Chinese prepositions and verbs in the neural system process and N280 was not the specific component for closed-class words.展开更多
The results of visual event-related potential(ERP)examinations and reactiontime(RT)tests were reported in 30 elders and compared with their performanceintellegence quotient(PIQ)scores.The subjects consisted of 18 male...The results of visual event-related potential(ERP)examinations and reactiontime(RT)tests were reported in 30 elders and compared with their performanceintellegence quotient(PIQ)scores.The subjects consisted of 18 males and 12 femalesaged 50-71(mean 61.4)years old.No history of central nervous system disease wasfound.The visual stimuli were randomly presented to the subject,including three sym-bols:E as target stimulus with 0.15 probability,and H and E as nontarget stimuliwith 0.15 and 0.70 probability respectively.The recording electrodes were placed on Fzand Pz.The duration from the subject seeing the target to touching a button immediatelywas considered as reaction time(RT).It was shown that the P3 latency at Pz was longer than that at Fz and the P3amplitude at Pz was larger than that at Fz,and that the RT was longer than P3 latencywith obvious effect of distribution(P【0.05 at Fz and P】0.05 at Pz)as well .The higherthe PIQ scores,the longer the RT and the P3 latency.It is suggested that the ERPmight reflect the differences of PIQ scores,and the P3 is an objective index.We considerthat the research of ERP is of great interest in the neuropsychological and neurological sci-ences.展开更多
基金Project supported the National Natural Science Foundation of China(Grant No.60975033)the Basic Scientific Research Project of International Centre for Bamboo Rattan(Grant No.1632009006)the Shanghai Leading Academic Discipline Project(Grant No.J50103)
文摘Temporal relation computation is one of the tasks of the extraction of temporal arguments from event, and it is also the ultimate goal of temporal information processing. However, temporal relation computation based on machine learning requires a lot of hand-marked work, and exploring more features from discourse. A method of two-stage machine learning based on temporal relation computation （TSMLTRC） is proposed in this paper for the shortcomings of current temporal relation computation between two events. The first stage is to get the main temporal attributes of event based on classification learning. The second stage is to compute the event temporal relation in the discourse through employing the result of the first stage as the basic features, and also employing some new linguistic characteristics. Experiments show that, compared with the artificial golden rule, the computational efficiency in the first stage is much higher, and the F1-Score of event temporal relation which is computed through combining multi-features may be increased at 85.8% in the second stage.
文摘This study explored the possibility of using event-related potentials （ERP） for the measurement of picture-recognition memory and examined its correlation with the Chinese Wechsler Memory Scale-revised （WMS-RC） in patients with memory disorder caused by severe traumatic brain injury （sTBI）. The subjects included 20 sTBI patients with memory disorder and 22 healthy individuals. Memory function was measured by using WMS-RC. Behavioral and ERP responses were recorded on-line during performance on a battery of picture recognition and the responses were analyzed off-line for recognition memory effects. Mean memory quotient （MQ） of patients with sTBI was significantly lower than that of the control group. Mean reaction time （RT） was significantly longer and the mean correctness rate （CR） of picture recognition was significantly lower in sTBI group than that of the controls. In controls, the main components of average ERP of picture recognition includes two positive-going waves, designated as P170 and P500, that appear 170 ms and 500 ms after stimulation when the subject could later successfully recall and recognize the pictures. P500 amplitude of target stimulus was significantly higher than that of non-target stimulus. Compared to controls, P500 responses of sTBI group were significantly delayed in latency （P〈0.001） and lower in amplitude （P〈0.001）. P500 latency showed significant negative correlation with MQ and the scores of ＂addition＂, ＂visual recognition＂, ＂picture recall＂, ＂visual reproduction＂ and ＂tactile memory＂ in WMS-RC. ERP of picture recognition provides a neurophysiological approach to directly assess memory impairment, and P500 may serve as a helpful index for memory disorder caused by sTBI in forensic practice.
文摘BACKGROUND Recent studies have indicated that triglyceride glucose(TyG)-waist height ratio(WHtR)and TyG-waist circumference(TyG-WC)are effective indicators for evaluating insulin resistance.However,research on the association in TyG-WHtR,TyG-WC,and the risk and prognosis of major adverse cardiovascular events(MACEs)in type 2 diabetes mellitus(T2DM)cases are limited.AIM To clarify the relation in TyG-WHtR,TyG-WC,and the risk of MACEs and overall mortality in T2DM patients.METHODS Information for this investigation was obtained from Action to Control Cardiovascular Risk in Diabetes(ACCORD)/ACCORD Follow-On(ACCORDION)study database.The Cox regression model was applied to assess the relation among TyG-WHtR,TyG-WC and future MACEs risk and overall mortality in T2DM cases.The RCS analysis was utilized to explore the nonlinear correlation.Subgroup and interaction analyses were conducted to prove the robustness.The receiver operating characteristic curves were applied to analysis the additional predicting value of TyG-WHtR and TyG-WC.RESULTS After full adjustment for confounding variables,the highest baseline TyG-WHtR cohort respectively exhibited a 1.353-fold and 1.420-fold higher risk for MACEs and overall mortality,than the lowest quartile group.Similarly,the highest baseline TyG-WC cohort showed a 1.314-fold and 1.480-fold higher risk for MACEs and overall mortality,respectively.Each 1 SD increase in TyG-WHtR was significantly related to an 11.7%increase in MACEs and a 14.9%enhance in overall mortality.Each 1 SD increase in TyG-WC corresponded to an 11.5%in MACEs and a 16.6%increase in overall mortality.Including these two indexes in conventional models significantly improved the predictive power for MACEs and overall mortality.CONCLUSION TyG-WHtR and TyG-WC were promising predictors of MACEs and overall mortality risk in T2DM cases.
文摘The present study investigated the relationships among event-related potentials (ERPs), memory, and schizophrenic symptoms in college students with schizotypal-traits. Scores on the Schizotypal Personality Questionnaire (SPQ) were used to categorize the participants into schizotypal-trait (n = 30) and normal control (n = 37) groups. ERPs were assessed using an auditory oddball paradigm, in which a series of standard tones (1000 Hz) and target tones (1500 Hz) were presented;participants were asked to count the number of presented target tones. The verbal memory and visual memory of the participants were evaluated using the Korean version of the California Verbal Learning Test (K-CVLT) and the Rey-Osterrieth Complex Figure Test (RCFT), respectively. The schizotypal-trait and control groups did not differ in terms of age, educational level, IQ score, accuracy on the auditory oddball task, or performance on the K-CVLT and RCFT measures. However, the schizotypal-trait group exhibited significantly smaller P300 amplitudes than the control group. Additionally, the P300 amplitudes measured at Cz and Pz were negatively correlated with the cognitive-perceptual factor scores on the SPQ. Thus, the present results indicate that reduced P300 amplitudes may represent a biological marker of schizophrenia.
文摘Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupuncture at Shenting（DU24）,Tianzhu（BL10）,Sishencong（Extra）,Yintang（Extra）,Renzhong（DU26）,Neiguan（PC6）,Shenmen（HT7）,Fengchi（GB20）,Wangu（GB12） and Baihui（DU20）（once a day for 56 days）.Compared with donepezil hydrochloride alone,P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture.Mini-Mental State Examination score was also higher.Moreover,these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture.These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia,and exerts neuroprotective effects against vascular dementia.
基金supported by the National Natural Science Foundation of China (81874514)
文摘Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscience.Methods: The experiments were designed as a 2(TCM terms vs. WM terms) × 2(correct terms vs.incorrect terms) × 2(analogical priming task vs. non-priming task) scheme. A total of 26 medical students completed a non-priming judgment task and an analogical priming judgment task on medical terms. During the tasks, the participants were asked to make correct/incorrect judgments on WM terms and TCM terms, and their behavioral data and event-related potentials(ERPs) were recorded.Results: Behaviorally, the response speed and accuracy of WM terms were higher than those of TCM terms(both P <.001), indicating a prominent concreteness effect. Analogical priming shortened the response time to medical terms(P <.001), and the response time to TCM terms was shortened more significantly(P =.001). For ERPs, WM terms induced a larger P200(an early positive ERP component), a smaller N400(a negative ERP component), and a higher late positive ERP component, indicating superiority of attention adjustment, smaller-scale semantic activation, and a higher cost of late semantic analysis and integration. However, the analogical priming eliminated the difference between WM and TCM terms in P200 and N400 while maintaining it in the LPC. This suggests that WM terms are sensitive to analogical attention adjustment, and TCM terms are susceptible to analogical semantic integration.Conclusion: Our findings suggest that WM and TCM disease behavior terms may initially differ in concreteness or the use of a verbal-linguistic system. Analogy is more conducive to understanding TCM terms. This research provides important neuroscientific evidence of the difference in thinking between TCM and WM.
基金supported by the National Natural Science Foundation of China(No.62071240)the Innovation Program for Quantum Science and Technology(No.2021ZD0302901)+1 种基金the Natural Science Foundation of Jiangsu Province(Nos.BK20220804 and BK20231142)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
文摘Event relation extraction plays a crucial role in constructing an event knowledge graph.However,current models only extract trigger words as event ontology representations,and do not consider node type during information aggregation,resulting in low accuracy in event relation extraction.To address these challenges,we propose an event relation extraction model based on heterogeneous graph attention networks and event ontology direction induction.To enhance the completeness of event information,we incorporate argument role information,in addition to trigger words,into the input text.A novel heterogeneous graph attention framework is proposed to reasonably allocate weights to trigger words,argument roles,and text information,and then perform two levels of aggregation,node-level and semantic-level,in sequence.To improve the accuracy of event direction discrimination,we construct an event ontology subgraph that includes trigger words and arguments to aggregate complete event structure information during direction induction.Finally,we evaluate our model on three datasets,TimeBank-Dense,MATRES,and HiEve,and demonstrate that our model outperforms state-of-the-art models by 1.2%,0.5%,and 0.8%,respectively,in terms of the Micro-F1 score.Our proposed model provides a promising solution for event relation extraction and can be applied in various natural language processing applications.
基金the Natural Science Foundation of China (31571151,31700985)the Scientific and Technological Commission of Shanghai(17080503100)
文摘Purpose:The purpose of present study was to investigate the impact of sport experience on response inhibition and response re-engagement in expert badminton athletes during the stop-signal task and change-signal task.Methods:A total of 19 badminton athletes and 20 nonathletes performed both the stop-signal task and change-signal task.Reaction times(RTs)and event-related potentials were recorded and analyzed.Results:Behavioral results indicated that badminton athletes responded faster than nonathletes to go stimuli and to change signals,with faster change RTs and change-signal RTs,which take into consideration the variable stimulus onset time mean.During successful change trials in the change-signal task,the amplitudes of the event-related potential components N2 and P3 were smaller for badminton athletes than for nonathletes.Moreover,change-signal RTs and N2 amplitudes as well as change RTs and P3 amplitudes were significantly correlated in badminton athletes.A significant correlation was also found between the amplitude of the event-related potential component N1 and response accuracy to change signals in badminton athletes.Conclusion:Moderation of brain cortical activity in badminton athletes was more associated with their ability to rapidly inhibit a planned movement and re-engage with a new movement compared with nonathletes.The superior inhibitory control and more efficient neural mechanisms in badminton athletes compared with nonathletes might be a result of badminton athletes’ professional training experience.
基金the National Natural Science Foundation of China, No. 30770772, 30971046the Foundation of Shanghai Science and Technology Commission, No. 09411968200 the Major State Basic Research Development Program of China (973 program), No. S2009051026
文摘BACKGROUND： Study results of event-refated potential in obsessive compulsive disorder （OCD） remain controversial, potentially as a result of different instruments utilized and their differing technical characteristics. OBJECTIVE： To investigate the differences in several common event-related potentials, Le. contingent negative variations, P300, and mismatch negativity （MMN）, in OCD patients, depression patients, generalized anxiety disorder （GAD） patients, and healthy controls. DESIGN, TIME AND SETTING： A case-control study was performed in the Department of Electrophysiology, Shanghai Mental Health Center from May 2002 to December 2005. PARTICIPANTS： A total of 38 OCD patients, 20 depression patients, and 18 GAD patients, who were diagnosed according to the criteria of Chinese Classification of Mental Disorders （Version 3）, formulated by the Chinese Psychiatry Association, were selected from the Outpatient Department of Shanghai Mental Health Center. Patients with two or more the above diseases were excluded. In addition, 28 healthy people, gender and age matched, were selected as controls. METHODS： Contingent negative variations, P300, and MMN were recorded by a Nicolet Spirit Instrument. All electrodes were attached at Cz according to the Intemationa11020 system, with the mastoid leads as reference and Fpz as ground. MAIN OUTCOME MEASURES： Amplitude and latency of contingent negative variations, P300, and MMN. RESULTS： The contingent negative variations, P300, and MMN were different （P 〈 0.01）. OCD patients showed an increased MI amplitude compared with controls, depression, and GAD patients （P 〈 0.01）. Target P300 amplitudes were significantly lower in OCD, depression, and GAD patients compared with controls （P 〈 0.01）. Moreover, N2 latency and latency of MMN were prolonged in OCD and depression groups compared with controls （P 〈 0.05）. CONCLUSION： Event-related potentials were different in depression, GAD, and OCD patients and healthy controls. In particular, OCD patients exhibited unique characteristics.
文摘Several investigations have shown that emotional events show superior recall than non-emotional ones. However, the cortical mechanisms underlying the episodic recall of emotional scenes are still poorly understood. Our main aim was to compare the magnitude of the Event-Related brain Potentials (ERP) old-new effect related to emotionally unpleasant, pleasant and neutral photographic images. As expected, correct recognition of all types of images elicited three topographically distinct ERP components sensitive to the classical old-new recognition effect. The results revealed that the behavioral performances were mainly sensitive to arousal, while the ERP old/new effect over posterior regions (300 - 1000 ms) was exclusively affected by unpleasantness. A later component (1000 - 1400 ms) showed an inverted old/ new effect at parietal sites, which was also sensitive to unpleasantness. These results imply that ERP reflecting episodic conscious recollection and post-retrieval monitoring are clearly affected both by valence and arousal.
基金the National Natural Science Foundation of China,No.30570609
文摘Patients with major depressive disorder （MDD） develop a negative cognitive bias, but how they respond to information in Chinese emotional words is unclear. Here we used a Stroop paradigm with subliminal Chinese emotional words to explore the event-related potential components of abnormal emotional processing Jn patients with MDD. The correct rate was similar in MDD and normal control groups, but MDD reaction time was longer than the normal controls, especially to the negative and neutral stimuli. In N270, repeated-measure analysis of variance demonstrated a significant main effect of the relation electrode and valence on peak amplitude and interactions between valence and electrode site. The peak amplitudes of the three kinds of words were different in the two groups （positive 〉 negative 〉 neutral）. The topography of the difference waves indicated that the difference distributed in the frontal and left parietal-temporal sites across the scalp. In N400, there was a significant main effect of the relation electrode and valence on peak amplitude, and the latency showed a main effect of the electrode and an interaction between electrode and group. The amplitudes induced by type of words were significantly different from each other in both groups （positive 〉 negative 〉 neutral）. The topography of the difference waves indicated that the effect of relation type was primarily at left and right frontal and central and left parietal-temporal regions. Both MDD patients and normal controls exhibited significant emotional Stroop effects during the processing of positive/negative Chinese emotional words. MDD patients showed interference in emotional stimuli in early cognitive processing that induced psychological resource intervention during late emotional information processing.
文摘Objective:To investigate the variations of contingent negative varisations(CNV),P300 and mismatch negativity (MMN) in patients with obsessive compulsive disorder(OCD),depressiopn and anxiety.MEthods:Event-related potentials CNV,P300 and MMN were recorded in 31 patients with OCD by Nicolet SPirit Instrument,and were compared with that of 20 depression controls(DC) and 17 anxiety controls(AC)and 28 normal controls(NC),Results:A significant difference of CNV among 4 sulbject groups was found in both post-imperative negative variation(PINV) and amplitudes(M1)(P<0.01)(emergence of PINV were 45%),60%,35%,and 4% in OCD,DC,AC and NC groups respectively),Compared with NC group,DC and AC groups showed decreased M1 amplitude(P<0.01).A significant difference of P300 among 4 groups was found in both latencies(Cz/N2) and P3 and nontarget-P2 amplitudes(P<0.05-0.01),The delayed MMN latencies of OCD and DC were similar to that of P300 changes,Conclusions:CNV,P300 and MMN are useful tools for assessing the brain malfunction of OCD,DC and AC,and its clinical application are suggested.The characteristics ERPs of those patients might be useful indexes in distinguishing OCD from DC and AC patients.
文摘Attention allocation research frequently focuses on the valence of emotion. However, there is increasing evidence to indicate that arousal may be more relevant at some stages of affective processing. The present study employed a combined priming and cue-target paradigm and examined event-related potentials (ERPs) in order to explore the effects of emotional conflict of arousal on attention allocation. The background context of arousal was manipulated (using photos of facial expressions) while subjects performed a cognitive task in which a central arrow cue indicated the location of a peripheric target square, and a response was made according to the direction of the square. There was no main effect between incongruent emotion and congruent emotion in the response time, which means the resolution of the emotional conflict facilitate the participant behavioral response. There was a main effect of different emotional states on ERP component. In the present study, incongruent arousal also triggered greater positive potential compared with congruent arousal.
文摘In this paper, the Lie-form invariance of a nonholonomic system of relative motion in event space is studied. Firstly, the definition and the criterion of the Lie-form invariance of the nonholonomic system of relative motion in event space is given. Secondly, the Hojman conserved quantity and a new type of conserved quantity deduced from the Lie-form invariance are obtained. An example is given to illustrate the application of the results.
文摘Immune checkpoint inhibitors have shown to be very effective when treating lung cancer. Nivolumab, a programmed death-1 (PD-1) inhibitor has been approved for the treatment of metastatic non-squamous and squamous NSCLC. Immunotherapy with checkpoint inhibitors are associated with toxicities defined as immune-related adverse events (irAEs). The most common irAEs are rash, colitis, hepatitis, pneumonitis, and endocrinopathies. Although any organ system can be affected, other rare irAEs can occur and affect the bone marrow, pancreas, and the neurologic and cardiac systems. Pericardial effusion induced by immunotherapy is uncommon and has been described only in a few case reports. Immune-related adverse events usually develop within the first weeks to months after treatment initiation. This is a case report of a 52-year-old male patient with metastatic squamous-cell lung cancer who had a massive pericardial effusion secondary to treatment with nivolumab as second line treatment. During his hospital stay, the patient underwent pericardiocentesis and treatment with corticosteroids. A CT scan after these treatments revealed complete tumor response and minimal pericardial effusion. Nivolumab was definitively ceased. The patient continues to show complete response for 16 months. In general, Nivolumab is well-tolerated and has an excellent safety profile. However, it is important to be aware of life-threatening immune-related adverse events, particularly cardiac toxicity. Consensus guidelines regarding the treatment of the most common irAEs have been established. The optimal management of irAEs is based on clinical experience. It’s crucial to report new or rare irAEs to conduct prospective trials to evaluate the best treatment strategy.
基金the National Natural Science Foundation of China(Grant Nos.71731005,Nos.72101073)。
文摘Owing to information asymmetry,evaluating the credit risk of small-and mediumsized enterprises(SMEs)is difficult.While previous studies evaluating the credit risk of SMEs have mostly focused on intrinsic risk generated by SMEs,our study considers both intrinsic and relational risks generated by neighbor firms’publicly available risk events.We propose a framework for quantifying relational risk based on publicly available risk events for SMEs’credit risk evaluation.Our proposed framework quantifies relational risk by weighting the impact of publicly available risk events of each firm in an interfirm network—considering the impact of interfirm network type,risk event type,and time dependence of risk events—and combines the relational risk score with financial and demographic features to evaluate SMEs credit risk.Our results reveal that relational risk score significantly improves both discrimination and granting performances of credit risk evaluation of SMEs,providing valuable managerial and practical implications for financial institutions.
基金supported by Foundation of Verification Researches for Army Control Technology (513310101)
文摘The relative amplitude method （RAM） is more suitable for source inversion of low magnitude earthquakes because it avoids the modeling of short-period waveforms. We introduced an improved relative amplitude method （IRAM） which is more robust in practical cases. The IRAM uses a certain function to quantify the fitness between the observed and the predicted relative amplitudes among direct P wave, surface reflected pP and sP waves for a given focal mechanism. Using the IRAM, we got the fault-plane solutions of two earthquakes of mb4.9 and mb3.8, occurred in Issyk-Kul lake, Kyrgyzstan. For the larger event, its fault-plane solutions are consistent with the Harvard＇s CMT solutions. As to the smaller one, the strikes of the solution are consistent with those of the main faults near the epicenter. The synthetic long period waveforms and the predicted P wave first motions of the solutions are consistent with observations at some of regional stations. Finally, we demonstrated that fault-solutions cannot interpret the characteristics of teleseismic P waveforms of the underground nuclear explosion detonated in Democratic People＇s Republic of Korea （DPRK） on October 9, 2006.
基金National Social Science Foundation in China,No.03BYY013The Science Foundation of Jiangsu Province,No."333" Project and QL200504
文摘BACKGROUND： Studies have shown that closed-class words, such as prepositions and conjunctions, induce a left anterior negativity （N280）, indicating that N280 should be a specific component of the word category. OBJECTIVE： To observe if Chinese prepositions and verbs exhibit different linguistic functions, to determine whether they are processed by different neural systems, and to verify that N280 is a specific component. DESIGN, TIME AND SETTING： The observed neurolinguistics experiment was performed at Xuzhou Normal University between November and December 2006. PARTICIPANTS： Sixteen undergraduate students, comprising 8 females and 8 males, with no mental or neuropathological history, were selected. METHODS： A total of 15 verbs and prepositions were used as linguistic stimuli, and each verb and preposition was combined to produce four correct phrase collocations and four incorrect ones. MAIN OUTCOME MEASURES： Event-related potentials were recorded in the subjects while they read correct or incorrect phases flashed upon a video screen. RESULTS： Both verbs and prepositions elicited negativity at the frontal site in a 230-330 ms window, as well as at the fronto-temporal and central sites in a 350-500 ms window. Neither exhibited significant differences in peak [F（1, 15） = 0.144, P = 0.710] and latency [F（1, 15） = 0.144, P= 0.710]. Both verbs and prepositions elicited negativity at the left and right hemisphere in a 270-400 ms window. CONCLUSION： There was no significant difference between Chinese prepositions and verbs in the neural system process and N280 was not the specific component for closed-class words.
文摘The results of visual event-related potential(ERP)examinations and reactiontime(RT)tests were reported in 30 elders and compared with their performanceintellegence quotient(PIQ)scores.The subjects consisted of 18 males and 12 femalesaged 50-71(mean 61.4)years old.No history of central nervous system disease wasfound.The visual stimuli were randomly presented to the subject,including three sym-bols:E as target stimulus with 0.15 probability,and H and E as nontarget stimuliwith 0.15 and 0.70 probability respectively.The recording electrodes were placed on Fzand Pz.The duration from the subject seeing the target to touching a button immediatelywas considered as reaction time(RT).It was shown that the P3 latency at Pz was longer than that at Fz and the P3amplitude at Pz was larger than that at Fz,and that the RT was longer than P3 latencywith obvious effect of distribution(P【0.05 at Fz and P】0.05 at Pz)as well .The higherthe PIQ scores,the longer the RT and the P3 latency.It is suggested that the ERPmight reflect the differences of PIQ scores,and the P3 is an objective index.We considerthat the research of ERP is of great interest in the neuropsychological and neurological sci-ences.
