Objective:The aim of our study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging(DMRI)in predicting early response to neoadjuvant chemotherapy(NAC)in patients with locally advanced breast...Objective:The aim of our study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging(DMRI)in predicting early response to neoadjuvant chemotherapy(NAC)in patients with locally advanced breast cancer(LABC)and to assess the accuracy of DMRI in evaluating residual disease after NAC.Methods:DMRI were per-formed in 43 women with LABC(44 lesions,all were invasive ductal carcinoma)before,after the first and final cycle of NAC.Tumour volume,early enhanced ratio(El),maximum enhanced ratio(Emax),and maximum enhanced time(Tmax),dynamic signal intensity-time curve were obtained during treatment.Residual tumour volumes obtained using DMRI were compared with pathological findings to assess the accuracy of DMRI.Results:After 1st cycle of NAC,the mean volume of responders decreased insignificantly,P〉0.05,but after NAC,mean volume of residual tumor decreased significantly(P〈0.01).Morphol-ogy change:29 cases showed a concentric shrinkage pattern while 7 cases showed a dendritic shrinkage pattern.Significant differences were found in El,Emax and Tmax between responders and non-responders(P〈0.05).After 1st cycle of NAC,El,Emax and Tmax of responders changed significantly(P〈0.001);while there is no significant change in non-responders(P〉0.05).After NAC,dynamic signal intensity-time types were changed in responders,and tended to be significantly flat-tening,while no significant change was found in non-responders.The residual tumour volume correlation coefficient between DMRI and pathology measurements was very high(r=0.866,P=0.000).Conclusion:DMRI is useful to evaluate the early response to NAC in LABC.The presence and volume of residual disease in LABC patients treated with NAC could be ac-curately evaluated by DMRI.展开更多
文摘Objective:The aim of our study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging(DMRI)in predicting early response to neoadjuvant chemotherapy(NAC)in patients with locally advanced breast cancer(LABC)and to assess the accuracy of DMRI in evaluating residual disease after NAC.Methods:DMRI were per-formed in 43 women with LABC(44 lesions,all were invasive ductal carcinoma)before,after the first and final cycle of NAC.Tumour volume,early enhanced ratio(El),maximum enhanced ratio(Emax),and maximum enhanced time(Tmax),dynamic signal intensity-time curve were obtained during treatment.Residual tumour volumes obtained using DMRI were compared with pathological findings to assess the accuracy of DMRI.Results:After 1st cycle of NAC,the mean volume of responders decreased insignificantly,P〉0.05,but after NAC,mean volume of residual tumor decreased significantly(P〈0.01).Morphol-ogy change:29 cases showed a concentric shrinkage pattern while 7 cases showed a dendritic shrinkage pattern.Significant differences were found in El,Emax and Tmax between responders and non-responders(P〈0.05).After 1st cycle of NAC,El,Emax and Tmax of responders changed significantly(P〈0.001);while there is no significant change in non-responders(P〉0.05).After NAC,dynamic signal intensity-time types were changed in responders,and tended to be significantly flat-tening,while no significant change was found in non-responders.The residual tumour volume correlation coefficient between DMRI and pathology measurements was very high(r=0.866,P=0.000).Conclusion:DMRI is useful to evaluate the early response to NAC in LABC.The presence and volume of residual disease in LABC patients treated with NAC could be ac-curately evaluated by DMRI.
