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A Two-Stage Feature Selection Method for Text Categorization by Using Category Correlation Degree and Latent Semantic Indexing 被引量:2
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作者 王飞 李彩虹 +2 位作者 王景山 徐娇 李廉 《Journal of Shanghai Jiaotong university(Science)》 EI 2015年第1期44-50,共7页
With the purpose of improving the accuracy of text categorization and reducing the dimension of the feature space,this paper proposes a two-stage feature selection method based on a novel category correlation degree(C... With the purpose of improving the accuracy of text categorization and reducing the dimension of the feature space,this paper proposes a two-stage feature selection method based on a novel category correlation degree(CCD)method and latent semantic indexing(LSI).In the first stage,a novel CCD method is proposed to select the most effective features for text classification,which is more effective than the traditional feature selection method.In the second stage,document representation requires a high dimensionality of the feature space and does not take into account the semantic relation between features,which leads to a poor categorization accuracy.So LSI method is proposed to solve these problems by using statistically derived conceptual indices to replace the individual terms which can discover the important correlative relationship between features and reduce the feature space dimension.Firstly,each feature in our algorithm is ranked depending on their importance of classification using CCD method.Secondly,we construct a new semantic space based on LSI method among features.The experimental results have proved that our method can reduce effectively the dimension of text vector and improve the performance of text categorization. 展开更多
关键词 text categorization feature selection latent semantic indexing(LSI) category correlation degree(CCD)
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Correlation Degree and Correlation Coefficient of Multi-Output Functions 被引量:1
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作者 JUGui-zhi ZHAOYa-qun 《Wuhan University Journal of Natural Sciences》 EI CAS 2005年第1期195-198,共4页
We present definitions of the correlation degree and correlation coefficient of multi-output functions. Two relationships about the correlation degree of multi-output functions are proved. One is between the correlati... We present definitions of the correlation degree and correlation coefficient of multi-output functions. Two relationships about the correlation degree of multi-output functions are proved. One is between the correlation degree and independency, the other is between the correlation degree and balance. Especially the paper discusses the correlation degree of affine multioutput functions. We demonstrate properties of the correlation coefficient of multi-output functions. One is the value range of the correlation coefficient, one is the relationship between the correlation coefficient and independency, and another is the sufficient and necessary condition that two multi-output functions are equivalent to each other. 展开更多
关键词 Key words multi output functions independency correlation degree BALANCE correlation coefficient
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The effects of degree correlations on network topologies and robustness 被引量:1
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作者 赵静 陶林 +3 位作者 俞鸿 骆建华 曹志伟 李亦学 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第12期3571-3580,共10页
Complex networks have been applied to model numerous interactive nonlinear systems in the real world. Knowledge about network topology is crucial to an understanding of the function, performance and evolution of compl... Complex networks have been applied to model numerous interactive nonlinear systems in the real world. Knowledge about network topology is crucial to an understanding of the function, performance and evolution of complex systems. In the last few years, many network metrics and models have been proposed to investigate the network topology, dynamics and evolution. Since these network metrics and models are derived from a wide range of studies, a systematic study is required to investigate the correlations among them. The present paper explores the effect of degree correlation on the other network metrics through studying an ensemble of graphs where the degree sequence (set of degrees) is fixed. We show that to some extent, the characteristic path length, clustering coefficient, modular extent and robustness of networks are directly influenced by the degree correlation. 展开更多
关键词 network dynamics random graphs complex networks degree correlation
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Application of Grey Correlation Degree Analysis in Broad Bean Strain Screening 被引量:1
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作者 Lin ZENG Chunqin WU +6 位作者 Guotian YANG Chaozhong ZHANG Shunsheng LU Yunfei SONG Yan LIU Lamei YANG Guixian WU 《Agricultural Biotechnology》 CAS 2018年第3期49-52,54,共5页
[Objectives] The aim was to clarify the target and approach to purifying and selecting Baoshan Touxinlv broad bean. [Methods] In 2012,5 homozygous strains were selected successfully as the material,and completely rand... [Objectives] The aim was to clarify the target and approach to purifying and selecting Baoshan Touxinlv broad bean. [Methods] In 2012,5 homozygous strains were selected successfully as the material,and completely randomized block arrangement was adopted with 3 repeated trials to analyze the effects of plant height,effective length of podding branches,branch number per plant,pod number per plant,grain number per pod and 100-grain weight on the yield of each plant in the system. [Results] The results showed that the effects of the various factors on the yield of Baoshan broad beans were in the order of grain number per pod 〉 effective length of podding branches 〉 100-grain weight 〉 pod number per plant 〉 branch number per plant 〉 plant height. [Conclusions]In breeding new strains of Baoshan broad beans,under the premise of ensuring the seed nature and quality of the original variety,priority should be given to the gain number per pod and the increment of effective length of podding branches,followed by the pod number per plant,branch number per plant,plant height,which is the best way to breed new strains of Baoshan Touxinlv broad beans. 展开更多
关键词 Touxinlv broad bean strain Economic characters Grey correlation degree ANALYSIS Baoshan
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Three vertex degree correlations of fixed act-size collaboration networks
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作者 雷敏 赵清贵 侯振挺 《Journal of Central South University》 SCIE EI CAS 2011年第3期830-833,共4页
A rate equation approach was presented for the exact computation of the three vertex degree correlations of the fixed act-size collaboration networks.Measurements of the three vertex degree correlations were based on ... A rate equation approach was presented for the exact computation of the three vertex degree correlations of the fixed act-size collaboration networks.Measurements of the three vertex degree correlations were based on a rate equation in the continuous degree and time approximation for the average degree of the nearest neighbors of vertices of degree k,with an appropriate boundary condition.The rate equation proposed can be generalized in more sophisticated growing network models,and also extended to deal with related correlation measurements.Finally,in order to check the theoretical prediction,a numerical example was solved to demonstrate the performance of the degree correlation function. 展开更多
关键词 fixed act-size collaboration networks degree correlation function clustering coefficient Markov chain
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Effect of degree correlation on edge controllability of real networks
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作者 Shu-Lin Liu Shao-Peng Pang 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第10期101-108,共8页
We use the controllability limit theory to study impact of correlation between in- and out-degrees (degree correlation) on edge controllability of real networks. Simulation results and analytic calculations show that ... We use the controllability limit theory to study impact of correlation between in- and out-degrees (degree correlation) on edge controllability of real networks. Simulation results and analytic calculations show that the degree correlation plays an important role in the edge controllability of real networks, especially dense real networks. The upper and lower controllability limits hold for all kinds of real networks. Any edge controllability in between the limits is achievable by properly adjusting the degree correlation. In addition, we find that the edge dynamics in some real networks with positive degree correlation may be difficult to control, and explain the rationality of this anomaly based on the controllability limit theory. 展开更多
关键词 complex network edge controllability degree correlation controllability limit
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An Analytical Approach for Degree Correlations in Complex Network
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作者 Kosuke Takagi 《World Journal of Mechanics》 2012年第3期171-174,共4页
We investigate correlations between neighbor degrees in the scale-free network. According to the empirical studies, it is known that the degree correlations exhibit nontrivial statistical behaviors. With using an anal... We investigate correlations between neighbor degrees in the scale-free network. According to the empirical studies, it is known that the degree correlations exhibit nontrivial statistical behaviors. With using an analytical approach, we show that the scale-freeness and one of statistical laws for degree correlations can be reproduced consistently in a unified framework. Our result would have its importance in understanding the mechanisms which generate the complex network. 展开更多
关键词 SCALE-FREE Network degree DISTRIBUTION degree correlationS POWER LAW
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Correlation analysis of climate comfort degree of tourism and annual variation of tourist flow in Tai’an, Shandong province
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作者 WANG Meng-wen LI Tong +1 位作者 QI Wei WANG Peng-tao 《Ecological Economy》 2019年第3期180-185,共6页
The tourism climate comfort degree can directly affect the trip of tourists,and can determine the length of the tourist season and the development of the tourist projects.In order to explore the relationship between t... The tourism climate comfort degree can directly affect the trip of tourists,and can determine the length of the tourist season and the development of the tourist projects.In order to explore the relationship between the climate comfort degree and the annual variation of tourist flow combined with 1981-2010 climate related data,this paper analyzes the comfort degree of tourism climate in Tai’an,the annual change divide tourist season into high season,shoulder season and off-season.With regression analysis,the correlation between tourism climate comfort degree and annual variation of passenger flow is analyzed.The final result is as follows:As for Tai’an,in May and September the rank of humiditytemperature index(THI)is A,with the most pleasant climate,the most suitable for tourism activities.In April,August and October the rank of THI is B or b,represented as suitable climate,suitable for tourism activities.In June and July,the climate is hot,with a low tourism suitability grade,In February,March and November,the climate is cold,with a poor tourism suitability grade.In January and December the climate is frigid,not suitable for tourism activities.The final conclusion is below:the tourist traffic variation within the year is mainly affected by climate comfort effect.The elastic coefficient is 0.927%.In addition,the tourist traffic variation within the year is also affected by the summer vacation,the Golden Week and the impact of preferential policies.All the above provide a scientific basis for the prediction of Tai’an’s tourist flow in a year,the development of tourism and tourist scenic management. 展开更多
关键词 CLIMATE COMFORT degree TOURIST flow correlation analysis Tai’an
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Predicting Macroscopic Properties of Amorphous Monolayer Carbon via Pair Correlation Function
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作者 Mouyang Cheng Chenyan Wang +4 位作者 Chenxin Qin Yuxiang Zhang Qingyuan Zhang Han Li Ji Chen 《Chinese Physics Letters》 2025年第6期78-101,共24页
Establishing the structure-property relationship in amorphous materials has been a long-term grand challenge due to the lack of a unified description of the degree of disorder.In this work,we develop SPRamNet,a neural... Establishing the structure-property relationship in amorphous materials has been a long-term grand challenge due to the lack of a unified description of the degree of disorder.In this work,we develop SPRamNet,a neural network based machine-learning pipeline that effectively predicts structure-property relationship of amorphous material via global descriptors.Applying SPRamNet on the recently discovered amorphous monolayer carbon,we successfully predict the thermal and electronic properties.More importantly,we reveal that a short range of pair correlation function can readily encode sufficiently rich information of the structure of amorphous material.Utilizing powerful machine learning architectures,the encoded information can be decoded to reconstruct macroscopic properties involving many-body and long-range interactions.Establishing this hidden relationship offers a unified description of the degree of disorder and eliminates the heavy burden of measuring atomic structure,opening a new avenue in studying amorphous materials. 展开更多
关键词 neural network machine learning amorphous materials global descriptorsapplying amorphous monolayer carbonwe degree disorderin amorphous material pair correlation function
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Application of grey weighted related degree to the ambient air quality assessment 被引量:3
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作者 孟宪林 沈晋 +1 位作者 孙丽欣 吕晓莹 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2006年第4期395-397,共3页
It is difficult to establish the integrated method to assess the ambient air quality because the atmospheric environmental system is composed of several environmental elements, which contains many contanination factor... It is difficult to establish the integrated method to assess the ambient air quality because the atmospheric environmental system is composed of several environmental elements, which contains many contanination factors. In view of the typical grey system character of the monitored data in the ambient air, this paper introduces the weighted value to obtain related degree during applying the method of grey related degree analvsis to assess ambient air quality by each polluting factor producing different effects on the environment quality. This method could give more reasonable and reliable evaluating results. Taking the monitored data of Harbin, a provincial city of Heilongjiang, for example in this paper, the result of assessment by this method was coincide,It with the actual environmental quality of Harbin. 展开更多
关键词 grey correlated degree environmental assessment weighting
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The Changes of Fiscal Agriculture-Supporting Expenditure and Farmers'Income Based on Grey Correlation Theory 被引量:2
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作者 LIU Yao-sen 《Asian Agricultural Research》 2011年第3期92-95,共4页
According to the relevant data of China Statistical Yearbook and Chinese Rural Statistical Yearbook in the year of 2009,the changes of grey correlation degree of farmers'net income,various items of incomes,nationa... According to the relevant data of China Statistical Yearbook and Chinese Rural Statistical Yearbook in the year of 2009,the changes of grey correlation degree of farmers'net income,various items of incomes,national gross agriculture-supporting expenditure and various items of expenditures,farmers'net income and various items of fiscal agriculture-supporting expenditure in the Eighth Five-Year Plan,Ninth Five-Year Plan and Tenth Five-Year Plan by using grey correlation degree and the by choosing seven indicators covering income from wage and salary,income from household business,transfer income and property income,agricultural production-supporting expenditure,agricultural basic construction expenditure,expenses of three items of agricultural technology and the fee of rural relief.The results show that the grey correlation degree of each time period and household net income shows the downward trend;from overall perspective,the grey correlation degree of national gross agriculture-supporting expenditure,agricultural basic construction expenditure and agricultural production-supporting expenditure shows the descending trend;the grey correlation degree of fiscal agricultural supporting expenditure and the expenditure of three items of agricultural technology and fee of rural relief show the upward trend;the influence of agricultural production-supporting expenditure on farmers'income shows downward trend;the influence of agricultural basic construction on farmers'income shows upward trend;the fee of rural relief play an active role in the promoting the farmers'income increase;the role played by fee of rural relief in promoting farmers'income increase should be further increased;the increase of farmers'income shows great reliance on agricultural science and technology.In the end,the relevant suggestions on establishing stable increase mechanism of fiscal agricultural support and insisting on the dynamic adjustment of the structure of fiscal agricultural supporting capital are put forward. 展开更多
关键词 Fiscal agricultural-supporting expenditure Farmers'income Grey correlation degree Grey correlation analysis China
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Characterization of the pairwise correlations in different quantum networks consisting of four-wave mixers and beamsplitters
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作者 祁健 忻俊 +1 位作者 王海龙 荆杰泰 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第7期153-160,共8页
We investigate the performances of the pairwise correlations(PCs) in different quantum networks consisting of fourwave mixers(FWMs) and beamsplitters(BSs). PCs with quantum correlation in different quantum netwo... We investigate the performances of the pairwise correlations(PCs) in different quantum networks consisting of fourwave mixers(FWMs) and beamsplitters(BSs). PCs with quantum correlation in different quantum networks can be verified by calculating the degree of relative intensity squeezing for any pair of all the output fields. More interestingly, the quantum correlation recovery and enhancement are present in the FWM+BS network and the repulsion effect phenomena(signal(idler)-frequency mode cannot be quantum correlated with the other two idler(signal)-frequency modes simultaneously)between the PCs with quantum correlation are predicted in the FWM + FWM and FWM + FWM + FWM networks. Our results presented here pave the way for the manipulation of the quantum correlation in quantum networks. 展开更多
关键词 pairwise correlation four-wave mixer degree of relative intensity squeezing quantum network
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Determining the degree of saturation of rocks as a function of time:A case study from mountainous area of Turkey
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作者 Serhat DAG 《Journal of Mountain Science》 SCIE CSCD 2018年第10期2307-2319,共13页
The aim of this study is to scrutinize whether, in terms of saturation, the 48 hour duration suggested by ISRM(International Society for Rock Mechanics) methods and ASTM(American Society for Testing and Materials) sta... The aim of this study is to scrutinize whether, in terms of saturation, the 48 hour duration suggested by ISRM(International Society for Rock Mechanics) methods and ASTM(American Society for Testing and Materials) standard in rocks is sufficient or not, and to examine how the degree of saturation of rocks may be determined as a function of time. For this purpose, samples from five different rock groups including igneous(andesite, granite, andesitic tuff) and sedimentary(limestone, sandstone) exposed in Gümü?hane city which is from mountainous area of north-eastern Turkey, have been compiled. Measurements were taken on the samples left for saturation under laboratory conditions as a result of which the degree of saturation values at the end of these time periods were determined. Similarly, at the end of 48 hours, the samples were left to dry under atmospheric conditions in the laboratory environment and their time dependent degree of saturation were also calculated at different times. The changes as a function of time in the degree of saturation were then examined mathematically using non-linear, exponential and logarithmic functions. Graphs and equations related with the acquired time-degree of saturation values and the correlation coefficient(r) values for these equalities have indicated a high accordance between time and degree of saturation for the studied rock groups. The applied methodology will be beneficial for determining the degree of saturation based on time for engineering studies that will be carried out in similar lithologies. 展开更多
关键词 degree of saturation POROSITY TIME correlation coefficient
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Analysis on the Change Characteristics of the Correlation between Land Use Structure and Energy Consumption and Carbon Emissions in Kunming from 1997 to 2017
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作者 Li Zhang Ping Wang 《Journal of Geoscience and Environment Protection》 2021年第6期155-166,共12页
This study takes Kunming City, Yunnan Province, China as the research area, to provide reference basis for revealing the change law of land use structure and energy consumption and carbon emissions in Kunming, optimiz... This study takes Kunming City, Yunnan Province, China as the research area, to provide reference basis for revealing the change law of land use structure and energy consumption and carbon emissions in Kunming, optimizing land use structure and realizing the development of low-carbon city. Based on the data of land use structure and energy consumption in Kunming from 1997 to 2017, based on the estimation of total energy consumption carbon emissions, carbon intensity and per capita carbon emissions, the correlation between land use structure and energy consumption carbon emissions in Kunming has been calculated and analyzed in the past 20 years. Results: 1) The total amount of carbon emissions in Kunming has increased significantly in the past 20 years. It increased from 34.46 × 10</span><sup><span style="font-family:Verdana;">5</span></sup><span style="font-family:Verdana;"> t to 95.09 × 10</span><sup><span style="font-family:Verdana;">5</span></sup><span style="font-family:Verdana;"> t, an increase of about 2.8 times. 2) The types of land use with the highest correlation between land use structure and total carbon emissions of energy consumption, carbon emission intensity and per capita carbon emissions are urban and village and industrial and mining land (0.8258), cultivated land (0.8733) and garden land (0.7971) respectively. 3) The correlation between construction land and total carbon emissions is greater than that of agricultural land. Conclusion: There is a close correlation between land use structure and carbon emissions from energy consumption in Kunming. 展开更多
关键词 Kunming City Land Use Structure Energy Consumption Carbon Emissions correlation degree
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A Correlation Analysis of Tourism Based on Gray Theory——A case of Xingwen County
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作者 WEI Ya-li HUI Wei WANG Li-guo 《四川地质学报》 2009年第S1期133-139,共7页
Tourism industry has already become an important part of national economy,which not only played a positive role in the development of the economy,but promoted the adjustment and optimization of industrial structure.Th... Tourism industry has already become an important part of national economy,which not only played a positive role in the development of the economy,but promoted the adjustment and optimization of industrial structure.The paper analyzes the correlation between the tourism industry and the other industry through changes of the Xingwen County tourism industrial output value in the past seven years.With the Gray Model,the correlation degree among the tourism industry and agriculture,industry,transport,wholesale and retail trade,postal and telecommunications industries is measured.The analysis result indicates that the order of the corresponding correlation degree:catering accommodation is 0.691>wholesale and retail is 0.617>agriculture is 0.616>Postal and telecommunications industry is 0.610>Transport is 0.602>Industry is 0.537.In accordance with the actual conditions of the industry in Xingwen,the industrial development policies and measures are put forward,which help the tourism industry Xingwen their rapid,coordinated and highly efficient operation. 展开更多
关键词 Tourism industry Enterprise Relationship Gray relational model correlation degree.
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基于空域抑制与轨迹关联优化的目标跟踪算法
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作者 陈志旺 高一铭 +2 位作者 吕昌昊 刘禄阳 彭勇 《控制与决策》 北大核心 2026年第1期165-174,共10页
传统目标跟踪算法更新模板的方式较为单一,无法在目标发生剧烈形变时有效更新,易导致算法对于剧烈形变和遮挡场景适应性不足.鉴于此,提出一种基于空域抑制与轨迹关联优化的目标跟踪方法.首先,在特征提取部分采用改进后的ResNet-50网络,... 传统目标跟踪算法更新模板的方式较为单一,无法在目标发生剧烈形变时有效更新,易导致算法对于剧烈形变和遮挡场景适应性不足.鉴于此,提出一种基于空域抑制与轨迹关联优化的目标跟踪方法.首先,在特征提取部分采用改进后的ResNet-50网络,引入空域抑制注意力(SIA),通过设计能量函数为具有空域抑制效应的神经元优化权重分配,增强对目标特征的关注强度;然后,加入选择性查询回忆策略(SQR),将Transformer训练重点放在后期阶段,避免解码器缺乏训练重点和多层解码结构的级联错误;接着,构建长期-短期-轨迹框架(LST),引入轨迹关联度(DTC),在传统模板更新算法的基础上加入DTC预测头,通过最小成本流算法(MCF)建模全局轨迹关联性,并使用连续二次规划进行反向传播,更新轨迹参考模板;最后,在GOT-10k、LaSOT、TrackingNet、NfS30、UAV123和OTB100等公开数据集上进行实验评估,实验结果验证了所提出算法的有效性. 展开更多
关键词 目标跟踪 Transformer结构 空域抑制注意力 选择性查询回忆 轨迹关联度 最小成本流
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双螺杆挤出胶粉活化度影响因素的灰色关联分析
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作者 李波 窦晖 +4 位作者 李晓民 李良英 刘朋光 刘鹏英 李冬娜 《兰州交通大学学报》 2026年第2期1-11,共11页
为了分析不同类型胶粉在不同双螺杆挤出工艺下内部物质、分子量及特征官能团等微观结构的变化情况及其对活化度的影响程度,以小车胎和大车胎为胶粉母料,通过调控活化助剂掺量、活化温度等双螺杆挤出工艺制备活化胶粉。采用索氏抽提法测... 为了分析不同类型胶粉在不同双螺杆挤出工艺下内部物质、分子量及特征官能团等微观结构的变化情况及其对活化度的影响程度,以小车胎和大车胎为胶粉母料,通过调控活化助剂掺量、活化温度等双螺杆挤出工艺制备活化胶粉。采用索氏抽提法测定胶粉的活化度,结合热重分析、凝胶渗透色谱和红外光谱分析不同工艺条件下胶粉活化的微观参数变化。在此基础上,引入灰色关联度分析方法,量化了影响双螺杆挤出胶粉活化度的宏微观因素。结果表明:可溶物质含量反映了胶粉在活化过程中的降解程度,其含量变化与活化度呈正相关;重均分子量和大分子量占比从分子链断裂的角度揭示了胶粉活化的本质,分子链断裂越多,大分子量物质脱落进入溶胶,重均分子量和大分子量占比增加,活化度也相应提高;主链和交联键峰强的降低表明活化过程中化学键的断裂是胶粉恢复反应活性的关键,其断裂程度与活化度高度相关;灰色关联分析得到影响大、小车胎胶粉活化度排序分别由大到小排序依次是:重均分子量、加工温度、可溶物质含量、交联键峰强度、主链峰强度、大分子量占比、脱硫助剂掺量,加工温度、大分子量占比、重均分子量、交联键峰强度、可溶物质含量、主链峰强度、脱硫助剂掺量。 展开更多
关键词 活化度 双螺杆挤出 灰色关联 活化胶粉 微观结构
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自由贸易区与港口互动分析——基于东南国际航运中心的实证研究
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作者 杨阿妮 《物流科技》 2026年第7期65-69,共5页
自贸区是我国深化开放的新平台,港口是连接世界的重要节点,自贸区的设立对于港口而言是一次重要机遇。文章以厦门自贸区和厦门港的发展数据为基础,研究区港互动关系,通过二者的耦合协调度分析,论证自贸区与港口之间的相互关联情况,然后... 自贸区是我国深化开放的新平台,港口是连接世界的重要节点,自贸区的设立对于港口而言是一次重要机遇。文章以厦门自贸区和厦门港的发展数据为基础,研究区港互动关系,通过二者的耦合协调度分析,论证自贸区与港口之间的相互关联情况,然后通过灰色关联度分析,确定自贸区各评价指标对港口各评价指标的影响程度,进而提出发展建议。 展开更多
关键词 厦门自贸区 厦门港 耦合协调度 灰色关联度
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基于超高效液相色谱及网络药理学的淫羊藿成分分析及质量标志物预测分析
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作者 刘晓燕 谢君 +2 位作者 柳春娣 孟颖 张月婵 《中南药学》 2026年第2期119-127,共9页
目的基于超高效液相色谱(UPLC)和网络药理学方法,分析淫羊藿的成分并预测其质量标志物(Q-Marker)。方法采用UPLC测定淫羊藿中15种化学成分的含量,并基于灰色关联度分析评价淫羊藿药材的质量,通过SwissTargetPrediction数据库获得淫羊藿... 目的基于超高效液相色谱(UPLC)和网络药理学方法,分析淫羊藿的成分并预测其质量标志物(Q-Marker)。方法采用UPLC测定淫羊藿中15种化学成分的含量,并基于灰色关联度分析评价淫羊藿药材的质量,通过SwissTargetPrediction数据库获得淫羊藿关键靶点,利用STRING数据库获得各蛋白之间的相互关系,使用DAVID数据库对淫羊藿关键靶点进行基因本体论(GO)和京都基因与基因组百科全书(KEGG)通路富集分析,利用Cytoscape 3.9.1软件构建成分-靶点、蛋白-蛋白相互作用、靶点-通路网络。结果建立了UPLC同时测定淫羊藿中淫羊藿苷等15种化学成分含量的方法,经网络药理学分析,筛选得到23个淫羊藿潜在活性成分,涉及185个潜在作用靶点和20条关键作用通路。初步预测淫羊藿苷、朝藿定C、淫羊藿苷A 3个成分为淫羊藿的Q-Marker。结论本研究建立了淫羊藿UPLC含量测定方法,预测淫羊藿Q-Marker,为其质量控制及药理作用研究奠定基础。 展开更多
关键词 淫羊藿 超高效液相色谱 化学成分 灰色关联度 网络药理学 质量标志物
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