Climate change is accelerating globally,raising significant concerns regarding the environmental risks associated with combined sewer overflows(CSOs).These rainfall events lead to the excessive discharge of multiple p...Climate change is accelerating globally,raising significant concerns regarding the environmental risks associated with combined sewer overflows(CSOs).These rainfall events lead to the excessive discharge of multiple pollutants into natural waters.However,greenhouse gas(GHG)emissions from CSOs,which are crucial for carbon neutrality in urban water systems,remain fragmented.Using the life-cycle assess-ment method expansion approach,this study breaks down the formation and discharge processes of CSOs and uncovers the underlying mechanisms driving GHG emissions during each period.Given the complex-ity and uncertainty in the spatial distribution of GHG emissions from CSOs,the development of standard monitoring and estimation methods is vital.This study identifies the factors influencing GHG emissions within the urban drainage system(UDS)and defines the interactive GHG emission boundaries and accounting framework related to CSOs.This framework is expanded to consider the hybrid nature of urban engineering and hydraulic interactions during the CSO events.Advanced modeling technologies have emerged as essential tools for predicting and managing GHG emissions from CSOs.This review pro-motes comprehensive data-driven methods for predicting GHG emissions from CSOs,fully considering the inherent heterogeneity of CSOs and the impact of multi-source contaminants discharged into aquatic environments.It emphasizes refining emission boundary definitions,novel accounting practices adapting data-driven methods,and comprehensive management strategies in line with the move toward carbon neutrality in the UDS.It advocates the adoption of solutions including advanced technologies and artifi-cial intelligent methods to mitigate CSO-related GHG emissions,stressing the significance of integrating low-carbon solutions and a comprehensive data-driven management framework in future research directions.展开更多
An integrated energy service company in an industrial park or commercial building is responsible for managing all energy sources in their local region, including electricity, water, gas, heating, and cooling. To reduc...An integrated energy service company in an industrial park or commercial building is responsible for managing all energy sources in their local region, including electricity, water, gas, heating, and cooling. To reduce energy wastage and increase energy utilization, it is necessary to perform efficiency analyses and diagnoses on integrated energy systems(IESs). However, the integrated energy data necessary for energy efficiency analyses and diagnoses come from a wide variety of instruments, each of which uses different transmission protocols and data formats. This makes it challenging to handle energy-flow data in a unified manner. Thus, we have constructed a unified model for diagnosing energy usage abnormalities in IESs. Using this model, the data are divided into working days and non-working days, and benchmark values are calculated after the data have been weighted to enable unified analysis of several types of energy data. The energy-flow data may then be observed, managed, and compared in all aspects to monitor sudden changes in energy usage and energy wastage. The abnormal data identified and selected by the unified model are then subjected to big-data analysis using technical management tools, enabling the detection of user problems such as abnormalities pertaining to acquisition device, metering, and energy usage. This model facilitates accurate metering of energy data and improves energy efficiency. The study has significant implications in terms of fulfilling the energy saving.展开更多
Water level prediction of river runoff is an important part of hydrological forecasting.The change of water level not only has the trend and seasonal characteristics,but also contains the noise factors.And the water l...Water level prediction of river runoff is an important part of hydrological forecasting.The change of water level not only has the trend and seasonal characteristics,but also contains the noise factors.And the water level prediction ability of a single model is limited.Since the traditional ARIMA(Autoregressive Integrated Moving Average)model is not accurate enough to predict nonlinear time series,and the WNN(Wavelet Neural Network)model requires a large training set,we proposed a new combined neural network prediction model which combines the WNN model with the ARIMA model on the basis of wavelet decomposition.The combined model fit the wavelet transform sequences whose frequency are high with the WNN,and the scale transform sequence which has low frequency is fitted by the ARIMA model,and then the prediction results of the above are reconstructed by wavelet transform.The daily average water level data of the Liuhe hydrological station in the Chu River Basin of Nanjing are used to forecast the average water level of one day ahead.The combined model is compared with other single models with MATLAB,and the experimental results show that the accuracy of the combined model is improved by 7%compared with the traditional wavelet network under the appropriate wavelet decomposition function and the combined model parameters.展开更多
Accurate prognosis prediction is essential for guiding cancer treatment and improving patient outcomes.While recent studies have demonstrated the potential of histopathological images in survival analysis,existing mod...Accurate prognosis prediction is essential for guiding cancer treatment and improving patient outcomes.While recent studies have demonstrated the potential of histopathological images in survival analysis,existing models are typically developed in a cancerspecific manner,lack extensive external validation,and often rely on molecular data that are not routinely available in clinical practice.To address these limitations,we present PROGPATH,a unified model capable of integrating histopathological image features with routinely collected clinical variables to achieve pancancer prognosis prediction.PROGPATH employs a weakly supervised deep learning architecture built upon the foundation model for image encoding.Morphological features are aggregated through an attention-guided multiple instance learning module and fused with clinical information via a cross-attention transformer.A router-based classification strategy further refines the prediction performance.PROGPATH was trained on 7999 whole-slide images(WSIs)from 6,670 patients across 15 cancer types,and extensively validated on 17 external cohorts with a total of 7374 WSIs from 4441 patients,covering 12 cancer types from 8 consortia and institutions across three continents.PROGPATH achieved consistently superior performance compared with state-of-the-art multimodal prognosis prediction models.It demonstrated strong generalizability across cancer types and robustness in stratified subgroups,including early-and advancedstage patients,treatment cohorts(radiotherapy and pharmaceutical therapy),and biomarker-defined subsets.We further provide model interpretability by identifying pathological patterns critical to PROGPATH’s risk predictions,such as the degree of cell differentiation and extent of necrosis.Together,these results highlight the potential of PROGPATH to support pancancer outcome prediction and inform personalized cancer management strategies.展开更多
负荷预测是综合能源系统(integrated energy system,IES)高效运行的前提,面对综合能源系统多元负荷强耦合相关性、强随机性的特点,单一模型在运行负荷特征提取方面存在不足。为充分利用负荷间的相关性、降低负荷数据的非平稳性、弥补单...负荷预测是综合能源系统(integrated energy system,IES)高效运行的前提,面对综合能源系统多元负荷强耦合相关性、强随机性的特点,单一模型在运行负荷特征提取方面存在不足。为充分利用负荷间的相关性、降低负荷数据的非平稳性、弥补单一模型的不足,提出一种基于TCN-TPABiLSTM组合模型和多任务学习框架的IES多元负荷超短期协同预测方法。首先对负荷间耦合相关性、负荷时间相关性和负荷影响因素进行分析以构建模型输入,再通过变分模态分解将负荷数据分解为一定数量的模态以降低非平稳性,最后以TCN-TPA-BiLSTM组合模型作为多任务学习框架的共享层进行预测。通过实际数据进行验证和对比,结果表明该方法能够充分发挥模型各部分优势,相较于其他模型也获得了更优的结果。展开更多
针对燃气-蒸汽联合循环且余热锅炉不补燃的热电联产机组(combined power and heat unit,CHP),首先,基于能量守恒建立天然气流量与电力电压、电流的等值关系,进而考虑功率进行变换的物理特性,构建CHP的气电变换等效电路;考虑功率进行传...针对燃气-蒸汽联合循环且余热锅炉不补燃的热电联产机组(combined power and heat unit,CHP),首先,基于能量守恒建立天然气流量与电力电压、电流的等值关系,进而考虑功率进行变换的物理特性,构建CHP的气电变换等效电路;考虑功率进行传递、释放的物理特性,构建CHP的气热转换、烟气排放及运行热损失方程;据此,确立CHP的物理特性等值模型,并定义该模型“以热定电”和“以电定热”策略下的控制参量。其次,利用牛顿法和管网水力计算基本原理,推导电潮流和气、热能流的修正方程及其雅可比元素表达式,提出计及CHP固有特性参数随系统运行状态变化的气-电-热混合能流统一分析方法。最后,通过具有不同CHP控制策略的气-电-热混合系统,验证所提方法的有效性及可行性。展开更多
基金supported by the National Natural Science Foun-dation of China(52325001,52170009,and 52400114)the National Key Research and Development Program of China(2021YFC3200700 and 2021YFC3200702)+1 种基金the Program of Shanghai Academic Research Leader,China(21XD1424000)the Fundamental Research Funds for the Central Universities.
文摘Climate change is accelerating globally,raising significant concerns regarding the environmental risks associated with combined sewer overflows(CSOs).These rainfall events lead to the excessive discharge of multiple pollutants into natural waters.However,greenhouse gas(GHG)emissions from CSOs,which are crucial for carbon neutrality in urban water systems,remain fragmented.Using the life-cycle assess-ment method expansion approach,this study breaks down the formation and discharge processes of CSOs and uncovers the underlying mechanisms driving GHG emissions during each period.Given the complex-ity and uncertainty in the spatial distribution of GHG emissions from CSOs,the development of standard monitoring and estimation methods is vital.This study identifies the factors influencing GHG emissions within the urban drainage system(UDS)and defines the interactive GHG emission boundaries and accounting framework related to CSOs.This framework is expanded to consider the hybrid nature of urban engineering and hydraulic interactions during the CSO events.Advanced modeling technologies have emerged as essential tools for predicting and managing GHG emissions from CSOs.This review pro-motes comprehensive data-driven methods for predicting GHG emissions from CSOs,fully considering the inherent heterogeneity of CSOs and the impact of multi-source contaminants discharged into aquatic environments.It emphasizes refining emission boundary definitions,novel accounting practices adapting data-driven methods,and comprehensive management strategies in line with the move toward carbon neutrality in the UDS.It advocates the adoption of solutions including advanced technologies and artifi-cial intelligent methods to mitigate CSO-related GHG emissions,stressing the significance of integrating low-carbon solutions and a comprehensive data-driven management framework in future research directions.
基金supported by National Key Research and Development Program of China (No.2017YFB903304)the State Grid Science and Technology Program (Hybrid Simnlation Key Technology for Integrated Energy System and Platform Construction)
文摘An integrated energy service company in an industrial park or commercial building is responsible for managing all energy sources in their local region, including electricity, water, gas, heating, and cooling. To reduce energy wastage and increase energy utilization, it is necessary to perform efficiency analyses and diagnoses on integrated energy systems(IESs). However, the integrated energy data necessary for energy efficiency analyses and diagnoses come from a wide variety of instruments, each of which uses different transmission protocols and data formats. This makes it challenging to handle energy-flow data in a unified manner. Thus, we have constructed a unified model for diagnosing energy usage abnormalities in IESs. Using this model, the data are divided into working days and non-working days, and benchmark values are calculated after the data have been weighted to enable unified analysis of several types of energy data. The energy-flow data may then be observed, managed, and compared in all aspects to monitor sudden changes in energy usage and energy wastage. The abnormal data identified and selected by the unified model are then subjected to big-data analysis using technical management tools, enabling the detection of user problems such as abnormalities pertaining to acquisition device, metering, and energy usage. This model facilitates accurate metering of energy data and improves energy efficiency. The study has significant implications in terms of fulfilling the energy saving.
文摘Water level prediction of river runoff is an important part of hydrological forecasting.The change of water level not only has the trend and seasonal characteristics,but also contains the noise factors.And the water level prediction ability of a single model is limited.Since the traditional ARIMA(Autoregressive Integrated Moving Average)model is not accurate enough to predict nonlinear time series,and the WNN(Wavelet Neural Network)model requires a large training set,we proposed a new combined neural network prediction model which combines the WNN model with the ARIMA model on the basis of wavelet decomposition.The combined model fit the wavelet transform sequences whose frequency are high with the WNN,and the scale transform sequence which has low frequency is fitted by the ARIMA model,and then the prediction results of the above are reconstructed by wavelet transform.The daily average water level data of the Liuhe hydrological station in the Chu River Basin of Nanjing are used to forecast the average water level of one day ahead.The combined model is compared with other single models with MATLAB,and the experimental results show that the accuracy of the combined model is improved by 7%compared with the traditional wavelet network under the appropriate wavelet decomposition function and the combined model parameters.
基金supported in part by the National Cancer Institute under award numbers R01CA268287A1,U01CA269181,R01CA26820701A1,R01CA249992-01A1,R01CA202752-01A1,R01CA208236-01A1,R01CA216579-01A1,R01CA220581-01A1,R01CA257612-01A1,1U01CA239055-01,1U01CA248226-01,1U54CA254566-01National Heart,Lung and Blood Institute 1R01HL15127701A1,R01HL15807101A1+8 种基金National Institute of Biomedical Imaging and Bioengineering 1R43EB028736-01VA Merit Review Award IBX004121A from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service the Office of the Assistant Secretary of Defense for Health Affairs,through the Breast Cancer Research Program(W81XWH-19-1-0668)the Prostate Cancer Research Program(W81XWH-20-1-0851)the Lung Cancer Research Program(W81XWH-18-1-0440,W81XWH-20-1-0595)the Peer Reviewed Cancer Research Program(W81XWH-18-1-0404,W81XWH-21-1-0345,W81XWH-211-0160)the Kidney Precision Medicine Project(KPMP)Glue Grant and sponsored research agreements from Bristol Myers-Squibb,Boehringer-Ingelheim,Eli-Lilly and Astrazenecasupported in part by the National Natural Science Foundation of China general program(No.61571314)the Sichuan University-Yibin City Strategic Cooperation Special Fund(No.2020CDYB-27)Support Program of Sichuan Science and Technology Department(No.2023YFS0327-LH).
文摘Accurate prognosis prediction is essential for guiding cancer treatment and improving patient outcomes.While recent studies have demonstrated the potential of histopathological images in survival analysis,existing models are typically developed in a cancerspecific manner,lack extensive external validation,and often rely on molecular data that are not routinely available in clinical practice.To address these limitations,we present PROGPATH,a unified model capable of integrating histopathological image features with routinely collected clinical variables to achieve pancancer prognosis prediction.PROGPATH employs a weakly supervised deep learning architecture built upon the foundation model for image encoding.Morphological features are aggregated through an attention-guided multiple instance learning module and fused with clinical information via a cross-attention transformer.A router-based classification strategy further refines the prediction performance.PROGPATH was trained on 7999 whole-slide images(WSIs)from 6,670 patients across 15 cancer types,and extensively validated on 17 external cohorts with a total of 7374 WSIs from 4441 patients,covering 12 cancer types from 8 consortia and institutions across three continents.PROGPATH achieved consistently superior performance compared with state-of-the-art multimodal prognosis prediction models.It demonstrated strong generalizability across cancer types and robustness in stratified subgroups,including early-and advancedstage patients,treatment cohorts(radiotherapy and pharmaceutical therapy),and biomarker-defined subsets.We further provide model interpretability by identifying pathological patterns critical to PROGPATH’s risk predictions,such as the degree of cell differentiation and extent of necrosis.Together,these results highlight the potential of PROGPATH to support pancancer outcome prediction and inform personalized cancer management strategies.
文摘负荷预测是综合能源系统(integrated energy system,IES)高效运行的前提,面对综合能源系统多元负荷强耦合相关性、强随机性的特点,单一模型在运行负荷特征提取方面存在不足。为充分利用负荷间的相关性、降低负荷数据的非平稳性、弥补单一模型的不足,提出一种基于TCN-TPABiLSTM组合模型和多任务学习框架的IES多元负荷超短期协同预测方法。首先对负荷间耦合相关性、负荷时间相关性和负荷影响因素进行分析以构建模型输入,再通过变分模态分解将负荷数据分解为一定数量的模态以降低非平稳性,最后以TCN-TPA-BiLSTM组合模型作为多任务学习框架的共享层进行预测。通过实际数据进行验证和对比,结果表明该方法能够充分发挥模型各部分优势,相较于其他模型也获得了更优的结果。
文摘针对燃气-蒸汽联合循环且余热锅炉不补燃的热电联产机组(combined power and heat unit,CHP),首先,基于能量守恒建立天然气流量与电力电压、电流的等值关系,进而考虑功率进行变换的物理特性,构建CHP的气电变换等效电路;考虑功率进行传递、释放的物理特性,构建CHP的气热转换、烟气排放及运行热损失方程;据此,确立CHP的物理特性等值模型,并定义该模型“以热定电”和“以电定热”策略下的控制参量。其次,利用牛顿法和管网水力计算基本原理,推导电潮流和气、热能流的修正方程及其雅可比元素表达式,提出计及CHP固有特性参数随系统运行状态变化的气-电-热混合能流统一分析方法。最后,通过具有不同CHP控制策略的气-电-热混合系统,验证所提方法的有效性及可行性。
