BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohor...BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.展开更多
Modern physical geography in China grew from Chinese traditional geography and has been profoundly influenced by the geographical disciplines of Euro-America and Russia. Since the 1950 s, integrated studies of physica...Modern physical geography in China grew from Chinese traditional geography and has been profoundly influenced by the geographical disciplines of Euro-America and Russia. Since the 1950 s, integrated studies of physical geography in China have made remarkable progress in the fields of comprehensive physical geographical regionalization, land studies, landscape ecology, and land surface geographical processes. During the past few decades, under the background of global change and rapid socio-economic transformation, a series of environmental and resources problems have boomed in China. To solve these problems and promote the development of integrated studies of physical geography, the following issues were proposed as research priorities：（1） coupling of land surface patterns and processes;（2） integrated research on regional responses and adaptation to global change;（3） analysis of human dimensions of the earth system;（4） ecosystem service research from a geographical perspective;（5） integration of multi-source data and model development;（6） integrated studies on unique geographical units; and（7） important global issues and relevant international programs.展开更多
Global change research and sustainable development need to be addressed at larger scales in the light of small scale process studies. Much remains to be done before the small scale, process level understanding of ecos...Global change research and sustainable development need to be addressed at larger scales in the light of small scale process studies. Much remains to be done before the small scale, process level understanding of ecosystem responses to global change can be reliably translated to larger scales. The paper reviews the status of scaling issues and tries to find how to extrapolate our observations and our findings at site scale up to regional scale and provide ecological information and interpretations at the regional scale. An integrated approach to scaling-up from site to region is proposed combining hierarchical theory, landscape ecology, remote sensing, geographical information system (GIS) with process/mechanistic modeling. Remote sensing and GIS will play key roles in spatial analysis, integration as well as cross scale modeling.展开更多
Based on the ADDIE model,we explored the integration path between Understanding Contemporary China:An English Reading and Writing Textbook and the main textbook of college English reading.Firstly,the basis of textbook...Based on the ADDIE model,we explored the integration path between Understanding Contemporary China:An English Reading and Writing Textbook and the main textbook of college English reading.Firstly,the basis of textbook integration was analyzed,followed by an explanation of the overall design scheme of textbook integration,and then a series of teaching resources were initially developed and used in teaching practice.Through testing,it was found that the integrative teaching of the two sets of textbooks under the ADDIE model achieved good teaching results,and promoted the three aspects of reading literacy,disciplinary literacy,and value leadership.展开更多
Integrating various data sets to provide one optimal subsurface image is a major goal of geophysicst. In this paper, there is a synergetic approach used to delineate the tectonic-structural framework with analyzing th...Integrating various data sets to provide one optimal subsurface image is a major goal of geophysicst. In this paper, there is a synergetic approach used to delineate the tectonic-structural framework with analyzing the hydrocarbon reservoir in the Lower Indus Platform basin of Pakistan. The reflected seismic profiles and potential field map constitute the data base of this study. Our study in the line of the previous research is resulted from important oil and gas discoveries contained in the Early Cretaceous and Upper Jurassic formations of the Lower Indus Platform basin area. The result shows trapping mechanism in the Lower Indus Platform basin involves of the fault blocks and stratigraphic traps are present in the area. The more refined images are interpreted to provide greater insight into detailed integrated geophysical study of area.展开更多
According to the Annex Technical Regulations for Integrated Curriculum Development(Trial)in Document No.30 of the General Office of the Ministry of Human Resources and Social Security(2012),this paper studies the form...According to the Annex Technical Regulations for Integrated Curriculum Development(Trial)in Document No.30 of the General Office of the Ministry of Human Resources and Social Security(2012),this paper studies the formulation of the curriculum standards for the integration of Chinese medicinal materials production.We focus on the formulation ideas of the curriculum standards for the integration of Chinese medicinal materials production,the formulation process of the curriculum standards for the integration of Chinese medicinal materials production,including the description of typical work tasks,the determination of curriculum objectives,the analysis of study content,the description of referential study tasks,teaching implementation suggestions,assessment and evaluation suggestions,which can provide a reference for the development and research of other related integrated courses.展开更多
This paper briefly describes the basic situation and features of Three Gorges Cascade, discusses the principle,functions, structure of the integrated automation system, and explains advanced techniques and principle a...This paper briefly describes the basic situation and features of Three Gorges Cascade, discusses the principle,functions, structure of the integrated automation system, and explains advanced techniques and principle and associated experiments of its monitoring and control展开更多
Background:Oral administration of indigo naturalis(IN)is used as a complementary and alternative medicine(CAM)regimen for the treatment of myelodysplastic syndromes(MDS).However,its mechanism of action has not been fu...Background:Oral administration of indigo naturalis(IN)is used as a complementary and alternative medicine(CAM)regimen for the treatment of myelodysplastic syndromes(MDS).However,its mechanism of action has not been fully elucidated and needs to be further explored.Methods:By searching the traditional Chinese medicine system and analyzing platforms(TCMSP),bioinformatics analysis tool for the molecular mechanism of traditional Chinese medicine(BATMAN-TCM),and Swiss Target Prediction network database,the main active components and potential targets of IN were obtained.Based on this,a component-target network was established by Cytoscape 3.6.1 software.Differentially expressed genes(DGEs)in MDS were obtained from three GEO(Gene Expression Omnibus)gene chips.Then,the protein-protein interaction(PPI)network of DGEs was constructed and analyzed by STRING database and Cytoscape 3.6.1 software.In addition,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)biological enrichment analysis were carried out using REVIGO and KEGG Orthology Based Annotation System(KOBAS)on DGEs,respectively.Identification of IN-MDS compound targets was performed by matching potential targets of active components with disease-related targets.The results of KEGG pathway enrichment analysis were combined with compound targets to screen key targets.In the end,molecular docking was performed by SYBYL-X2.1 to verify the key targets.Results:Nine active components of IN and 439 potential targets of IN were identified by analyzing TCMSP,BATMAN-TCM,and Swiss Target Prediction network databases.Three MDS disease-related gene microarray chips were obtained from the GEO databases:GSE4619,GSE19429,and GSE58831.Through this analysis,87 DEGs were finally obtained using the Venn diagram.A PPI network of DEGs was then constructed,in which 18 genes were upregulated and 69 genes were downregulated.After the GO enrichment results were de-redundant,the representative GO terms were obtained by using REVIGO semantic similarity measuremen.The KEGG biological pathway analysis using the KOBAS indicated that the Hippo signaling pathway is important in MDS.The Hippo signaling pathway involves four genes:AREG,LEF1,SMAD7,and TCF4.By matching and mapping DEGs with potential targets,six IN-MDS compound targets were obtained:PDE4B,PLAUR,ELANE,NR3C1,AREG,and LEF1.We found that AREG and LEF1 are consistent with the genes involved in the Hippo signaling pathway.Through molecular docking simulation,we found that the indican binds best to AREG and LEF1.Conclusion:Based on the integrated pharmacology model,the material basis of the efficacy and biological molecular mechanism of IN in the treatment of MDS was systematically studied,which provided a novel indication of the CAM regimen for the improvement of MDS management.展开更多
Language and culture have been mutually dependent through their history. The moral principle—honesty and integrity isone of the most significant categories of human's culture.The author does a literary review of ...Language and culture have been mutually dependent through their history. The moral principle—honesty and integrity isone of the most significant categories of human's culture.The author does a literary review of the relationship between language andculture. Then she makes an analysis of an empirical study on Chinese and Western concepts of"honesty and integrity".In light ofthe empirical study, the author has found that Chinese mainly come into contact with the idea of"honesty and integrity"from theirparents, while the Westerners learn this concept mostly from school education.展开更多
OBJECTIVE: To evaluate the efficacy of integrated Traditional Chinese Medicine-Western Medicine(TCM-WM) in the treatment of acute onset pulmonary heart disease(PHD).METHODS: A total of 240 patients met the inclusion c...OBJECTIVE: To evaluate the efficacy of integrated Traditional Chinese Medicine-Western Medicine(TCM-WM) in the treatment of acute onset pulmonary heart disease(PHD).METHODS: A total of 240 patients met the inclusion criteria and were enrolled. These inpatients were divided into group A(treatment group) and B(control group) in order of admission according to the principles of randomization and control. The research was performed simultaneously in three hospitals. Two groups were given basic treatment that included: controlled oxygen therapy, active and effective anti-infection, maintaining airway patency,correcting O_2 deficiency and CO_2 retention, correcting acid-base imbalance and electrolyte disturbance, reducing pulmonary hypertension and treating right heart failure, nutritional support and treatment of complications. Group A was given basic treatment and integrated Traditional Chinese Medi-cine(TCM) differentiating therapy; group B was given basic therapy and a placebo that was similar in appearance and taste to TCM medicinal broth of pharmaceutical preparations, provided by Yibin Pharmaceutical Company(Yibin, China, Wuliangye Group).RESULTS: The mortality in the treatment group decreased by 4.98% compared with the control group. The treatment group reported improved ventilation, corrected hypoxemia, improved nutritional status and promoted digestive functions. It also significantly improved the patient's self-life skills, improved the patient's quality of life and could shorten the length of hospital stay.CONCLUSION: Comprehensive integrated TCMWM treatment showed good clinical efficacy toward the acute onset period of PHD patients.展开更多
Objective: To evaluate the efficacy of integrative Chinese and western medicine (ICWM) in treating severe acute respiratory syndrome (SARS) patients. Methods: Through parallel control design, 49 SARS patients were obs...Objective: To evaluate the efficacy of integrative Chinese and western medicine (ICWM) in treating severe acute respiratory syndrome (SARS) patients. Methods: Through parallel control design, 49 SARS patients were observed. Used as control, there were in the western medicine (WM) group 29 patients, who were treated with Ribavirin, Levofloxacin, Thymopentin, Azithromycin, methylprednisolone, etc. , on the basis of 'Recommended Protocol for Infectious Atypical Pneumonia' (abbreviated as 'Recommended Protocol') issueed by Ministry of Health. As the treated group, there were in the ICWM 20 cases. The protocol for treatment of SARS in 'Special Science and Technological Action to Prevent and Treat SARS' (abbreviated as 'Special S-T Action'), issued by Ministry of Science and Technology, together with the same WM as those for the control group. Results: (1) Time from the disease onset to the symptom improvement were 5.10±2. 83 days and 7. 62±2. 27 days in ICWM and WM group respectively, P<0.05; (2) As to corticosteroid (CS) amount and days before reducing dosage, 2 groups showed no significant difference, P>0. 05;(3) There was no significant difference in the time from disease onset to the body temperature normalization and the total amount of CS and the duration of using CS before reducing it to 80 mg between the ICWM group and the WM group; (4) The days and amounts for use CS after reducing between the ICWM group and the WM group were significantly different (P<0. 05). Conclusion: There were obvious advantages in ICWM to treat SARS, compared with that of WM alone, especially in improving the clinical symptoms, promoting the recovery of immune function, promoting the absorption of pulmonary inflammation and reducing the dosage and duration of CS treatment.展开更多
Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treat...Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treatment of S ARS and its influence on the chief indexes in the process of the disease. Methods: The clinical study involving observation of 135 patients of SARS was conducted in the randomized, synchronously controlled and open way. The patients were divided into two groups, 68 in the ICWM group and 67 in the c ontrol group, all of whom were treated with the same basic treatment of western medicine, but to the ICWM group, Chinese drugs for clearing Heat, detoxifying an d removing Dampness were given additionally. The comprehensive effect on relievi ng fever, cell mediated immunity, pulmonary inflammation and secondary infect ion was compared between the two groups. Results: The therapeutic effect in the ICWM group was better than that in the control group in such aspects as steadily lowering body temperature, alleviating general symptoms, accelerating the absorption of pulmonary infiltra tion and easing cellular immunity suppression. Conclusion: The therapeutic effect of ICWM is better in treating SARS than that of western medicine alone.展开更多
On the basis of analyzing the development of suburban forest parks, the paper proposed the combination of eco-city construction and suburban forest parks, and the construction of "mega-landscape" mode, which...On the basis of analyzing the development of suburban forest parks, the paper proposed the combination of eco-city construction and suburban forest parks, and the construction of "mega-landscape" mode, which offers a new concept for the development of suburban forest parks.展开更多
Background: A Randomized Controlled Trial (RCT) has been elaborated where goal directed fluid and hemodynamic therapy (GDFHT) will be realized with trans-thoracic echocardiographic aortic blood flow peak velocity vari...Background: A Randomized Controlled Trial (RCT) has been elaborated where goal directed fluid and hemodynamic therapy (GDFHT) will be realized with trans-thoracic echocardiographic aortic blood flow peak velocity variation (ΔVpeak) and distance minute (DM) to guide fluid therapy and hemodynamics in high risk pediatric surgical patients. This RCT will clarify the impact of GDFHT with ΔVpeak and DM on postoperative outcome in terms of morbidity, length of stay in the intensive care unit (LOSICU), length of mechanical ventilation (LMV) and length of hospital stay (LOS) in children. To determine values of ΔVpeak, DM and VTI predictive of these postoperative outcomes, an observational pilot study will be realized. This pilot study is described here. The primary objective of this study is to determine values of ΔVpeak, DM and ITV predictive of postoperative outcome in children in terms of morbidity. The secondary objectives are to determine values of ΔVpeak, DM and ITV predictive of LOSICU, LMV, LOS, intraoperative, postoperative fluid administration and vasoactive-inotropic therapy. Methods: 500 - 1000 children aged less than 18 years will be included prospectively. Statistic analysis will be realized with XLSTAT 2019.4.2 software or plus. Results and Conclusions: This trial protocol will determine values of ΔVpeak, DM and ITV with echocardiography predictive of postoperative outcome in children.展开更多
This paper collects and synthesizes the technical requirements, implementation, and validation methods for quasi-steady agent-based simulations of interconnectionscale models with particular attention to the integrati...This paper collects and synthesizes the technical requirements, implementation, and validation methods for quasi-steady agent-based simulations of interconnectionscale models with particular attention to the integration of renewable generation and controllable loads. Approaches for modeling aggregated controllable loads are presented and placed in the same control and economic modeling framework as generation resources for interconnection planning studies. Model performance is examined with system parameters that are typical for an interconnection approximately the size of the Western Electricity Coordinating Council(WECC) and a control area about 1/100 the size of the system. These results are used to demonstrate and validate the methods presented.展开更多
Background: In the past we have shown the preservation and improvement of cognitive tasks in depressed and demented patients after 24 and 36 months of combined pharmacological and non-pharmacological treatment. Here w...Background: In the past we have shown the preservation and improvement of cognitive tasks in depressed and demented patients after 24 and 36 months of combined pharmacological and non-pharmacological treatment. Here we present the results of our ongoing, naturalistic study, in the same outpatient setting, at 60 month follow up. Materials and Methods: The study group consisted of 156 medically ill, physically disabled patients with mild to moderate dementia and depression. Patients were treated with antidepressants, cholinesterase inhibitors, and NMDA antagonists, along with their regular medication regimen. Non-pharmacological intervention was centered on a home-based program of physical and cognitive exercises paired with vitamins and supplements (multivitamins, vitamin E, L-methylfolate, alphalipoic acid, acetyl-L-carnitine, omega-3, and coenzyme Q-10) and diet modification. Cognitive assessments were performed yearly. Results: After 60 months of treatment, performance of all tasks remained at or above baseline. The MMSE, Cognistat-Attention, Cognistat-Judgment, and RFFT-Total Unique Designs demonstrated significant improvement. Conclusion: Our results, for the first time, demonstrate arrest in cognitive decline in demented/depressed patients with multiple medical co-morbidities for 60 months. Future investigations addressing the application of a combined, integrative treatment model are warranted.展开更多
Parametric study is carried out in the present article to investigate the unsteady performance of solar energy gain and heat retention of two different integrated-collector-storage systems. The systems are the convent...Parametric study is carried out in the present article to investigate the unsteady performance of solar energy gain and heat retention of two different integrated-collector-storage systems. The systems are the conventional rectangular-shaped storage tank and the modified tank shaped as rectangular cuboid with one semi -circular top. The two systems have the same absorber surface area and volume for water. The heat and fluid flow is assumed to be unsteady, two-dimensional, laminar and incompressible. The performances of the two systems are evaluated based on the maximum temperature in the system during daytime heating period and nighttime cooling period. For comprehensive study, 24 hours simulations for 3 cases with different wall boundary condition impose on the absorber plate are investigated. The simulation results show that the modified system has better heat retain than the conventional system. Periodic variations of both systems are investigated, and it is found that both systems show consistent results on different days. The modified system is able to store most of the thermal energy in the semi-circular top region with higher temperature than that of the conventional system.展开更多
The network integration provides users with a new network with long connection time and a high data rate when needed, but it also brings the defects of all the networks that integrate together into the integrated netw...The network integration provides users with a new network with long connection time and a high data rate when needed, but it also brings the defects of all the networks that integrate together into the integrated network. This will cause all kinds of existing and some new security problems in the operation of the integrated network. A complete protection based on recovery is proposed in the paper. It uses the public-key algorithm to authorize and private-key algorithm to encrypt the communicating data. This solution can provide the system with reliable security, and avoid Denial of Service (DoS) of the user. This solution has been proposed lately, and we should further identify the correct action of all the layers and figure out how to react when a legal node is framed by multiple malicious nodes.展开更多
基金Supported by National Natural Science Foundation of China,No.82174461Hospital Capability Enhancement Project of Xiyuan Hospital,CACMS,No.XYZX0201-22Technology Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A01811.
文摘BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.
基金National Natural Science Foundation of China,No.41230745
文摘Modern physical geography in China grew from Chinese traditional geography and has been profoundly influenced by the geographical disciplines of Euro-America and Russia. Since the 1950 s, integrated studies of physical geography in China have made remarkable progress in the fields of comprehensive physical geographical regionalization, land studies, landscape ecology, and land surface geographical processes. During the past few decades, under the background of global change and rapid socio-economic transformation, a series of environmental and resources problems have boomed in China. To solve these problems and promote the development of integrated studies of physical geography, the following issues were proposed as research priorities：（1） coupling of land surface patterns and processes;（2） integrated research on regional responses and adaptation to global change;（3） analysis of human dimensions of the earth system;（4） ecosystem service research from a geographical perspective;（5） integration of multi-source data and model development;（6） integrated studies on unique geographical units; and（7） important global issues and relevant international programs.
基金the Important Directional Project of Knowledge Innovation of the Chinese Academy of Sciences (No: KZCX2-308-4).
文摘Global change research and sustainable development need to be addressed at larger scales in the light of small scale process studies. Much remains to be done before the small scale, process level understanding of ecosystem responses to global change can be reliably translated to larger scales. The paper reviews the status of scaling issues and tries to find how to extrapolate our observations and our findings at site scale up to regional scale and provide ecological information and interpretations at the regional scale. An integrated approach to scaling-up from site to region is proposed combining hierarchical theory, landscape ecology, remote sensing, geographical information system (GIS) with process/mechanistic modeling. Remote sensing and GIS will play key roles in spatial analysis, integration as well as cross scale modeling.
基金funded by Project Information:2022 Guangzhou Municipal Higher Education Teaching Research and Reform Key Research Project:“Innovation and Practice of English Reading Curriculum Ideological and Political in Colleges and Universities:A Study on the Integration of Understanding Contemporary China:An English Reading and Writing Textbook and English Reading Teaching”(2023JGZDXM001).
文摘Based on the ADDIE model,we explored the integration path between Understanding Contemporary China:An English Reading and Writing Textbook and the main textbook of college English reading.Firstly,the basis of textbook integration was analyzed,followed by an explanation of the overall design scheme of textbook integration,and then a series of teaching resources were initially developed and used in teaching practice.Through testing,it was found that the integrative teaching of the two sets of textbooks under the ADDIE model achieved good teaching results,and promoted the three aspects of reading literacy,disciplinary literacy,and value leadership.
文摘Integrating various data sets to provide one optimal subsurface image is a major goal of geophysicst. In this paper, there is a synergetic approach used to delineate the tectonic-structural framework with analyzing the hydrocarbon reservoir in the Lower Indus Platform basin of Pakistan. The reflected seismic profiles and potential field map constitute the data base of this study. Our study in the line of the previous research is resulted from important oil and gas discoveries contained in the Early Cretaceous and Upper Jurassic formations of the Lower Indus Platform basin area. The result shows trapping mechanism in the Lower Indus Platform basin involves of the fault blocks and stratigraphic traps are present in the area. The more refined images are interpreted to provide greater insight into detailed integrated geophysical study of area.
基金Supported by Scientific Research Fund Project of Yunnan Provincial Department of Education (2023J2034).
文摘According to the Annex Technical Regulations for Integrated Curriculum Development(Trial)in Document No.30 of the General Office of the Ministry of Human Resources and Social Security(2012),this paper studies the formulation of the curriculum standards for the integration of Chinese medicinal materials production.We focus on the formulation ideas of the curriculum standards for the integration of Chinese medicinal materials production,the formulation process of the curriculum standards for the integration of Chinese medicinal materials production,including the description of typical work tasks,the determination of curriculum objectives,the analysis of study content,the description of referential study tasks,teaching implementation suggestions,assessment and evaluation suggestions,which can provide a reference for the development and research of other related integrated courses.
文摘This paper briefly describes the basic situation and features of Three Gorges Cascade, discusses the principle,functions, structure of the integrated automation system, and explains advanced techniques and principle and associated experiments of its monitoring and control
文摘Background:Oral administration of indigo naturalis(IN)is used as a complementary and alternative medicine(CAM)regimen for the treatment of myelodysplastic syndromes(MDS).However,its mechanism of action has not been fully elucidated and needs to be further explored.Methods:By searching the traditional Chinese medicine system and analyzing platforms(TCMSP),bioinformatics analysis tool for the molecular mechanism of traditional Chinese medicine(BATMAN-TCM),and Swiss Target Prediction network database,the main active components and potential targets of IN were obtained.Based on this,a component-target network was established by Cytoscape 3.6.1 software.Differentially expressed genes(DGEs)in MDS were obtained from three GEO(Gene Expression Omnibus)gene chips.Then,the protein-protein interaction(PPI)network of DGEs was constructed and analyzed by STRING database and Cytoscape 3.6.1 software.In addition,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)biological enrichment analysis were carried out using REVIGO and KEGG Orthology Based Annotation System(KOBAS)on DGEs,respectively.Identification of IN-MDS compound targets was performed by matching potential targets of active components with disease-related targets.The results of KEGG pathway enrichment analysis were combined with compound targets to screen key targets.In the end,molecular docking was performed by SYBYL-X2.1 to verify the key targets.Results:Nine active components of IN and 439 potential targets of IN were identified by analyzing TCMSP,BATMAN-TCM,and Swiss Target Prediction network databases.Three MDS disease-related gene microarray chips were obtained from the GEO databases:GSE4619,GSE19429,and GSE58831.Through this analysis,87 DEGs were finally obtained using the Venn diagram.A PPI network of DEGs was then constructed,in which 18 genes were upregulated and 69 genes were downregulated.After the GO enrichment results were de-redundant,the representative GO terms were obtained by using REVIGO semantic similarity measuremen.The KEGG biological pathway analysis using the KOBAS indicated that the Hippo signaling pathway is important in MDS.The Hippo signaling pathway involves four genes:AREG,LEF1,SMAD7,and TCF4.By matching and mapping DEGs with potential targets,six IN-MDS compound targets were obtained:PDE4B,PLAUR,ELANE,NR3C1,AREG,and LEF1.We found that AREG and LEF1 are consistent with the genes involved in the Hippo signaling pathway.Through molecular docking simulation,we found that the indican binds best to AREG and LEF1.Conclusion:Based on the integrated pharmacology model,the material basis of the efficacy and biological molecular mechanism of IN in the treatment of MDS was systematically studied,which provided a novel indication of the CAM regimen for the improvement of MDS management.
文摘Language and culture have been mutually dependent through their history. The moral principle—honesty and integrity isone of the most significant categories of human's culture.The author does a literary review of the relationship between language andculture. Then she makes an analysis of an empirical study on Chinese and Western concepts of"honesty and integrity".In light ofthe empirical study, the author has found that Chinese mainly come into contact with the idea of"honesty and integrity"from theirparents, while the Westerners learn this concept mostly from school education.
文摘OBJECTIVE: To evaluate the efficacy of integrated Traditional Chinese Medicine-Western Medicine(TCM-WM) in the treatment of acute onset pulmonary heart disease(PHD).METHODS: A total of 240 patients met the inclusion criteria and were enrolled. These inpatients were divided into group A(treatment group) and B(control group) in order of admission according to the principles of randomization and control. The research was performed simultaneously in three hospitals. Two groups were given basic treatment that included: controlled oxygen therapy, active and effective anti-infection, maintaining airway patency,correcting O_2 deficiency and CO_2 retention, correcting acid-base imbalance and electrolyte disturbance, reducing pulmonary hypertension and treating right heart failure, nutritional support and treatment of complications. Group A was given basic treatment and integrated Traditional Chinese Medi-cine(TCM) differentiating therapy; group B was given basic therapy and a placebo that was similar in appearance and taste to TCM medicinal broth of pharmaceutical preparations, provided by Yibin Pharmaceutical Company(Yibin, China, Wuliangye Group).RESULTS: The mortality in the treatment group decreased by 4.98% compared with the control group. The treatment group reported improved ventilation, corrected hypoxemia, improved nutritional status and promoted digestive functions. It also significantly improved the patient's self-life skills, improved the patient's quality of life and could shorten the length of hospital stay.CONCLUSION: Comprehensive integrated TCMWM treatment showed good clinical efficacy toward the acute onset period of PHD patients.
基金The study is supporded by The Ministry of Science Technology of 863 Programme "The Developing the Key of Technique and Products for Preventing SARS" (No.2003AA208101)
文摘Objective: To evaluate the efficacy of integrative Chinese and western medicine (ICWM) in treating severe acute respiratory syndrome (SARS) patients. Methods: Through parallel control design, 49 SARS patients were observed. Used as control, there were in the western medicine (WM) group 29 patients, who were treated with Ribavirin, Levofloxacin, Thymopentin, Azithromycin, methylprednisolone, etc. , on the basis of 'Recommended Protocol for Infectious Atypical Pneumonia' (abbreviated as 'Recommended Protocol') issueed by Ministry of Health. As the treated group, there were in the ICWM 20 cases. The protocol for treatment of SARS in 'Special Science and Technological Action to Prevent and Treat SARS' (abbreviated as 'Special S-T Action'), issued by Ministry of Science and Technology, together with the same WM as those for the control group. Results: (1) Time from the disease onset to the symptom improvement were 5.10±2. 83 days and 7. 62±2. 27 days in ICWM and WM group respectively, P<0.05; (2) As to corticosteroid (CS) amount and days before reducing dosage, 2 groups showed no significant difference, P>0. 05;(3) There was no significant difference in the time from disease onset to the body temperature normalization and the total amount of CS and the duration of using CS before reducing it to 80 mg between the ICWM group and the WM group; (4) The days and amounts for use CS after reducing between the ICWM group and the WM group were significantly different (P<0. 05). Conclusion: There were obvious advantages in ICWM to treat SARS, compared with that of WM alone, especially in improving the clinical symptoms, promoting the recovery of immune function, promoting the absorption of pulmonary inflammation and reducing the dosage and duration of CS treatment.
文摘Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treatment of S ARS and its influence on the chief indexes in the process of the disease. Methods: The clinical study involving observation of 135 patients of SARS was conducted in the randomized, synchronously controlled and open way. The patients were divided into two groups, 68 in the ICWM group and 67 in the c ontrol group, all of whom were treated with the same basic treatment of western medicine, but to the ICWM group, Chinese drugs for clearing Heat, detoxifying an d removing Dampness were given additionally. The comprehensive effect on relievi ng fever, cell mediated immunity, pulmonary inflammation and secondary infect ion was compared between the two groups. Results: The therapeutic effect in the ICWM group was better than that in the control group in such aspects as steadily lowering body temperature, alleviating general symptoms, accelerating the absorption of pulmonary infiltra tion and easing cellular immunity suppression. Conclusion: The therapeutic effect of ICWM is better in treating SARS than that of western medicine alone.
基金Sponsored by"Twelfth Five-year Plan"of Jiangxi Provincial Social Sciences Program(14SH05)
文摘On the basis of analyzing the development of suburban forest parks, the paper proposed the combination of eco-city construction and suburban forest parks, and the construction of "mega-landscape" mode, which offers a new concept for the development of suburban forest parks.
文摘Background: A Randomized Controlled Trial (RCT) has been elaborated where goal directed fluid and hemodynamic therapy (GDFHT) will be realized with trans-thoracic echocardiographic aortic blood flow peak velocity variation (ΔVpeak) and distance minute (DM) to guide fluid therapy and hemodynamics in high risk pediatric surgical patients. This RCT will clarify the impact of GDFHT with ΔVpeak and DM on postoperative outcome in terms of morbidity, length of stay in the intensive care unit (LOSICU), length of mechanical ventilation (LMV) and length of hospital stay (LOS) in children. To determine values of ΔVpeak, DM and VTI predictive of these postoperative outcomes, an observational pilot study will be realized. This pilot study is described here. The primary objective of this study is to determine values of ΔVpeak, DM and ITV predictive of postoperative outcome in children in terms of morbidity. The secondary objectives are to determine values of ΔVpeak, DM and ITV predictive of LOSICU, LMV, LOS, intraoperative, postoperative fluid administration and vasoactive-inotropic therapy. Methods: 500 - 1000 children aged less than 18 years will be included prospectively. Statistic analysis will be realized with XLSTAT 2019.4.2 software or plus. Results and Conclusions: This trial protocol will determine values of ΔVpeak, DM and ITV with echocardiography predictive of postoperative outcome in children.
文摘This paper collects and synthesizes the technical requirements, implementation, and validation methods for quasi-steady agent-based simulations of interconnectionscale models with particular attention to the integration of renewable generation and controllable loads. Approaches for modeling aggregated controllable loads are presented and placed in the same control and economic modeling framework as generation resources for interconnection planning studies. Model performance is examined with system parameters that are typical for an interconnection approximately the size of the Western Electricity Coordinating Council(WECC) and a control area about 1/100 the size of the system. These results are used to demonstrate and validate the methods presented.
文摘Background: In the past we have shown the preservation and improvement of cognitive tasks in depressed and demented patients after 24 and 36 months of combined pharmacological and non-pharmacological treatment. Here we present the results of our ongoing, naturalistic study, in the same outpatient setting, at 60 month follow up. Materials and Methods: The study group consisted of 156 medically ill, physically disabled patients with mild to moderate dementia and depression. Patients were treated with antidepressants, cholinesterase inhibitors, and NMDA antagonists, along with their regular medication regimen. Non-pharmacological intervention was centered on a home-based program of physical and cognitive exercises paired with vitamins and supplements (multivitamins, vitamin E, L-methylfolate, alphalipoic acid, acetyl-L-carnitine, omega-3, and coenzyme Q-10) and diet modification. Cognitive assessments were performed yearly. Results: After 60 months of treatment, performance of all tasks remained at or above baseline. The MMSE, Cognistat-Attention, Cognistat-Judgment, and RFFT-Total Unique Designs demonstrated significant improvement. Conclusion: Our results, for the first time, demonstrate arrest in cognitive decline in demented/depressed patients with multiple medical co-morbidities for 60 months. Future investigations addressing the application of a combined, integrative treatment model are warranted.
文摘Parametric study is carried out in the present article to investigate the unsteady performance of solar energy gain and heat retention of two different integrated-collector-storage systems. The systems are the conventional rectangular-shaped storage tank and the modified tank shaped as rectangular cuboid with one semi -circular top. The two systems have the same absorber surface area and volume for water. The heat and fluid flow is assumed to be unsteady, two-dimensional, laminar and incompressible. The performances of the two systems are evaluated based on the maximum temperature in the system during daytime heating period and nighttime cooling period. For comprehensive study, 24 hours simulations for 3 cases with different wall boundary condition impose on the absorber plate are investigated. The simulation results show that the modified system has better heat retain than the conventional system. Periodic variations of both systems are investigated, and it is found that both systems show consistent results on different days. The modified system is able to store most of the thermal energy in the semi-circular top region with higher temperature than that of the conventional system.
文摘The network integration provides users with a new network with long connection time and a high data rate when needed, but it also brings the defects of all the networks that integrate together into the integrated network. This will cause all kinds of existing and some new security problems in the operation of the integrated network. A complete protection based on recovery is proposed in the paper. It uses the public-key algorithm to authorize and private-key algorithm to encrypt the communicating data. This solution can provide the system with reliable security, and avoid Denial of Service (DoS) of the user. This solution has been proposed lately, and we should further identify the correct action of all the layers and figure out how to react when a legal node is framed by multiple malicious nodes.
